Brilliant Violet 570™ anti-mouse CD8a | BioLegend 100739 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Brilliant Violet 570™ anti-mouse CD8a

catalog :

100739

quantity :

125 μL

price :

198 USD

clonality :

monoclonal

host :

rat

conjugate :

Brilliant Violet 570

clone name :

53-6.7

reactivity :

mouse

application :

flow cytometry

more info or order :

BioLegend product webpage

citations: 14

Reference
VanDyke D, Iglesias M, Tomala J, Young A, Smith J, Perry J, et al. Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection. Cell Rep. 2022;41:111478 pubmed publisher
Sun Y, Yan L, Sun J, Xiao M, Lai W, Song G, et al. Nanoscale organization of two-dimensional multimeric pMHC reagents with DNA origami for CD8+ T cell detection. Nat Commun. 2022;13:3916 pubmed publisher
de Picciotto S, DeVita N, Hsiao C, Honan C, Tse S, Nguyen M, et al. Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein. Nat Commun. 2022;13:3866 pubmed publisher
Pandey S, Bender M, McPherson A, Phelps C, Sanchez L, Rana M, et al. Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis. Cell Host Microbe. 2022;30:1003-1019.e10 pubmed publisher
Espinal A, Epperly M, Mukherjee A, Fisher R, Shields D, Wang H, et al. Intestinal Radiation Protection and Mitigation by Second-Generation Probiotic Lactobacillus-reuteri Engineered to Deliver Interleukin-22. Int J Mol Sci. 2022;23: pubmed publisher
Kfoury Y, Baryawno N, Severe N, Mei S, Gustafsson K, Hirz T, et al. Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment. Cancer Cell. 2021;39:1464-1478.e8 pubmed publisher
MARCHELLETTA R, Krishnan M, Spalinger M, Placone T, Alvarez R, Sayoc Becerra A, et al. T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling. J Clin Invest. 2021;131: pubmed publisher
Goddery E, Fain C, Lipovsky C, Ayasoufi K, Yokanovich L, Malo C, et al. Microglia and Perivascular Macrophages Act as Antigen Presenting Cells to Promote CD8 T Cell Infiltration of the Brain. Front Immunol. 2021;12:726421 pubmed publisher
Pattabiraman G, Bell Cohn A, Murphy S, Mazur D, Schaeffer A, Thumbikat P. Mast cell function in prostate inflammation, fibrosis, and smooth muscle cell dysfunction. Am J Physiol Renal Physiol. 2021;321:F466-F479 pubmed publisher
Zhao B, Yang J, He B, Li X, Yan H, Liu S, et al. A safe and effective mucosal RSV vaccine in mice consisting of RSV phosphoprotein and flagellin variant. Cell Rep. 2021;36:109401 pubmed publisher
Baldwin S, Reese V, Larsen S, Beebe E, Guderian J, Orr M, et al. Prophylactic efficacy against Mycobacterium tuberculosis using ID93 and lipid-based adjuvant formulations in the mouse model. PLoS ONE. 2021;16:e0247990 pubmed publisher
Fedele C, Li S, Teng K, Foster C, Peng D, Ran H, et al. SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling. J Exp Med. 2021;218: pubmed publisher
Severe N, Karabacak N, Gustafsson K, Baryawno N, Courties G, Kfoury Y, et al. Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping. Cell Stem Cell. 2019;25:570-583.e7 pubmed publisher
Ponzetta A, Carriero R, Carnevale S, Barbagallo M, Molgora M, Perucchini C, et al. Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors. Cell. 2019;178:346-360.e24 pubmed publisher

product information

Antigen :

CD8alpha

Apps. Abbrev. :

Cat # :

100739

Clone :

53-6.7

Item :

Brilliant Violet 570™ anti-mouse CD8a

Isotype :

Rat IgG2a, κ

Other Names :

T8, Lyt2, Ly-2

Size :

125 μL

Price (USD) :

198 USD

Reactivity :

Mouse

Clonality :

Monoclonal

Host :

Rat

Conjugate/Tag/Label :

BV570

Immunogen :

Mouse thymus or spleen

Application Notes :

Clone 53-6.7 antibody competes with clone 5H10-1 antibody for binding to thymocytes^3. The 53-6.7 antibody has been reported to block antigen presentation via MHC class I and inhibit T cell responses to IL-2. This antibody has also been used for depletion of CD8a^+ cells. Additional reported applications (for the relevant formats) include: immunoprecipitation^1,3, in vivo and in vitro cell depletion^2,10,15, inhibition of CD8 T cell proliferation^3, blocking of cytotoxicity^3,4, immunohistochemical staining^5,6 of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections, and spatial biology (IBEX)^29,30. Clone 53-6.7 is not recommended for immunohistochemistry of formalin-fixed paraffin sections. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays or in vivo studies (Cat No. 100746).;

more info or order :

BioLegend product webpage