product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
APC anti-mouse CD62L
catalog :
104412
quantity :
100 μg
price :
193 USD
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
MEL-14
reactivity :
human, mouse
application :
flow cytometry
more info or order :
citations: 82
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig s3a
Fahy N, Palomares Cabeza V, Lolli A, Witte Bouma J, Merino A, Ridwan Y, et al. Chondrogenically Primed Human Mesenchymal Stem Cells Persist and Undergo Early Stages of Endochondral Ossification in an Immunocompetent Xenogeneic Model. Front Immunol. 2021;12:715267 pubmed publisher
  • flow cytometry; mouse; fig 2c
Bohannon C, Ende Z, Cao W, Mboko W, Ranjan P, Kumar A, et al. Influenza Virus Infects and Depletes Activated Adaptive Immune Responders. Adv Sci (Weinh). 2021;8:e2100693 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2e
Meryk A, Grasse M, Balasco L, Kapferer W, Grubeck Loebenstein B, Pangrazzi L. Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice. Antioxidants (Basel). 2020;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1c
Ramstead A, Wallace J, Lee S, Bauer K, Tang W, Ekiz H, et al. Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development. Cell Rep. 2020;30:2889-2899.e6 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1a
Angenendt A, Steiner R, Knörck A, Schwär G, Konrad M, Krause E, et al. Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8+ T cells of elderly mice. Aging (Albany NY). 2020;12:3266-3286 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3
Zhao Y, Yang Q, Jin C, Feng Y, Xie S, Xie H, et al. Changes of CD103-expressing pulmonary CD4+ and CD8+ T cells in S. japonicum infected C57BL/6 mice. BMC Infect Dis. 2019;19:999 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1h
Mani V, Bromley S, Aijö T, Mora Buch R, Carrizosa E, Warner R, et al. Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate. Science. 2019;366: pubmed publisher
  • flow cytometry; mouse; 1:120; loading ...; fig 1a
Koike T, Harada K, Horiuchi S, Kitamura D. The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets. elife. 2019;8: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1c
James K, Cosway E, LUCAS B, White A, Parnell S, Carvalho Gaspar M, et al. Endothelial cells act as gatekeepers for LTβR-dependent thymocyte emigration. J Exp Med. 2018;215:2984-2993 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4c
Ernszt D, Banfai K, Kellermayer Z, Pap A, Lord J, Pongracz J, et al. PPARgamma Deficiency Counteracts Thymic Senescence. Front Immunol. 2017;8:1515 pubmed publisher
  • flow cytometry; mouse; 1:400; loading ...; fig 2f
Guo Z, Kong Q, Liu C, Zhang S, Zou L, Yan F, et al. DCAF1 controls T-cell function via p53-dependent and -independent mechanisms. Nat Commun. 2016;7:10307 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Ngiow S, Young A, Jacquelot N, Yamazaki T, Enot D, Zitvogel L, et al. A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1. Cancer Res. 2015;75:3800-11 pubmed publisher
  • flow cytometry; mouse
White C, Villarino N, Sloan S, Ganusov V, Schmidt N. Plasmodium suppresses expansion of T cell responses to heterologous infections. J Immunol. 2015;194:697-708 pubmed publisher
Duan Q, Ding J, Li F, Liu X, Zhao Y, Yu H, et al. Sirtuin 5 is Dispensable for CD8+ T Cell Effector and Memory Differentiation. Front Cell Dev Biol. 2021;9:761193 pubmed publisher
Bae S, Park P, Lee Y, Mun S, Giannopoulou E, Fujii T, et al. MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages. Cell Rep. 2021;35:109264 pubmed publisher
Yu Z, Qin C, Cao M, He X, Ren H, Liu H. The Potential Genes Mediate the Pathogenicity of Allogeneic CD4+T Cell in aGVHD Mouse Model. Biomed Res Int. 2021;2021:9958745 pubmed publisher
Glassman C, Su L, Majri Morrison S, Winkelmann H, Mo F, Li P, et al. Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist. elife. 2021;10: pubmed publisher
Vaena S, Chakraborty P, Lee H, Janneh A, Kassir M, Beeson G, et al. Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response. Cell Rep. 2021;35:109076 pubmed publisher
Mitchell J, Lund M, Starmer J, Ge K, Magnuson T, Shpargel K, et al. UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability. Cell Rep. 2021;35:108966 pubmed publisher
Delacher M, Simon M, Sanderink L, Hotz Wagenblatt A, Wuttke M, Schambeck K, et al. Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells. Immunity. 2021;54:702-720.e17 pubmed publisher
Daneshmandi S, Cassel T, Lin P, Higashi R, Wulf G, Boussiotis V, et al. Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function. Cell Rep. 2021;34:108831 pubmed publisher
Qi T, Sun M, Zhang C, Chen P, Xiao C, Chang X. Ascorbic Acid Promotes Plasma Cell Differentiation through Enhancing TET2/3-Mediated DNA Demethylation. Cell Rep. 2020;33:108452 pubmed publisher
Shapiro M, Yeh W, Longfield J, Gallagher J, Infante C, Wellford S, et al. CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation. Front Immunol. 2020;11:2180 pubmed publisher
Faust H, Zhang H, Han J, Wolf M, Jeon O, Sadtler K, et al. IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis. J Clin Invest. 2020;130:5493-5507 pubmed publisher
Asadi Shahmirzadi A, Edgar D, Liao C, Hsu Y, Lucanic M, Asadi Shahmirzadi A, et al. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metab. 2020;32:447-456.e6 pubmed publisher
Fu X, Luo H, Zheng Y, Wang S, Zhong Z, Wang Y, et al. CTLA-4 immunotherapy exposes differences in immune response along with different tumor progression in colorectal cancer. Aging (Albany NY). 2020;12:15656-15669 pubmed publisher
Borges da Silva H, Peng C, Wang H, Wanhainen K, Ma C, Lopez S, et al. Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β. Immunity. 2020;53:158-171.e6 pubmed publisher
Roy S, Goel R, Aggarwal S, Asthana S, Yadav A, Awasthi A. Proteome analysis revealed the essential functions of protein phosphatase PP2A in the induction of Th9 cells. Sci Rep. 2020;10:10992 pubmed publisher
Li Y, Chen Y, Mao S, Kaundal R, Jing Z, Chen Q, et al. In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice. Nat Commun. 2020;11:2781 pubmed publisher
Lin J, Devlin J, Yeung F, McCauley C, Leung J, Chen Y, et al. Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition. Cell Host Microbe. 2020;27:830-840.e4 pubmed publisher
Parriott G, Deal K, Crean S, Richardson E, Nylen E, Barber A. T-cells expressing a chimeric-PD1-Dap10-CD3zeta receptor reduce tumour burden in multiple murine syngeneic models of solid cancer. Immunology. 2020;160:280-294 pubmed publisher
Martens R, Permanyer M, Werth K, Yu K, Braun A, Halle O, et al. Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance. Nat Commun. 2020;11:1114 pubmed publisher
Webb L, Sengupta S, Edell C, Piedra Quintero Z, Amici S, Miranda J, et al. Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity. J Clin Invest. 2020;130:1683-1698 pubmed publisher
Kretschmer L, Flossdorf M, Mir J, Cho Y, Plambeck M, Treise I, et al. Differential expansion of T central memory precursor and effector subsets is regulated by division speed. Nat Commun. 2020;11:113 pubmed publisher
Thi V, Jeon H, Park S, Lee H, Kim Y. Cell-Based IL-15:IL-15Rα Secreting Vaccine as an Effective Therapy for CT26 Colon Cancer in Mice. Mol Cells. 2019;42:869-883 pubmed publisher
Sasaki K, Himeno A, Nakagawa T, Sasaki Y, Kiyonari H, Iwai K. Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death. Nat Commun. 2019;10:3878 pubmed publisher
Amezcua Vesely M, Pallis P, Bielecki P, Low J, Zhao J, Harman C, et al. Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection. Cell. 2019;178:1176-1188.e15 pubmed publisher
Chakraborty P, Vaena S, Thyagarajan K, Chatterjee S, Al Khami A, Selvam S, et al. Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity. Cell Rep. 2019;28:1879-1893.e7 pubmed publisher
Yang B, Wang K, Wan S, Liang Y, Yuan X, Dong Y, et al. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019;27:3629-3645.e6 pubmed publisher
Timilshina M, You Z, Lacher S, Acharya S, Jiang L, Kang Y, et al. Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells. Cell Rep. 2019;27:2948-2961.e7 pubmed publisher
Baptista A, Gola A, Huang Y, Milanez Almeida P, Torabi Parizi P, Urban J, et al. The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity. Immunity. 2019;50:1188-1201.e6 pubmed publisher
Yue X, Lio C, Samaniego Castruita D, Li X, Rao A. Loss of TET2 and TET3 in regulatory T cells unleashes effector function. Nat Commun. 2019;10:2011 pubmed publisher
Ma X, Bi E, Lu Y, Su P, Huang C, Liu L, et al. Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment. Cell Metab. 2019;: pubmed publisher
Sinclair L, Howden A, Brenes A, Spinelli L, Hukelmann J, Macintyre A, et al. Antigen receptor control of methionine metabolism in T cells. elife. 2019;8: pubmed publisher
Luo Y, Xue Y, Wang J, Dang J, Fang Q, Huang G, et al. Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4+ Foxp3+ Regulatory T Cells. Cell Rep. 2019;26:1869-1879.e3 pubmed publisher
Webb L, Barbarulo A, Huysentruyt J, Vanden Berghe T, Takahashi N, Ley S, et al. Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB. Immunity. 2019;50:348-361.e4 pubmed publisher
Parks C, Henning K, Pavelko K, Hansen M, Van Keulen V, Reed B, et al. Breaking tolerance with engineered class I antigen-presenting molecules. Proc Natl Acad Sci U S A. 2019;116:3136-3145 pubmed publisher
Yoshida H, Lareau C, Ramirez R, Rose S, Maier B, Wroblewska A, et al. The cis-Regulatory Atlas of the Mouse Immune System. Cell. 2019;176:897-912.e20 pubmed publisher
Jayachandran R, Gumienny A, Bolinger B, Ruehl S, Lang M, Fucile G, et al. Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity. Immunity. 2019;50:152-165.e8 pubmed publisher
Liu Y, Teng Y, Cheng P, Kong H, Lv Y, Mao F, et al. Abrogation of cathepsin C by Helicobacter pylori impairs neutrophil activation to promote gastric infection. FASEB J. 2019;33:5018-5033 pubmed publisher
Ren S, Chen X, Huang R, Zhou G, Yuan Z. SOCS4 expressed by recombinant HSV protects against cytokine storm in a mouse model. Oncol Rep. 2019;41:1509-1520 pubmed publisher
Uchimura T, Oyama Y, Deng M, Guo H, Wilson J, Rampanelli E, et al. The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity. Immunity. 2018;49:1049-1061.e6 pubmed publisher
Kim C, Lee C, Jung J, Ghosh A, Hasan S, Hwang S, et al. The Transcription Factor Ets1 Suppresses T Follicular Helper Type 2 Cell Differentiation to Halt the Onset of Systemic Lupus Erythematosus. Immunity. 2018;49:1034-1048.e8 pubmed publisher
Gilleron J, Bouget G, Ivanov S, Méziat C, Ceppo F, Vergoni B, et al. Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance. Cell Rep. 2018;25:3329-3341.e5 pubmed publisher
Chen S, Fang L, Guo W, Zhou Y, Yu G, Li W, et al. Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells. Nat Commun. 2018;9:5298 pubmed publisher
Biton M, Haber A, Rogel N, Burgin G, Beyaz S, Schnell A, et al. T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation. Cell. 2018;175:1307-1320.e22 pubmed publisher
Fan M, Low J, Tanimine N, Finn K, Priyadharshini B, Germana S, et al. Differential Roles of IL-2 Signaling in Developing versus Mature Tregs. Cell Rep. 2018;25:1204-1213.e4 pubmed publisher
Morimoto Y, Hirahara K, Kiuchi M, Wada T, Ichikawa T, Kanno T, et al. Amphiregulin-Producing Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin and Facilitate Airway Fibrosis. Immunity. 2018;49:134-150.e6 pubmed publisher
Hirata Y, Furuhashi K, Ishii H, Li H, Pinho S, Ding L, et al. CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine. Cell Stem Cell. 2018;22:445-453.e5 pubmed publisher
Shimba A, Cui G, Tani ichi S, Ogawa M, Abe S, Okazaki F, et al. Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4. Immunity. 2018;48:286-298.e6 pubmed publisher
Koh A, Miller E, Buenrostro J, Moskowitz D, Wang J, Greenleaf W, et al. Rapid chromatin repression by Aire provides precise control of immune tolerance. Nat Immunol. 2018;19:162-172 pubmed publisher
