product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE anti-mouse Ly-6A/E (Sca-1)
catalog :
108108
quantity :
200 μg
price :
293 USD
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
D7
reactivity :
mouse, rat
application :
flow cytometry
more info or order :
citations: 64
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...
Yang M, Li C, Xiao Y, Guo Q, Huang Y, Su T, et al. Ophiopogonin D promotes bone regeneration by stimulating CD31hi EMCNhi vessel formation. Cell Prolif. 2020;53:e12784 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig s1a
LaFleur M, Nguyen T, Coxe M, Yates K, Trombley J, Weiss S, et al. A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system. Nat Commun. 2019;10:1668 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...
Lu X, Chen Q, Rong Y, Yang G, Li C, Xu N, et al. LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells. Nat Commun. 2016;7:12719 pubmed publisher
  • flow cytometry; rat; fig 4
Zhao W, Wang C, Liu R, Wei C, Duan J, Liu K, et al. Effect of TGF-β1 on the Migration and Recruitment of Mesenchymal Stem Cells after Vascular Balloon Injury: Involvement of Matrix Metalloproteinase-14. Sci Rep. 2016;6:21176 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Koh F, Lizama C, Wong P, Hawkins J, Zovein A, Ramalho Santos M. Emergence of hematopoietic stem and progenitor cells involves a Chd1-dependent increase in total nascent transcription. Proc Natl Acad Sci U S A. 2015;112:E1734-43 pubmed publisher
  • flow cytometry; mouse; fig 1
Li C, Cheng P, Liang M, Chen Y, Lu Q, Wang J, et al. MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation. J Clin Invest. 2015;125:1509-22 pubmed publisher
  • flow cytometry; mouse; fig 3
Sakamoto H, Takeda N, Arai F, Hosokawa K, García P, Suda T, et al. Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes. Stem Cells. 2015;33:479-90 pubmed publisher
Zhou Y, Ye Z, Wei W, Zhang M, Huang F, Li J, et al. Macrophages maintain mammary stem cell activity and mammary homeostasis via TNF-α-PI3K-Cdk1/Cyclin B1 axis. NPJ Regen Med. 2023;8:23 pubmed publisher
Xiao Y, Cai G, Feng X, Li Y, Guo W, Guo Q, et al. Splicing factor YBX1 regulates bone marrow stromal cell fate during aging. EMBO J. 2023;42:e111762 pubmed publisher
Sang H, Zhao R, Lai G, Deng Z, Zhuang W, Wu M, et al. Bone marrow mesenchymal stem cell-derived exosomes attenuate the maturation of dendritic cells and reduce the rejection of allogeneic transplantation. Adv Clin Exp Med. 2023;32:551-561 pubmed publisher
Guan H, Zhang W, Xie D, Nie Y, Chen S, Sun X, et al. Cytosolic Release of Mitochondrial DNA and Associated cGAS Signaling Mediates Radiation-Induced Hematopoietic Injury of Mice. Int J Mol Sci. 2023;24: pubmed publisher
Han X, Mei Y, Mishra R, Bi H, Jain A, Schiltz G, et al. Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models. J Clin Invest. 2023;133: pubmed publisher
Guo J, Wang F, Hu Y, Luo Y, Wei Y, Xu K, et al. Exosome-based bone-targeting drug delivery alleviates impaired osteoblastic bone formation and bone loss in inflammatory bowel diseases. Cell Rep Med. 2023;4:100881 pubmed publisher
Gómez Salinero J, Itkin T, Houghton S, Badwe C, Lin Y, Kalna V, et al. Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis. Nat Cardiovasc Res. 2022;1:882-899 pubmed publisher
Kobayashi S, Ogasawara N, Watanabe S, Yoneyama Y, Kirino S, Hiraguri Y, et al. Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation. Inflamm Regen. 2022;42:49 pubmed publisher
Yoshida K, Satoh Y, Uchimura A, Misumi M, Kyoizumi S, Taga M, et al. Massive expansion of multiple clones in the mouse hematopoietic system long after whole-body X-irradiation. Sci Rep. 2022;12:17276 pubmed publisher
Hutter K, R xfc licke T, Szabó T, Andersen L, Villunger A, Herzog S. The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression. Front Immunol. 2022;13:967914 pubmed publisher
Cui Z, Wu H, Xiao Y, Xu T, Jia J, Lin H, et al. Endothelial PDGF-BB/PDGFR-β signaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation. Bone Res. 2022;10:58 pubmed publisher
Li Y, Shen Z, Jiang X, Wang Y, Yang Z, Mao Y, et al. Mouse mesenchymal stem cell-derived exosomal miR-466f-3p reverses EMT process through inhibiting AKT/GSK3β pathway via c-MET in radiation-induced lung injury. J Exp Clin Cancer Res. 2022;41:128 pubmed publisher
Li J, Li X, Sun W, Zhang J, Yan Q, Wu J, et al. Specific overexpression of SIRT1 in mesenchymal stem cells rescues hematopoiesis niche in BMI1 knockout mice through promoting CXCL12 expression. Int J Biol Sci. 2022;18:2091-2103 pubmed publisher
Xu X, Li Y, Shi L, He K, Sun Y, Ding Y, et al. Myeloid-derived growth factor (MYDGF) protects bone mass through inhibiting osteoclastogenesis and promoting osteoblast differentiation. EMBO Rep. 2022;23:e53509 pubmed publisher
Flommersfeld S, B xf6 ttcher J, Ersching J, Flossdorf M, Meiser P, Pachmayr L, et al. Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection. Immunity. 2021;54:2288-2304.e7 pubmed publisher
Marinescu C, Preda M, Burlacu A. A procedure for in vitro evaluation of the immunosuppressive effect of mouse mesenchymal stem cells on activated T cell proliferation. Stem Cell Res Ther. 2021;12:319 pubmed publisher
Young K, Eudy E, Bell R, Loberg M, Stearns T, Sharma D, et al. Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging. Cell Stem Cell. 2021;28:1473-1482.e7 pubmed publisher
Hu Y, Li X, Zhang Q, Gu Z, Luo Y, Guo J, et al. Exosome-guided bone targeted delivery of Antagomir-188 as an anabolic therapy for bone loss. Bioact Mater. 2021;6:2905-2913 pubmed publisher
Oka Y, Hamada M, Nakazawa Y, Muramatsu H, Okuno Y, Higasa K, et al. Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome. Sci Adv. 2020;6: pubmed publisher
Wang L, Chen R, Li G, Wang Z, Liu J, Liang Y, et al. FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping. Cell Metab. 2020;32:860-877.e9 pubmed publisher
Ha T, Stahlhut M, Rothe M, Paul G, Dziadek V, Morgan M, et al. Multiple Genes Surrounding Bcl-xL, a Common Retroviral Insertion Site, Can Influence Hematopoiesis Individually or in Concert. Hum Gene Ther. 2021;32:458-472 pubmed publisher
Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, et al. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. Brain Commun. 2020;2:fcaa133 pubmed publisher
Phan Q, Fine G, Salz L, Herrera G, Wildman B, Driskell I, et al. Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds. elife. 2020;9: pubmed publisher
Zelco A, Rocha Ferreira E, Nazmi A, Ardalan M, Chumak T, Nilsson G, et al. Type 2 Innate Lymphoid Cells Accumulate in the Brain After Hypoxia-Ischemia but Do Not Contribute to the Development of Preterm Brain Injury. Front Cell Neurosci. 2020;14:249 pubmed publisher
Li Z, Fu X, Chai C, Sun F, Xiao F, Huang Y, et al. A single copy of large tumor suppressor 1 or large tumor suppressor 2 is sufficient for normal hematopoiesis. Chin Med J (Engl). 2020;133:1943-1951 pubmed publisher
Kwiecien K, Brzoza P, Bak M, Majewski P, Skulimowska I, Bednarczyk K, et al. The methylation status of the chemerin promoter region located from - 252 to + 258 bp regulates constitutive but not acute-phase cytokine-inducible chemerin expression levels. Sci Rep. 2020;10:13702 pubmed publisher
Ludwik K, Sandusky Z, Stauffer K, Li Y, Boyd K, O Doherty G, et al. RSK2 Maintains Adult Estrogen Homeostasis by Inhibiting ERK1/2-Mediated Degradation of Estrogen Receptor Alpha. Cell Rep. 2020;32:107931 pubmed publisher
Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, et al. m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development. Immunity. 2020;52:1007-1021.e8 pubmed publisher
Bao Z, Li J, Zhang P, Pan Q, Liu B, Zhu J, et al. Toll-Like Receptor 3 Activator Preconditioning Enhances Modulatory Function of Adipose‑Derived Mesenchymal Stem Cells in a Fully MHC-Mismatched Murine Model of Heterotopic Heart Transplantation. Ann Transplant. 2020;25:e921287 pubmed publisher
Wu R, Liu C, Deng X, Chen L, Hao S, Ma L. Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells. J Cell Mol Med. 2020;24:1684-1699 pubmed publisher
Tran N, Sommermann T, Graf R, Trombke J, Pempe J, Petsch K, et al. Efficient CRISPR/Cas9-Mediated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells. Cell Rep. 2019;28:3510-3522.e5 pubmed publisher
Maluski M, Ghosh A, Herbst J, Scholl V, Baumann R, Huehn J, et al. Chimeric antigen receptor-induced BCL11B suppression propagates NK-like cell development. J Clin Invest. 2019;129:5108-5122 pubmed publisher
Woods B, Chen W, Chiu S, Marinaccio C, Fu C, Gu L, et al. Activation of JAK/STAT signaling in megakaryocytes sustains myeloproliferation in vivo. Clin Cancer Res. 2019;: pubmed publisher
Wilkinson A, Ishida R, Kikuchi M, Sudo K, Morita M, Crisostomo R, et al. Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation. Nature. 2019;: pubmed publisher
Hughes R, Simons B, Khan H, Miller R, Kugler V, Torquato S, et al. Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression. Cancer Res. 2019;: pubmed publisher
Nowlan B, Williams E, Doran M, Levesque J. CD27, CD201, FLT3, CD48, and CD150 cell surface staining identifies long-term mouse hematopoietic stem cells in immunodeficient non-obese diabetic severe combined immune deficient derived strains. Haematologica. 2019;: pubmed publisher
Vannini N, Campos V, Girotra M, Trachsel V, Rojas Sutterlin S, Tratwal J, et al. The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance. Cell Stem Cell. 2019;24:405-418.e7 pubmed publisher
Li J, Wada S, Weaver L, Biswas C, Behrens E, Arany Z. Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis. JCI Insight. 2019;5: pubmed publisher
Chen Z, Amro E, Becker F, Holzer M, Rasa S, Njeru S, et al. Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation. J Exp Med. 2019;216:152-175 pubmed publisher
Li C, Xiao Y, Yang M, Su T, Sun X, Guo Q, et al. Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging. J Clin Invest. 2018;128:5251-5266 pubmed publisher
Li Z, Liu S, Xu J, Zhang X, Han D, Liu J, et al. Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors. Immunity. 2018;49:640-653.e5 pubmed publisher
Hamanaka S, Umino A, Sato H, Hayama T, Yanagida A, Mizuno N, et al. Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation. Stem Cell Reports. 2018;11:988-997 pubmed publisher
Golan K, Kumari A, Kollet O, Khatib Massalha E, Subramaniam M, Ferreira Z, et al. Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance. Cell Stem Cell. 2018;23:572-585.e7 pubmed publisher
Sun J, He X, Zhu Y, Ding Z, Dong H, Feng Y, et al. SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function. Cell Stem Cell. 2018;23:355-369.e9 pubmed publisher
Miura Y, Matsui S, Miyata N, Harada K, Kikkawa Y, Ohmuraya M, et al. Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration. elife. 2018;7: pubmed publisher
Wang X, Chu Q, Jiang X, Yu Y, Wang L, Cui Y, et al. Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway. Cell Death Dis. 2018;9:578 pubmed publisher
Zhao J, Zhou X, Tang Q, Yu R, Yu S, Long Y, et al. BMAL1 Deficiency Contributes to Mandibular Dysplasia by Upregulating MMP3. Stem Cell Reports. 2018;10:180-195 pubmed publisher
Ge Q, Zhang H, Hou J, Wan L, Cheng W, Wang X, et al. VEGF secreted by mesenchymal stem cells mediates the differentiation of endothelial progenitor cells into endothelial cells via paracrine mechanisms. Mol Med Rep. 2017;: pubmed publisher
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Schwörer S, Becker F, Feller C, Baig A, Köber U, Henze H, et al. Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals. Nature. 2016;540:428-432 pubmed publisher
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Sieveking D, Lim P, Chow R, Dunn L, Bao S, McGrath K, et al. A sex-specific role for androgens in angiogenesis. J Exp Med. 2010;207:345-52 pubmed publisher
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product information
Antigen :
Ly-6A/E
Apps. Abbrev. :
FC
Cat # :
108108
Clone :
D7
Item :
PE anti-mouse Ly-6A/E (Sca-1)
Isotype :
Rat IgG2a, κ
Other Names :
Sca-1
Size :
200 μg
Price (USD) :
293 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PE
Immunogen :
IL-2-dependent mouse T-cell line (CTL-L)
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA