product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE anti-mouse CD117 (c-kit)
catalog :
105807
quantity :
50 μg
price :
98 USD
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
2B8
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 37
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig s1a
Han Y, Liu Q, Hou J, Gu Y, Zhang Y, Chen Z, et al. Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression. Cell. 2018;173:634-648.e12 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2a
Kunimoto H, Meydan C, Nazir A, Whitfield J, Shank K, Rapaport F, et al. Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity. Cancer Cell. 2018;33:44-59.e8 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Ando T, Kashiwakura J, Itoh Nagato N, Yamashita H, Baba M, Kawakami Y, et al. Histamine-releasing factor enhances food allergy. J Clin Invest. 2017;127:4541-4553 pubmed publisher
  • flow cytometry; mouse
Svahn S, Grahnemo L, Pálsdóttir V, Nookaew I, Wendt K, Gabrielsson B, et al. Dietary polyunsaturated fatty acids increase survival and decrease bacterial load during septic Staphylococcus aureus infection and improve neutrophil function in mice. Infect Immun. 2015;83:514-21 pubmed publisher
Klimovich B, Meyer L, Merle N, Neumann M, König A, Ananikidis N, et al. Partial p53 reactivation is sufficient to induce cancer regression. J Exp Clin Cancer Res. 2022;41:80 pubmed publisher
Nguyen N, Gudmundsson K, Soltis A, Oakley K, Roy K, Han Y, et al. Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation. iScience. 2022;25:103679 pubmed publisher
Groenen A, La Rose A, Li M, Bazioti V, Svendsen A, Kloosterhuis N, et al. Elevated granulocyte-colony stimulating factor and hematopoietic stem cell mobilization in Niemann-Pick type C1 disease. J Lipid Res. 2022;63:100167 pubmed publisher
Kawakami R, Kitagawa Y, Chen K, Arai M, Ohara D, Nakamura Y, et al. Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells. Immunity. 2021;54:947-961.e8 pubmed publisher
Shu Z, Liu Q, Xing C, Zhang Y, Zhou Y, Zhang J, et al. Viridicatol Isolated from Deep-Sea Penicillium Griseofulvum Alleviates Anaphylaxis and Repairs the Intestinal Barrier in Mice by Suppressing Mast Cell Activation. Mar Drugs. 2020;18: pubmed publisher
Casellas Román H, Venugopal K, Feng Y, Shabashvili D, Posada L, Li J, et al. DNMT3A alterations associated with myeloid malignancies dictate differential responses to hypomethylating agents. Leuk Res. 2020;94:106372 pubmed publisher
Zhong C, Zheng M, Cui K, Martins A, Hu G, Li D, et al. Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells. Immunity. 2020;52:83-95.e4 pubmed publisher
Viny A, Bowman R, Liu Y, Lavallée V, Eisman S, Xiao W, et al. Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation. Cell Stem Cell. 2019;25:682-696.e8 pubmed publisher
Severe N, Karabacak N, Gustafsson K, Baryawno N, Courties G, Kfoury Y, et al. Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping. Cell Stem Cell. 2019;25:570-583.e7 pubmed publisher
Tamura M, Yonezawa T, Liu X, Asada S, Hayashi Y, Fukuyama T, et al. Opposing effects of acute versus chronic inhibition of p53 on decitabine's efficacy in myeloid neoplasms. Sci Rep. 2019;9:8171 pubmed publisher
Zhou J, Huang S, Wang Z, Huang J, Xu L, Tang X, et al. Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation. Nat Commun. 2019;10:2427 pubmed publisher
Sakashita A, Wakai T, Kawabata Y, Nishimura C, Sotomaru Y, Alavattam K, et al. XY oocytes of sex-reversed females with a Sry mutation deviate from the normal developmental process beyond the mitotic stage†. Biol Reprod. 2019;100:697-710 pubmed publisher
Zhu Y, Padgett L, Dinh H, Marcovecchio P, Blatchley A, Wu R, et al. Identification of an Early Unipotent Neutrophil Progenitor with Pro-tumoral Activity in Mouse and Human Bone Marrow. Cell Rep. 2018;24:2329-2341.e8 pubmed publisher
SCHMITT M, Schewe M, Sacchetti A, Feijtel D, van de Geer W, Teeuwssen M, et al. Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling. Cell Rep. 2018;24:2312-2328.e7 pubmed publisher
Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, et al. Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis. Nat Commun. 2018;9:2733 pubmed publisher
