product summary
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company name :
Bio-Rad
other brands :
Biogenesis, Serotec, AbD Serotec, Oxford Biotechnology
product type :
antibody
product name :
Mouse anti Human CD126/Il-6R
catalog :
MCA822
quantity :
0.1 mg
price :
249 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B-R6
reactivity :
human
application :
ELISA, immunocytochemistry, immunoprecipitation, flow cytometry
more info or order :
citations: 1
Reference
McKay B, De Lisio M, Johnston A, O Reilly C, Phillips S, Tarnopolsky M, et al. Association of interleukin-6 signalling with the muscle stem cell response following muscle-lengthening contractions in humans. PLoS ONE. 2009;4:e6027 pubmed publisher
image
image 1 :
Bio-Rad MCA822 image 1
Published customer image: . Mouse anti Human CD126 antibody, clone B-R6 used for the evaluation of IL6R expression on human muscle tissue by immunofluorescence. Image caption: . Circulating IL-6 and muscle IL-6 mRNA and IL-6 receptor response muscle lengthening contractions (MLC).(1a) Average serum interleukin-6 (IL-6) concentration. Time 0 hr corresponds to pre-intervention values; all other time-points correspond to post-intervention time (hr). (1b) Relative IL-6 mRNA expression, expressed as fold-change from 0 hr. (1c) Pearson correlation of serum IL-6 concentration versus muscle IL-6 mRNA (fold-change), correlation is representative of the individual data points and presented as mean values ( )±SD (error bars). (1d) Relative IL-6 receptor (IL-6R ) mRNA expression, expressed as fold-change from 0 hr. (1e) Immunofluorescent image (40×) of a muscle cross-section triple-stained for Pax7 (red), IL-6R (green) and nuclei (DAPI = blue); IL-6R staining is apparent on the sarcolemma and satellite cell membrane. White arrow denotes one of the Pax7+ nuclei which co-localized with IL-6R (scale bar = 100 um). Values are reported as mean S.E.M. Mean values represent the mean for all 8 subjects per time-point (8 samples per time-point, 40 samples total). *p 0.05 vs. 0 hr. From: McKay BR, De Lisio M, Johnston APW, O Reilly CE, Phillips SM, Tarnopolsky MA, et al . (2009). Association of Interleukin-6 Signalling with the Muscle Stem Cell Response Following Muscle-Lengthening Contractions in Humans. PLoS ONE 4(6): e6027 . This is from an open access article distributed under the terms of the Creative Commons Attribution License .
product information
Entity Type :
Monoclonal Antibody
Entity Category :
Antibodies
ProductCode :
MCA822
Description :
Mouse anti Human CD126/Il-6R
Specificity :
CD126
TargetSpecies :
Human
Host :
Mouse
Format :
Purified
Isotypes :
IgG1
Applications :
E,IF,F,C,IP
ApplicationTypes :
ELISA,Immunofluorescence,Flow Cytometry,Immunohistology - Frozen,Immunoprecipitation
Clone :
B-R6
Quantity :
0.1 mg
Quantity Value :
0.1
Quantity Type :
mg
GO Accessions :
GO:0002384,GO:0002446,GO:0002548,GO:0002690,GO:0006953,GO:0005615,GO:0005896,GO:0050830,GO:0050829,GO:0010536,GO:0016323,GO:0016324,GO:0042981,GO:0019899,GO:0031018,GO:0032717,GO:0032722,GO:0032755,GO:0032966,GO:0034097,GO:0042517,GO:0042803,GO:0043410,GO:0045669,GO:0045768,GO:0048661,GO:0070102,GO:0070119,GO:0070120
GOTerms :
hepatic immune response,neutrophil mediated immunity,monocyte chemotaxis,positive regulation of leukocyte chemotaxis,acute-phase response,extracellular space,interleukin-6 receptor complex,defense response to Gram-positive bacterium,defense response to Gram-negative bacterium,positive regulation of activation of Janus kinase activity,basolateral plasma membrane,apical plasma membrane,regulation of apoptosis,enzyme binding,endocrine pancreas development,negative regulation of interleukin-8 production,positive regulation of chemokine production,positive regulation of interleukin-6 production,negative regulation of collagen biosynthetic process,response to cytokine stimulus,positive regulation of tyrosine phosphorylation of Stat3 protein,protein homodimerization activity,positive regulation of MAPKKK cascade,positive regulation of osteoblast differentiation,positive regulation of anti-apoptosis,positive regulation of smooth muscle cell proliferation,interleukin-6-mediated signaling pathway,ciliary neurotrophic factor binding,ciliary neurotrophic factor-mediated signaling pathway
Uniprot Accessions :
P08887
Gene :
IL6R
GeneID URL :
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3570
Published Synonyms :
Interleukin-6 Receptor
Entity Formats :
Purified
UNSPSC :
41116161
Concentration :
IgG concentration 1.0 mg/ml
Product Form :
Purified IgG - liquid
PriceGBP :
178
PriceEUR :
249
PriceUSD :
249 USD
PriceCHF :
271
PriceSEK :
2714
PriceNOK :
2728
PriceDKK :
1856
more info or order :
company information
Bio-Rad
Endeavour House, Langford Business Park
Langford Lane, Kidlington
OXON, OX5 1GE
antibody_sales_uk@bio-rad.com
https://www.bio-rad-antibodies.com
1 800 265 7376 (North America)
44 (0)1865 852 700 (Rest of World)
headquarters: UK
Bio-Rad is one of the world's leading antibody manufacturers, offering over 12,000 antibodies and related reagents for a focused range of research areas such as immunology, cancer, veterinary research and cell biology through its antibody experts formerly known as AbD Serotec.
The range includes apoptosis kits, autophagy reagents, CD markers, epitope tag antibodies, immunology antibodies, neuroscience antibodies, and veterinary reagents.
Bio-Rad has an ISO 9001 and ISO 13485 certified production facility in the United Kingdom as well as ISO 9001 certified facilities in Germany and the United States.
Our expertise extends to traditional and recombinant antibody generation and production services. Our custom generation service delivers antibodies in as little as 8 weeks with greater than 90% success. The in vitro technology enables selection of antibodies to challenging targets, long term consistent supply, and provision of the antibody sequence.
At Bio-Rad we are committed to your success when using our antibodies and we focus on providing the technology, products and all the supporting information you need to excel in your research.