APC anti-mouse CD49d | BioLegend 103622 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

APC anti-mouse CD49d

catalog :

103622

quantity :

100 μg

price :

232 USD

clonality :

monoclonal

host :

rat

conjugate :

APC

clone name :

R1-2

reactivity :

mouse

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 5

Reference
Horková V, Drobek A, Paprckova D, Niederlova V, Prasai A, Uleri V, et al. Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells. Nat Immunol. 2023;24:174-185 pubmed publisher
Ohyagi M, Nagata T, Ihara K, Yoshida Tanaka K, Nishi R, Miyata H, et al. DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo. Nat Commun. 2021;12:7344 pubmed publisher
Hiltensperger M, Beltrán E, Kant R, Tyystjärvi S, Lepennetier G, Domínguez Moreno H, et al. Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity. Nat Immunol. 2021;22:880-892 pubmed publisher
Zhuang Z, Lai X, Sun J, Chen Z, Zhang Z, Dai J, et al. Mapping and role of T cell response in SARS-CoV-2-infected mice. J Exp Med. 2021;218: pubmed publisher
Ballesteros I, Rubio Ponce A, Genua M, Lusito E, Kwok I, Fernández Calvo G, et al. Co-option of Neutrophil Fates by Tissue Environments. Cell. 2020;183:1282-1297.e18 pubmed publisher

product information

Antigen :

CD49d

Apps. Abbrev. :

Cat # :

103622

Clone :

R1-2

Item :

APC anti-mouse CD49d

Isotype :

Rat IgG2b, κ

Other Names :

α4 integrin, VLA-4 α chain, integrin α4, ITGA4

Size :

100 μg

Price (USD) :

232 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Rat

Conjugate/Tag/Label :

APC

Immunogen :

AKR/Cum mouse spontaneous T lymphoma line TK1

Application Notes :

The R1-2 antibody has been shown to partially block CD49d mediated interactions and, in combination with the 9C10 (MFR4.B) antibody, completely blocks VCAM-1 binding to VLA-4. Additional reported applications (for the relevant formats) include: in vitro and in vivo blocking of cell-cell adhesion and T cell costimulation^1-4, immunoprecipitation^1, and immunohistochemistry of frozen sections^5. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 103629 and 103630;).;

more info or order :

BioLegend product webpage