product summary
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company name :
Bio-Rad
other brands :
Biogenesis, Serotec, AbD Serotec, Oxford Biotechnology
product type :
antibody
product name :
Mouse anti Myelin Proteolipid Protein
catalog :
MCA839G
quantity :
0.1 mg
price :
406 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
plpc1
reactivity :
marmosets and tamarins, marmosets, human, mouse, rat, bovine, pigs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Bio-Rad product webpage
citations: 41
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:500; loading ...; fig 1a
Ramaglia V, Dubey M, Malpede M, Petersen N, de Vries S, Ahmed S, et al. Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory. Acta Neuropathol. 2021;142:643-667 pubmed publisher
  • immunohistochemistry; mouse; 1:500
Borggrewe M, Kooistra S, Wesseling E, Gierschek F, Brummer M, Nowak E, et al. VISTA regulates microglia homeostasis and myelin phagocytosis, and is associated with MS lesion pathology. Acta Neuropathol Commun. 2021;9:91 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig s4k
Safaiyan S, Besson Girard S, Kaya T, Cantuti Castelvetri L, Liu L, Ji H, et al. White matter aging drives microglial diversity. Neuron. 2021;109:1100-1117.e10 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:5000; loading ...; fig 2-a1
Rohr S, Greiner T, Joost S, Amor S, Valk P, Schmitz C, et al. Aquaporin-4 Expression during Toxic and Autoimmune Demyelination. Cells. 2020;9: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:3000; loading ...; fig 4d
Wolf N, Breur M, Plug B, Beerepoot S, Westerveld A, van Rappard D, et al. Metachromatic leukodystrophy and transplantation: remyelination, no cross-correction. Ann Clin Transl Neurol. 2020;7:169-180 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1, 2, 7
Ward L, Lee D, Sharma A, Wang A, Naouar I, Ma X, et al. Siponimod therapy implicates Th17 cells in a preclinical model of subpial cortical injury. JCI Insight. 2020;5: pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 1a
Fransen N, Crusius J, Smolders J, Mizee M, Van Eden C, Luchetti S, et al. Post-mortem multiple sclerosis lesion pathology is influenced by single nucleotide polymorphisms. Brain Pathol. 2020;30:106-119 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 1d
Michailidou I, Naessens D, Hametner S, Guldenaar W, Kooi E, Geurts J, et al. Complement C3 on microglial clusters in multiple sclerosis occur in chronic but not acute disease: Implication for disease pathogenesis. Glia. 2017;65:264-277 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:3000; fig st4
Dooves S, Bugiani M, Postma N, Polder E, Land N, Horan S, et al. Astrocytes are central in the pathomechanisms of vanishing white matter. J Clin Invest. 2016;126:1512-24 pubmed publisher
  • immunohistochemistry - paraffin section; marmosets; loading ...; fig 5b
Dunham J, Lee L, van Driel N, Laman J, Ni I, Zhai W, et al. Blockade of CD127 Exerts a Dichotomous Clinical Effect in Marmoset Experimental Autoimmune Encephalomyelitis. J Neuroimmune Pharmacol. 2016;11:73-83 pubmed publisher
  • immunohistochemistry; mouse; 1:1000
Alme M, Nystad A, Bø L, Myhr K, Vedeler C, Wergeland S, et al. Fingolimod does not enhance cerebellar remyelination in the cuprizone model. J Neuroimmunol. 2015;285:180-6 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 3
  • western blot; human; loading ...; fig 1c
  • immunoprecipitation; pigs ; loading ...; fig 3
  • western blot; pigs ; loading ...; fig 1d,3
Betzer C, Movius A, Shi M, Gai W, Zhang J, Jensen P. Identification of synaptosomal proteins binding to monomeric and oligomeric α-synuclein. PLoS ONE. 2015;10:e0116473 pubmed publisher
  • immunohistochemistry; human; 1:1000
Yao B, Hametner S, van Gelderen P, Merkle H, Chen C, Lassmann H, et al. 7 Tesla magnetic resonance imaging to detect cortical pathology in multiple sclerosis. PLoS ONE. 2014;9:e108863 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 8
Schneider Hohendorf T, Rossaint J, Mohan H, Böning D, Breuer J, Kuhlmann T, et al. VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. J Exp Med. 2014;211:1833-46 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000
  • immunohistochemistry - paraffin section; human; 1:1000
  • immunohistochemistry - paraffin section; rat; 1:1000
Schuh C, Wimmer I, Hametner S, Haider L, van Dam A, Liblau R, et al. Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models. Acta Neuropathol. 2014;128:247-66 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:1000
Prins M, Eriksson C, Wierinckx A, Bol J, Binnekade R, Tilders F, et al. Interleukin-1β and interleukin-1 receptor antagonist appear in grey matter additionally to white matter lesions during experimental multiple sclerosis. PLoS ONE. 2013;8:e83835 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1,000
Hametner S, Wimmer I, Haider L, Pfeifenbring S, Bruck W, Lassmann H. Iron and neurodegeneration in the multiple sclerosis brain. Ann Neurol. 2013;74:848-61 pubmed publisher
  • immunohistochemistry - paraffin section; marmosets and tamarins
Haanstra K, Jagessar S, Bauchet A, Doussau M, Fovet C, Heijmans N, et al. Induction of experimental autoimmune encephalomyelitis with recombinant human myelin oligodendrocyte glycoprotein in incomplete Freund's adjuvant in three non-human primate species. J Neuroimmune Pharmacol. 2013;8:1251-64 pubmed publisher
  • immunohistochemistry; mouse
Maurin H, Seymour C, Lechat B, Borghgraef P, Devijver H, Jaworski T, et al. Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare. PLoS ONE. 2013;8:e63589 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1,000
Misu T, Hoftberger R, Fujihara K, Wimmer I, Takai Y, Nishiyama S, et al. Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica. Acta Neuropathol. 2013;125:815-27 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:5000
Schmidt T, Awad H, Slowik A, Beyer C, Kipp M, Clarner T. Regional heterogeneity of cuprizone-induced demyelination: topographical aspects of the midline of the corpus callosum. J Mol Neurosci. 2013;49:80-8 pubmed publisher
  • immunohistochemistry; mouse; 1:500
  • immunohistochemistry - paraffin section; human; 1:3000
Clarner T, Diederichs F, Berger K, Denecke B, Gan L, van der Valk P, et al. Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions. Glia. 2012;60:1468-80 pubmed publisher
Böttcher C, van der Poel M, Fernández Zapata C, Schlickeiser S, Leman J, Hsiao C, et al. Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis. Acta Neuropathol Commun. 2020;8:136 pubmed publisher
Pallebage Gamarallage M, Foxley S, Menke R, Huszar I, Jenkinson M, Tendler B, et al. Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology. BMC Neurosci. 2018;19:11 pubmed publisher
Luchetti S, Fransen N, Van Eden C, Ramaglia V, Mason M, Huitinga I. Progressive multiple sclerosis patients show substantial lesion activity that correlates with clinical disease severity and sex: a retrospective autopsy cohort analysis. Acta Neuropathol. 2018;135:511-528 pubmed publisher
Zrzavy T, Machado Santos J, Christine S, Baumgartner C, Weiner H, Butovsky O, et al. Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts. Brain Pathol. 2017;: pubmed publisher
van Nierop G, van Luijn M, Michels S, Melief M, Janssen M, Langerak A, et al. Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients. Acta Neuropathol. 2017;134:383-401 pubmed publisher
Espitia Pinzon N, Sanz Morello B, Brevé J, Bol J, Drukarch B, Bauer J, et al. Astrocyte-derived tissue Transglutaminase affects fibronectin deposition, but not aggregation, during cuprizone-induced demyelination. Sci Rep. 2017;7:40995 pubmed publisher
Dal Bianco A, Grabner G, Kronnerwetter C, Weber M, Hoftberger R, Berger T, et al. Slow expansion of multiple sclerosis iron rim lesions: pathology and 7 T magnetic resonance imaging. Acta Neuropathol. 2017;133:25-42 pubmed publisher
Haider L, Simeonidou C, Steinberger G, Hametner S, Grigoriadis N, Deretzi G, et al. Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron. J Neurol Neurosurg Psychiatry. 2014;85:1386-95 pubmed publisher
Nakajima M, Kawamura T, Tokui R, Furuta K, Sugino M, Nakanishi M, et al. Enhanced accumulation of Kir4.1 protein, but not mRNA, in a murine model of cuprizone-induced demyelination. Brain Res. 2013;1537:340-9 pubmed publisher
Fischer M, Wimmer I, Hoftberger R, Gerlach S, Haider L, Zrzavy T, et al. Disease-specific molecular events in cortical multiple sclerosis lesions. Brain. 2013;136:1799-815 pubmed publisher
Herder V, Hansmann F, Wohlsein P, Peters M, Varela M, Palmarini M, et al. Immunophenotyping of inflammatory cells associated with Schmallenberg virus infection of the central nervous system of ruminants. PLoS ONE. 2013;8:e62939 pubmed publisher
Haider L, Fischer M, Frischer J, Bauer J, Hoftberger R, Botond G, et al. Oxidative damage in multiple sclerosis lesions. Brain. 2011;134:1914-24 pubmed publisher
Clarner T, Parabucki A, Beyer C, Kipp M. Corticosteroids impair remyelination in the corpus callosum of cuprizone-treated mice. J Neuroendocrinol. 2011;23:601-11 pubmed publisher
Bramow S, Frischer J, Lassmann H, Koch Henriksen N, Lucchinetti C, Sørensen P, et al. Demyelination versus remyelination in progressive multiple sclerosis. Brain. 2010;133:2983-98 pubmed publisher
Zeis T, Kinter J, Herrero Herranz E, Weissert R, Schaeren Wiemers N. Gene expression analysis of normal appearing brain tissue in an animal model for multiple sclerosis revealed grey matter alterations, but only minor white matter changes. J Neuroimmunol. 2008;205:10-9 pubmed publisher
Bramow S, Faber Rod J, Jacobsen C, Kutzelnigg A, Patrikios P, Sorensen P, et al. Fatal neurogenic pulmonary edema in a patient with progressive multiple sclerosis. Mult Scler. 2008;14:711-5 pubmed publisher
Bailey S, Schreiner B, McMahon E, Miller S. CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE. Nat Immunol. 2007;8:172-80 pubmed
Patrikios P, Stadelmann C, Kutzelnigg A, Rauschka H, Schmidbauer M, Laursen H, et al. Remyelination is extensive in a subset of multiple sclerosis patients. Brain. 2006;129:3165-72 pubmed
Gilmore C, Bö L, Owens T, Lowe J, Esiri M, Evangelou N. Spinal cord gray matter demyelination in multiple sclerosis-a novel pattern of residual plaque morphology. Brain Pathol. 2006;16:202-8 pubmed
image
image 1 :
Bio-Rad MCA839G image 1
Published customer image: . Mouse anti myelin proteolipid protein antibody, clone plpc1 ( MCA839G ) used for the detection of proteolipid protein on formalin fixed, paraffin embedded brain tissue. Image caption: . NL scheme and PLP staining. (A) Type-I NL with demyelination of the whole width of the cortex (#) and adjacent WM (*). (B) Type-II intracortical lesion evolving around a vessel. (C) Type-III subpial NL. Demyelination spreads from the pial surface until cortical layer 3. Scale bars represent 500 um. From:. Yao B, Hametner S, van Gelderen P, Merkle H, Chen C, et al . (2014). 7 Tesla Magnetic Resonance Imaging to Detect Cortical Pathology in Multiple Sclerosis. PLoS ONE 9(10): e108863 .
product information
Entity Type :
Monoclonal Antibody
Entity Category :
Antibodies
ProductCode :
MCA839G
Description :
Mouse anti Myelin Proteolipid Protein
Specificity :
Myelin Proteolipid Protein
TargetSpecies :
Bovine
Host :
Mouse
Format :
Purified
Isotypes :
IgG2a
Applications :
WB,P,IF,F,C
ApplicationTypes :
Western Blotting,Immunohistology - Paraffin,Immunofluorescence,Flow Cytometry,Immunohistology - Frozen
Cross Reactivities :
Human,Tenerife lizard (Gallotia galloti)
Clone :
plpc1
Quantity :
0.1 mg
Quantity Value :
0.1
Quantity Type :
mg
GO Accessions :
GO:0016021
GOTerms :
integral to membrane
Uniprot Accessions :
P04116
Gene :
PLP1
GeneID URL :
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=281410
Published Synonyms :
DM20,PLP
Entity Formats :
Purified
UNSPSC :
41116161
Concentration :
IgG concentration 1 mg/ml
Product Form :
Purified IgG - liquid
PriceGBP :
291
PriceEUR :
406
PriceUSD :
406 USD
PriceCHF :
442
PriceSEK :
4425
PriceNOK :
4447
PriceDKK :
3027
more info or order :
Bio-Rad product webpage
company information
Bio-Rad
Endeavour House, Langford Business Park
Langford Lane, Kidlington
OXON, OX5 1GE
antibody_sales_uk@bio-rad.com
https://www.bio-rad-antibodies.com
1 800 265 7376 (North America)
44 (0)1865 852 700 (Rest of World)
headquarters: UK
Bio-Rad is one of the world's leading antibody manufacturers, offering over 12,000 antibodies and related reagents for a focused range of research areas such as immunology, cancer, veterinary research and cell biology through its antibody experts formerly known as AbD Serotec.
The range includes apoptosis kits, autophagy reagents, CD markers, epitope tag antibodies, immunology antibodies, neuroscience antibodies, and veterinary reagents.
Bio-Rad has an ISO 9001 and ISO 13485 certified production facility in the United Kingdom as well as ISO 9001 certified facilities in Germany and the United States.
Our expertise extends to traditional and recombinant antibody generation and production services. Our custom generation service delivers antibodies in as little as 8 weeks with greater than 90% success. The in vitro technology enables selection of antibodies to challenging targets, long term consistent supply, and provision of the antibody sequence.
At Bio-Rad we are committed to your success when using our antibodies and we focus on providing the technology, products and all the supporting information you need to excel in your research.