FITC anti-mouse CD49d | BioLegend 103606 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

FITC anti-mouse CD49d

catalog :

103606

quantity :

500 μg

price :

293 USD

clonality :

monoclonal

host :

rat

conjugate :

FITC

clone name :

R1-2

reactivity :

mouse

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 12

Reference
Chryplewicz A, Scotton J, Tichet M, Zomer A, Shchors K, Joyce J, et al. Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity. Cancer Cell. 2022;40:1111-1127.e9 pubmed publisher
Leary N, Walser S, He Y, Cousin N, Pereira P, Gallo A, et al. Melanoma-derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes. J Extracell Vesicles. 2022;11:e12197 pubmed publisher
Anastasiou M, Newton G, Kaur K, Carrillo Salinas F, Smolgovsky S, Bayer A, et al. Endothelial STING controls T cell transmigration in an IFNI-dependent manner. JCI Insight. 2021;6: pubmed publisher
O CONNOR T, Zhou X, Kosla J, Adili A, García Beccaria M, Kotsiliti E, et al. Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention. Cancer Cell. 2019;36:250-267.e9 pubmed publisher
Dieterich L, Kapaklikaya K, Cetintas T, Proulx S, Commerford C, Ikenberg K, et al. Transcriptional profiling of breast cancer-associated lymphatic vessels reveals VCAM-1 as regulator of lymphatic invasion and permeability. Int J Cancer. 2019;145:2804-2815 pubmed publisher
Buzzelli J, O Connor L, Scurr M, Chung Nien Chin S, Catubig A, Ng G, et al. Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT driver mutations. Am J Physiol Gastrointest Liver Physiol. 2019;316:G251-G262 pubmed publisher
Rydyznski C, Cranert S, Zhou J, Xu H, Kleinstein S, Singh H, et al. Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers. Cell Rep. 2018;24:3367-3373.e4 pubmed publisher
Cabrera Mora M, Fonseca J, Singh B, Zhao C, Makarova N, Dmitriev I, et al. A Recombinant Chimeric Ad5/3 Vector Expressing a Multistage Plasmodium Antigen Induces Protective Immunity in Mice Using Heterologous Prime-Boost Immunization Regimens. J Immunol. 2016;197:2748-61 pubmed publisher
DÃ¤britz J, Judd L, Chalinor H, Menheniott T, Giraud A. Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells. Sci Rep. 2016;6:20584 pubmed publisher
Salinas Tejedor L, Berner G, Jacobsen K, Gudi V, Jungwirth N, Hansmann F, et al. Mesenchymal stem cells do not exert direct beneficial effects on CNS remyelination in the absence of the peripheral immune system. Brain Behav Immun. 2015;50:155-165 pubmed publisher
Dalla Santa S, Merlo A, Bobisse S, Ronconi E, Boldrin D, Milan G, et al. Functional avidity-driven activation-induced cell death shapes CTL immunodominance. J Immunol. 2014;193:4704-11 pubmed publisher
Tomov V, Osborne L, Dolfi D, Sonnenberg G, Monticelli L, Mansfield K, et al. Persistent enteric murine norovirus infection is associated with functionally suboptimal virus-specific CD8 T cell responses. J Virol. 2013;87:7015-31 pubmed publisher

product information

Antigen :

CD49d

Apps. Abbrev. :

Cat # :

103606

Clone :

R1-2

Item :

FITC anti-mouse CD49d

Isotype :

Rat IgG2b, κ

Other Names :

α4 integrin, VLA-4 α chain, integrin α4, ITGA4

Size :

500 μg

Price (USD) :

293 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Rat

Conjugate/Tag/Label :

FITC

Immunogen :

AKR/Cum mouse spontaneous T lymphoma line TK1

Application Notes :

The R1-2 antibody has been shown to partially block CD49d mediated interactions and, in combination with the 9C10 (MFR4.B) antibody, completely blocks VCAM-1 binding to VLA-4. Additional reported applications (for the relevant formats) include: in vitro and in vivo blocking of cell-cell adhesion and T cell costimulation^1-4, immunoprecipitation^1, and immunohistochemistry of frozen sections^5. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 103629 and 103630;).;

more info or order :

BioLegend product webpage