product summary
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company name :
Bio-Rad
other brands :
Biogenesis, Serotec, AbD Serotec, Oxford Biotechnology
product type :
antibody
product name :
Rat anti Mouse CD206
catalog :
MCA2235GA
quantity :
0.1 mg
price :
249 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
MR5D3
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
Bio-Rad product webpage
citations: 27
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig 5b
Burfeind K, Zhu X, Norgard M, Levasseur P, Huisman C, Buenafe A, et al. Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer. elife. 2020;9: pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 4g
Jordão M, Sankowski R, Brendecke S, Sagar -, Locatelli G, Tai Y, et al. Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation. Science. 2019;363: pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 3s2
Ma W, Silverman S, Zhao L, Villasmil R, Campos M, Amaral J, et al. Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization. elife. 2019;8: pubmed publisher
  • flow cytometry; mouse; fig s1c
Wang X, Cao Q, Yu L, Shi H, Xue B, Shi H. Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity. JCI Insight. 2016;1:e87748 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; tbl s1
Tan S, Krasnow M. Developmental origin of lung macrophage diversity. Development. 2016;143:1318-27 pubmed publisher
  • flow cytometry; mouse; fig 1
Onodera T, Fukuhara A, Jang M, Shin J, Aoi K, Kikuta J, et al. Adipose tissue macrophages induce PPARγ-high FOXP3(+) regulatory T cells. Sci Rep. 2015;5:16801 pubmed publisher
  • flow cytometry; mouse; 1:10; fig 2
Choi E, Park H, Sul O, Rajasekaran M, Yu R, Choi H. Carbon monoxide reverses adipose tissue inflammation and insulin resistance upon loss of ovarian function. Am J Physiol Endocrinol Metab. 2015;308:E621-30 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:500; tbl 1
Almolda B, de Labra C, Barrera I, Gruart A, Delgado Garcia J, Villacampa N, et al. Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10. Brain Behav Immun. 2015;45:80-97 pubmed publisher
  • flow cytometry; mouse; fig 4
Mehta P, Nuotio Antar A, Smith C. γδ T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice. J Leukoc Biol. 2015;97:121-34 pubmed publisher
  • immunocytochemistry; mouse; fig 3
Rauen J, Kreer C, Paillard A, van Duikeren S, Benckhuijsen W, Camps M, et al. Enhanced cross-presentation and improved CD8+ T cell responses after mannosylation of synthetic long peptides in mice. PLoS ONE. 2014;9:e103755 pubmed publisher
  • flow cytometry; human
Zhu Y, Knolhoff B, Meyer M, Nywening T, West B, Luo J, et al. CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. Cancer Res. 2014;74:5057-69 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Anders C, Ashton N, Ranjzad P, Dilworth M, Woolf A. Ex vivo modeling of chemical synergy in prenatal kidney cystogenesis. PLoS ONE. 2013;8:e57797 pubmed publisher
Hirata W, Itatani Y, Masui H, Kawada K, Mizuno R, Yamamoto T, et al. Downregulation of osteoprotegerin in colorectal cancer cells promotes liver metastasis via activating tumor-associated macrophage. Sci Rep. 2023;13:22217 pubmed publisher
Lund H, Pieber M, Parsa R, Han J, Grommisch D, Ewing E, et al. Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells. Nat Commun. 2018;9:4845 pubmed publisher
Beckers L, Stroobants S, D Hooge R, Baes M. Neuronal Dysfunction and Behavioral Abnormalities Are Evoked by Neural Cells and Aggravated by Inflammatory Microglia in Peroxisomal β-Oxidation Deficiency. Front Cell Neurosci. 2018;12:136 pubmed publisher
Maxson M, Naj X, O Meara T, Plumb J, Cowen L, Grinstein S. Integrin-based diffusion barrier separates membrane domains enabling the formation of microbiostatic frustrated phagosomes. elife. 2018;7: pubmed publisher
Park L, Uekawa K, Garcia Bonilla L, Koizumi K, Murphy M, Pistik R, et al. Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides. Circ Res. 2017;121:258-269 pubmed publisher
Kim J, Park K, Ryu J, Lee J, Lee M, Cho H, et al. Intravascular optical imaging of high-risk plaques in vivo by targeting macrophage mannose receptors. Sci Rep. 2016;6:22608 pubmed publisher
Bisht K, Sharma K, Lecours C, Sánchez M, El Hajj H, Milior G, et al. Dark microglia: A new phenotype predominantly associated with pathological states. Glia. 2016;64:826-39 pubmed publisher
Arnold L, Perrin H, de Chanville C, Saclier M, Hermand P, Poupel L, et al. CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production. Nat Commun. 2015;6:8972 pubmed publisher
Ohtsuki T, Kimura K, Tokunaga Y, Tsukiyama Kohara K, Tateno C, Hayashi Y, et al. M2 Macrophages Play Critical Roles in Progression of Inflammatory Liver Disease in Hepatitis C Virus Transgenic Mice. J Virol. 2016;90:300-7 pubmed publisher
Sinadinos A, Young C, Al Khalidi R, Teti A, Kalinski P, