product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Ultra-LEAF™ Purified anti-mouse CD28
catalog :
102121
quantity :
5 mg
price :
539 USD
clonality :
monoclonal
host :
Syrian golden hamster
conjugate :
nonconjugated
clone name :
37.51
reactivity :
mouse
application :
neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments
more info or order :
citations: 98
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; fig 6a
Laffey K, Stiles R, Ludescher M, Davis T, Khwaja S, Bram R, et al. Early expression of mature αβ TCR in CD4-CD8- T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations. Proc Natl Acad Sci U S A. 2022;119:e2118529119 pubmed publisher
  • blocking or activating experiments; mouse; 2.5 ug/ml; loading ...; fig 1a
Aarts J, van Caam A, Chen X, Marijnissen R, Helsen M, Walgreen B, et al. Local inhibition of TGF-β1 signaling improves Th17/Treg balance but not joint pathology during experimental arthritis. Sci Rep. 2022;12:3182 pubmed publisher
  • blocking or activating experiments; mouse; loading ...; fig s2
Liu H, Pedros C, Kong K, Canonigo Balancio A, Xue W, Altman A. Leveraging the Treg-intrinsic CTLA4-PKCη signaling pathway for cancer immunotherapy. J Immunother Cancer. 2021;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Nian Y, Iske J, Maenosono R, Minami K, Heinbokel T, Quante M, et al. Targeting age-specific changes in CD4+ T cell metabolism ameliorates alloimmune responses and prolongs graft survival. Aging Cell. 2021;20:e13299 pubmed publisher
  • blocking or activating experiments; mouse; 1 ug/ml; loading ...; fig 1h
Chen H, Cong X, Wu C, Wu X, Wang J, Mao K, et al. Intratumoral delivery of CCL25 enhances immunotherapy against triple-negative breast cancer by recruiting CCR9+ T cells. Sci Adv. 2020;6:eaax4690 pubmed publisher
  • blocking or activating experiments; mouse; 1-10 ug/ml; fig 2a
Krovi S, Kappler J, Marrack P, Gapin L. Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules. Proc Natl Acad Sci U S A. 2019;116:22252-22261 pubmed publisher
  • blocking or activating experiments; mouse; 0.5 ug/ml; loading ...; fig 1a
Rasoulouniriana D, Santana Magal N, Gutwillig A, Farhat Younis L, Wine Y, Saperia C, et al. A distinct subset of FcγRI-expressing Th1 cells exert antibody-mediated cytotoxic activity. J Clin Invest. 2019;129:4151-4164 pubmed publisher
  • flow cytometry; mouse; fig 1b
Humeniuk P, Geiselhart S, Battin C, Webb T, Steinberger P, Paster W, et al. Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor. Sci Rep. 2019;9:7426 pubmed publisher
Yao R, Zhao P, Li Z, Liu Y, Zheng L, Duan Y, et al. Single-cell transcriptome profiling of sepsis identifies HLA-DRlowS100Ahigh monocytes with immunosuppressive function. Mil Med Res. 2023;10:27 pubmed publisher
Wang T, Zhao R, Zhi J, Liu Z, Wu A, Yang Z, et al. Tox4 regulates transcriptional elongation and reinitiation during murine T cell development. Commun Biol. 2023;6:613 pubmed publisher
Vereertbrugghen A, Pizzano M, Sabbione F, Keitelman I, Shiromizu C, Aguilar D, et al. An ocular Th1 immune response promotes corneal nerve damage independently of the development of corneal epitheliopathy. J Neuroinflammation. 2023;20:120 pubmed publisher
Xiao X, Shi J, He C, Bu X, Sun Y, Gao M, et al. ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. Nat Commun. 2023;14:2859 pubmed publisher
Mabire M, Hegde P, Hammoutene A, Wan J, Ca xeb r C, Sayegh R, et al. MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming. Nat Commun. 2023;14:1830 pubmed publisher
Mammadli M, Suo L, Sen J, Karimi M. TCF-1 Is Required for CD4 T Cell Persistence Functions during AlloImmunity. Int J Mol Sci. 2023;24: pubmed publisher
Li X, Li Y, Dong L, Chang Y, Zhang X, Wang C, et al. Decitabine priming increases anti-PD-1 antitumor efficacy by promoting CD8+ progenitor exhausted T cell expansion in tumor models. J Clin Invest. 2023;133: pubmed publisher
Aso K, Kono M, Kanda M, Kudo Y, Sakiyama K, Hisada R, et al. Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming. Nat Commun. 2023;14:984 pubmed publisher
Pitmon E, Meehan E, Ahmadi E, Adler A, Wang K. High glucose promotes regulatory T cell differentiation. PLoS ONE. 2023;18:e0280916 pubmed publisher
Jiang X, Deng W, Tao S, Tang Z, Chen Y, Tian M, et al. A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma. Cell Discov. 2023;9:7 pubmed publisher
Yang H, Zhang X, Lao M, Sun K, He L, Xu J, et al. Targeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer. Cell Death Differ. 2023;30:560-575 pubmed publisher
Liu T, Meng Z, Liu J, Li J, Zhang Y, Deng Z, et al. Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells. Cardiovasc Res. 2023;119:1046-1061 pubmed publisher
Jiang Y, Wen J, Zhao X, Gao Y, Ma X, Song S, et al. The Flavonoid Naringenin Alleviates Collagen-Induced Arthritis through Curbing the Migration and Polarization of CD4+ T Lymphocyte Driven by Regulating Mitochondrial Fission. Int J Mol Sci. 2022;24: pubmed publisher
Wang Z, Qin X, Hu D, Huang J, Guo E, Xiao R, et al. Akkermansia supplementation reverses the tumor-promoting effect of the fecal microbiota transplantation in ovarian cancer. Cell Rep. 2022;41:111890 pubmed publisher
Zhang H, Zhu X, Friesen T, Kwak J, Pisarenko T, Mekvanich S, et al. Annexin A2/TLR2/MYD88 pathway induces arginase 1 expression in tumor-associated neutrophils. J Clin Invest. 2022;132: pubmed publisher
Xu L, Wei C, Chen Y, Wu Y, Shou X, Chen W, et al. IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection. Nat Commun. 2022;13:6881 pubmed publisher
Koch K, Lindner M, Fleck A, Liebmann M, Eschborn M, Zondler L, et al. CNS Pericytes Modulate Local T Cell Infiltration in EAE. Int J Mol Sci. 2022;23: pubmed publisher
Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler P, Braun A, et al. Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. Immunity. 2022;55:2059-2073.e8 pubmed publisher
Klaus T, Wilson A, Vicari E, Hadaschik E, Klein M, Helbich S, et al. Impaired Treg-DC interactions contribute to autoimmunity in leukocyte adhesion deficiency type 1. JCI Insight. 2022;7: pubmed publisher
Kumar V, Rosenzweig R, Asalla S, Nehra S, Prabhu S, Bansal S. TNFR1 Contributes to Activation-Induced Cell Death of Pathological CD4+ T Lymphocytes During Ischemic Heart Failure. JACC Basic Transl Sci. 2022;7:1038-1049 pubmed publisher
Krishnamurty A, Shyer J, Thai M, Gandham V, Buechler M, Yang Y, et al. LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity. Nature. 2022;611:148-154 pubmed publisher
Sobecki M, Chen J, Krzywinska E, Nagarajan S, Fan Z, Nelius E, et al. Vaccination-based immunotherapy to target profibrotic cells in liver and lung. Cell Stem Cell. 2022;29:1459-1474.e9 pubmed publisher
Mirji G, Worth A, Bhat S, El Sayed M, Kannan T, Goldman A, et al. The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer. Sci Immunol. 2022;7:eabn0704 pubmed publisher
Kanno T, Miyako K, Nakajima T, Yokoyama S, Sasamoto S, Asou H, et al. SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4+ T cells. Front Immunol. 2022;13:904875 pubmed publisher
Potluri H, Ferreira C, Grudzinski J, Massey C, Aluicio Sarduy E, Engle J, et al. Antitumor efficacy of 90Y-NM600 targeted radionuclide therapy and PD-1 blockade is limited by regulatory T cells in murine prostate tumors. J Immunother Cancer. 2022;10: pubmed publisher
Chen C, Yin Y, Shi G, Zhou Y, Shao S, Wei Y, et al. A highly selective JAK3 inhibitor is developed for treating rheumatoid arthritis by suppressing γc cytokine-related JAK-STAT signal. Sci Adv. 2022;8:eabo4363 pubmed publisher
Gudgeon N, Munford H, Bishop E, Hill J, Fulton Ward T, Bending D, et al. Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation. Cell Rep. 2022;40:111193 pubmed publisher
Ye Q, Wu M, Zhou C, Lu X, Huang B, Zhang N, et al. Rational development of a combined mRNA vaccine against COVID-19 and influenza. NPJ Vaccines. 2022;7:84 pubmed publisher
Pfenninger P, Yerly L, Abe J. Naïve Primary Mouse CD8+ T Cells Retain In Vivo Immune Responsiveness After Electroporation-Based CRISPR/Cas9 Genetic Engineering. Front Immunol. 2022;13:777113 pubmed publisher
Guo Z, Zhang J, Liu X, Unsinger J, Hotchkiss R, Cao Y. Low-dose interleukin-2 reverses chronic migraine-related sensitizations through peripheral interleukin-10 and transforming growth factor beta-1 signaling. Neurobiol Pain. 2022;12:100096 pubmed publisher
Li X, Yong T, Wei Z, Bie N, Zhang X, Zhan G, et al. Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts. Nat Commun. 2022;13:2794 pubmed publisher
Zhang R, Wang Y, Liu D, Luo Q, Du P, Zhang H, et al. Sodium Tanshinone IIA Sulfonate as a Potent IDO1/TDO2 Dual Inhibitor Enhances Anti-PD1 Therapy for Colorectal Cancer in Mice. Front Pharmacol. 2022;13:870848 pubmed publisher
Peng L, Renauer P, xd6 kten A, Fang Z, Park J, Zhou X, et al. Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2. Cell Rep Med. 2022;3:100634 pubmed publisher
Kwon H, Schafer J, Song N, Kaneko S, Li A, Xiao T, et al. Androgen conspires with the CD8+ T cell exhaustion program and contributes to sex bias in cancer. Sci Immunol. 2022;7:eabq2630 pubmed publisher
Ye L, Park J, Peng L, Yang Q, Chow R, Lam S, et al. A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy. Cell Metab. 2022;34:595-614.e14 pubmed publisher
Wang D, Xiu J, Zhao J, Luo J. miR-AB, a miRNA-based shRNA viral toolkit for multicolor-barcoded multiplex RNAi at a single-cell level. EMBO Rep. 2022;23:e53691 pubmed publisher
Krone A, Fu Y, Schreiber S, Kotrba J, Borde L, Nötzold A, et al. Ionic mitigation of CD4+ T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc. Sci Rep. 2022;12:1943 pubmed publisher
Kerdidani D, Aerakis E, Verrou K, Angelidis I, Douka K, Maniou M, et al. Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts. J Exp Med. 2022;219: pubmed publisher
Du Y, Peng Q, Cheng D, Pan T, Sun W, Wang H, et al. Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing γδ T cells. Nat Commun. 2022;13:231 pubmed publisher
Qi Z, Xu Z, Zhang L, Zou Y, Li J, Yan W, et al. Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by intermittent anti-PI3Kα/β/δ treatment. Nat Commun. 2022;13:182 pubmed publisher
Cheng B, Ding K, Chen P, Ji J, Luo T, Guo X, et al. Anti-PD-L1/TGF-βR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer. Cancer Commun (Lond). 2022;42:17-36 pubmed publisher
Li H, Xiao Y, Li Q, Yao J, Yuan X, Zhang Y, et al. The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. Cancer Cell. 2022;40:36-52.e9 pubmed publisher
Hajjar S, Nathan N, Joseph J, Mottawea W, Ariana A, Pyatibrat S, et al. Foxo3a tempers excessive glutaminolysis in activated T cells to prevent fatal gut inflammation in the murine IL-10-/- model of colitis. Cell Death Differ. 2022;29:585-599 pubmed publisher
Herrera F, Ronet C, Ochoa de Olza M, Barras D, Crespo I, Andreatta M, et al. Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy. Cancer Discov. 2022;12:108-133 pubmed publisher
Okubo A, Uchida Y, Higashi Y, Sato T, Ogawa Y, Ryuge A, et al. CD147 Is Essential for the Development of Psoriasis via the Induction of Th17 Cell Differentiation. Int J Mol Sci. 2021;23: pubmed publisher
Yuan Y, Zhang X, Chen R, Li Y, Wu B, Li R, et al. A bivalent nanoparticle vaccine exhibits potent cross-protection against the variants of SARS-CoV-2. Cell Rep. 2021;:110256 pubmed publisher
Mammadli M, Harris R, Suo L, May A, Gentile T, Waickman A, et al. Interleukin-2-inducible T-cell kinase (Itk) signaling regulates potent noncanonical regulatory T cells. Clin Transl Med. 2021;11:e625 pubmed publisher
Otano I, Azpilikueta A, Glez Vaz J, Alvarez M, Medina Echeverz J, Cortés Domínguez I, et al. CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation. Nat Commun. 2021;12:7296 pubmed publisher
Teh M, Frost J, Armitage A, Drakesmith H. Analysis of Iron and Iron-Interacting Protein Dynamics During T-Cell Activation. Front Immunol. 2021;12:714613 pubmed publisher
Xu Y, Liu E, Xie X, Wang J, Zheng H, Ju Y, et al. Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases. iScience. 2021;24:103445 pubmed publisher
Zhai X, Liu K, Fang H, Zhang Q, Gao X, Liu F, et al. Mitochondrial C1qbp promotes differentiation of effector CD8+ T cells via metabolic-epigenetic reprogramming. Sci Adv. 2021;7:eabk0490 pubmed publisher
Liu Y, Debo B, Li M, Shi Z, Sheng W, Shi Y. LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade. Nat Commun. 2021;12:6831 pubmed publisher
Ohtsuka J, Imai M, Fukumura M, Maeda M, Eguchi A, Ono R, et al. Non-propagative human parainfluenza virus type 2 nasal vaccine robustly protects the upper and lower airways against SARS-CoV-2. iScience. 2021;24:103379 pubmed publisher
Stump C, Roehle K, Manjarrez Orduno N, Dougan S. Radiation combines with immune checkpoint blockade to enhance T cell priming in a murine model of poorly immunogenic pancreatic cancer. Open Biol. 2021;11:210245 pubmed publisher
Jairaman A, Cahalan M. Calcium Imaging in T Lymphocytes: a Protocol for Use with Genetically Encoded or Chemical Ca2+ Indicators. Bio Protoc. 2021;11:e4170 pubmed publisher
Zhang Z, Yang C, Li L, Zhu Y, Su K, Zhai L, et al. "γδT Cell-IL17A-Neutrophil" Axis Drives Immunosuppression and Confers Breast Cancer Resistance to High-Dose Anti-VEGFR2 Therapy. Front Immunol. 2021;12:699478 pubmed publisher
Daneshmandi S, Cassel T, Higashi R, Fan T, Seth P. 6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function. elife. 2021;10: pubmed publisher
Menzel L, Zschummel M, Crowley T, Franke V, Grau M, Ulbricht C, et al. Lymphocyte access to lymphoma is impaired by high endothelial venule regression. Cell Rep. 2021;37:109878 pubmed publisher
Zhao X, Liu J, Zhang C, Yu N, Lu Z, Zhang S, et al. Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase. Int J Oral Sci. 2021;13:31 pubmed publisher
Mammadli M, Harris R, Mahmudlu S, Verma A, May A, Dhawan R, et al. Human Wnt/β-Catenin Regulates Alloimmune Signaling during Allogeneic Transplantation. Cancers (Basel). 2021;13: pubmed publisher
James O, Vandereyken M, Marchingo J, Singh F, Bray S, Wilson J, et al. IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes. Nat Commun. 2021;12:4290 pubmed publisher
Gkountidi A, Garnier L, Dubrot J, Angelillo J, Harl xe9 G, Brighouse D, et al. MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell-Suppressive Functions. Cancer Immunol Res. 2021;9:748-764 pubmed publisher
Luo Z, Xia K, Liu Y, Liu J, Rao S, Hu X, et al. Extracellular Vesicles from Akkermansia muciniphila Elicit Antitumor Immunity Against Prostate Cancer via Modulation of CD8+ T Cells and Macrophages. Int J Nanomedicine. 2021;16:2949-2963 pubmed publisher
Mitchell J, Lund M, Starmer J, Ge K, Magnuson T, Shpargel K, et al. UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability. Cell Rep. 2021;35:108966 pubmed publisher
Li X, Dong L, Liu J, Wang C, Zhang Y, Mei Q, et al. Low-Dose Decitabine Augments the Activation and Anti-Tumor Immune Response of IFN-γ+ CD4+ T Cells Through Enhancing IκBα Degradation and NF-κB Activation. Front Cell Dev Biol. 2021;9:647713 pubmed publisher
Han K, Singh K, Rodman M, Hassanzadeh S, Wu K, Nguyen A, et al. Fasting-induced FOXO4 blunts human CD4+ T helper cell responsiveness. Nat Metab. 2021;3:318-326 pubmed publisher
Daneshmandi S, Cassel T, Lin P, Higashi R, Wulf G, Boussiotis V, et al. Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function. Cell Rep. 2021;34:108831 pubmed publisher
Frost J, Tan T, Abbas M, Wideman S, Bonadonna M, Stoffel N, et al. Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection. Med. 2021;2:164-179.e12 pubmed publisher
Woo M, Ufer F, Rothammer N, Di Liberto G, Binkle L, Haferkamp U, et al. Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation. J Exp Med. 2021;218: pubmed publisher
Liu W, Zhou N, Liu Y, Zhang W, Li X, Wang Y, et al. Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells. Stem Cell Res Ther. 2021;12:153 pubmed publisher
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Yi M, Zhang J, Li A, Niu M, Yan Y, Jiao Y, et al. The construction, expression, and enhanced anti-tumor activity of YM101: a bispecific antibody simultaneously targeting TGF-β and PD-L1. J Hematol Oncol. 2021;14:27 pubmed publisher
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Liu J, Yang C, Liu T, Deng Z, Fang W, Zhang X, et al. Eosinophils improve cardiac function after myocardial infarction. Nat Commun. 2020;11:6396 pubmed publisher
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Saragovi A, Abramovich I, Omar I, Arbib E, Toker O, Gottlieb E, et al. Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest. elife. 2020;9: pubmed publisher
Byun J, Park M, Lee S, Yun J, Lee J, Kim J, et al. Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity. Mol Cell. 2020;80:592-606.e8 pubmed publisher
Saito S, Kakizaki N, Okuno A, Maekawa T, Tsuji N. Lactococcus lactis subsp. Cremoris C60 restores T Cell Population in Small Intestinal Lamina Propria in Aged Interleukin-18 Deficient Mice. Nutrients. 2020;12: pubmed publisher
Jiang C, Liu J, Guo M, Gao X, Wu X, Bai N, et al. The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response. Int J Biol Sci. 2020;16:3075-3084 pubmed publisher
Montes De Oca M, de Labastida Rivera F, Winterford C, Frame T, Ng S, Amante F, et al. IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection. PLoS Pathog. 2020;16:e1008994 pubmed publisher
Bromley S, Akbaba H, Mani V, Mora Buch R, Chasse A, Sama A, et al. CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response. Cell Rep. 2020;32:108085 pubmed publisher
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Zhang C, Yue C, Herrmann A, Song J, Egelston C, Wang T, et al. STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth. Cell Metab. 2020;31:148-161.e5 pubmed publisher
He Y, Schreiber K, Wolf S, Wen F, Steentoft C, Zerweck J, et al. Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell. JCI Insight. 2019;4: pubmed publisher
Garo L, Ajay A, Fujiwara M, Beynon V, Kuhn C, Gabriely G, et al. Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity. Cell Rep. 2019;28:3353-3366.e5 pubmed publisher
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Wu J, Ma S, Sandhoff R, Ming Y, Hotz Wagenblatt A, Timmerman V, et al. Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness. Immunity. 2019;50:1218-1231.e5 pubmed publisher
Sekiya T, Hibino S, Saeki K, Kanamori M, Takaki S, Yoshimura A. Nr4a Receptors Regulate Development and Death of Labile Treg Precursors to Prevent Generation of Pathogenic Self-Reactive Cells. Cell Rep. 2018;24:1627-1638.e6 pubmed publisher
Yuan X, Yang B, Dong Y, Yamamura A, Fu W. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells. elife. 2017;6: pubmed publisher
product information
Antigen :
CD28
Apps. Abbrev. :
FC, IP, IHC-F, Costim, Block
Cat # :
102121
Clone :
37.51
Item :
Ultra-LEAF™ Purified anti-mouse CD28
Isotype :
Syrian Hamster IgG
Other Names :
Tp44, T44
Size :
5 mg
Price (USD) :
539 USD
Reactivity :
Mouse
Clonality :
Monoclonal
Host :
Syrian Hamster
Conjugate/Tag/Label :
ULEAF
Immunogen :
C57BL/6 mouse T-cell lymphoma EL-4
Application Notes :
Additional reported applications (for the relevant formats) include: immunoprecipitation^1, in vitro costimulation of T and NK cells^1, in vitro blocking of allogeneic mixed leukocyte response and inhibition of MHC-unrestricted CTL cytotoxicity^3,4, in vitro induction of thymocyte differentiation^2,5-9,11, and immunohistochemical staining of acetone-fixed frozen sections. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 102116).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA