product summary
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company name :
Bio X Cell
product type :
antibody
product name :
InVivoMAb anti-mouse IL-4
catalog :
BE0045-25MG
quantity :
25 mg
price :
1,306.00 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
11B11
reactivity :
human, mouse
application :
western blot, flow cytometry, blocking or activating experiments
more info or order :
citations: 41
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; mouse; 10 ug/ml; loading ...; fig s2
  • blocking or activating experiments; human; 10 ug/ml; loading ...; fig 1a
Hu X, Majchrzak K, Liu X, Wyatt M, Spooner C, Moisan J, et al. In Vitro Priming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and Stemness In Vivo. Cancer Res. 2018;78:3888-3898 pubmed publisher
Lee J, Hall J, Kroehling L, Wu L, Najar T, Nguyen H, et al. Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease. Cell. 2020;180:79-91.e16 pubmed publisher
Gaylo Moynihan A, Prizant H, Popovic M, Fernandes N, Anderson C, Chiou K, et al. Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites. Immunity. 2019;51:298-309.e6 pubmed publisher
Puleston D, Buck M, Klein Geltink R, Kyle R, Caputa G, O Sullivan D, et al. Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. Cell Metab. 2019;: pubmed publisher
Kotov J, Kotov D, Linehan J, Bardwell V, Gearhart M, Jenkins M. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216:1450-1464 pubmed publisher
Kimura S, Kobayashi N, Nakamura Y, Kanaya T, Takahashi D, Fujiki R, et al. Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice. J Exp Med. 2019;216:831-846 pubmed publisher
Harris A, Mirchandani A, Lynch R, Murphy F, Delaney L, Small D, et al. IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo. Am J Respir Crit Care Med. 2019;: pubmed publisher
Sanin D, Matsushita M, Klein Geltink R, Grzes K, van Teijlingen Bakker N, Corrado M, et al. Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2. Immunity. 2018;49:1021-1033.e6 pubmed publisher
Uche U, Piccirillo A, Kataoka S, Grebinoski S, D Cruz L, Kane L. PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt. J Exp Med. 2018;215:3165-3179 pubmed publisher
Singh M, Ni M, Sullivan J, Hamerman J, Campbell D. B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation. J Exp Med. 2018;215:2429-2443 pubmed publisher
Cummings M, Arumanayagam A, Zhao P, Kannanganat S, Stuve O, Karandikar N, et al. Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis. PLoS ONE. 2018;13:e0200752 pubmed publisher
Wang Z, Yin W, Zhu L, Li J, Yao Y, Chen F, et al. Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production. Immunity. 2018;49:80-92.e7 pubmed publisher
Tejero J, Armand N, Finn C, Dhume K, Strutt T, Chai K, et al. Cigarette smoke extract acts directly on CD4 T cells to enhance Th1 polarization and reduce memory potential. Cell Immunol. 2018;331:121-129 pubmed publisher
Tanaka S, Jiang Y, Martinez G, Tanaka K, Yan X, Kurosaki T, et al. Trim33 mediates the proinflammatory function of Th17 cells. J Exp Med. 2018;215:1853-1868 pubmed publisher
Schneider C, O Leary C, von Moltke J, Liang H, Ang Q, Turnbaugh P, et al. A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling. Cell. 2018;174:271-284.e14 pubmed publisher
Langenhorst D, Haack S, Göb S, Uri A, Luhder F, Vanhove B, et al. CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo. Front Immunol. 2018;9:1060 pubmed publisher
Stüve P, Minarrieta L, Erdmann H, Arnold Schrauf C, Swallow M, Guderian M, et al. De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages. Front Immunol. 2018;9:495 pubmed publisher
Sage P, Schildberg F, Sobel R, Kuchroo V, Freeman G, Sharpe A. Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function. J Immunol. 2018;200:2592-2602 pubmed publisher
Xu M, Pokrovskii M, Ding Y, Yi R, Au C, Harrison O, et al. c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont. Nature. 2018;554:373-377 pubmed publisher
Delong J, Hall A, Konradt C, Coppock G, Park J, Harms Pritchard G, et al. Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1. J Immunol. 2018;200:1761-1770 pubmed publisher
Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, et al. Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells. Cell. 2018;172:517-533.e20 pubmed publisher
Zhang S, Takaku M, Zou L, Gu A, Chou W, Zhang G, et al. Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation. Nature. 2017;551:105-109 pubmed publisher
Simeonov D, Gowen B, Boontanrart M, Roth T, Gagnon J, Mumbach M, et al. Discovery of stimulation-responsive immune enhancers with CRISPR activation. Nature. 2017;549:111-115 pubmed publisher
Ye J, Wang Y, Liu X, Li L, Opejin A, Hsueh E, et al. TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy. J Immunol. 2017;199:941-954 pubmed publisher
Montoya M, Maul J, Singh P, Pua H, Dahlström F, Wu N, et al. A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation. J Immunol. 2017;199:559-569 pubmed publisher
Minutti C, Jackson Jones L, Garcia Fojeda B, Knipper J, Sutherland T, Logan N, et al. Local amplifiers of IL-4R?-mediated macrophage activation promote repair in lung and liver. Science. 2017;356:1076-1080 pubmed publisher
Koh B, Hufford M, Sun X, Kaplan M. Etv5 Regulates IL-10 Production in Th Cells. J Immunol. 2017;198:2165-2171 pubmed publisher
Clever D, Roychoudhuri R, Constantinides M, Askenase M, Sukumar M, Klebanoff C, et al. Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche. Cell. 2016;166:1117-1131.e14 pubmed publisher
Peroumal D, Abimannan T, Tagirasa R, Parida J, Singh S, Padhan P, et al. Inherent low Erk and p38 activity reduce Fas Ligand expression and degranulation in T helper 17 cells leading to activation induced cell death resistance. Oncotarget. 2016;7:54339-54359 pubmed publisher
Hou L, Cooley J, Swanson R, Ong P, Pike R, Bogyo M, et al. The protease cathepsin L regulates Th17 cell differentiation. J Autoimmun. 2015;65:56-63 pubmed publisher
Choi Y, Gullicksrud J, Xing S, Zeng Z, Shan Q, Li F, et al. LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6. Nat Immunol. 2015;16:980-90 pubmed publisher
Kim Y, Lim H, Jung H, Wetsel R, Chung Y. Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells. PLoS ONE. 2015;10:e0120294 pubmed publisher
Hill E, Ng T, Burton B, Oakley C, Malik K, Wraith D. Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter. Eur J Immunol. 2015;45:1103-15 pubmed publisher
Gu A, Zhang S, Wang Y, Xiong H, Curtis T, Wan Y. A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor β receptor signaling. Immunity. 2015;42:68-79 pubmed publisher
McKinstry K, Strutt T, Bautista B, Zhang W, Kuang Y, Cooper A, et al. Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2. Nat Commun. 2014;5:5377 pubmed publisher
Tang W, Wang H, Claudio E, Tassi I, Ha H, Saret S, et al. The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells. Immunity. 2014;41:555-66 pubmed publisher
Burton B, Britton G, Fang H, Verhagen J, Smithers B, Sabatos Peyton C, et al. Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy. Nat Commun. 2014;5:4741 pubmed publisher
Heinemann C, Heink S, Petermann F, Vasanthakumar A, Rothhammer V, Doorduijn E, et al. IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1. Nat Commun. 2014;5:3770 pubmed publisher
Mishra P, Patel N, Wu W, Bleich D, Gause W. Prevention of type 1 diabetes through infection with an intestinal nematode parasite requires IL-10 in the absence of a Th2-type response. Mucosal Immunol. 2013;6:297-308 pubmed publisher
Ueda A, Zhou L, Stein P. Fyn promotes Th17 differentiation by regulating the kinetics of ROR?t and Foxp3 expression. J Immunol. 2012;188:5247-56 pubmed publisher
Li X, Murray F, Koide N, Goldstone J, Dann S, Chen J, et al. Divergent requirement for G?s and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets. J Clin Invest. 2012;122:963-73 pubmed publisher
product information
Catalog Number :
BE0045-25MG
Product Name :
InVivoMAb anti-mouse IL-4
Host :
Rat
Clonality :
Monoclonal
Label/Conjugation :
No
Antigen Modification :
No
Category :
Antibody
Size :
25 mg
Regular Price :
$2,009.00
Academic Price :
1,306.00 USD
Clone Name :
11B11
Isotype :
11B11
Immunogen :
Partially purified native mouse IL-4
Reactivity :
Mouse
Concentration/Amount :
Lot specific,typically between 4-11 mg/ml
Reported Applications :
in vivo IL-4 neutralization, in vitro IL-4 neutralization, in vivo IL-4 receptor stimulation (as a complex with IL-4), Flow cytometry, Western blot
Recommended Storage Conditions :
The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
more info or order :
company information
Bio X Cell
10 Technology Dr., Suite 2B
Lebanon, NH 03784-1671
customerservice@bxcell.com
http://bxcell.com
1-866-787-3444
headquarters: USA