Resch T, Wang Y, Moon S, Joyce J, Li S, PRAUSNITZ M, et al. Inactivated rotavirus vaccine by parenteral administration induces mucosal immunity in mice. Sci Rep. 2018;8:561 pubmed publisher
Wiese A, Ender F, Quell K, Antoniou K, Vollbrandt T, Konig P, et al. The C5a/C5aR1 axis controls the development of experimental allergic asthma independent of LysM-expressing pulmonary immune cells. PLoS ONE. 2017;12:e0184956 pubmed publisher
Ender F, Wiese A, Schmudde I, Sun J, Vollbrandt T, Konig P, et al. Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase. PLoS ONE. 2017;12:e0172446 pubmed publisher
Angela M, Endo Y, Asou H, Yamamoto T, Tumes D, Tokuyama H, et al. Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPAR? directs early activation of T cells. Nat Commun. 2016;7:13683 pubmed publisher
Xu Y, Zhao F, Qiu Q, Chen K, Wei J, Kong Q, et al. The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity. Nat Commun. 2016;7:12073 pubmed publisher
Rezende R, da Cunha A, Kuhn C, Rubino S, M Hamdi H, Gabriely G, et al. Identification and characterization of latency-associated peptide-expressing γδ T cells. Nat Commun. 2015;6:8726 pubmed publisher
Kim B, Sasaki Y, Egawa T. Restriction of Nonpermissive RUNX3 Protein Expression in T Lymphocytes by the Kozak Sequence. J Immunol. 2015;195:1517-23 pubmed publisher
Schaffert S, Loh C, Wang S, Arnold C, Axtell R, Newell E, et al. mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function. J Immunol. 2015;195:1470-9 pubmed publisher
Polikowsky H, Wogsland C, Diggins K, Huse K, Irish J. Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells. J Immunol. 2015;195:1364-1367 pubmed publisher
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Nagaoka M, Hatta Y, Kawaoka Y, Malherbe L. Antigen signal strength during priming determines effector CD4 T cell function and antigen sensitivity during influenza virus challenge. J Immunol. 2014;193:2812-20 pubmed publisher
Coquery C, Wade N, Loo W, Kinchen J, Cox K, Jiang C, et al. Neutrophils contribute to excess serum BAFF levels and promote CD4+ T cell and B cell responses in lupus-prone mice. PLoS ONE. 2014;9:e102284 pubmed publisher
Cowan J, McCarthy N, Parnell S, White A, Bacon A, Serge A, et al. Differential requirement for CCR4 and CCR7 during the development of innate and adaptive ??T cells in the adult thymus. J Immunol. 2014;193:1204-12 pubmed publisher
Cowan J, Parnell S, Nakamura K, Caamano J, Lane P, Jenkinson E, et al. The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development. J Exp Med. 2013;210:675-81 pubmed publisher
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de Vries V, Wasiuk A, Bennett K, Benson M, Elgueta R, Waldschmidt T, et al. Mast cell degranulation breaks peripheral tolerance. Am J Transplant. 2009;9:2270-80 pubmed publisher
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Fukushima A, Yamaguchi T, Ishida W, Fukata K, Yagita H, Ueno H. Roles of OX40 in the development of murine experimental allergic conjunctivitis: exacerbation and attenuation by stimulation and blocking of OX40. Invest Ophthalmol Vis Sci. 2006;47:657-63 pubmed
product information
Antigen :
CD62L
Apps. Abbrev. :
FC
Cat # :
104412
Clone :
MEL-14
Item :
APC anti-mouse CD62L
Isotype :
Rat IgG2a, κ
Other Names :
L-selectin, LECAM-1, Ly-22, LAM-1, MEL-14
Size :
100 μg
Price (USD) :
193 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
APC
Immunogen :
C3H/eb mouse B lymphoma 38C-13
Application Notes :
Additional reported applications (for the relevant formats) include: immunoprecipitation^1-3, complement-dependent cytotoxicity^4, in vivo and in vitro blocking of adhesion^1-3,5, and immunohistochemical staining of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections^6. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 104457-104462).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA