product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE/Cyanine7 anti-mouse Ly-6A/E (Sca-1)
catalog :
108113
quantity :
25 μg
price :
102 USD
clonality :
monoclonal
host :
rat
conjugate :
PE/Cy7
clone name :
D7
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 104
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 1a
Jin Y, Sun X, Pei F, Zhao Z, Mao J. Wnt16 signaling promotes osteoblast differentiation of periosteal derived cells in vitro and in vivo. Peerj. 2020;8:e10374 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1a
Han Y, Liu Q, Hou J, Gu Y, Zhang Y, Chen Z, et al. Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression. Cell. 2018;173:634-648.e12 pubmed publisher
  • flow cytometry; mouse; fig 6a
Aryal B, Rotllan N, Araldi E, Ramírez C, He S, Chousterman B, et al. ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression. Nat Commun. 2016;7:12313 pubmed publisher
  • flow cytometry; mouse
García Prat L, Martínez Vicente M, Perdiguero E, Ortet L, Rodríguez Ubreva J, Rebollo E, et al. Autophagy maintains stemness by preventing senescence. Nature. 2016;529:37-42 pubmed publisher
  • flow cytometry; mouse; fig 3
Sakamoto H, Takeda N, Arai F, Hosokawa K, García P, Suda T, et al. Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes. Stem Cells. 2015;33:479-90 pubmed publisher
  • flow cytometry; mouse
Mise Omata S, Alles N, Fukazawa T, Aoki K, Ohya K, Jimi E, et al. NF-?B RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation. Int Immunol. 2014;26:607-18 pubmed publisher
  • flow cytometry; mouse
Sousa Victor P, Gutarra S, García Prat L, Rodriguez Ubreva J, Ortet L, Ruiz Bonilla V, et al. Geriatric muscle stem cells switch reversible quiescence into senescence. Nature. 2014;506:316-21 pubmed publisher
Bobadilla Mu xf1 oz M, Orbe J, Abizanda G, Machado F, Vilas A, Ullate Agote A, et al. Loss of the matrix metalloproteinase-10 causes premature features of aging in satellite cells. Front Cell Dev Biol. 2023;11:1128534 pubmed publisher
Pioli K, Lau K, Pioli P. Thymus antibody-secreting cells possess an interferon gene signature and are preferentially expanded in young female mice. iScience. 2023;26:106223 pubmed publisher
Huang D, Han Y, Tang T, Yang L, Jiang P, Qian W, et al. Dlk1 maintains adult mice long-term HSCs by activating Notch signaling to restrict mitochondrial metabolism. Exp Hematol Oncol. 2023;12:11 pubmed publisher
Moiseeva V, Cisneros A, Sica V, Deryagin O, Lai Y, Jung S, et al. Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration. Nature. 2023;613:169-178 pubmed publisher
Haase C, Gustafsson K, Mei S, Yeh S, Richter D, Milosević J, et al. Image-seq: spatially resolved single-cell sequencing guided by in situ and in vivo imaging. Nat Methods. 2022;19:1622-1633 pubmed publisher
Matsumura T, Totani H, Gunji Y, Fukuda M, Yokomori R, Deng J, et al. A Myb enhancer-guided analysis of basophil and mast cell differentiation. Nat Commun. 2022;13:7064 pubmed publisher
Yoshinaga M, Han K, Morgens D, Horii T, Kobayashi R, Tsuruyama T, et al. The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity. Nat Commun. 2022;13:6435 pubmed publisher
Hong X, Isern J, Campanario S, Perdiguero E, Ram xed rez Pardo I, Segal xe9 s J, et al. Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy. Cell Stem Cell. 2022;29:1298-1314.e10 pubmed publisher
Wu J, Zhang B, Li S, Chen W, Mao J, Li K, et al. Peptidoglycan-Mediated Bone Marrow Autonomic Neuropathy Impairs Hematopoietic Stem/Progenitor Cells via a NOD1-Dependent Pathway in db/db Mice. Stem Cells Int. 2022;2022:4249843 pubmed publisher
Gupta S, Dovey O, Domingues A, Cyran O, Cash C, Giotopoulos G, et al. Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis. Sci Adv. 2022;8:eabn4886 pubmed publisher
Kinkel S, Liu J, Beck T, Breslin K, Iminitoff M, Hickey P, et al. Epigenetic modifier SMCHD1 maintains a normal pool of long-term hematopoietic stem cells. iScience. 2022;25:104684 pubmed publisher
Omatsu Y, Aiba S, Maeta T, Higaki K, Aoki K, Watanabe H, et al. Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells. Nat Commun. 2022;13:2654 pubmed publisher
Wang D, Tanaka Yano M, Meader E, Kinney M, Morris V, Lummertz da Rocha E, et al. Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis. Cell Rep. 2022;39:110587 pubmed publisher
G xf3 mez Salinero J, Izzo F, Lin Y, Houghton S, Itkin T, Geng F, et al. Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction. Cell Stem Cell. 2022;29:593-609.e7 pubmed publisher
Chavez J, Rabe J, Hernandez G, Mills T, Niño K, Davizon Castillo P, et al. PU.1 Expression Defines Distinct Functional Activities in the Phenotypic HSC Compartment of a Murine Inflammatory Stress Model. Cells. 2022;11: pubmed publisher
Fielding C, García García A, Korn C, Gadomski S, Fang Z, Reguera J, et al. Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis. Nat Commun. 2022;13:543 pubmed publisher
Wang S, Ren D, Arkoun B, Kaushik A, Matherat G, Lecluse Y, et al. Lyl-1 regulates primitive macrophages and microglia development. Commun Biol. 2021;4:1382 pubmed publisher
Hoffman D, Tevet Y, Trzebanski S, Rosenberg G, Vainman L, Solomon A, et al. A non-classical monocyte-derived macrophage subset provides a splenic replication niche for intracellular Salmonella. Immunity. 2021;54:2712-2723.e6 pubmed publisher
Shen Y, Jiang L, Iyer V, Raposo B, Dubnovitsky A, Boddul S, et al. A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system. Comput Struct Biotechnol J. 2021;19:5360-5370 pubmed publisher
Zhang B, Vogelzang A, Miyajima M, Sugiura Y, Wu Y, Chamoto K, et al. B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity. Nature. 2021;599:471-476 pubmed publisher
Zheng Z, Li Y, Jia S, Zhu M, Cao L, Tao M, et al. Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3. Nat Commun. 2021;12:6202 pubmed publisher
Man N, Mas G, Karl D, Sun J, Liu F, Yang Q, et al. p300 suppresses the transition of myelodysplastic syndromes to acute myeloid leukemia. JCI Insight. 2021;6: pubmed publisher
Cho K, Ushiki T, Ishiguro H, Tamura S, Araki M, Suwabe T, et al. Altered microbiota by a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic SOCS3 deficiency. iScience. 2021;24:103117 pubmed publisher
Beauchamp E, Leventhal M, Bernard E, Hoppe E, Todisco G, Creignou M, et al. ZBTB33 is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing. Blood Cancer Discov. 2021;2:500-517 pubmed publisher
Kim S, Srivatsan S, Chavez M, Shirai C, White B, Ahmed T, et al. Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice. Cell Rep. 2021;36:109626 pubmed publisher
Jütte B, Krollmann C, Cieslak K, Koerber R, Boor P, Graef C, et al. Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency. iScience. 2021;24:102833 pubmed publisher
Chappaz S, McArthur K, Kealy L, Law C, Tailler M, Lane R, et al. Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells. Cell Rep. 2021;36:109430 pubmed publisher
Ankawa R, Goldberger N, Yosefzon Y, Koren E, Yusupova M, Rösner D, et al. Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration. Dev Cell. 2021;56:1900-1916.e5 pubmed publisher
Gutiérrez Gutiérrez Ó, Felix D, Salvetti A, Amro E, Thems A, Pietsch S, et al. Regeneration in starved planarians depends on TRiC/CCT subunits modulating the unfolded protein response. EMBO Rep. 2021;22:e52905 pubmed publisher
Liu F, Zhang X, Peng Y, Zhang L, Yu Y, Hua P, et al. miR-24 controls the regenerative competence of hair follicle progenitors by targeting Plk3. Cell Rep. 2021;35:109225 pubmed publisher
Dell Orso S, Juan A, Moiseeva V, García Prat L, Munoz Canoves P, Sartorelli V. Protocol for RNA-seq library preparation starting from a rare muscle stem cell population or a limited number of mouse embryonic stem cells. STAR Protoc. 2021;2:100451 pubmed publisher
Bota Rabassedas N, Banerjee P, Niu Y, Cao W, Luo J, Xi Y, et al. Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity. Cell Rep. 2021;35:109009 pubmed publisher
Yi W, Zhang Y, Liu B, Zhou Y, Liao D, Qiao X, et al. Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration. Cell Rep. 2021;34:108922 pubmed publisher
Jassinskaja M, Pimková K, Arh N, Johansson E, Davoudi M, Pereira C, et al. Ontogenic shifts in cellular fate are linked to proteotype changes in lineage-biased hematopoietic progenitor cells. Cell Rep. 2021;34:108894 pubmed publisher
Kang M, Thalji G, Huang C, Shirazi S, Lu Y, Ravindran S, et al. Macrophage Control of Incipient Bone Formation in Diabetic Mice. Front Cell Dev Biol. 2020;8:596622 pubmed publisher
Mohrin M, Liu J, Zavala Solorio J, Bhargava S, Maxwell Trumble J, Brito A, et al. Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells. Aging Cell. 2021;20:e13313 pubmed publisher
Campanario S, Ram xed rez Pardo I, Hong X, Isern J, Mu xf1 oz C xe1 noves P. Assessing Autophagy in Muscle Stem Cells. Front Cell Dev Biol. 2020;8:620409 pubmed publisher
Dong S, Wang Q, Kao Y, Díaz A, Tasset I, Kaushik S, et al. Chaperone-mediated autophagy sustains haematopoietic stem-cell function. Nature. 2021;591:117-123 pubmed publisher
Wang L, Yu S, Chan E, Chen K, Liu C, Che D, et al. Notch-Regulated Dendritic Cells Restrain Inflammation-Associated Colorectal Carcinogenesis. Cancer Immunol Res. 2021;9:348-361 pubmed publisher
Onai N, Ogasawara C. Calcium Pyrophosphate Dihydrate Crystals Increase the Granulocyte/Monocyte Progenitor (GMP) and Enhance Granulocyte and Monocyte Differentiation In Vivo. Int J Mol Sci. 2020;22: pubmed publisher
Arai F, Stumpf P, Ikushima Y, Hosokawa K, Roch A, Lutolf M, et al. Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal. Cell Syst. 2020;11:640-652.e5 pubmed publisher
Zaro B, Noh J, Mascetti V, Demeter J, George B, Zukowska M, et al. Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells. elife. 2020;9: pubmed publisher
Nosho S, Tosa I, Ono M, Hara E, Ishibashi K, Mikai A, et al. Distinct Osteogenic Potentials of BMP-2 and FGF-2 in Extramedullary and Medullary Microenvironments. Int J Mol Sci. 2020;21: pubmed publisher
Montel Hagen A, Sun V, Casero D, Tsai S, Zampieri A, Jackson N, et al. In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells. Cell Rep. 2020;33:108320 pubmed publisher
Dagher T, Maslah N, Edmond V, Cassinat B, Vainchenker W, Giraudier S, et al. JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML. J Exp Med. 2021;218: pubmed publisher
Tripathi H, Al Darraji A, Abo Aly M, Peng H, Shokri E, Chelvarajan L, et al. Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction. J Mol Cell Cardiol. 2020;149:95-114 pubmed publisher
Zhang C, Xu Z, Yang S, Sun G, Jia L, Zheng Z, et al. tagHi-C Reveals 3D Chromatin Architecture Dynamics during Mouse Hematopoiesis. Cell Rep. 2020;32:108206 pubmed publisher
Lerbs T, Cui L, King M, Chai T, Muscat C, Chung L, et al. CD47 prevents the elimination of diseased fibroblasts in scleroderma. JCI Insight. 2020;5: pubmed publisher
Hacein Bey Abina S, Estienne M, Bessoles S, Echchakir H, Pederzoli Ribeil M, Chiron A, et al. Erythropoietin is a major regulator of thrombopoiesis in thrombopoietin-dependent and -independent contexts. Exp Hematol. 2020;88:15-27 pubmed publisher
Iwanami N, Takeshita K, Lawir D, Suetake I, Tajima S, Sikora K, et al. Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1. iScience. 2020;23:101260 pubmed publisher
Kwok I, Becht E, Xia Y, Ng M, Teh Y, Tan L, et al. Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor. Immunity. 2020;: pubmed publisher
Bellomo A, Mondor I, Spinelli L, Lagueyrie M, Stewart B, Brouilly N, et al. Reticular Fibroblasts Expressing the Transcription Factor WT1 Define a Stromal Niche that Maintains and Replenishes Splenic Red Pulp Macrophages. Immunity. 2020;53:127-142.e7 pubmed publisher
Christin J, Wang C, Chung C, Liu Y, Dravis C, Tang W, et al. Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer. Cell Rep. 2020;31:107742 pubmed publisher
