Purified anti-mouse TCR γ/δ | BioLegend 107502 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Purified anti-mouse TCR γ/δ

catalog :

107502

quantity :

500 μg

price :

115 USD

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

UC7-13D5

reactivity :

mouse

application :

immunoprecipitation, flow cytometry, blocking or activating experiments

more info or order :

BioLegend product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 3g	Jun H, Yu H, Gong J, Jiang J, Qiao X, Perkey E, et al. An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling. Nat Med. 2018;24:814-822 pubmed publisher
blocking or activating experiments; mouse; fig 5	Bieber K, Witte M, Sun S, Hundt J, Kalies K, Dräger S, et al. T cells mediate autoantibody-induced cutaneous inflammation and blistering in epidermolysis bullosa acquisita. Sci Rep. 2016;6:38357 pubmed publisher
	Rezende R, Lanser A, Rubino S, Kuhn C, Skillin N, Moreira T, et al. γδ T cells control humoral immune response by inducing T follicular helper cell differentiation. Nat Commun. 2018;9:3151 pubmed publisher
	Ritchie N, Ritchie R, Bayes H, Mitchell T, Evans T. IL-17 can be protective or deleterious in murine pneumococcal pneumonia. PLoS Pathog. 2018;14:e1007099 pubmed publisher
	Dong P, Zhang S, Cai M, Kang N, Hu Y, Cui L, et al. Global characterization of differential gene expression profiles in mouse VÎ³1+ and VÎ³4+ Î³Î´ T cells. PLoS ONE. 2014;9:e112964 pubmed publisher
	Pöllinger B, Junt T, Metzler B, Walker U, Tyndall A, Allard C, et al. Th17 cells, not IL-17+ ?? T cells, drive arthritic bone destruction in mice and humans. J Immunol. 2011;186:2602-12 pubmed publisher

product information

Antigen :

TCR gamma/delta

Apps. Abbrev. :

Flow Cytometry, IP, Stim, Depletion

Cat # :

107502

Clone :

UC7-13D5

Item :

Purified anti-mouse TCR γ/δ

Isotype :

Armenian Hamster IgG

Other Names :

TCR-γ/δ, γ/δ TCR

Size :

500 μg

Price (USD) :

115 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Armenian Hamster

Conjugate/Tag/Label :

PURE

Application Notes :

Additional reported applications (for the relevant formats) include: immunoprecipitation 1 , in vitro stimulation 1,2,4 . Although several papers have reported in vivo depletion 3, 5,6 , another study found that the effect of the antibody could be the functional blocking of the TCR signaling, rather than cell depletion 7 . The Ultra-LEAF™ purified antibody (Endotoxin 0.01 EU/μg, Azide-Free, 0.2 μm filtered) is recommended for functional assays (Cat. Nos. 107515 - 107520 ). Though clone UC7-13D5 has been used for the depletion of TCR γ/δ T cells in vivo 3-5 , there is a report suggesting that binding of clone UC7-13D5 to the γ/δ TCR leads to downregulation of the γ/δ TCR, making the γ/δ T cells undetectable although they are still present 7 .

more info or order :

BioLegend product webpage