product summary
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company name :
Bio X Cell
product type :
antibody
product name :
RecombiMAb anti-mouse CTLA-4 (CD152)
catalog :
CP146-1MG
quantity :
1 mg
price :
1,970.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
9H10-CP146
reactivity :
mouse
application :
western blot
more info or order :
citations: 13
Reference
Ariyan C, Brady M, Siegelbaum R, Hu J, Bello D, Rand J, et al. Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade. Cancer Immunol Res. 2018;6:189-200 pubmed publisher
Gao J, Shi L, Zhao H, Chen J, Xiong L, He Q, et al. Loss of IFN-? Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy. Cell. 2016;167:397-404.e9 pubmed publisher
Bartkowiak T, Singh S, Yang G, Galvan G, Haria D, Ai M, et al. Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine. Proc Natl Acad Sci U S A. 2015;112:E5290-9 pubmed publisher
Spranger S, Bao R, Gajewski T. Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity. Nature. 2015;523:231-5 pubmed publisher
Twyman Saint Victor C, Rech A, Maity A, Rengan R, Pauken K, Stelekati E, et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature. 2015;520:373-7 pubmed publisher
Stephan S, Taber A, Jileaeva I, Pegues E, Sentman C, Stephan M. Biopolymer implants enhance the efficacy of adoptive T-cell therapy. Nat Biotechnol. 2015;33:97-101 pubmed publisher
Ozdemir B, Pentcheva Hoang T, Carstens J, Zheng X, Wu C, Simpson T, et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 2014;25:719-34 pubmed publisher
Krummey S, Floyd T, Liu D, Wagener M, Song M, Ford M. Candida-elicited murine Th17 cells express high Ctla-4 compared with Th1 cells and are resistant to costimulation blockade. J Immunol. 2014;192:2495-504 pubmed publisher
Goding S, Wilson K, Xie Y, Harris K, Baxi A, Akpinarli A, et al. Restoring immune function of tumor-specific CD4+ T cells during recurrence of melanoma. J Immunol. 2013;190:4899-909 pubmed publisher
Hervieu A, Rébé C, Vegran F, Chalmin F, Bruchard M, Vabres P, et al. Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth. J Invest Dermatol. 2013;133:499-508 pubmed publisher
Balachandran V, Cavnar M, Zeng S, Bamboat Z, Ocuin L, Obaid H, et al. Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido. Nat Med. 2011;17:1094-100 pubmed publisher
Pedicord V, Montalvo W, Leiner I, Allison J. Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance. Proc Natl Acad Sci U S A. 2011;108:266-71 pubmed publisher
Quezada S, Simpson T, Peggs K, Merghoub T, Vider J, Fan X, et al. Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts. J Exp Med. 2010;207:637-50 pubmed publisher
product information
Catalog Number :
CP146-1MG
Product Name :
RecombiMAb anti-mouse CTLA-4 (CD152)
Host :
Mouse
Clonality :
Monoclonal
Label/Conjugation :
No
Antigen Modification :
No
Category :
Antibody
Size :
1 mg
Regular Price :
$3,030.00
Academic Price :
1,970.00 USD
Isotype :
9H10-CP146
Immunogen :
Mouse CTLA-4-human IgG1 fusion protein
Reactivity :
Mouse
Concentration/Amount :
Lot specific,typically between 4-11 mg/ml
Reported Applications :
in vivo CTLA-4 neutralization*, in vitro CTLA-4 neutralization*, Western blot, *Reported for the original Syrian hamster IgG 9H10 antibody
Recommended Storage Conditions :
The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
more info or order :
company information
Bio X Cell
10 Technology Dr., Suite 2B
Lebanon, NH 03784-1671
customerservice@bxcell.com
http://bxcell.com
1-866-787-3444
headquarters: USA