Bennett F, Bennett M, Yaqoob F, Mulinyawe S, Grant G, Hayden Gephart M, et al. A Combination of Ontogeny and CNS Environment Establishes Microglial Identity. Neuron. 2018;98:1170-1183.e8 pubmed publisher
Hirota K, Hashimoto M, Ito Y, Matsuura M, Ito H, Tanaka M, et al. Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis. Immunity. 2018;48:1220-1232.e5 pubmed publisher
Johnson J, Georgakilas G, Petrovic J, Kurachi M, Cai S, Harly C, et al. Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells. Immunity. 2018;48:243-257.e10 pubmed publisher
Mitroulis I, Ruppova K, Wang B, Chen L, Grzybek M, Grinenko T, et al. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell. 2018;172:147-161.e12 pubmed publisher
Kleppe M, Koche R, Zou L, van Galen P, Hill C, Dong L, et al. Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms. Cancer Cell. 2018;33:29-43.e7 pubmed publisher
Shimokawa C, Kanaya T, Hachisuka M, Ishiwata K, Hisaeda H, Kurashima Y, et al. Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections. Immunity. 2017;46:863-874.e4 pubmed publisher
Sykes D, Kfoury Y, Mercier F, Wawer M, Law J, Haynes M, et al. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. 2016;167:171-186.e15 pubmed publisher
Liu Q, Chen L, Atkinson J, Claxton D, Wang H. Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model. Cell Death Dis. 2016;7:e2361 pubmed publisher
Svahn S, Ulleryd M, Grahnemo L, Ståhlman M, Borén J, Nilsson S, et al. Dietary Omega-3 Fatty Acids Increase Survival and Decrease Bacterial Load in Mice Subjected to Staphylococcus aureus-Induced Sepsis. Infect Immun. 2016;84:1205-1213 pubmed publisher
Yamazaki S, Nakano N, Honjo A, Hara M, Maeda K, Nishiyama C, et al. The Transcription Factor Ehf Is Involved in TGF-β-Induced Suppression of FcεRI and c-Kit Expression and FcεRI-Mediated Activation in Mast Cells. J Immunol. 2015;195:3427-35 pubmed publisher
Chung Y, Kim E, Abdel Wahab O. Femoral bone marrow aspiration in live mice. J Vis Exp. 2014;: pubmed publisher
Silvescu C, Sackstein R. G-CSF induces membrane expression of a myeloperoxidase glycovariant that operates as an E-selectin ligand on human myeloid cells. Proc Natl Acad Sci U S A. 2014;111:10696-701 pubmed publisher
Ghazaryan S, Sy C, Hu T, An X, Mohandas N, Fu H, et al. Inactivation of Rb and E2f8 synergizes to trigger stressed DNA replication during erythroid terminal differentiation. Mol Cell Biol. 2014;34:2833-47 pubmed publisher
Kakiuchi K, Tsuda A, Goto Y, Shimada T, Taniguchi K, Takagishi K, et al. Cell-surface DEAD-box polypeptide 4-immunoreactive cells and gonocytes are two distinct populations in postnatal porcine testes. Biol Reprod. 2014;90:82 pubmed publisher
Takayama G, Ohtani M, Minowa A, Matsuda S, Koyasu S. Class I PI3K-mediated Akt and ERK signals play a critical role in Fc?RI-induced degranulation in mast cells. Int Immunol. 2013;25:215-20 pubmed publisher
Quick M, Mukherjee S, Rudick C, Done J, Schaeffer A, Thumbikat P. CCL2 and CCL3 are essential mediators of pelvic pain in experimental autoimmune prostatitis. Am J Physiol Regul Integr Comp Physiol. 2012;303:R580-9 pubmed publisher
Nakano N, Nishiyama C, Yagita H, Koyanagi A, Ogawa H, Okumura K. Notch1-mediated signaling induces MHC class II expression through activation of class II transactivator promoter III in mast cells. J Biol Chem. 2011;286:12042-8 pubmed publisher
Wang C, Cherng W, Yang N, Hsu C, Yeh C, Lan Y, et al. Cyclosporine increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system. Am J Physiol Regul Integr Comp Physiol. 2008;294:R811-8 pubmed
product information
Antigen :
CD117
Apps. Abbrev. :
FC
Cat # :
105807
Clone :
2B8
Item :
PE anti-mouse CD117 (c-kit)
Isotype :
Rat IgG2b, κ
Other Names :
c-KIT, Stem Cell Factor Receptor (SCFR)
Size :
50 μg
Price (USD) :
98 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PE
Immunogen :
Mouse bone marrow mast cells
Application Notes :
Additional reported applications (for the relevant formats) include: immunoprecipitation^1, immunohistochemistry of acetone fixed frozen sections^2, and spatial biology (IBEX)^5,6. The 2B8 antibody does not block c-Kit activity.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA