Ultra-LEAF™ Purified anti-mouse TCR γ/δ | BioLegend 107515 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Ultra-LEAF™ Purified anti-mouse TCR γ/δ

catalog :

107515

quantity :

100 μg

price :

110 USD

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

UC7-13D5

The same clone is also sold as:

US Biological: T2040-06L
Bio X Cell: BE0070-50MG, BE0070-5MG, BE0070-25MG, BE0070-1MG, BE0070-100MG
Invitrogen: A15406, 11-5811-85, MA5-28830, 16-5811-38, A15407, 16-5811-85, 11-5811-82, 16-5811-050, 13-5811-85, 13-5811-82, 16-5811-025

reactivity :

mouse

application :

immunoprecipitation, flow cytometry

citations: 1

Reference
Gruber C, Patel R, Trachtman R, Lepow L, Amanat F, Krammer F, et al. Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C). Cell. 2020;183:982-995.e14 pubmed publisher

product information

Antigen :

TCR gamma/delta

Apps. Abbrev. :

Flow Cytometry, IP, Stim, Depletion

Cat # :

107515

Clone :

UC7-13D5

Item :

Ultra-LEAF™ Purified anti-mouse TCR γ/δ

Isotype :

Armenian Hamster IgG

Other Names :

TCR-γ/δ, γ/δ TCR

Size :

100 μg

Price (USD) :

110 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Armenian Hamster

Conjugate/Tag/Label :

ULEAF

Application Notes :

Additional reported applications (for the relevant formats) include: immunoprecipitation 1 , in vitro stimulation 1,2,4 . Although several papers have reported in vivo depletion 3, 5,6 , another study found that the effect of the antibody could be the functional blocking of the TCR signaling, rather than cell depletion 7 . The Ultra-LEAF™ purified antibody (Endotoxin 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 107515 - 107520 ). Though clone UC7-13D5 has been used for the depletion of TCR ?/d T cells in vivo 3-5 , there is a report suggesting that binding of clone UC7-13D5 to the ?/d TCR leads to downregulation of the ?/d TCR, making the ?/d T cells undetectable although they are still present 7 .