product summary
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company name :
Bio X Cell
product type :
antibody
product name :
InVivoMAb anti-mouse CD25 (IL-2Rα)
catalog :
BE0012-5MG
quantity :
5 mg
price :
390.00 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
PC-61.5.3
reactivity :
mouse
application :
flow cytometry, blocking or activating experiments
more info or order :
citations: 27
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; mouse; fig 2e
Yokomizo K, Waki K, Ozawa M, Yamamoto K, Ogasawara S, Yano H, et al. Knockout of high-mobility group box 1 in B16F10 melanoma cells induced host immunity-mediated suppression of in vivo tumor growth. Med Oncol. 2022;39:58 pubmed publisher
  • blocking or activating experiments; mouse; ; fig 6c
Fu Y, Ding Y, Wang Q, Zhu F, Tan Y, Lu X, et al. Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2. Sci Adv. 2020;6:eaay9269 pubmed publisher
Li T, Li X, Zamani A, Wang W, Lee C, Li M, et al. c-Rel Is a Myeloid Checkpoint for Cancer Immunotherapy. Nat Cancer. 2020;1:507-517 pubmed publisher
Long Y, Tao H, Karachi A, Grippin A, Jin L, Chang Y, et al. Dysregulation of Glutamate Transport Enhances Treg Function That Promotes VEGF Blockade Resistance in Glioblastoma. Cancer Res. 2020;80:499-509 pubmed publisher
Wang E, Dai Z, Ferrante A, Drake C, Christiano A. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth. Cell Stem Cell. 2019;: pubmed publisher
Thyagarajan H, Lancaster J, Lira S, Ehrlich L. CCR8 is expressed by post-positive selection CD4-lineage thymocytes but is dispensable for central tolerance induction. PLoS ONE. 2018;13:e0200765 pubmed publisher
Nalawade S, Ji N, Raphael I, Pratt A, Kraig E, Forsthuber T. Aire is not essential for regulating neuroinflammatory disease in mice transgenic for human autoimmune-diseases associated MHC class II genes HLA-DR2b and HLA-DR4. Cell Immunol. 2018;331:38-48 pubmed publisher
Barr J, Wang X, Kreiger P, Lieberman S. Salivary-gland-protective regulatory T-cell dysfunction underlies female-specific sialadenitis in the non-obese diabetic mouse model of Sjögren syndrome. Immunology. 2018;155:225-237 pubmed publisher
Chen D, Xie J, Fiskesund R, Dong W, Liang X, Lv J, et al. Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype. Nat Commun. 2018;9:873 pubmed publisher
Xu D, Robinson A, Ishii T, Duncan D, Alden T, Goings G, et al. Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy. J Exp Med. 2018;215:1169-1186 pubmed publisher
Wang Q, Racine J, Ratiu J, Wang S, Ettinger R, Wasserfall C, et al. Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy. J Immunol. 2017;199:3757-3770 pubmed publisher
Göschl L, Preglej T, Hamminger P, Bonelli M, Andersen L, Boucheron N, et al. A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis. J Autoimmun. 2018;86:51-61 pubmed publisher
Schuldt N, Auger J, Spanier J, Martinov T, Breed E, Fife B, et al. Cutting Edge: Dual TCR? Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation. J Immunol. 2017;199:33-38 pubmed publisher
Clemente Casares X, Blanco J, Ambalavanan P, Yamanouchi J, Singha S, Fandos C, et al. Expanding antigen-specific regulatory networks to treat autoimmunity. Nature. 2016;530:434-40 pubmed publisher
Miller M, Daniels M, Wang T, Chen J, Young J, Xu J, et al. Spontaneous restoration of transplantation tolerance after acute rejection. Nat Commun. 2015;6:7566 pubmed publisher
Park H, Park J, Jeong Y, Son J, Ban Y, Lee B, et al. PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells. J Immunol. 2015;194:5801-11 pubmed publisher
Glatigny S, Duhen R, Arbelaez C, Kumari S, Bettelli E. Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4. Sci Rep. 2015;5:7834 pubmed publisher
Christensen A, Skov S, Kvist P, Haase C. Depletion of regulatory T cells in a hapten-induced inflammation model results in prolonged and increased inflammation driven by T cells. Clin Exp Immunol. 2015;179:485-99 pubmed publisher
Deligne C, Metidji A, Fridman W, Teillaud J. Anti-CD20 therapy induces a memory Th1 response through the IFN-γ/IL-12 axis and prevents protumor regulatory T-cell expansion in mice. Leukemia. 2015;29:947-57 pubmed publisher
Sarraj B, Ye J, Akl A, Chen G, Wang J, Zhang Z, et al. Impaired selectin-dependent leukocyte recruitment induces T-cell exhaustion and prevents chronic allograft vasculopathy and rejection. Proc Natl Acad Sci U S A. 2014;111:12145-50 pubmed publisher
Allam A, Swiecki M, Vermi W, Ashwell J, Colonna M. Dual function of CD70 in viral infection: modulator of early cytokine responses and activator of adaptive responses. J Immunol. 2014;193:871-8 pubmed publisher
Richter K, Perriard G, Behrendt R, Schwendener R, Sexl V, Dunn R, et al. Macrophage and T cell produced IL-10 promotes viral chronicity. PLoS Pathog. 2013;9:e1003735 pubmed publisher
Tang S, Moore M, Grayson J, Dubey P. Increased CD8+ T-cell function following castration and immunization is countered by parallel expansion of regulatory T cells. Cancer Res. 2012;72:1975-85 pubmed publisher
Locatelli G, Wörtge S, Buch T, Ingold B, Frommer F, Sobottka B, et al. Primary oligodendrocyte death does not elicit anti-CNS immunity. Nat Neurosci. 2012;15:543-50 pubmed publisher
Mohamadzadeh M, Pfeiler E, Brown J, Zadeh M, Gramarossa M, Managlia E, et al. Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid. Proc Natl Acad Sci U S A. 2011;108 Suppl 1:4623-30 pubmed publisher
Akins E, Moore M, Tang S, Willingham M, Tooze J, Dubey P. In situ vaccination combined with androgen ablation and regulatory T-cell depletion reduces castration-resistant tumor burden in prostate-specific pten knockout mice. Cancer Res. 2010;70:3473-82 pubmed publisher
D Alessio F, Tsushima K, Aggarwal N, West E, Willett M, Britos M, et al. CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J Clin Invest. 2009;119:2898-913 pubmed publisher
product information
Catalog Number :
BE0012-5MG
Product Name :
InVivoMAb anti-mouse CD25 (IL-2Rα)
Host :
Rat
Clonality :
Monoclonal
Label/Conjugation :
No
Antigen Modification :
No
Category :
Antibody
Size :
5 mg
Regular Price :
$600.00
Academic Price :
390.00 USD
Clone Name :
PC-61.5.3
Isotype :
PC-61.5.3
Immunogen :
IL-2-dependent cytolytic mouse T cell clone B6.1
Reactivity :
Mouse
Concentration/Amount :
Lot specific,typically between 4-11 mg/ml
Reported Applications :
in vivo regulatory T cell depletion, Flow cytometry
Recommended Storage Conditions :
The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
more info or order :
company information
Bio X Cell
10 Technology Dr., Suite 2B
Lebanon, NH 03784-1671
customerservice@bxcell.com
http://bxcell.com
1-866-787-3444
headquarters: USA