LEAF™ Purified anti-mouse 4-1BB Ligand (CD137L) | BioLegend 107108 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

LEAF™ Purified anti-mouse 4-1BB Ligand (CD137L)

catalog :

107108

quantity :

500 μg

price :

280 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

TKS-1

reactivity :

mouse

application :

neutralization, flow cytometry, blocking or activating experiments

citations: 8

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig s15d	Sugiura D, Maruhashi T, Okazaki I, Shimizu K, Maeda T, Takemoto T, et al. Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses. Science. 2019;364:558-566 pubmed publisher
blocking or activating experiments; mouse; 10 ug/ml; loading ...; fig 5b	Choi I, Wang Z, Ke Q, Hong M, Qian Y, Zhao X, et al. Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses. Proc Natl Acad Sci U S A. 2018;115:E686-E695 pubmed publisher
flow cytometry; mouse; fig 1	Lee Chang C, Bodogai M, Moritoh K, Chen X, Wersto R, Sen R, et al. Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers. J Immunol. 2016;196:3385-97 pubmed publisher
	Itoh A, Ortiz L, Kachapati K, Wu Y, Adams D, Bednar K, et al. Soluble CD137 Ameliorates Acute Type 1 Diabetes by Inducing T Cell Anergy. Front Immunol. 2019;10:2566 pubmed publisher
	Horiguchi H, Kadomatsu T, Kurahashi R, Hara C, Miyata K, Baba M, et al. Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity. Genes Dev. 2019;33:1641-1656 pubmed publisher
	Liu M, Hu Y, Yuan Y, Tian Z, Zhang C. γδT Cells Suppress Liver Fibrosis via Strong Cytolysis and Enhanced NK Cell-Mediated Cytotoxicity Against Hepatic Stellate Cells. Front Immunol. 2019;10:477 pubmed publisher
	Garg G, Nikolouli E, Hardtke Wolenski M, Toker A, Ohkura N, Beckstette M, et al. Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells. Oncotarget. 2017;8:35542-35557 pubmed publisher
	Nishimoto H, Lee S, Hong H, Potter K, Maeda Yamamoto M, Kinoshita T, et al. Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor. Blood. 2005;106:4241-8 pubmed

product information

Antigen :

CD137L

Apps. Abbrev. :

Flow Cytometry, Block

Cat # :

107108

Clone :

TKS-1

Item :

LEAF™ Purified anti-mouse 4-1BB Ligand (CD137L)

Isotype :

Rat IgG2a, κ

Other Names :

4-1BBL, CD137L, TNFSF9, 4-1BB Ligand

Size :

500 μg

Price (USD) :

280 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Rat

Conjugate/Tag/Label :

LEAF

Immunogen :

BALB/c mouse B lymphoma line 2PK-3

Application Notes :

The TKS-1 antibody inhibits binding of soluble 4-1BB to 4-1BBL in vitro . Additional reported applications (for the relevant formats) include: in vitro blocking the binding of 4-1BB to 4-1BBL 1 . For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 107106) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated antibody (Cat. No. 107104) or biotinylated anti-rat IgG second step (Cat. No. 405402), followed by SAv-PE (Cat. No. 405204)). The LEAF™ purified antibody (Endotoxin 0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 107108).