product summary
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company name :
Bio-Rad
other brands :
Biogenesis, Serotec, AbD Serotec, Oxford Biotechnology
product type :
antibody
product name :
Rat anti Mouse CD11b
catalog :
MCA711GT
quantity :
25 µg
price :
100 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
5C6
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
Bio-Rad product webpage
citations: 19
Published Application/Species/Sample/DilutionReference
  • immunoprecipitation; mouse; loading ...; fig s1e
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4k
Rangan P, Lobo F, Parrella E, Rochette N, Morselli M, Stephen T, et al. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell Rep. 2022;40:111417 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3b
Thygesen C, Ilkjær L, Kempf S, Hemdrup A, von Linstow C, Babcock A, et al. Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease. Front Cell Neurosci. 2018;12:397 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:250; loading ...; fig 1c
Laurent C, Dorothee G, Hunot S, Martin E, Monnet Y, Duchamp M, et al. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain. 2017;140:184-200 pubmed publisher
  • immunohistochemistry; mouse; fig 4
Bisht K, Sharma K, Lecours C, Sánchez M, El Hajj H, Milior G, et al. Dark microglia: A new phenotype predominantly associated with pathological states. Glia. 2016;64:826-39 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 2
Chen H, Sun Y, Lai L, Wu H, Xiao Y, Ming B, et al. Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice. Neuroscience. 2015;308:157-68 pubmed publisher
  • immunohistochemistry - frozen section; mouse
Kan M, Lee J, Wilson J, Everhart A, Brown C, Hoofnagle A, et al. Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. J Neurosci. 2015;35:5969-82 pubmed publisher
  • immunocytochemistry; human; 1:100; fig s3
Zhou W, Ke S, Huang Z, Flavahan W, Fang X, Paul J, et al. Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. Nat Cell Biol. 2015;17:170-82 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; fig 2
Tyzack G, Sitnikov S, Barson D, Adams Carr K, Lau N, Kwok J, et al. Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression. Nat Commun. 2014;5:4294 pubmed publisher
  • immunocytochemistry; mouse
  • immunohistochemistry; mouse
de Waard M, van der Pluijm I, Zuiderveen Borgesius N, Comley L, Haasdijk E, Rijksen Y, et al. Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice. Acta Neuropathol. 2010;120:461-75 pubmed publisher
Badimon A, Strasburger H, Ayata P, Chen X, Nair A, Ikegami A, et al. Negative feedback control of neuronal activity by microglia. Nature. 2020;: pubmed publisher
Pulido Salgado M, Vidal Taboada J, Garcia Díaz Barriga G, Serratosa J, Valente T, Castillo P, et al. Myeloid C/EBP? deficiency reshapes microglial gene expression and is protective in experimental autoimmune encephalomyelitis. J Neuroinflammation. 2017;14:54 pubmed publisher
Wang Q, Chu C, Qian L, Chen S, Wilson B, Oyarzabal E, et al. Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase. J Neurosci. 2014;34:12490-503 pubmed publisher
Ahuja N, Andres Hernando A, Altmann C, Bhargava R, Bacalja J, Webb R, et al. Circulating IL-6 mediates lung injury via CXCL1 production after acute kidney injury in mice. Am J Physiol Renal Physiol. 2012;303:F864-72 pubmed publisher
Sharma Y, Cojocaru R, Ritter L, Khattree N, Brooks M, Scott A, et al. Protective gene expression changes elicited by an inherited defect in photoreceptor structure. PLoS ONE. 2012;7:e31371 pubmed publisher
Straccia M, Gresa Arribas N, Dentesano G, Ejarque Ortiz A, Tusell J, Serratosa J, et al. Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein ?. J Neuroinflammation. 2011;8:156 pubmed publisher
Armentano M, Canalia N, Crociara P, Bonfanti L. Culturing conditions remarkably affect viability and organization of mouse subventricular zone in ex vivo cultured forebrain slices. J Neurosci Methods. 2011;197:65-81 pubmed publisher
Dohi K, Ohtaki H, Nakamachi T, Yofu S, Satoh K, Miyamoto K, et al. Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury. J Neuroinflammation. 2010;7:41 pubmed publisher
Engwerda C, Mynott T, Sawhney S, de Souza J, Bickle Q, Kaye P. Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria. J Exp Med. 2002;195:1371-7 pubmed
Carenini S, Maurer M, Werner A, Blazyca H, Toyka K, Schmid C, et al. The role of macrophages in demyelinating peripheral nervous system of mice heterozygously deficient in p0. J Cell Biol. 2001;152:301-8 pubmed
image
image 1 :
Bio-Rad MCA711GT image 1
Figure A. Alexa Fluor 700 conjugated Rat anti Mouse GR-1 ( MCA2387A700 ) and Pacific Blue conjugated Rat IgG2b isotype control ( MCA6006PB ). Figure B. Alexa Fluor 700 conjugated Rat anti Mouse GR-1 ( MCA2387A700 ) and Pacific Blue conjugated Rat anti Mouse CD11b ( MCA711PB ). All experiments performed on red cell lysed mouse bone marrow gated on mononuclear cells in the presence of Mouse Seroblock ( BUF041A ). Data acquired on the ZE5 cell analyzer.
product information
Entity Type :
Monoclonal Antibody
Entity Category :
Antibodies
ProductCode :
MCA711GT
Description :
Rat anti Mouse CD11b
Specificity :
CD11b
TargetSpecies :
Mouse
Host :
Rat
Format :
Purified
Isotypes :
IgG2b
Applications :
F,C,IF,IP
ApplicationTypes :
Flow Cytometry,Immunohistology - Frozen,Immunofluorescence,Immunoprecipitation
Cross Reactivities :
Human
Clone :
5C6
Quantity :
25 µg
Quantity Value :
25
Quantity Type :
µg
GO Accessions :
GO:0001846,GO:0004872,GO:0008305,GO:0005634,GO:0007159,GO:0007229,GO:0008201,GO:0009897,GO:0030593,GO:0043395,GO:0045123,GO:0050798
GOTerms :
opsonin binding,receptor activity,integrin complex,nucleus,leukocyte cell-cell adhesion,integrin-mediated signaling pathway,heparin binding,external side of plasma membrane,neutrophil chemotaxis,heparan sulfate proteoglycan binding,cellular extravasation,activated T cell proliferation
Uniprot Accessions :
P05555
Gene :
Itgam
GeneID URL :
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=16409
Published Synonyms :
Integrin Alpha M Chain,MAC-1
Entity Formats :
Alexa Fluor® 647,FITC,Low Endotoxin,Pacific Blue®,Purified,RPE,StarBright Blue 700,StarBright Violet 440,StarBright Violet 515,StarBright Violet 610,StarBright Violet 670,StarBright Violet 570,StarBright Violet 710,StarBright Violet 790,StarBright Violet 475,StarBright UltraViolet 400,StarBright UltraViolet 665,StarBright UltraViolet 795,StarBright Violet 760,StarBright UltraViolet 445,StarBright UltraViolet 510,StarBright UltraViolet 740,StarBright UltraViolet 575,StarBright UltraViolet 605,StarBright Blue 580,StarBright Blue 615,StarBright Blue 675,StarBright Blue 765,StarBright Blue 810,StarBright Yellow 575,StarBright Yellow 605,StarBright Yellow 665,StarBright Yellow 800,StarBright Yellow 720,StarBright Red 670,StarBright Red 715,StarBright Red 775,StarBright Red 815
UNSPSC :
41116161
Concentration :
IgG concentration 1 mg/ml
Product Form :
Purified IgG - liquid
PriceGBP :
71
PriceEUR :
100
PriceUSD :
100 USD
PriceCHF :
109
PriceSEK :
1090
PriceNOK :
1095
PriceDKK :
746
more info or order :
Bio-Rad product webpage
company information
Bio-Rad
Endeavour House, Langford Business Park
Langford Lane, Kidlington
OXON, OX5 1GE
antibody_sales_uk@bio-rad.com
https://www.bio-rad-antibodies.com
1 800 265 7376 (North America)
44 (0)1865 852 700 (Rest of World)
headquarters: UK
Bio-Rad is one of the world's leading antibody manufacturers, offering over 12,000 antibodies and related reagents for a focused range of research areas such as immunology, cancer, veterinary research and cell biology through its antibody experts formerly known as AbD Serotec.
The range includes apoptosis kits, autophagy reagents, CD markers, epitope tag antibodies, immunology antibodies, neuroscience antibodies, and veterinary reagents.
Bio-Rad has an ISO 9001 and ISO 13485 certified production facility in the United Kingdom as well as ISO 9001 certified facilities in Germany and the United States.
Our expertise extends to traditional and recombinant antibody generation and production services. Our custom generation service delivers antibodies in as little as 8 weeks with greater than 90% success. The in vitro technology enables selection of antibodies to challenging targets, long term consistent supply, and provision of the antibody sequence.
At Bio-Rad we are committed to your success when using our antibodies and we focus on providing the technology, products and all the supporting information you need to excel in your research.