Published Application/Species/Sample/Dilution | Reference |
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- blocking or activating experiments; mouse; 1 ug/ml; loading ...; fig 3a
| Park Y, Cho M, Choi G, Na H, Chung Y. A Critical Regulation of Th17 Cell Responses and Autoimmune Neuro-Inflammation by Ginsenoside Rg3. Biomolecules. 2020;10: pubmed publisher
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- blocking or activating experiments; mouse; 10 ug/ml; loading ...
| Anandagoda N, Willis J, Hertweck A, Roberts L, Jackson I, Gökmen M, et al. microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance. J Clin Invest. 2019;129:1257-1271 pubmed publisher
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- blocking or activating experiments; mouse; 0.8 ug/ml; loading ...; fig 4a
| Klement J, Paschall A, Redd P, Ibrahim M, Lu C, Yang D, et al. An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion. J Clin Invest. 2018;128:5549-5560 pubmed publisher
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- blocking or activating experiments; mouse; 2 ug/ml; fig 1a
| Qiao G, Bucsek M, Winder N, Chen M, Giridharan T, Olejniczak S, et al. β-Adrenergic signaling blocks murine CD8+ T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress. Cancer Immunol Immunother. 2019;68:11-22 pubmed publisher
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- blocking or activating experiments; mouse; loading ...; fig 2a
| Wei X, Zhang J, Gu Q, Huang M, Zhang W, Guo J, et al. Reciprocal Expression of IL-35 and IL-10 Defines Two Distinct Effector Treg Subsets that Are Required for Maintenance of Immune Tolerance. Cell Rep. 2017;21:1853-1869 pubmed publisher
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- blocking or activating experiments; mouse; ; loading ...; fig 2b
| Ritter A, Kapnick S, Murugesan S, Schwartzberg P, Griffiths G, Lippincott Schwartz J. Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 2017;114:E6585-E6594 pubmed publisher
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- blocking or activating experiments; mouse; fig 6a
| Laurent C, Dorothee G, Hunot S, Martin E, Monnet Y, Duchamp M, et al. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain. 2017;140:184-200 pubmed publisher
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- blocking or activating experiments; mouse; loading ...; fig s1b
| Peng M, Yin N, Chhangawala S, Xu K, Leslie C, Li M. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science. 2016;354:481-484 pubmed
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- blocking or activating experiments; human; loading ...
| Arbore G, West E, Spolski R, Robertson A, Klos A, Rheinheimer C, et al. T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⺠T cells. Science. 2016;352:aad1210 pubmed publisher
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- blocking or activating experiments; mouse; loading ...; fig 4a
| Gu A, Zhang S, Wang Y, Xiong H, Curtis T, Wan Y. A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor β receptor signaling. Immunity. 2015;42:68-79 pubmed publisher
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- flow cytometry; mouse; fig s1
| Becker A, Walcheck B, Bhattacharya D. ADAM17 limits the expression of CSF1R on murine hematopoietic progenitors. Exp Hematol. 2015;43:44-52.e1-3 pubmed publisher
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- blocking or activating experiments; mouse; loading ...; fig 1a
| Bertin S, Lozano Ruiz B, Bachiller V, GarcÃa MartÃnez I, Herdman S, Zapater P, et al. Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice. Mucosal Immunol. 2015;8:505-15 pubmed publisher
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| Wu B, Zhang S, Guo Z, Bi Y, Zhou M, Li P, et al. The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation. Immunity. 2021;54:308-323.e6 pubmed publisher
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| Zhang H, Madi A, Yosef N, Chihara N, Awasthi A, Pot C, et al. An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets. Cell Rep. 2020;33:108433 pubmed publisher
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| Nasrallah R, Imianowski C, Bossini Castillo L, Grant F, Dogan M, Placek L, et al. A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells. Nature. 2020;583:447-452 pubmed publisher
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| Waaler J, Mygland L, Tveita A, Strand M, Solberg N, Olsen P, et al. Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Commun Biol. 2020;3:196 pubmed publisher
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| Lee J, Hall J, Kroehling L, Wu L, Najar T, Nguyen H, et al. Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease. Cell. 2020;180:79-91.e16 pubmed publisher
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| Merve A, Zhang X, Pomella N, Acquati S, Hoeck J, Dumas A, et al. c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism. Acta Neuropathol Commun. 2019;7:2 pubmed publisher
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| Staedtke V, Bai R, Kim K, Darvas M, DAVILA M, Riggins G, et al. Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome. Nature. 2018;564:273-277 pubmed publisher
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| Wu B, Zhang S, Guo Z, Wang G, Zhang G, Xie L, et al. RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs. Immunity. 2018;49:886-898.e5 pubmed publisher
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| Koh B, Abdul Qayum A, Srivastava R, Fu Y, Ulrich B, Janga S, et al. A conserved enhancer regulates Il9 expression in multiple lineages. Nat Commun. 2018;9:4803 pubmed publisher
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| Uche U, Piccirillo A, Kataoka S, Grebinoski S, D Cruz L, Kane L. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018;215:3165-3179 pubmed publisher
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| Shi H, Liu C, Tan H, Li Y, Nguyen T, Dhungana Y, et al. Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity. Immunity. 2018;49:899-914.e6 pubmed publisher
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| Fan X, Moltedo B, Mendoza A, Davydov A, Faire M, Mazutis L, et al. CD49b defines functionally mature Treg cells that survey skin and vascular tissues. J Exp Med. 2018;215:2796-2814 pubmed publisher
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| Ogawa C, Bankoti R, Nguyen T, Hassanzadeh Kiabi N, Nadeau S, Porritt R, et al. Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells. Cell Rep. 2018;25:19-28.e5 pubmed publisher
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| Lacher S, Thurm C, Distler U, Mohebiany A, Israel N, Kitic M, et al. NF-κB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling. J Autoimmun. 2018;94:110-121 pubmed publisher
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| Woo J, Srikanth S, Kim K, Elsaesser H, Lu J, Pellegrini M, et al. CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol. 2018;201:1174-1185 pubmed publisher
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| Wang Z, Yin W, Zhu L, Li J, Yao Y, Chen F, et al. Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production. Immunity. 2018;49:80-92.e7 pubmed publisher
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| Buchele V, Abendroth B, Büttner Herold M, Vogler T, Rothamer J, Ghimire S, et al. Targeting Inflammatory T Helper Cells via Retinoic Acid-Related Orphan Receptor Gamma t Is Ineffective to Prevent Allo-Response-Driven Colitis. Front Immunol. 2018;9:1138 pubmed publisher
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| Wendland K, Niss K, Kotarsky K, Wu N, White A, Jendholm J, et al. Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis. J Immunol. 2018;201:524-532 pubmed publisher
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| Wilhelmson A, Lantero Rodriguez M, Stubelius A, Fogelstrand P, Johansson I, Buechler M, et al. Testosterone is an endogenous regulator of BAFF and splenic B cell number. Nat Commun. 2018;9:2067 pubmed publisher
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| Daenthanasanmak A, Wu Y, Iamsawat S, Nguyen H, Bastian D, Zhang M, et al. PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity. J Clin Invest. 2018;128:2787-2801 pubmed publisher
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| Xiao W, Klement J, Lu C, Ibrahim M, Liu K. IFNAR1 Controls Autocrine Type I IFN Regulation of PD-L1 Expression in Myeloid-Derived Suppressor Cells. J Immunol. 2018;201:264-277 pubmed publisher
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| Barr J, Wang X, Kreiger P, Lieberman S. Salivary-gland-protective regulatory T-cell dysfunction underlies female-specific sialadenitis in the non-obese diabetic mouse model of Sjögren syndrome. Immunology. 2018;155:225-237 pubmed publisher
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| Stüve P, Minarrieta L, Erdmann H, Arnold Schrauf C, Swallow M, Guderian M, et al. De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages. Front Immunol. 2018;9:495 pubmed publisher
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| Chen D, Xie J, Fiskesund R, Dong W, Liang X, Lv J, et al. Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype. Nat Commun. 2018;9:873 pubmed publisher
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| Ullrich E, Abendroth B, Rothamer J, Huber C, Büttner Herold M, Buchele V, et al. BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease. J Clin Invest. 2018;128:916-930 pubmed publisher
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| Delong J, Hall A, Konradt C, Coppock G, Park J, Harms Pritchard G, et al. Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1. J Immunol. 2018;200:1761-1770 pubmed publisher
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| Glasner A, Levi A, Enk J, Isaacson B, Viukov S, Orlanski S, et al. NKp46 Receptor-Mediated Interferon-? Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis. Immunity. 2018;48:107-119.e4 pubmed publisher
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| Steinbuck M, Arakcheeva K, Winandy S. Novel TCR-Mediated Mechanisms of Notch Activation and Signaling. J Immunol. 2018;200:997-1007 pubmed publisher
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| Mostafa H, Vogel P, Srinivasan A, Russell C. Dynamics of Sendai Virus Spread, Clearance, and Immunotherapeutic Efficacy after Hematopoietic Cell Transplant Imaged Noninvasively in Mice. J Virol. 2018;92: pubmed publisher
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| Zhang S, Takaku M, Zou L, Gu A, Chou W, Zhang G, et al. Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation. Nature. 2017;551:105-109 pubmed publisher
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| Malik S, Sadhu S, Elesela S, Pandey R, Chawla A, Sharma D, et al. Transcription factor Foxo1 is essential for IL-9 induction in T helper cells. Nat Commun. 2017;8:815 pubmed publisher
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| Na H, Lim H, Choi G, Kim B, Kim S, Chang Y, et al. Concomitant suppression of TH2 and TH17 cell responses in allergic asthma by targeting retinoic acid receptor-related orphan receptor ?t. J Allergy Clin Immunol. 2018;141:2061-2073.e5 pubmed publisher
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| Yi W, Gupta S, Ricker E, Manni M, Jessberger R, Chinenov Y, et al. The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity. Nat Commun. 2017;8:254 pubmed publisher
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| Xie M, Koh B, Hollister K, Wu H, Sun J, Kaplan M, et al. Bcl6 promotes follicular helper T-cell differentiation and PD-1 expression in a Blimp1-independent manner in mice. Eur J Immunol. 2017;47:1136-1141 pubmed publisher
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| Jiang R, Wang J, Peng S, Huang T, Wang C, Cannella F, et al. Spontaneous and Vaccine-Induced Clearance of Mus Musculus Papillomavirus 1 Infection. J Virol. 2017;91: pubmed publisher
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| Lagumersindez Denis N, Wrzos C, Mack M, Winkler A, van der Meer F, Reinert M, et al. Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis. Acta Neuropathol. 2017;134:15-34 pubmed publisher
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| Qiao G, Qin J, Kunda N, Calata J, Mahmud D, Gann P, et al. LIGHT Elevation Enhances Immune Eradication of Colon Cancer Metastases. Cancer Res. 2017;77:1880-1891 pubmed publisher
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| Thaker Y, Recino A, Raab M, Jabeen A, Wallberg M, Fernandez N, et al. Activated Cdc42-associated kinase 1 (ACK1) binds the sterile ? motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines. J Biol Chem. 2017;292:6281-6290 pubmed publisher
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| Koh B, Hufford M, Sun X, Kaplan M. Etv5 Regulates IL-10 Production in Th Cells. J Immunol. 2017;198:2165-2171 pubmed publisher
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| Shirakawa K, Yan X, Shinmura K, Endo J, Kataoka M, Katsumata Y, et al. Obesity accelerates T cell senescence in murine visceral adipose tissue. J Clin Invest. 2016;126:4626-4639 pubmed publisher
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| Yang R, Masters A, Fortner K, Champagne D, Yanguas Casás N, Silberger D, et al. IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells. J Exp Med. 2016;213:2281-2291 pubmed
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| Peroumal D, Abimannan T, Tagirasa R, Parida J, Singh S, Padhan P, et al. Inherent low Erk and p38 activity reduce Fas Ligand expression and degranulation in T helper 17 cells leading to activation induced cell death resistance. Oncotarget. 2016;7:54339-54359 pubmed publisher
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| Kannan Y, Li Y, Coomes S, Okoye I, Pelly V, Sriskantharajah S, et al. Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells. J Allergy Clin Immunol. 2017;139:655-666.e7 pubmed publisher
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| Ron Harel N, Santos D, Ghergurovich J, Sage P, Reddy A, Lovitch S, et al. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metab. 2016;24:104-17 pubmed publisher
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| Gill R, Pagni P, Kupfer T, Wasserfall C, Deng S, Posgai A, et al. A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice. Diabetes. 2016;65:1310-6 pubmed publisher
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| Xu H, Chaudhri V, Wu Z, Biliouris K, Dienger Stambaugh K, Rochman Y, et al. Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8. Nat Immunol. 2015;16:1274-81 pubmed publisher
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| Awe O, Hufford M, Wu H, Pham D, Chang H, Jabeen R, et al. PU.1 Expression in T Follicular Helper Cells Limits CD40L-Dependent Germinal Center B Cell Development. J Immunol. 2015;195:3705-15 pubmed publisher
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| Liu H, Schneider H, Recino A, Richardson C, Goldberg M, Rudd C. The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells. Mol Cell. 2015;59:840-9 pubmed publisher
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| Kim Y, Lim H, Jung H, Wetsel R, Chung Y. Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells. PLoS ONE. 2015;10:e0120294 pubmed publisher
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| Huang Y, Clarke F, Karimi M, Roy N, Williamson E, Okumura M, et al. CRK proteins selectively regulate T cell migration into inflamed tissues. J Clin Invest. 2015;125:1019-32 pubmed publisher
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| Tang W, Wang H, Claudio E, Tassi I, Ha H, Saret S, et al. The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells. Immunity. 2014;41:555-66 pubmed publisher
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| Bertin S, Aoki Nonaka Y, de Jong P, Nohara L, Xu H, Stanwood S, et al. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4? T cells. Nat Immunol. 2014;15:1055-1063 pubmed publisher
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| Rabenstein H, Behrendt A, Ellwart J, Naumann R, Horsch M, Beckers J, et al. Differential kinetics of antigen dependency of CD4+ and CD8+ T cells. J Immunol. 2014;192:3507-17 pubmed publisher
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| Sledzińska A, Hemmers S, Mair F, Gorka O, Ruland J, Fairbairn L, et al. TGF-? signalling is required for CD4? T cell homeostasis but dispensable for regulatory T cell function. PLoS Biol. 2013;11:e1001674 pubmed publisher
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| Berger H, Vegran F, Chikh M, Gilardi F, Ladoire S, Bugaut H, et al. SOCS3 transactivation by PPAR? prevents IL-17-driven cancer growth. Cancer Res. 2013;73:3578-90 pubmed publisher
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| Goswami R, Jabeen R, Yagi R, Pham D, Zhu J, Goenka S, et al. STAT6-dependent regulation of Th9 development. J Immunol. 2012;188:968-75 pubmed publisher
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| Peng B, Ye P, Rawlings D, Ochs H, Miao C. Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy. Blood. 2009;114:4373-82 pubmed publisher
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| Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel R, et al. IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol. 2008;9:1347-55 pubmed publisher
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