Azazmeh N, Assouline B, Winter E, Ruppo S, Nevo Y, Maly A, et al. Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation. Nat Commun. 2020;11:2711 pubmed publisher
Witkowski M, Dolgalev I, Evensen N, Ma C, Chambers T, Roberts K, et al. Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2020;37:867-882.e12 pubmed publisher
Yokomizo Nakano T, Kubota S, Bai J, Hamashima A, Morii M, Sun Y, et al. Overexpression of RUNX3 Represses RUNX1 to Drive Transformation of Myelodysplastic Syndrome. Cancer Res. 2020;80:2523-2536 pubmed publisher
Jin J, Jung I, Moon S, Jeon S, Jeong S, Sonn S, et al. CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b-CD103+ DCs. Cell Rep. 2020;30:4124-4136.e5 pubmed publisher
Lang J, Bohn P, Bhat H, Jastrow H, Walkenfort B, Cansiz F, et al. Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease. Nat Commun. 2020;11:1338 pubmed publisher
Domingues A, Kulkarni R, Giotopoulos G, Gupta S, Vinnenberg L, Arede L, et al. Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells. elife. 2020;9: pubmed publisher
Kang Y, Pietras E, Passegue E. Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia. J Exp Med. 2020;217: pubmed publisher
Stifter S, Bhattacharyya N, Sawyer A, Cootes T, Stambas J, Doyle S, et al. Visualizing the Selectivity and Dynamics of Interferon Signaling In Vivo. Cell Rep. 2019;29:3539-3550.e4 pubmed publisher
Viny A, Bowman R, Liu Y, Lavallée V, Eisman S, Xiao W, et al. Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation. Cell Stem Cell. 2019;25:682-696.e8 pubmed publisher
Gu W, Nowak W, Xie Y, Le Bras A, Hu Y, Deng J, et al. Single-Cell RNA-Sequencing and Metabolomics Analyses Reveal the Contribution of Perivascular Adipose Tissue Stem Cells to Vascular Remodeling. Arterioscler Thromb Vasc Biol. 2019;39:2049-2066 pubmed publisher
Yamashita M, Passegue E. TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration. Cell Stem Cell. 2019;: pubmed publisher
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Goldstein J, Tabebordbar M, Zhu K, Wang L, Messemer K, Peacker B, et al. In Situ Modification of Tissue Stem and Progenitor Cell Genomes. Cell Rep. 2019;27:1254-1264.e7 pubmed publisher
Kubota S, Tokunaga K, Umezu T, Yokomizo Nakano T, Sun Y, Oshima M, et al. Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm. Nat Commun. 2019;10:1653 pubmed publisher
Barman P, Pang J, Urao N, Koh T. Skin Wounding-Induced Monocyte Expansion in Mice Is Not Abrogated by IL-1 Receptor 1 Deficiency. J Immunol. 2019;202:2720-2727 pubmed publisher
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Tan D, Li Y, Yang C, Li J, Tan S, Chin D, et al. PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells. Cell Rep. 2019;26:2316-2328.e6 pubmed publisher
Yoshida H, Lareau C, Ramirez R, Rose S, Maier B, Wroblewska A, et al. The cis-Regulatory Atlas of the Mouse Immune System. Cell. 2019;176:897-912.e20 pubmed publisher
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Chen Z, Amro E, Becker F, Holzer M, Rasa S, Njeru S, et al. Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation. J Exp Med. 2019;216:152-175 pubmed publisher
Nakamura Ishizu A, Matsumura T, Stumpf P, Umemoto T, Takizawa H, Takihara Y, et al. Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation. Cell Rep. 2018;25:1772-1785.e6 pubmed publisher
Youssif C, Cubillos Rojas M, Comalada M, Llonch E, Perna C, Djouder N, et al. Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis. EMBO Mol Med. 2018;10: pubmed publisher
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product information
Antigen :
Ly-6A/E
Apps. Abbrev. :
FC
Cat # :
108113
Clone :
D7
Item :
PE/Cyanine7 anti-mouse Ly-6A/E (Sca-1)
Isotype :
Rat IgG2a, κ
Other Names :
Sca-1
Size :
25 μg
Price (USD) :
102 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PE_CYANINE7
Immunogen :
IL-2-dependent mouse T-cell line (CTL-L)
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA