product summary
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company name :
Bio X Cell
product type :
antibody
product name :
RecombiMAb anti-mouse PD-L1 (B7-H1)
catalog :
CP168-25MG
quantity :
25 mg
price :
564.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
10F.9G2-CP168
reactivity :
mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 17
Reference
Grasselly C, Denis M, Bourguignon A, Talhi N, Mathé D, Tourette A, et al. The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent. Front Immunol. 2018;9:2100 pubmed publisher
Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt F, Liniany L, Knight D, et al. PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells. Immunity. 2018;49:247-263.e7 pubmed publisher
Kim J, Jeong Ryu S, Oh K, Ju J, Yeong Jeon J, Nam G, et al. Memory programming in CD8(+) T-cell differentiation is intrinsic and is not determined by CD4 help. Nat Commun. 2015;6:7994 pubmed publisher
Ngiow S, Young A, Jacquelot N, Yamazaki T, Enot D, Zitvogel L, et al. A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1. Cancer Res. 2015;75:3800-11 pubmed publisher
Tkachev V, Goodell S, Opipari A, Hao L, Franchi L, Glick G, et al. Programmed death-1 controls T cell survival by regulating oxidative metabolism. J Immunol. 2015;194:5789-800 pubmed publisher
Zander R, Obeng Adjei N, Guthmiller J, Kulu D, Li J, Ongoiba A, et al. PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity. Cell Host Microbe. 2015;17:628-41 pubmed publisher
Twyman Saint Victor C, Rech A, Maity A, Rengan R, Pauken K, Stelekati E, et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature. 2015;520:373-7 pubmed publisher
Jaworska K, Ratajczak J, Huang L, Whalen K, Yang M, Stevens B, et al. Both PD-1 ligands protect the kidney from ischemia reperfusion injury. J Immunol. 2015;194:325-33 pubmed publisher
Dolina J, Braciale T, Hahn Y. Liver-primed CD8+ T cells suppress antiviral adaptive immunity through galectin-9-independent T-cell immunoglobulin and mucin 3 engagement of high-mobility group box 1 in mice. Hepatology. 2014;59:1351-65 pubmed publisher
Yang X, Zhang X, Fu M, Weichselbaum R, Gajewski T, Guo Y, et al. Targeting the tumor microenvironment with interferon-? bridges innate and adaptive immune responses. Cancer Cell. 2014;25:37-48 pubmed publisher
Deng L, Liang H, Burnette B, Beckett M, Darga T, Weichselbaum R, et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest. 2014;124:687-95 pubmed publisher
Dietze K, Zelinskyy G, Liu J, Kretzmer F, Schimmer S, Dittmer U. Combining regulatory T cell depletion and inhibitory receptor blockade improves reactivation of exhausted virus-specific CD8+ T cells and efficiently reduces chronic retroviral loads. PLoS Pathog. 2013;9:e1003798 pubmed publisher
Rutigliano J, Sharma S, Morris M, Oguin T, McClaren J, Doherty P, et al. Highly pathological influenza A virus infection is associated with augmented expression of PD-1 by functionally compromised virus-specific CD8+ T cells. J Virol. 2014;88:1636-51 pubmed publisher
Willimsky G, Schmidt K, Loddenkemper C, Gellermann J, Blankenstein T. Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance. J Clin Invest. 2013;123:1032-43 pubmed publisher
Hafalla J, Claser C, Couper K, Grau G, Renia L, de Souza J, et al. The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology. PLoS Pathog. 2012;8:e1002504 pubmed publisher
Riella L, Watanabe T, Sage P, Yang J, Yeung M, Azzi J, et al. Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts. Am J Transplant. 2011;11:832-40 pubmed publisher
Zhang L, Gajewski T, Kline J. PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model. Blood. 2009;114:1545-52 pubmed publisher
product information
Catalog Number :
CP168-25MG
Product Name :
RecombiMAb anti-mouse PD-L1 (B7-H1)
Host :
Mouse
Clonality :
Monoclonal
Label/Conjugation :
No
Antigen Modification :
No
Category :
Antibody
Size :
25 mg
Regular Price :
$868.00
Academic Price :
564.00 USD
Isotype :
10F.9G2™-CP168
Immunogen :
Mouse CD274
Reactivity :
Mouse
Concentration/Amount :
Lot specific,typically between 4-11 mg/ml
Reported Applications :
in vivo PD-L1 blockade*, Immunofluorescence*, Immunohistochemistry (frozen)*, Flow cytometry*, Western blot*, *Reported for the original rat IgG2a RMP1-14 antibody
Recommended Storage Conditions :
The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
more info or order :
company information
Bio X Cell
10 Technology Dr., Suite 2B
Lebanon, NH 03784-1671
customerservice@bxcell.com
http://bxcell.com
1-866-787-3444
headquarters: USA