PE anti-mouse TCR γ/δ | BioLegend 107508 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

PE anti-mouse TCR γ/δ

catalog :

107508

quantity :

100 μg

price :

250 USD

clonality :

monoclonal

host :

hamsters

conjugate :

clone name :

UC7-13D5

reactivity :

mouse

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 4

Reference
Fiala G, Schaffer A, Merches K, Morath A, Swann J, Herr L, et al. Proximal Lck Promoter-Driven Cre Function Is Limited in Neonatal and Ineffective in Adult γδ T Cell Development. J Immunol. 2019;: pubmed publisher
Schreurs R, Baumdick M, Sagebiel A, Kaufmann M, Mokry M, Klarenbeek P, et al. Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life. Immunity. 2019;50:462-476.e8 pubmed publisher
Sullivan S, Zhu M, Bao S, Lewis C, Ou Yang C, Zhang W. The role of LAT-PLC?1 interaction in ?? T cell development and homeostasis. J Immunol. 2014;192:2865-74 pubmed publisher
Pöllinger B, Junt T, Metzler B, Walker U, Tyndall A, Allard C, et al. Th17 cells, not IL-17+ ?? T cells, drive arthritic bone destruction in mice and humans. J Immunol. 2011;186:2602-12 pubmed publisher

product information

Antigen :

TCR gamma/delta

Apps. Abbrev. :

Flow Cytometry

Cat # :

107508

Clone :

UC7-13D5

Item :

PE anti-mouse TCR γ/δ

Isotype :

Armenian Hamster IgG

Other Names :

TCR-γ/δ, γ/δ TCR

Size :

100 μg

Price (USD) :

250 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Armenian Hamster

Conjugate/Tag/Label :

Application Notes :

Additional reported applications (for the relevant formats) include: immunoprecipitation 1 , in vitro stimulation 1,2,4 . Although several papers have reported in vivo depletion 3, 5,6 , another study found that the effect of the antibody could be the functional blocking of the TCR signaling, rather than cell depletion 7 . The Ultra-LEAF™ purified antibody (Endotoxin 0.01 EU/μg, Azide-Free, 0.2 μm filtered) is recommended for functional assays (Cat. Nos. 107515 - 107520 ). Though clone UC7-13D5 has been used for the depletion of TCR γ/δ T cells in vivo 3-5 , there is a report suggesting that binding of clone UC7-13D5 to the γ/δ TCR leads to downregulation of the γ/δ TCR, making the γ/δ T cells undetectable although they are still present 7 .

more info or order :

BioLegend product webpage