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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Brilliant Violet 510™ anti-mouse/human CD11b
catalog :
101263
quantity :
50 μg
price :
257 USD
clonality :
monoclonal
host :
rat
conjugate :
BV510
clone name :
M1/70
reactivity :
human, mouse
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 72
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...
Hemmi T, Ainai A, Hashiguchi T, Tobiume M, Kanno T, Iwata Yoshikawa N, et al. Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathology. Vaccine. 2022;40:5892-5903 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...
Cortés A, Solas M, Pejenaute A, Abellanas M, Garcia Lacarte M, Aymerich M, et al. Expression of Endothelial NOX5 Alters the Integrity of the Blood-Brain Barrier and Causes Loss of Memory in Aging Mice. Antioxidants (Basel). 2021;10: pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3a
Petermann M, Orfanos Z, Sellau J, Gharaibeh M, Lotter H, Fleischer B, et al. CCR2 Deficiency Impairs Ly6Clo and Ly6Chi Monocyte Responses in Orientia tsutsugamushi Infection. Front Immunol. 2021;12:670219 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2d
Gangoso E, Southgate B, Bradley L, Rus S, Gálvez Cancino F, McGivern N, et al. Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion. Cell. 2021;184:2454-2470.e26 pubmed publisher
  • flow cytometry; mouse; 1:500; fig 2i
Celorrio M, Abellanas M, Rhodes J, Goodwin V, Moritz J, Vadivelu S, et al. Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis. Acta Neuropathol Commun. 2021;9:40 pubmed publisher
  • flow cytometry; mouse; fig 4
Karsten C, Laumonnier Y, Eurich B, Ender F, Bröker K, Roy S, et al. Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse. J Immunol. 2015;194:1841-55 pubmed publisher
Yuan M, Zhai Y, Men Y, Zhao M, Sun X, Ma Z, et al. Anlotinib Enhances the Antitumor Activity of High-Dose Irradiation Combined with Anti-PD-L1 by Potentiating the Tumor Immune Microenvironment in Murine Lung Cancer. Oxid Med Cell Longev. 2022;2022:5479491 pubmed publisher
Ercoli G, Ramos Sevillano E, Pearce E, Ragab S, Goldblatt D, Weckbecker G, et al. Maintained partial protection against Streptococcus pneumoniae despite B-cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine. Clin Transl Immunology. 2022;11:e1366 pubmed publisher
Ahn D, Bhushan G, McConville T, Annavajhala M, Soni R, Wong Fok Lung T, et al. An acquired acyltransferase promotes Klebsiella pneumoniae ST258 respiratory infection. Cell Rep. 2021;35:109196 pubmed publisher
Shmuel Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, et al. Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells. Immunity. 2021;54:1137-1153.e8 pubmed publisher
Platt D, Lawrence D, Rodgers R, Schriefer L, Qian W, Miner C, et al. Transferrable protection by gut microbes against STING-associated lung disease. Cell Rep. 2021;35:109113 pubmed publisher
Affò S, Nair A, Brundu F, Ravichandra A, Bhattacharjee S, Matsuda M, et al. Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell. 2021;39:866-882.e11 pubmed publisher
Gern B, Adams K, Plumlee C, Stoltzfus C, Shehata L, Moguche A, et al. TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma. Cell Host Microbe. 2021;29:594-606.e6 pubmed publisher
Plumlee C, Duffy F, Gern B, Delahaye J, Cohen S, Stoltzfus C, et al. Ultra-low Dose Aerosol Infection of Mice with Mycobacterium tuberculosis More Closely Models Human Tuberculosis. Cell Host Microbe. 2021;29:68-82.e5 pubmed publisher
Mincham K, Jones A, Bodinier M, Scott N, Lauzon Joset J, Stumbles P, et al. Transplacental Innate Immune Training via Maternal Microbial Exposure: Role of XBP1-ERN1 Axis in Dendritic Cell Precursor Programming. Front Immunol. 2020;11:601494 pubmed publisher
Ringel A, Drijvers J, Baker G, Catozzi A, García Cañaveras J, Gassaway B, et al. Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell. 2020;183:1848-1866.e26 pubmed publisher
Wang Y, Wang Q, Wang B, Gu Y, Yu H, Yang W, et al. Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells. Cell Death Dis. 2020;11:1024 pubmed publisher
Wang J, Xu Y, Chen Z, Liang J, Lin Z, Liang H, et al. Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia. Cell. 2020;183:1867-1883.e26 pubmed publisher
Ballesteros I, Rubio Ponce A, Genua M, Lusito E, Kwok I, Fernández Calvo G, et al. Co-option of Neutrophil Fates by Tissue Environments. Cell. 2020;183:1282-1297.e18 pubmed publisher
El Amki M, Glück C, Binder N, Middleham W, Wyss M, Weiss T, et al. Neutrophils Obstructing Brain Capillaries Are a Major Cause of No-Reflow in Ischemic Stroke. Cell Rep. 2020;33:108260 pubmed publisher
Kerkhofs D, Van Hagen B, Milanova I, Schell K, van Essen H, Wijnands E, et al. Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension. Theranostics. 2020;10:9512-9527 pubmed publisher
McCauley M, O Rourke J, Yáñez A, Markman J, Ho R, Wang X, et al. C9orf72 in myeloid cells suppresses STING-induced inflammation. Nature. 2020;585:96-101 pubmed publisher
Briukhovetska D, Ohm B, Mey F, Aliberti J, Kleingarn M, Huber Lang M, et al. C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection. Front Immunol. 2020;11:1397 pubmed publisher
BURNS J, Cotleur B, Walther D, Bajrami B, Rubino S, Wei R, et al. Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain. elife. 2020;9: pubmed publisher
Wong J, Tai C, Hurt A, Tan H, Kent S, Wheatley A. Sequencing B cell receptors from ferrets (Mustela putorius furo). PLoS ONE. 2020;15:e0233794 pubmed publisher
Lee C, Jeong H, Lee H, Hong M, Park S, Bae H. Magnolol Attenuates Cisplatin-Induced Muscle Wasting by M2c Macrophage Activation. Front Immunol. 2020;11:77 pubmed publisher
Schaffert A, Hanić M, Novokmet M, Zaytseva O, Krištić J, Lux A, et al. Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo. Front Immunol. 2019;10:3024 pubmed publisher
Lauterbach M, Hanke J, Serefidou M, Mangan M, Kolbe C, Hess T, et al. Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase. Immunity. 2019;51:997-1011.e7 pubmed publisher
Bhattacherjee A, Rodrigues E, Jung J, Luzentales Simpson M, Enterina J, Galleguillos D, et al. Repression of phagocytosis by human CD33 is not conserved with mouse CD33. Commun Biol. 2019;2:450 pubmed publisher
Huang B, Chen Z, Geng L, Wang J, Liang H, Cao Y, et al. Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways. Cell. 2019;179:1160-1176.e24 pubmed publisher
Schadt L, Sparano C, Schweiger N, Silina K, Cecconi V, Lucchiari G, et al. Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity. Cell Rep. 2019;29:1236-1248.e7 pubmed publisher
Smith C, Tyrell D, Kulkarni U, Wood S, Leng L, Zemans R, et al. Macrophage migration inhibitory factor enhances influenza-associated mortality in mice. JCI Insight. 2019;4: pubmed publisher
Ramakrishna C, Kujawski M, Chu H, Li L, Mazmanian S, CANTIN E. Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis. Nat Commun. 2019;10:2153 pubmed publisher
Eremenko E, Mittal K, Berner O, Kamenetsky N, Nemirovsky A, Elyahu Y, et al. BDNF-producing, amyloid β-specific CD4 T cells as targeted drug-delivery vehicles in Alzheimer's disease. EBioMedicine. 2019;43:424-434 pubmed publisher
Meixiong J, Anderson M, Limjunyawong N, Sabbagh M, Hu E, Mack M, et al. Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch. Immunity. 2019;50:1163-1171.e5 pubmed publisher
Uderhardt S, Martins A, Tsang J, Lämmermann T, Germain R. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. 2019;177:541-555.e17 pubmed publisher
Green D, Limjunyawong N, Gour N, Pundir P, Dong X. A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain. Neuron. 2019;101:412-420.e3 pubmed publisher
Nakamoto N, Sasaki N, Aoki R, Miyamoto K, Suda W, Teratani T, et al. Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis. Nat Microbiol. 2019;4:492-503 pubmed publisher
Cheng Y, Tang X, Li Y, Zhao D, Cao Q, Wu H, et al. Depression-Induced Neuropeptide Y Secretion Promotes Prostate Cancer Growth by Recruiting Myeloid Cells. Clin Cancer Res. 2019;25:2621-2632 pubmed publisher
Luo J, Qian A, Oetjen L, Yu W, Yang P, Feng J, et al. TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells. Immunity. 2018;49:107-119.e4 pubmed publisher
Hoffmann F, Berger J, Lingel I, Laumonnier Y, Lewkowich I, Schmudde I, et al. Distribution and Interaction of Murine Pulmonary Phagocytes in the Naive and Allergic Lung. Front Immunol. 2018;9:1046 pubmed publisher
Gentek R, Ghigo C, Hoeffel G, Bulle M, Msallam R, Gautier G, et al. Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells. Immunity. 2018;48:1160-1171.e5 pubmed publisher
Lyons J, Ghazi P, Starchenko A, Tovaglieri A, Baldwin K, Poulin E, et al. The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. PLoS Biol. 2018;16:e2002417 pubmed publisher
Lamothe R, Kolte P, Vo T, Ferrari J, Gelsinger T, Wong J, et al. Tolerogenic Nanoparticles Induce Antigen-Specific Regulatory T Cells and Provide Therapeutic Efficacy and Transferrable Tolerance against Experimental Autoimmune Encephalomyelitis. Front Immunol. 2018;9:281 pubmed publisher
Lyons J, Brubaker D, Ghazi P, Baldwin K, Edwards A, Boukhali M, et al. Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis. Sci Signal. 2018;11: pubmed publisher
Christ A, Günther P, Lauterbach M, Duewell P, Biswas D, Pelka K, et al. Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming. Cell. 2018;172:162-175.e14 pubmed publisher
Le T, Takarada Iemata M, Ta H, Roboon J, Ishii H, Tamatani T, et al. Ndrg2 deficiency ameliorates neurodegeneration in experimental autoimmune encephalomyelitis. J Neurochem. 2018;145:139-153 pubmed publisher
Feng J, Yang P, Mack M, Dryn D, Luo J, Gong X, et al. Sensory TRP channels contribute differentially to skin inflammation and persistent itch. Nat Commun. 2017;8:980 pubmed publisher
McDonald L, Johnson S, Russell D, Young M, LaRue A. Role of a novel immune modulating DDR2-expressing population in silica-induced pulmonary fibrosis. PLoS ONE. 2017;12:e0180724 pubmed publisher
Ender F, Wiese A, Schmudde I, Sun J, Vollbrandt T, Konig P, et al. Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase. PLoS ONE. 2017;12:e0172446 pubmed publisher
Di Marco Barros R, Roberts N, Dart R, Vantourout P, Jandke A, Nussbaumer O, et al. Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments. Cell. 2016;167:203-218.e17 pubmed publisher
Vicetti Miguel R, Quispe Calla N, Pavelko S, Cherpes T. Intravaginal Chlamydia trachomatis Challenge Infection Elicits TH1 and TH17 Immune Responses in Mice That Promote Pathogen Clearance and Genital Tract Damage. PLoS ONE. 2016;11:e0162445 pubmed publisher
Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander L, Mitchell T, et al. NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence. Sci Rep. 2016;6:30943 pubmed publisher
Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, et al. Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival. Proc Natl Acad Sci U S A. 2016;113:4476-81 pubmed publisher
Peterson T, Kirkpatrick N, Huang Y, Farrar C, Marijt K, Kloepper J, et al. Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages. Proc Natl Acad Sci U S A. 2016;113:4470-5 pubmed publisher
Woods T, Du M, Carmody A, Peterson K. Neuropeptide Y Negatively Influences Monocyte Recruitment to the Central Nervous System during Retrovirus Infection. J Virol. 2015;90:2783-93 pubmed publisher
Zhang Y, Tam J, Mena P, van der Velden A, Bliska J. CCR2+ Inflammatory Dendritic Cells and Translocation of Antigen by Type III Secretion Are Required for the Exceptionally Large CD8+ T Cell Response to the Protective YopE69-77 Epitope during Yersinia Infection. PLoS Pathog. 2015;11:e1005167 pubmed publisher
Ferreira R, Pinto Ribeiro I, Wen X, Marcos Pinto R, Dinis Ribeiro M, Carneiro F, et al. Helicobacter pylori cagA Promoter Region Sequences Influence CagA Expression and Interleukin 8 Secretion. J Infect Dis. 2016;213:669-73 pubmed publisher
Cardoso M, Silva T, Resende M, Appelberg R, Borges M. Lack of the Transcription Factor Hypoxia-Inducible Factor 1α (HIF-1α) in Macrophages Accelerates the Necrosis of Mycobacterium avium-Induced Granulomas. Infect Immun. 2015;83:3534-44 pubmed publisher
Doni A, Musso T, Morone D, Bastone A, Zambelli V, Sironi M, et al. An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode. J Exp Med. 2015;212:905-25 pubmed publisher
Price P, Bánki Z, Scheideler A, Stoiber H, Verschoor A, Sutter G, et al. Complement component C5 recruits neutrophils in the absence of C3 during respiratory infection with modified vaccinia virus Ankara. J Immunol. 2015;194:1164-8 pubmed publisher
Ashok A, Rai N, Tripathi S, Bandyopadhyay S. Exposure to As-, Cd-, and Pb-mixture induces Aβ, amyloidogenic APP processing and cognitive impairments via oxidative stress-dependent neuroinflammation in young rats. Toxicol Sci. 2015;143:64-80 pubmed publisher
Weber G, Chousterman B, Hilgendorf I, Robbins C, Theurl I, Gerhardt L, et al. Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis. J Exp Med. 2014;211:1243-56 pubmed publisher
Charles N, Hardwick D, Daugas E, Illei G, Rivera J. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med. 2010;16:701-7 pubmed publisher
Baumgartner C, Ferrante A, Nagaoka M, Gorski J, Malherbe L. Peptide-MHC class II complex stability governs CD4 T cell clonal selection. J Immunol. 2010;184:573-81 pubmed publisher
Norian L, Rodriguez P, O Mara L, Zabaleta J, Ochoa A, Cella M, et al. Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism. Cancer Res. 2009;69:3086-94 pubmed publisher
Kim D, Miwa T, Kimura Y, Schwendener R, van Lookeren Campagne M, Song W. Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg. Blood. 2008;112:1109-19 pubmed publisher
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Tan S, Zhao J, Bi C, Chen X, Hepburn D, Wang J, et al. Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice. J Immunol. 2006;176:2872-9 pubmed
product information
Antigen :
CD11b
Apps. Abbrev. :
Flow Cytometry, ICC
Cat # :
101263
Clone :
M1/70
Item :
Brilliant Violet 510™ anti-mouse/human CD11b
Isotype :
Rat IgG2b, κ
Other Names :
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Size :
50 μg
Price (USD) :
257 USD
Reactivity :
Mouse, Human, Cynomolgus, Rhesus
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
BV510
Immunogen :
C57BL/10 splenocytes
Application Notes :
Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F). Additional reported applications (for relevant formats of this clone) include: immunoprecipitation 1,4 , in vitro blocking 3,9,12 , depletion 2,8 , immunofluorescence microscopy 6,7,10 , immunohistochemistry of acetone-fixed frozen sections 5,11-13 , and spatial biology (IBEX) 35,36 . For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF purified antibody (Endotoxin 0.01 EU/ug, Azide-Free, 0.2 um filtered) (Cat. No. 101248).
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA