product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE/Cyanine7 anti-mouse CD62L
catalog :
104418
quantity :
100 μg
price :
215 USD
clonality :
monoclonal
host :
rat
conjugate :
PE/Cy7
clone name :
MEL-14
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 70
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig s2b
Barker K, Etesami N, Shenoy A, Arafa E, Lyon de Ana C, Smith N, et al. Lung-resident memory B cells protect against bacterial pneumonia. J Clin Invest. 2021;131: pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...
Merkenschlager J, Finkin S, Ramos V, Kraft J, Cipolla M, Nowosad C, et al. Dynamic regulation of TFH selection during the germinal centre reaction. Nature. 2021;591:458-463 pubmed publisher
  • flow cytometry; mouse; 1:1000; loading ...; fig 2s1b
Danzer H, Glaesner J, Baerenwaldt A, Reitinger C, Lux A, Heger L, et al. Human Fcγ-receptor IIb modulates pathogen-specific versus self-reactive antibody responses in lyme arthritis. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Rasoulouniriana D, Santana Magal N, Gutwillig A, Farhat Younis L, Wine Y, Saperia C, et al. A distinct subset of FcγRI-expressing Th1 cells exert antibody-mediated cytotoxic activity. J Clin Invest. 2019;129:4151-4164 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Vuckovic S, Minnie S, Smith D, Gartlan K, Watkins T, Markey K, et al. Bone marrow transplantation generates T cell-dependent control of myeloma in mice. J Clin Invest. 2019;129:106-121 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1c
Tilstra J, Avery L, Menk A, Gordon R, Smita S, Kane L, et al. Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted. J Clin Invest. 2018;128:4884-4897 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s6a
van der Weyden L, Arends M, Campbell A, Bald T, Wardle Jones H, Griggs N, et al. Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature. 2017;541:233-236 pubmed publisher
  • flow cytometry; mouse; fig 5
Mikyšková R, Štěpánek I, Indrová M, Bieblová J, Šímová J, Truxová I, et al. Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure induce strong immune responses and display therapeutic effects both in murine TC-1 and TRAMP-C2 tumors when combined with docetaxel chemotherapy. Int J Oncol. 2016;48:953-64 pubmed publisher
Hu Y, Paris S, Barsoumian H, Abana C, He K, Sezen D, et al. A radioenhancing nanoparticle mediated immunoradiation improves survival and generates long-term antitumor immune memory in an anti-PD1-resistant murine lung cancer model. J Nanobiotechnology. 2021;19:416 pubmed publisher
He X, Zhou S, Dolan M, Shi Y, Wang J, Quinn B, et al. Immunization with short peptide particles reveals a functional CD8+ T-cell neoepitope in a murine renal carcinoma model. J Immunother Cancer. 2021;9: pubmed publisher
Xu C, Sun S, Johnson T, Qi R, Zhang S, Zhang J, et al. The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity. Cell Rep. 2021;35:109235 pubmed publisher
Uzhachenko R, Bharti V, Ouyang Z, Blevins A, Mont S, Saleh N, et al. Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors. Cell Rep. 2021;35:108944 pubmed publisher
Xu W, Snell L, Guo M, Boukhaled G, Macleod B, Li M, et al. Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection. Immunity. 2021;54:526-541.e7 pubmed publisher
Ringel A, Drijvers J, Baker G, Catozzi A, García Cañaveras J, Gassaway B, et al. Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell. 2020;183:1848-1866.e26 pubmed publisher
Jiang L, Wang Y, Zhao J, Uehara M, Hou Q, Kasinath V, et al. Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy. Cell. 2020;183:1219-1233.e18 pubmed publisher
León Letelier R, Castro Medina D, Badillo Godinez O, Tepale Segura A, Huanosta Murillo E, Aguilar Flores C, et al. Induction of Progenitor Exhausted Tissue-Resident Memory CD8+ T Cells Upon Salmonella Typhi Porins Adjuvant Immunization Correlates With Melanoma Control and Anti-PD-1 Immunotherapy Cooperation. Front Immunol. 2020;11:583382 pubmed publisher
Jaeger N, McDonough R, Rosen A, Hernandez Leyva A, Wilson N, Lint M, et al. Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation. Cell Rep. 2020;33:108331 pubmed publisher
Barsoumian H, Ramapriyan R, Younes A, Caetano M, Menon H, Comeaux N, et al. Low-dose radiation treatment enhances systemic antitumor immune responses by overcoming the inhibitory stroma. J Immunother Cancer. 2020;8: pubmed publisher
Laczkó D, Hogan M, Toulmin S, Hicks P, Lederer K, Gaudette B, et al. A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice. Immunity. 2020;53:724-732.e7 pubmed publisher
Fernandes R, Li C, Wang G, Yang X, Savvides C, Glassman C, et al. Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo. elife. 2020;9: pubmed publisher
Hamaidi I, Zhang L, Kim N, Wang M, Iclozan C, Fang B, et al. Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells. Cell Metab. 2020;32:420-436.e12 pubmed publisher
Kitamoto S, Nagao Kitamoto H, Jiao Y, Gillilland M, Hayashi A, Imai J, et al. The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis. Cell. 2020;182:447-462.e14 pubmed publisher
Corbett K, Edwards D, Leist S, Abiona O, Boyoglu Barnum S, Gillespie R, et al. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness. Nature. 2020;586:567-571 pubmed publisher
Wu J, Weisshaar N, Hotz Wagenblatt A, Madi A, Ma S, Mieg A, et al. Skeletal muscle antagonizes antiviral CD8+ T cell exhaustion. Sci Adv. 2020;6:eaba3458 pubmed publisher
Kinder J, Turner L, Stelzer I, Miller Handley H, Burg A, Shao T, et al. CD8+ T Cell Functional Exhaustion Overrides Pregnancy-Induced Fetal Antigen Alloimmunization. Cell Rep. 2020;31:107784 pubmed publisher
He C, Huang X, Zhang Y, Lin X, Li S. T-cell activation and immune memory enhancement induced by irreversible electroporation in pancreatic cancer. Clin Transl Med. 2020;10:e39 pubmed publisher
Jing Y, Dai X, Yang L, Kang D, Jiang P, Li N, et al. STING couples with PI3K to regulate actin reorganization during BCR activation. Sci Adv. 2020;6:eaax9455 pubmed publisher
Wu J, Madi A, Mieg A, Hotz Wagenblatt A, Weisshaar N, Ma S, et al. T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development. Cell Rep. 2020;31:107484 pubmed publisher
Horková V, Drobek A, Mueller D, Gubser C, Niederlova V, Wyss L, et al. Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells. Cell Rep. 2020;30:1504-1514.e7 pubmed publisher
Morris A, Farley C, Pinelli D, Adams L, Cragg M, Boss J, et al. Signaling through the Inhibitory Fc Receptor FcγRIIB Induces CD8+ T Cell Apoptosis to Limit T Cell Immunity. Immunity. 2020;52:136-150.e6 pubmed publisher
Kretschmer L, Flossdorf M, Mir J, Cho Y, Plambeck M, Treise I, et al. Differential expansion of T central memory precursor and effector subsets is regulated by division speed. Nat Commun. 2020;11:113 pubmed publisher
Zhang H, Christensen C, Dries R, Oser M, Deng J, Diskin B, et al. CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Cancer Cell. 2019;: pubmed publisher
Gordan S, Albert H, Danzer H, Lux A, Biburger M, Nimmerjahn F. The Immunological Organ Environment Dictates the Molecular and Cellular Pathways of Cytotoxic Antibody Activity. Cell Rep. 2019;29:3033-3046.e4 pubmed publisher
Kim C, Jadhav R, Gustafson C, Smithey M, Hirsch A, Uhrlaub J, et al. Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency. Cell Rep. 2019;29:2202-2216.e5 pubmed publisher
Gupta S, Sharp R, Hofferek C, Kuai L, Dorn G, Wang J, et al. NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells. Cell Rep. 2019;29:1862-1877.e7 pubmed publisher
Pham D, Moseley C, Gao M, Savic D, Winstead C, Sun M, et al. Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf. Cell Rep. 2019;29:1203-1220.e7 pubmed publisher
LaFleur M, Nguyen T, Coxe M, Miller B, Yates K, Gillis J, et al. PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity. Nat Immunol. 2019;20:1335-1347 pubmed publisher
Niven J, Madelon N, Page N, Caruso A, Harlé G, Lemeille S, et al. Macroautophagy in Dendritic Cells Controls the Homeostasis and Stability of Regulatory T Cells. Cell Rep. 2019;28:21-29.e6 pubmed publisher
Yang B, Wang K, Wan S, Liang Y, Yuan X, Dong Y, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27:3629-3645.e6 pubmed publisher
Komuczki J, Tuzlak S, Friebel E, Hartwig T, Spath S, Rosenstiel P, et al. Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β. Immunity. 2019;: pubmed publisher
LaFleur M, Nguyen T, Coxe M, Yates K, Trombley J, Weiss S, et al. A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system. Nat Commun. 2019;10:1668 pubmed publisher
Mohammed R, Wehenkel S, Galkina E, Yates E, Preece G, Newman A, et al. ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. Sci Rep. 2019;9:5487 pubmed publisher
Oh Hora M, Lu X, Shiokawa M, Takayanagi H, Yamasaki S. Stromal Interaction Molecule Deficiency in T Cells Promotes Spontaneous Follicular Helper T Cell Development and Causes Type 2 Immune Disorders. J Immunol. 2019;202:2616-2627 pubmed publisher
Nagai Y, Ji M, Zhu F, Xiao Y, Tanaka Y, Kambayashi T, et al. PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185erbB2/neu Tumor Immunotherapy. Front Immunol. 2019;10:174 pubmed publisher
Yu X, Chen L, Liu J, Dai B, Xu G, Shen G, et al. Immune modulation of liver sinusoidal endothelial cells by melittin nanoparticles suppresses liver metastasis. Nat Commun. 2019;10:574 pubmed publisher
Yoshida H, Lareau C, Ramirez R, Rose S, Maier B, Wroblewska A, et al. The cis-Regulatory Atlas of the Mouse Immune System. Cell. 2019;176:897-912.e20 pubmed publisher
Masiuk K, Laborada J, Roncarolo M, Hollis R, Kohn D. Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome. Cell Stem Cell. 2019;24:309-317.e7 pubmed publisher
Bhatt K, Machado H, Osório N, Sousa J, Cardoso F, Magalhães C, et al. A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis. mSphere. 2018;3: pubmed publisher
Snell L, Macleod B, Law J, Osokine I, Elsaesser H, Hezaveh K, et al. CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity. Immunity. 2018;49:678-694.e5 pubmed publisher
Robinett R, Guan N, Lux A, Biburger M, Nimmerjahn F, Meyer A. Dissecting Fc?R Regulation through a Multivalent Binding Model. Cell Syst. 2018;7:41-48.e5 pubmed publisher
Motwani M, Colas R, George M, Flint J, Dalli J, Richard Loendt A, et al. Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation. JCI Insight. 2018;3: pubmed publisher
Place D, Williamson D, Yuzefpolskiy Y, Katkere B, Sarkar S, Kalia V, et al. Development of a novel Francisella tularensis Live Vaccine Strain expressing ovalbumin provides insight into antigen-specific CD8+ T cell responses. PLoS ONE. 2017;12:e0190384 pubmed publisher
Nguyen T, Tan A, Xiang S, Goubier A, Harland K, Clemens E, et al. Understanding CD8+ T-cell responses toward the native and alternate HLA-A*02:01-restricted WT1 epitope. Clin Transl Immunology. 2017;6:e134 pubmed publisher
Laidlaw B, Schmidt T, Green J, Allen C, Okada T, Cyster J. The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells. J Exp Med. 2017;214:639-649 pubmed publisher
Angela M, Endo Y, Asou H, Yamamoto T, Tumes D, Tokuyama H, et al. Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPAR? directs early activation of T cells. Nat Commun. 2016;7:13683 pubmed publisher
Geiger R, Rieckmann J, Wolf T, Basso C, Feng Y, Fuhrer T, et al. L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. Cell. 2016;167:829-842.e13 pubmed publisher
Li B, Chen L, Sun H, Yang W, Hu J, He Y, et al. Immunodominant epitope-specific Th1 but not Th17 responses mediate protection against Helicobacter pylori infection following UreB vaccination of BALB/c mice. Sci Rep. 2015;5:14793 pubmed publisher
Martina M, Noel S, Saxena A, Bandapalle S, Majithia R, Jie C, et al. Double-Negative αβ T Cells Are Early Responders to AKI and Are Found in Human Kidney. J Am Soc Nephrol. 2016;27:1113-23 pubmed publisher
Ibrahim M, Widjajanto E, Widodo M, Sumitro S. EMSA Eritin Drives Expansion of Regulatory T Cells and Promotes T Cells Differentiation in Irradiated Mice. J Evid Based Complementary Altern Med. 2016;21:171-6 pubmed publisher
Charlton J, Tsoukatou D, Mamalaki C, Chatzidakis I. Programmed death 1 regulates memory phenotype CD4 T cell accumulation, inhibits expansion of the effector memory phenotype subset and modulates production of effector cytokines. PLoS ONE. 2015;10:e0119200 pubmed publisher
Burrack K, Montgomery S, Homann D, Morrison T. CD8+ T cells control Ross River virus infection in musculoskeletal tissues of infected mice. J Immunol. 2015;194:678-89 pubmed publisher
Huang W, Jeong A, Kannan A, Huang L, August A. IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function. J Immunol. 2014;193:2267-72 pubmed publisher
Seeling M, Hillenhoff U, David J, Schett G, Tuckermann J, Lux A, et al. Inflammatory monocytes and Fc? receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice. Proc Natl Acad Sci U S A. 2013;110:10729-34 pubmed publisher
Hirose M, Matsumura R, Sato K, Murai T, Kawashima H. Binding of L-selectin to its vascular and extravascular ligands is differentially regulated by pH. Biochem Biophys Res Commun. 2011;414:437-42 pubmed publisher
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Shigeta A, Matsumoto M, Tedder T, Lowe J, Miyasaka M, Hirata T. An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation. Blood. 2008;112:4915-23 pubmed publisher
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Fukushima A, Yamaguchi T, Ishida W, Fukata K, Yagita H, Ueno H. Roles of OX40 in the development of murine experimental allergic conjunctivitis: exacerbation and attenuation by stimulation and blocking of OX40. Invest Ophthalmol Vis Sci. 2006;47:657-63 pubmed
product information
Antigen :
CD62L
Apps. Abbrev. :
FC
Cat # :
104418
Clone :
MEL-14
Item :
PE/Cyanine7 anti-mouse CD62L
Isotype :
Rat IgG2a, κ
Other Names :
L-selectin, LECAM-1, Ly-22, LAM-1, MEL-14
Size :
100 μg
Price (USD) :
215 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PE_CYANINE7
Immunogen :
C3H/eb mouse B lymphoma 38C-13
Application Notes :
Additional reported applications (for the relevant formats) include: immunoprecipitation^1-3, complement-dependent cytotoxicity^4, in vivo and in vitro blocking of adhesion^1-3,5, and immunohistochemical staining of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections^6. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 104457-104462).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA