LEAF™ Purified anti-mouse CD49d | BioLegend 103610 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

LEAF™ Purified anti-mouse CD49d

catalog :

103610

quantity :

500 μg

price :

230 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

R1-2

reactivity :

mouse

application :

neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments

citations: 6

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig s1	Zhang S, Liang W, Luo L, Sun S, Wang F. The role of T cell trafficking in CTLA-4 blockade-induced gut immunopathology. BMC Biol. 2020;18:29 pubmed publisher
flow cytometry; mouse; loading ...; fig s3a	Fu Y, Ding Y, Wang Q, Zhu F, Tan Y, Lu X, et al. Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2. Sci Adv. 2020;6:eaay9269 pubmed publisher
flow cytometry; mouse; loading ...; fig 3d	Capece T, Walling B, Lim K, Kim K, Bae S, Chung H, et al. A novel intracellular pool of LFA-1 is critical for asymmetric CD8+ T cell activation and differentiation. J Cell Biol. 2017;216:3817-3829 pubmed publisher
blocking or activating experiments; mouse; fig 2b flow cytometry; mouse; fig 2a	Yokota Nakatsuma A, Ohoka Y, Takeuchi H, Song S, Iwata M. Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties. Sci Rep. 2016;6:37914 pubmed publisher
flow cytometry; mouse; fig 2	Cabrera Perez J, Condotta S, James B, Kashem S, Brincks E, Rai D, et al. Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge. J Immunol. 2015;194:1609-20 pubmed publisher
	Foster G, Xu L, Chidambaram A, Soderberg S, Armstrong E, Wu H, et al. CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia. J Immunol. 2015;195:5380-92 pubmed publisher

product information

Antigen :

CD49d

Apps. Abbrev. :

Flow Cytometry, IP, Block, IHC-F

Cat # :

103610

Clone :

R1-2

Item :

LEAF™ Purified anti-mouse CD49d

Isotype :

Rat IgG2b, κ

Other Names :

α4 integrin, VLA-4 α chain, integrin α4, ITGA4

Size :

500 μg

Price (USD) :

230 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Rat

Conjugate/Tag/Label :

LEAF

Immunogen :

AKR/Cum mouse spontaneous T lymphoma line TK1

Application Notes :

The R1-2 antibody has been shown to partially block CD49d mediated interactions and, in combination with the 9C10 (MFR4.B) antibody, completely blocks VCAM-1 binding to VLA-4. Additional reported applications (for the relevant formats) include: in vitro and in vivo blocking of cell-cell adhesion and T cell costimulation 1-4 , immunoprecipitation 1 , and immunohistochemistry of frozen sections 5 . The Ultra-LEAF™ purified antibody (Endotoxin 0.01 EU/μg, Azide-Free, 0.2 μm filtered) is recommended for functional assays (Cat. No. 103629 and 103630 ).