product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE/Cyanine5 anti-mouse/human CD11b
catalog :
101210
quantity :
100 μg
price :
220 USD
clonality :
monoclonal
host :
rat
conjugate :
PE-Cy5
clone name :
M1/70
reactivity :
human, mouse
application :
flow cytometry
more info or order :
citations: 58
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 3a
Omatsu Y, Aiba S, Maeta T, Higaki K, Aoki K, Watanabe H, et al. Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells. Nat Commun. 2022;13:2654 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a, s2
Halvarsson C, Rörby E, Eliasson P, Lang S, Soneji S, Jönsson J. Putative role of NF-kB but not HIF-1α in hypoxia-dependent regulation of oxidative stress in hematopoietic stem and progenitor cells. Antioxid Redox Signal. 2019;: pubmed publisher
  • flow cytometry; mouse
Kent D, Li J, Tanna H, Fink J, Kirschner K, Pask D, et al. Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion. PLoS Biol. 2013;11:e1001576 pubmed publisher
Koide S, Sigurdsson V, Radulović V, Saito K, Zheng Z, Lang S, et al. CD244 expression represents functional decline of murine hematopoietic stem cells after in vitro culture. iScience. 2022;25:103603 pubmed publisher
Okajima T, Shigemori S, Namai F, Ogita T, Sato T, Shimosato T. Free Feeding of CpG-Oligodeoxynucleotide Particles Prophylactically Attenuates Allergic Airway Inflammation and Hyperresponsiveness in Mice. Front Immunol. 2021;12:738041 pubmed publisher
Chen D, Gregory A, Li X, Wei J, Burton C, Gibson G, et al. RIP3-dependent necroptosis contributes to the pathogenesis of chronic obstructive pulmonary disease. JCI Insight. 2021;6: pubmed publisher
Jassinskaja M, Pimková K, Arh N, Johansson E, Davoudi M, Pereira C, et al. Ontogenic shifts in cellular fate are linked to proteotype changes in lineage-biased hematopoietic progenitor cells. Cell Rep. 2021;34:108894 pubmed publisher
Kurosawa M, Shikama Y, Furukawa M, Arakaki R, Ishimaru N, Matsushita K. Chemokines Up-Regulated in Epithelial Cells Control Senescence-Associated T Cell Accumulation in Salivary Glands of Aged and Sjögren's Syndrome Model Mice. Int J Mol Sci. 2021;22: pubmed publisher
Nita A, Muto Y, Katayama Y, Matsumoto A, Nishiyama M, Nakayama K. The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells. Cell Rep. 2021;34:108688 pubmed publisher
Wara A, Wang S, Wu C, Fang F, Haemmig S, Weber B, et al. KLF10 Deficiency in CD4+ T Cells Triggers Obesity, Insulin Resistance, and Fatty Liver. Cell Rep. 2020;33:108550 pubmed publisher
Cervera Carrascon V, Quixabeira D, Santos J, Havunen R, Zafar S, Hemminki O, et al. Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition. Oncoimmunology. 2020;9:1761229 pubmed publisher
Wilkes M, Siva K, Chen J, Varetti G, Youn M, Chae H, et al. Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase. Nat Commun. 2020;11:3344 pubmed publisher
Kinder J, Turner L, Stelzer I, Miller Handley H, Burg A, Shao T, et al. CD8+ T Cell Functional Exhaustion Overrides Pregnancy-Induced Fetal Antigen Alloimmunization. Cell Rep. 2020;31:107784 pubmed publisher
Perry J, Tian S, Sengottuvel N, Harrison E, Gorentla B, Kapadia C, et al. Pulmonary Delivery of Nanoparticle-Bound Toll-like Receptor 9 Agonist for the Treatment of Metastatic Lung Cancer. ACS Nano. 2020;14:7200-7215 pubmed publisher
Wei H, Xu Y, Chen Q, Chen H, Zhu X, Li Y. Mesenchymal stem cell-derived exosomal miR-223 regulates neuronal cell apoptosis. Cell Death Dis. 2020;11:290 pubmed publisher
Di Genua C, Valletta S, Buono M, Stoilova B, Sweeney C, Rodriguez Meira A, et al. C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor. Cancer Cell. 2020;37:690-704.e8 pubmed publisher
Ghandhi S, Smilenov L, Shuryak I, Pujol Canadell M, Amundson S. Discordant gene responses to radiation in humans and mice and the role of hematopoietically humanized mice in the search for radiation biomarkers. Sci Rep. 2019;9:19434 pubmed publisher
Søndergaard E, Rauch A, Michaut M, Rapin N, Rehn M, Wilhelmson A, et al. ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination. Cell Rep. 2019;29:2756-2769.e6 pubmed publisher
Nowak W, Grendas L, Sanmarco L, Estecho I, Arena Á, Eberhardt N, et al. Pro-inflammatory monocyte profile in patients with major depressive disorder and suicide behaviour and how ketamine induces anti-inflammatory M2 macrophages by NMDAR and mTOR. EBioMedicine. 2019;50:290-305 pubmed publisher
Zhang H, Alsaleh G, Feltham J, Sun Y, Napolitano G, Riffelmacher T, et al. Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. Mol Cell. 2019;76:110-125.e9 pubmed publisher
Kaiser T, Feng G. Tmem119-EGFP and Tmem119-CreERT2 Transgenic Mice for Labeling and Manipulating Microglia. Eneuro. 2019;6: pubmed publisher
Tomay F, Marinelli A, Leoni V, Caccia C, Matros A, Mock H, et al. Purple corn extract induces long-lasting reprogramming and M2 phenotypic switch of adipose tissue macrophages in obese mice. J Transl Med. 2019;17:237 pubmed publisher
Radulović V, van der Garde M, Koide S, Sigurdsson V, Lang S, Kaneko S, et al. Junctional Adhesion Molecule 2 Represents a Subset of Hematopoietic Stem Cells with Enhanced Potential for T Lymphopoiesis. Cell Rep. 2019;27:2826-2836.e5 pubmed publisher
Di Genua C, Norfo R, Rodriguez Meira A, Wen W, Drissen R, Booth C, et al. Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation. Haematologica. 2019;: pubmed publisher
Shao T, Ang W, Jiang T, Huang F, Andersen H, Kinder J, et al. Commensal Candida albicans Positively Calibrates Systemic Th17 Immunological Responses. Cell Host Microbe. 2019;25:404-417.e6 pubmed publisher
Tzelepis K, De Braekeleer E, Aspris D, Barbieri I, Vijayabaskar M, Liu W, et al. SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4. Nat Commun. 2018;9:5378 pubmed publisher
Säwén P, Eldeeb M, Erlandsson E, Kristiansen T, Laterza C, Kokaia Z, et al. Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging. elife. 2018;7: pubmed publisher
Mann M, Mehta A, de Boer C, Kowalczyk M, Lee K, Haldeman P, et al. Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age. Cell Rep. 2018;25:2992-3005.e5 pubmed publisher
Porrello A, Leslie P, Harrison E, Gorentla B, Kattula S, Ghosh S, et al. Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking. Nat Commun. 2018;9:1988 pubmed publisher
Heger L, Balk S, Lühr J, Heidkamp G, Lehmann C, Hatscher L, et al. CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion. Front Immunol. 2018;9:744 pubmed publisher
Gozdecka M, Meduri E, Mazan M, Tzelepis K, Dudek M, Knights A, et al. UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs. Nat Genet. 2018;50:883-894 pubmed publisher
Booth C, Barkas N, Neo W, Boukarabila H, Soilleux E, Giotopoulos G, et al. Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors. Cancer Cell. 2018;33:274-291.e8 pubmed publisher
Mamedov M, Scholzen A, Nair R, Cumnock K, Kenkel J, Oliveira J, et al. A Macrophage Colony-Stimulating-Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence. Immunity. 2018;48:350-363.e7 pubmed publisher
Khoramian Tusi B, Socolovsky M. High-throughput single-cell fate potential assay of murine hematopoietic progenitors in vitro. Exp Hematol. 2018;60:21-29.e3 pubmed publisher
Barbieri I, Tzelepis K, Pandolfini L, Shi J, Millán Zambrano G, Robson S, et al. Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control. Nature. 2017;552:126-131 pubmed publisher
Dave K, Sur I, Yan J, Zhang J, Kaasinen E, Zhong F, et al. Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth. elife. 2017;6: pubmed publisher
Amouzegar A, Mittal S, Sahu A, Sahu S, Chauhan S. Mesenchymal Stem Cells Modulate Differentiation of Myeloid Progenitor Cells During Inflammation. Stem Cells. 2017;35:1532-1541 pubmed publisher
Dawar S, Shahrin N, Sladojevic N, D Andrea R, Dorstyn L, Hiwase D, et al. Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice. Cell Death Dis. 2016;7:e2509 pubmed publisher
Rowe R, Wang L, Coma S, Han A, Mathieu R, Pearson D, et al. Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis. J Exp Med. 2016;213:1497-512 pubmed publisher
Yu H, Sui Y, Wang Y, Sato N, Frey B, Xia Z, et al. Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes. PLoS ONE. 2015;10:e0143001 pubmed publisher
Ferreira R, Pinto Ribeiro I, Wen X, Marcos Pinto R, Dinis Ribeiro M, Carneiro F, et al. Helicobacter pylori cagA Promoter Region Sequences Influence CagA Expression and Interleukin 8 Secretion. J Infect Dis. 2016;213:669-73 pubmed publisher
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Morales J, Saleem S, Martin R, Saunders B, Barnstein B, Faber T, et al. Myeloid-derived suppressor cells enhance IgE-mediated mast cell responses. J Leukoc Biol. 2014;95:643-50 pubmed publisher
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Charles N, Hardwick D, Daugas E, Illei G, Rivera J. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med. 2010;16:701-7 pubmed publisher
Baumgartner C, Ferrante A, Nagaoka M, Gorski J, Malherbe L. Peptide-MHC class II complex stability governs CD4 T cell clonal selection. J Immunol. 2010;184:573-81 pubmed publisher
Norian L, Rodriguez P, O Mara L, Zabaleta J, Ochoa A, Cella M, et al. Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism. Cancer Res. 2009;69:3086-94 pubmed publisher
Kim D, Miwa T, Kimura Y, Schwendener R, van Lookeren Campagne M, Song W. Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg. Blood. 2008;112:1109-19 pubmed publisher
Elgazar Carmon V, Rudich A, Hadad N, Levy R. Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding. J Lipid Res. 2008;49:1894-903 pubmed publisher
Guo Y, Maillard I, Chakraborti S, Rothenberg E, Speck N. Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification. Blood. 2008;112:480-92 pubmed publisher
Napimoga M, Vieira S, Dal Secco D, Freitas A, Souto F, Mestriner F, et al. Peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J2, reduces neutrophil migration via a nitric oxide pathway. J Immunol. 2008;180:609-17 pubmed
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Tan S, Zhao J, Bi C, Chen X, Hepburn D, Wang J, et al. Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice. J Immunol. 2006;176:2872-9 pubmed
Ponomarev E, Dittel B. Gamma delta T cells regulate the extent and duration of inflammation in the central nervous system by a Fas ligand-dependent mechanism. J Immunol. 2005;174:4678-87 pubmed
product information
Antigen :
CD11b
Apps. Abbrev. :
Flow Cytometry
Cat # :
101210
Clone :
M1/70
Item :
PE/Cyanine5 anti-mouse/human CD11b
Isotype :
Rat IgG2b, κ
Other Names :
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Size :
100 μg
Price (USD) :
220 USD
Reactivity :
Mouse, Human, Cynomolgus, Rhesus
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PE_CYANINE5
Immunogen :
C57BL/10 splenocytes
Application Notes :
Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F). Additional reported applications (for relevant formats of this clone) include: immunoprecipitation 1,4 , in vitro blocking 3,9,12 , depletion 2,8 , immunofluorescence microscopy 6,7,10 , immunohistochemistry of acetone-fixed frozen sections 5,11-13 , and spatial biology (IBEX) 35,36 . For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF purified antibody (Endotoxin 0.01 EU/ug, Azide-Free, 0.2 um filtered) (Cat. No. 101248).
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA