product summary
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company name :
Bio-Rad
other brands :
Biogenesis, Serotec, AbD Serotec, Oxford Biotechnology
product type :
antibody
product name :
Rat anti Mouse CD11b
catalog :
MCA711
quantity :
1 mg
price :
622 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
5C6
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
citations: 95
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 4f
Dorrier C, Aran D, Haenelt E, Sheehy R, Hoi K, Pintarić L, et al. CNS fibroblasts form a fibrotic scar in response to immune cell infiltration. Nat Neurosci. 2021;24:234-244 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3b
Thygesen C, Ilkjær L, Kempf S, Hemdrup A, von Linstow C, Babcock A, et al. Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease. Front Cell Neurosci. 2018;12:397 pubmed publisher
  • immunocytochemistry; mouse; fig 2c
Betlazar C, Harrison Brown M, Middleton R, Banati R, Liu G. Cellular Sources and Regional Variations in the Expression of the Neuroinflammatory Marker Translocator Protein (TSPO) in the Normal Brain. Int J Mol Sci. 2018;19: pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 2a
Schuhmann M, Guthmann J, Stoll G, Nieswandt B, Kraft P, Kleinschnitz C. Blocking of platelet glycoprotein receptor Ib reduces "thrombo-inflammation" in mice with acute ischemic stroke. J Neuroinflammation. 2017;14:18 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:250; loading ...; fig 1c
Laurent C, Dorothee G, Hunot S, Martin E, Monnet Y, Duchamp M, et al. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain. 2017;140:184-200 pubmed publisher
  • immunocytochemistry; mouse; 1:200; fig 2e
Thomsen M, Birkelund S, Burkhart A, Stensballe A, Moos T. Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier. J Neurochem. 2017;140:741-754 pubmed publisher
  • immunocytochemistry; rat; fig 5
Christensen D, Ejlerskov P, Rasmussen I, Vilhardt F. Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis. J Neuroinflammation. 2016;13:59 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:5000; fig 2
Hristova M, Rocha Ferreira E, Fontana X, Thei L, Buckle R, Christou M, et al. Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) reduces neonatal hypoxic-ischaemic brain damage. J Neurochem. 2016;136:981-94 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:100
Gautier H, Evans K, Volbracht K, James R, Sitnikov S, Lundgaard I, et al. Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors. Nat Commun. 2015;6:8518 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 2
Chen H, Sun Y, Lai L, Wu H, Xiao Y, Ming B, et al. Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice. Neuroscience. 2015;308:157-68 pubmed publisher
  • immunohistochemistry; mouse; 1:50; fig ev2
Zhao L, Zabel M, Wang X, Ma W, Shah P, Fariss R, et al. Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration. EMBO Mol Med. 2015;7:1179-97 pubmed publisher
  • immunohistochemistry - frozen section; mouse
Kan M, Lee J, Wilson J, Everhart A, Brown C, Hoofnagle A, et al. Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. J Neurosci. 2015;35:5969-82 pubmed publisher
  • immunocytochemistry; mouse; 1:300
Zarruk J, Berard J, Passos Dos Santos R, Kroner A, Lee J, Arosio P, et al. Expression of iron homeostasis proteins in the spinal cord in experimental autoimmune encephalomyelitis and their implications for iron accumulation. Neurobiol Dis. 2015;81:93-107 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 5d
Filézac de L Etang A, Maharjan N, Cordeiro Braña M, Ruegsegger C, Rehmann R, Goswami A, et al. Marinesco-Sjögren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS. Nat Neurosci. 2015;18:227-38 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 2
Lambertsen K, Østergaard K, Clausen B, Hansen S, Stenvang J, Thorsen S, et al. No effect of ablation of surfactant protein-D on acute cerebral infarction in mice. J Neuroinflammation. 2014;11:123 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; fig 2
Tyzack G, Sitnikov S, Barson D, Adams Carr K, Lau N, Kwok J, et al. Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression. Nat Commun. 2014;5:4294 pubmed publisher
  • immunohistochemistry; mouse
Tepavcevic V, Kerninon C, Aigrot M, Meppiel E, Mozafari S, Arnould Laurent R, et al. Early netrin-1 expression impairs central nervous system remyelination. Ann Neurol. 2014;76:252-68 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 5b
Neher M, Rich M, Keene C, Weckbach S, Bolden A, Losacco J, et al. Deficiency of complement receptors CR2/CR1 in Cr2?/? mice reduces the extent of secondary brain damage after closed head injury. J Neuroinflammation. 2014;11:95 pubmed publisher
  • immunocytochemistry; mouse; 1:200
  • immunohistochemistry; mouse; 1:200
O Brien E, Kersemans V, Tredwell M, Checa B, Serres S, Soto M, et al. Glial activation in the early stages of brain metastasis: TSPO as a diagnostic biomarker. J Nucl Med. 2014;55:275-80 pubmed publisher
  • immunohistochemistry; mouse; 1:500
  • western blot; mouse; 1:1000
Chittoor V, Sooyeon L, Rangaraju S, Nicks J, Schmidt J, Madorsky I, et al. Biochemical characterization of protein quality control mechanisms during disease progression in the C22 mouse model of CMT1A. ASN Neuro. 2013;5:e00128 pubmed publisher
  • immunocytochemistry; mouse
  • immunohistochemistry; mouse
de Waard M, van der Pluijm I, Zuiderveen Borgesius N, Comley L, Haasdijk E, Rijksen Y, et al. Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice. Acta Neuropathol. 2010;120:461-75 pubmed publisher
  • immunohistochemistry; human
Chaudhry U, Zhuang H, Crain B, DORE S. Elevated microsomal prostaglandin-E synthase-1 in Alzheimer's disease. Alzheimers Dement. 2008;4:6-13 pubmed publisher
  • immunohistochemistry; mouse; 1:1000
Bulloch K, Miller M, Gal Toth J, Milner T, Gottfried Blackmore A, Waters E, et al. CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain. J Comp Neurol. 2008;508:687-710 pubmed publisher
Bieber M, Schuhmann M, Volz J, Kumar G, Vaidya J, Nieswandt B, et al. Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function. Stroke. 2019;50:478-486 pubmed publisher
Mouton Liger F, Rosazza T, Sepulveda Diaz J, Ieang A, Hassoun S, Claire E, et al. Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop. Glia. 2018;: pubmed publisher
Rizzi C, Tiberi A, Giustizieri M, Marrone M, Gobbo F, Carucci N, et al. NGF steers microglia toward a neuroprotective phenotype. Glia. 2018;66:1395-1416 pubmed publisher
Pulido Salgado M, Vidal Taboada J, Garcia Díaz Barriga G, Serratosa J, Valente T, Castillo P, et al. Myeloid C/EBP? deficiency reshapes microglial gene expression and is protective in experimental autoimmune encephalomyelitis. J Neuroinflammation. 2017;14:54 pubmed publisher
Hopp S, Nolte M, Stetter C, Kleinschnitz C, SIREN A, Albert Weissenberger C. Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa. J Neuroinflammation. 2017;14:39 pubmed publisher
Rabl R, Breitschaedel C, Flunkert S, Duller S, Amschl D, Neddens J, et al. Early start of progressive motor deficits in Line 61 ?-synuclein transgenic mice. BMC Neurosci. 2017;18:22 pubmed publisher
Allodi I, Comley L, Nichterwitz S, Nizzardo M, Simone C, Benitez J, et al. Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS. Sci Rep. 2016;6:25960 pubmed publisher
Wlodarczyk A, Cédile O, Jensen K, Jasson A, Mony J, Khorooshi R, et al. Pathologic and Protective Roles for Microglial Subsets and Bone Marrow- and Blood-Derived Myeloid Cells in Central Nervous System Inflammation. Front Immunol. 2015;6:463 pubmed publisher
Alam J. Selective Brain-Targeted Antagonism of p38 MAPKα Reduces Hippocampal IL-1β Levels and Improves Morris Water Maze Performance in Aged Rats. J Alzheimers Dis. 2015;48:219-27 pubmed publisher
Khorooshi R, Mørch M, Holm T, Berg C, Dieu R, Dræby D, et al. Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis. Acta Neuropathol. 2015;130:107-18 pubmed publisher
Albert Weissenberger C, Mencl S, Schuhmann M, Salur I, Göb E, Langhauser F, et al. C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation. Front Cell Neurosci. 2014;8:269 pubmed publisher
Mencl S, Hennig N, Hopp S, Schuhmann M, Albert Weissenberger C, SIREN A, et al. FTY720 does not protect from traumatic brain injury in mice despite reducing posttraumatic inflammation. J Neuroimmunol. 2014;274:125-31 pubmed publisher
Löffler T, Flunkert S, Havas D, Schweinzer C, Uger M, Windisch M, et al. Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivo model of Alzheimer's disease. J Neuroinflammation. 2014;11:84 pubmed publisher
Valero J, Mastrella G, Neiva I, S nchez S, Malva J. Long-term effects of an acute and systemic administration of LPS on adult neurogenesis and spatial memory. Front Neurosci. 2014;8:83 pubmed publisher
Vacca V, Marinelli S, Pieroni L, Urbani A, Luvisetto S, Pavone F. Higher pain perception and lack of recovery from neuropathic pain in females: a behavioural, immunohistochemical, and proteomic investigation on sex-related differences in mice. Pain. 2014;155:388-402 pubmed publisher
Nielsen G, Vorup Jensen T. Detection of soluble CR3 (CD11b/CD18) by time-resolved immunofluorometry. Methods Mol Biol. 2014;1100:355-64 pubmed publisher
Orre M, Kamphuis W, Osborn L, Melief J, Kooijman L, Huitinga I, et al. Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice. Neurobiol Aging. 2014;35:1-14 pubmed publisher
Harhausen D, Sudmann V, Khojasteh U, Müller J, Zille M, Graham K, et al. Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke. PLoS ONE. 2013;8:e69529 pubmed publisher
Montalvo V, Quigley L, Vistica B, Boelte K, Nugent L, Takai T, et al. Environmental factors determine DAP12 deficiency to either enhance or suppress immunopathogenic processes. Immunology. 2013;140:475-82 pubmed publisher
Bracchi Ricard V, Lambertsen K, Ricard J, Nathanson L, Karmally S, Johnstone J, et al. Inhibition of astroglial NF-?B enhances oligodendrogenesis following spinal cord injury. J Neuroinflammation. 2013;10:92 pubmed publisher
Löffler T, Flunkert S, Havas D, Santha M, Hutter Paier B, Steyrer E, et al. Impact of ApoB-100 expression on cognition and brain pathology in wild-type and hAPPsl mice. Neurobiol Aging. 2013;34:2379-88 pubmed publisher
Yamanaka M, Ishikawa T, Griep A, Axt D, Kummer M, Heneka M. PPAR?/RXR?-induced and CD36-mediated microglial amyloid-? phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. J Neurosci. 2012;32:17321-31 pubmed publisher
Siopi E, Llufriu Dabén G, Cho A, Vidal Lletjós S, Plotkine M, Marchand Leroux C, et al. Etazolate, an ?-secretase activator, reduces neuroinflammation and offers persistent neuroprotection following traumatic brain injury in mice. Neuropharmacology. 2013;67:183-92 pubmed publisher
Yang J, Pattanayak A, Song M, Kou J, Taguchi H, Paul S, et al. Muscle-directed anti-A? single-chain antibody delivery via AAV1 reduces cerebral A? load in an Alzheimer's disease mouse model. J Mol Neurosci. 2013;49:277-88 pubmed publisher
Ma W, Coon S, Zhao L, Fariss R, Wong W. A2E accumulation influences retinal microglial activation and complement regulation. Neurobiol Aging. 2013;34:943-60 pubmed publisher
Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, et al. Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model. Neurodegener Dis. 2013;11:194-205 pubmed publisher
Heydenreich N, Nolte M, Göb E, Langhauser F, Hofmeister M, Kraft P, et al. C1-inhibitor protects from brain ischemia-reperfusion injury by combined antiinflammatory and antithrombotic mechanisms. Stroke. 2012;43:2457-67 pubmed publisher
Liao H, Franck E, Freret M, Adriouch S, Baba Amer Y, Authier F, et al. Myoinjury transiently activates muscle antigen-specific CD8+ T cells in lymph nodes in a mouse model. Arthritis Rheum. 2012;64:3441-51 pubmed publisher
Sato A, Ohtaki H, Tsumuraya T, Song D, Ohara K, Asano M, et al. Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury. J Neuroinflammation. 2012;9:65 pubmed publisher
Sarkar J, Chaudhary S, Namavari A, Ozturk O, Chang J, Yco L, et al. Corneal neurotoxicity due to topical benzalkonium chloride. Invest Ophthalmol Vis Sci. 2012;53:1792-802 pubmed publisher
Kou J, Song M, Pattanayak A, Lim J, Yang J, Cao D, et al. Combined treatment of A? immunization with statin in a mouse model of Alzheimer's disease. J Neuroimmunol. 2012;244:70-83 pubmed publisher
Straccia M, Gresa Arribas N, Dentesano G, Ejarque Ortiz A, Tusell J, Serratosa J, et al. Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein ?. J Neuroinflammation. 2011;8:156 pubmed publisher
Carta A, Frau L, Pisanu A, Wardas J, Spiga S, Carboni E. Rosiglitazone decreases peroxisome proliferator receptor-? levels in microglia and inhibits TNF-? production: new evidences on neuroprotection in a progressive Parkinson's disease model. Neuroscience. 2011;194:250-61 pubmed publisher
Song M, Jin J, Lim J, Kou J, Pattanayak A, Rehman J, et al. TLR4 mutation reduces microglial activation, increases A? deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease. J Neuroinflammation. 2011;8:92 pubmed publisher
Siopi E, Cho A, Homsi S, Croci N, Plotkine M, Marchand Leroux C, et al. Minocycline restores sAPP? levels and reduces the late histopathological consequences of traumatic brain injury in mice. J Neurotrauma. 2011;28:2135-43 pubmed publisher
Zhao L, Ma W, Fariss R, Wong W. Minocycline attenuates photoreceptor degeneration in a mouse model of subretinal hemorrhage microglial: inhibition as a potential therapeutic strategy. Am J Pathol. 2011;179:1265-77 pubmed publisher
Terwel D, Steffensen K, Verghese P, Kummer M, Gustafsson J, Holtzman D, et al. Critical role of astroglial apolipoprotein E and liver X receptor-? expression for microglial A? phagocytosis. J Neurosci. 2011;31:7049-59 pubmed publisher
Füchtbauer L, Groth Rasmussen M, Holm T, Løbner M, Toft Hansen H, Khorooshi R, et al. Angiotensin II Type 1 receptor (AT1) signaling in astrocytes regulates synaptic degeneration-induced leukocyte entry to the central nervous system. Brain Behav Immun. 2011;25:897-904 pubmed publisher
Hasegawa Ishii S, Takei S, Inaba M, Umegaki H, Chiba Y, Furukawa A, et al. Defects in cytokine-mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence-accelerated mouse. Brain Behav Immun. 2011;25:83-100 pubmed publisher
Dohi K, Ohtaki H, Nakamachi T, Yofu S, Satoh K, Miyamoto K, et al. Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury. J Neuroinflammation. 2010;7:41 pubmed publisher
Khorooshi R, Owens T. Injury-induced type I IFN signaling regulates inflammatory responses in the central nervous system. J Immunol. 2010;185:1258-64 pubmed publisher
Gottfried Blackmore A, Sierra A, McEwen B, Ge R, Bulloch K. Microglia express functional 11 beta-hydroxysteroid dehydrogenase type 1. Glia. 2010;58:1257-66 pubmed publisher
Heneka M, Nadrigny F, Regen T, Martinez Hernandez A, Dumitrescu Ozimek L, Terwel D, et al. Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine. Proc Natl Acad Sci U S A. 2010;107:6058-63 pubmed publisher
Homsi S, Piaggio T, Croci N, Noble F, Plotkine M, Marchand Leroux C, et al. Blockade of acute microglial activation by minocycline promotes neuroprotection and reduces locomotor hyperactivity after closed head injury in mice: a twelve-week follow-up study. J Neurotrauma. 2010;27:911-21 pubmed publisher
Frontini A, Giordano A. Leptin-sensitive neurons in mouse preoptic area express alpha 1A- and alpha 2A-adrenergic receptor isoforms. Neurosci Lett. 2010;471:83-8 pubmed publisher
Uceyler N, Göbel K, Meuth S, Ortler S, Stoll G, Sommer C, et al. Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve. Exp Neurol. 2010;222:153-60 pubmed publisher
Makwana M, Werner A, Acosta Saltos A, Gonitel R, Pararajasingam A, Pararajasingham A, et al. Peripheral facial nerve axotomy in mice causes sprouting of motor axons into perineuronal central white matter: time course and molecular characterization. J Comp Neurol. 2010;518:699-721 pubmed publisher
Santos A, Martín Oliva D, Ferrer Martín R, Tassi M, Calvente R, Sierra A, et al. Microglial response to light-induced photoreceptor degeneration in the mouse retina. J Comp Neurol. 2010;518:477-92 pubmed publisher
Nielsen M, Lambertsen K, Clausen B, Meldgaard M, Diemer N, Zimmer J, et al. Nuclear translocation of endonuclease G in degenerating neurons after permanent middle cerebral artery occlusion in mice. Exp Brain Res. 2009;194:17-27 pubmed publisher
Christensen J, Simonsen S, Fenger C, Sørensen M, Moos T, Christensen J, et al. Fulminant lymphocytic choriomeningitis virus-induced inflammation of the CNS involves a cytokine-chemokine-cytokine-chemokine cascade. J Immunol. 2009;182:1079-87 pubmed
Clausen B, Lambertsen K, Babcock A, Holm T, Dagnaes Hansen F, Finsen B. Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice. J Neuroinflammation. 2008;5:46 pubmed publisher
Jin J, Kim H, Maxwell J, Li L, Fukuchi K. Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease. J Neuroinflammation. 2008;5:23 pubmed publisher
Lehrmann E, Guidetti P, Love A, Williamson J, Bertram E, Schwarcz R. Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice. Epilepsia. 2008;49 Suppl 2:13-23 pubmed publisher
Kondo Y, Lemere C, Seabrook T. Osteopetrotic (op/op) mice have reduced microglia, no Abeta deposition, and no changes in dopaminergic neurons. J Neuroinflammation. 2007;4:31 pubmed
Herber D, Mercer M, Roth L, Symmonds K, Maloney J, Wilson N, et al. Microglial activation is required for Abeta clearance after intracranial injection of lipopolysaccharide in APP transgenic mice. J Neuroimmune Pharmacol. 2007;2:222-31 pubmed
Dissing Olesen L, Ladeby R, Nielsen H, Toft Hansen H, Dalmau I, Finsen B. Axonal lesion-induced microglial proliferation and microglial cluster formation in the mouse. Neuroscience. 2007;149:112-22 pubmed
He P, Zhong Z, Lindholm K, Berning L, Lee W, Lemere C, et al. Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice. J Cell Biol. 2007;178:829-41 pubmed
Sierra A, Gottfried Blackmore A, McEwen B, Bulloch K. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia. 2007;55:412-24 pubmed
Kim Y, Choi D, Block M, Lorenzl S, Yang L, Kim Y, et al. A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation. FASEB J. 2007;21:179-87 pubmed
Mennini T, De Paola M, Bigini P, Mastrotto C, Fumagalli E, Barbera S, et al. Nonhematopoietic erythropoietin derivatives prevent motoneuron degeneration in vitro and in vivo. Mol Med. 2006;12:153-60 pubmed
Hsu J, McKeon R, Goussev S, Werb Z, Lee J, Trivedi A, et al. Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. J Neurosci. 2006;26:9841-50 pubmed
Pedersen M, Minuzzi L, Wirenfeldt M, Meldgaard M, Slidsborg C, Cumming P, et al. Up-regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain. Eur J Neurosci. 2006;24:991-1000 pubmed
Fenger C, Drojdahl N, Wirenfeldt M, Sylvest L, Jorgensen O, Meldgaard M, et al. Tumor necrosis factor and its p55 and p75 receptors are not required for axonal lesion-induced microgliosis in mouse fascia dentata. Glia. 2006;54:591-605 pubmed
Kalinin S, Gavrilyuk V, Polak P, Vasser R, Zhao J, Heneka M, et al. Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease. Neurobiol Aging. 2007;28:1206-14 pubmed
Herber D, Maloney J, Roth L, Freeman M, Morgan D, Gordon M. Diverse microglial responses after intrahippocampal administration of lipopolysaccharide. Glia. 2006;53:382-91 pubmed
Heneka M, Sastre M, Dumitrescu Ozimek L, Dewachter I, Walter J, Klockgether T, et al. Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice. J Neuroinflammation. 2005;2:22 pubmed
Schütz B, Reimann J, Dumitrescu Ozimek L, Kappes Horn K, Landreth G, Schürmann B, et al. The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice. J Neurosci. 2005;25:7805-12 pubmed
Raptis S, Shapiro S, Simmons P, Cheng A, Pham C. Serine protease cathepsin G regulates adhesion-dependent neutrophil effector functions by modulating integrin clustering. Immunity. 2005;22:679-91 pubmed
Hebert G, Mingam R, Arsaut J, Dantzer R, Demotes Mainard J. Cellular distribution of interleukin-1alpha-immunoreactivity after MPTP intoxication in mice. Brain Res Mol Brain Res. 2005;138:156-63 pubmed
Ladeby R, Wirenfeldt M, Dalmau I, Gregersen R, Garcia Ovejero D, Babcock A, et al. Proliferating resident microglia express the stem cell antigen CD34 in response to acute neural injury. Glia. 2005;50:121-31 pubmed
Engwerda C, Mynott T, Sawhney S, de Souza J, Bickle Q, Kaye P. Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria. J Exp Med. 2002;195:1371-7 pubmed
Carenini S, Maurer M, Werner A, Blazyca H, Toyka K, Schmid C, et al. The role of macrophages in demyelinating peripheral nervous system of mice heterozygously deficient in p0. J Cell Biol. 2001;152:301-8 pubmed
image
image 1 :
Bio-Rad MCA711 image 1
Figure A. Alexa Fluor 700 conjugated Rat anti Mouse GR-1 ( MCA2387A700 ) and Pacific Blue conjugated Rat IgG2b isotype control ( MCA6006PB ). Figure B. Alexa Fluor 700 conjugated Rat anti Mouse GR-1 ( MCA2387A700 ) and Pacific Blue conjugated Rat anti Mouse CD11b ( MCA711PB ). All experiments performed on red cell lysed mouse bone marrow gated on mononuclear cells in the presence of Mouse Seroblock ( BUF041A ). Data acquired on the ZE5 cell analyzer.
product information
Entity Type :
Monoclonal Antibody
Entity Category :
Antibodies
ProductCode :
MCA711
Description :
Rat anti Mouse CD11b
Specificity :
CD11b
TargetSpecies :
Mouse
Host :
Rat
Format :
Purified
Isotypes :
IgG2b
Applications :
IF,IP,F,C
ApplicationTypes :
Immunofluorescence,Immunoprecipitation,Flow Cytometry,Immunohistology - Frozen
Cross Reactivities :
Human
Clone :
5C6
Quantity :
1 mg
Quantity Value :
1
Quantity Type :
mg
GO Accessions :
GO:0001846,GO:0004872,GO:0008305,GO:0005634,GO:0007159,GO:0007229,GO:0008201,GO:0009897,GO:0030593,GO:0043395,GO:0045123,GO:0050798
GOTerms :
opsonin binding,receptor activity,integrin complex,nucleus,leukocyte cell-cell adhesion,integrin-mediated signaling pathway,heparin binding,external side of plasma membrane,neutrophil chemotaxis,heparan sulfate proteoglycan binding,cellular extravasation,activated T cell proliferation
Uniprot Accessions :
P05555
Gene :
Itgam
GeneID URL :
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=16409
Published Synonyms :
Integrin Alpha M Chain,MAC-1
Entity Formats :
Alexa Fluor® 647,FITC,Low Endotoxin,Pacific Blue®,Purified,RPE,StarBright Blue 700,StarBright Violet 440,StarBright Violet 515,StarBright Violet 610,StarBright Violet 670,StarBright Violet 570,StarBright Violet 710,StarBright Violet 790,StarBright Violet 475,StarBright UltraViolet 400,StarBright UltraViolet 665,StarBright UltraViolet 795,StarBright Violet 760,StarBright UltraViolet 445,StarBright UltraViolet 510,StarBright UltraViolet 740,StarBright UltraViolet 575,StarBright UltraViolet 605,StarBright Blue 580,StarBright Blue 615,StarBright Blue 675,StarBright Blue 765,StarBright Blue 810,StarBright Yellow 575,StarBright Yellow 605,StarBright Yellow 665,StarBright Yellow 800,StarBright Yellow 720,StarBright Red 670,StarBright Red 715,StarBright Red 775,StarBright Red 815
UNSPSC :
41116161
Concentration :
IgG concentration 1 mg/ml
Product Form :
Purified IgG - liquid
PriceGBP :
445
PriceEUR :
622
PriceUSD :
622 USD
PriceCHF :
677
PriceSEK :
6780
PriceNOK :
6814
PriceDKK :
4637
more info or order :
company information
Bio-Rad
Endeavour House, Langford Business Park
Langford Lane, Kidlington
OXON, OX5 1GE
antibody_sales_uk@bio-rad.com
https://www.bio-rad-antibodies.com
1 800 265 7376 (North America)
44 (0)1865 852 700 (Rest of World)
headquarters: UK
Bio-Rad is one of the world's leading antibody manufacturers, offering over 12,000 antibodies and related reagents for a focused range of research areas such as immunology, cancer, veterinary research and cell biology through its antibody experts formerly known as AbD Serotec.
The range includes apoptosis kits, autophagy reagents, CD markers, epitope tag antibodies, immunology antibodies, neuroscience antibodies, and veterinary reagents.
Bio-Rad has an ISO 9001 and ISO 13485 certified production facility in the United Kingdom as well as ISO 9001 certified facilities in Germany and the United States.
Our expertise extends to traditional and recombinant antibody generation and production services. Our custom generation service delivers antibodies in as little as 8 weeks with greater than 90% success. The in vitro technology enables selection of antibodies to challenging targets, long term consistent supply, and provision of the antibody sequence.
At Bio-Rad we are committed to your success when using our antibodies and we focus on providing the technology, products and all the supporting information you need to excel in your research.