product summary
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company name :
Bio-Rad
other brands :
Biogenesis, Serotec, AbD Serotec, Oxford Biotechnology
product type :
antibody
product name :
Rat anti Mouse CD11b
catalog :
MCA74G
quantity :
0.25 mg
price :
384 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
M1/70.15
reactivity :
human, mouse, rat
application :
immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Bio-Rad product webpage
citations: 32
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 2c
Groh J, Berve K, Martini R. Immune modulation attenuates infantile neuronal ceroid lipofuscinosis in mice before and after disease onset. Brain Commun. 2021;3:fcab047 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 2a
Kjell J, Gotz M. Filling the Gaps - A Call for Comprehensive Analysis of Extracellular Matrix of the Glial Scar in Region- and Injury-Specific Contexts. Front Cell Neurosci. 2020;14:32 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig s3
Gacem N, Kavo A, Zerad L, Richard L, Mathis S, Kapur R, et al. ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development. Nat Commun. 2020;11:198 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig s4
Rossaert E, Pollari E, Jaspers T, Van Helleputte L, Jarpe M, Van Damme P, et al. Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model. Acta Neuropathol Commun. 2019;7:107 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:500; loading ...; fig st3
Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
  • flow cytometry; human; fig 6c
Wiesmeier M, Gautam S, Kirschnek S, Hacker G. Characterisation of Neutropenia-Associated Neutrophil Elastase Mutations in a Murine Differentiation Model In Vitro and In Vivo. PLoS ONE. 2016;11:e0168055 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; fig 4
Alves S, Marais T, Biferi M, Furling D, Marinello M, El Hachimi K, et al. Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins. Mol Neurodegener. 2016;11:58 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:600; loading ...; fig 7r
Clausen B, Degn M, Sivasaravanaparan M, Fogtmann T, Andersen M, Trojanowsky M, et al. Conditional ablation of myeloid TNF increases lesion volume after experimental stroke in mice, possibly via altered ERK1/2 signaling. Sci Rep. 2016;6:29291 pubmed publisher
  • immunocytochemistry; mouse; fig 1
Tam W, Au N, Ma C. The association between laminin and microglial morphology in vitro. Sci Rep. 2016;6:28580 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 2a
Oñate M, Catenaccio A, Martínez G, Armentano D, Parsons G, Kerr B, et al. Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury. Sci Rep. 2016;6:21709 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5
Catarinella M, Monestiroli A, Escobar G, Fiocchi A, Tran N, Aiolfi R, et al. IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment. EMBO Mol Med. 2016;8:155-70 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig s4
Castillo V, Oñate M, Woehlbier U, Rozas P, Andreu C, Medinas D, et al. Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration. PLoS ONE. 2015;10:e0136620 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; fig 3
Liu S, Mi W, Li Q, Zhang M, Han P, Hu S, et al. Spinal IL-33/ST2 Signaling Contributes to Neuropathic Pain via Neuronal CaMKII-CREB and Astroglial JAK2-STAT3 Cascades in Mice. Anesthesiology. 2015;123:1154-69 pubmed publisher
  • immunohistochemistry; human; 1:50; fig 5
Lee I, Jung K, Kim I, Lee H, Kim M, Yun S, et al. Human neural stem cells alleviate Alzheimer-like pathology in a mouse model. Mol Neurodegener. 2015;10:38 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig  4
Syhr K, Kallenborn Gerhardt W, Lu R, Olbrich K, Schmitz K, Männich J, et al. Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice. Pharmacol Biochem Behav. 2014;124:389-95 pubmed publisher
  • flow cytometry; mouse
Wickström S, Oberg L, Kärre K, Johansson M. A genetic defect in mice that impairs missing self recognition despite evidence for normal maturation and MHC class I-dependent education of NK cells. J Immunol. 2014;192:1577-86 pubmed publisher
Olesen M, Christiansen J, Petersen S, Jensen P, Paslawski W, Romero Ramos M, et al. CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology. Heliyon. 2018;4:e00513 pubmed publisher
Kigerl K, Hall J, Wang L, Mo X, Yu Z, Popovich P. Gut dysbiosis impairs recovery after spinal cord injury. J Exp Med. 2016;213:2603-2620 pubmed
Lin S, Barrette A, Chapin C, Gonzales L, Gonzalez R, Dobbs L, et al. Expression of human carcinoembryonic antigen-related cell adhesion molecule 6 and alveolar progenitor cells in normal and injured lungs of transgenic mice. Physiol Rep. 2015;3: pubmed publisher
Tam W, Ma C. Bipolar/rod-shaped microglia are proliferating microglia with distinct M1/M2 phenotypes. Sci Rep. 2014;4:7279 pubmed publisher
Ren Q, Zhang J, Ma M, Fujita Y, Wu J, Hashimoto K. 7,8-Dihydroxyflavone, a TrkB agonist, attenuates behavioral abnormalities and neurotoxicity in mice after administration of methamphetamine. Psychopharmacology (Berl). 2014;231:159-66 pubmed publisher
Marabelle A, Kohrt H, Sagiv Barfi I, Ajami B, Axtell R, Zhou G, et al. Depleting tumor-specific Tregs at a single site eradicates disseminated tumors. J Clin Invest. 2013;123:2447-63 pubmed
Valenzuela V, Collyer E, Armentano D, Parsons G, Court F, Hetz C. Activation of the unfolded protein response enhances motor recovery after spinal cord injury. Cell Death Dis. 2012;3:e272 pubmed publisher
Chen H, Wu J, Zhang J, Fujita Y, Ishima T, Iyo M, et al. Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine. Psychopharmacology (Berl). 2012;222:37-45 pubmed publisher
Voloboueva L, Lee S, Emery J, Palmer T, Giffard R. Mitochondrial protection attenuates inflammation-induced impairment of neurogenesis in vitro and in vivo. J Neurosci. 2010;30:12242-51 pubmed publisher
Hulse R, Swenson W, Kunkler P, White D, Kraig R. Monomeric IgG is neuroprotective via enhancing microglial recycling endocytosis and TNF-alpha. J Neurosci. 2008;28:12199-211 pubmed publisher
Troen A, Shea Budgell M, Shukitt Hale B, Smith D, Selhub J, Rosenberg I. B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proc Natl Acad Sci U S A. 2008;105:12474-9 pubmed publisher
Frenkel D, Puckett L, Petrovic S, Xia W, Chen G, Vega J, et al. A nasal proteosome adjuvant activates microglia and prevents amyloid deposition. Ann Neurol. 2008;63:591-601 pubmed publisher
Connor K, SanGiovanni J, Lofqvist C, Aderman C, Chen J, Higuchi A, et al. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007;13:868-873 pubmed publisher
Zhang L, Shirayama Y, Shimizu E, Iyo M, Hashimoto K. Protective effects of minocycline on 3,4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain. Eur J Pharmacol. 2006;544:1-9 pubmed
Zhang L, Kitaichi K, Fujimoto Y, Nakayama H, Shimizu E, Iyo M, et al. Protective effects of minocycline on behavioral changes and neurotoxicity in mice after administration of methamphetamine. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30:1381-93 pubmed
Frenkel D, Maron R, Burt D, Weiner H. Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease. J Clin Invest. 2005;115:2423-33 pubmed
image
image 1 :
Bio-Rad MCA74G image 1
Immunofluorescence staining of mouse lymph node cryosection using Rat anti Mouse CD11b antibody ( MCA74GA ), green in A and Rat anti Mouse CD8 antibody ( MCA1108 ), red in B, Merged image in C
product information
Entity Type :
Monoclonal Antibody
Entity Category :
Antibodies
ProductCode :
MCA74G
Description :
Rat anti Mouse CD11b
Specificity :
CD11b
TargetSpecies :
Mouse
Host :
Rat
Format :
Purified
Isotypes :
IgG2b
Applications :
P,IP,F,C,IF
ApplicationTypes :
Immunohistology - Paraffin,Immunoprecipitation,Flow Cytometry,Immunohistology - Frozen,Immunofluorescence
Cross Reactivities :
Human,Rabbit
Clone :
M1/70.15
Quantity :
0.25 mg
Quantity Value :
0.25
Quantity Type :
mg
GO Accessions :
GO:0001846,GO:0004872,GO:0008305,GO:0005634,GO:0007159,GO:0007229,GO:0008201,GO:0009897,GO:0030593,GO:0043395,GO:0045123,GO:0050798
GOTerms :
opsonin binding,receptor activity,integrin complex,nucleus,leukocyte cell-cell adhesion,integrin-mediated signaling pathway,heparin binding,external side of plasma membrane,neutrophil chemotaxis,heparan sulfate proteoglycan binding,cellular extravasation,activated T cell proliferation
Uniprot Accessions :
P05555
Gene :
Itgam
GeneID URL :
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=16409
Published Synonyms :
Integrin Alpha M Chain,MAC-1
Entity Formats :
Alexa Fluor® 488,Alexa Fluor® 647,Biotin,FITC,Low Endotoxin,Pacific Blue®,Purified,RPE,RPE-Alexa Fluor® 750,Alexa Fluor® 700,Amethyst Orange
UNSPSC :
41116161
Concentration :
IgG concentration 1.0 mg/ml
Product Form :
Purified IgG - liquid
PriceGBP :
274
PriceEUR :
384
PriceUSD :
384 USD
PriceCHF :
418
PriceSEK :
4378
PriceNOK :
4371
PriceDKK :
2864
more info or order :
Bio-Rad product webpage
company information
Bio-Rad
Endeavour House, Langford Business Park
Langford Lane, Kidlington
OXON, OX5 1GE
antibody_sales_uk@bio-rad.com
https://www.bio-rad-antibodies.com
1 800 265 7376 (North America)
44 (0)1865 852 700 (Rest of World)
headquarters: UK
Bio-Rad is one of the world's leading antibody manufacturers, offering over 12,000 antibodies and related reagents for a focused range of research areas such as immunology, cancer, veterinary research and cell biology through its antibody experts formerly known as AbD Serotec.
The range includes apoptosis kits, autophagy reagents, CD markers, epitope tag antibodies, immunology antibodies, neuroscience antibodies, and veterinary reagents.
Bio-Rad has an ISO 9001 and ISO 13485 certified production facility in the United Kingdom as well as ISO 9001 certified facilities in Germany and the United States.
Our expertise extends to traditional and recombinant antibody generation and production services. Our custom generation service delivers antibodies in as little as 8 weeks with greater than 90% success. The in vitro technology enables selection of antibodies to challenging targets, long term consistent supply, and provision of the antibody sequence.
At Bio-Rad we are committed to your success when using our antibodies and we focus on providing the technology, products and all the supporting information you need to excel in your research.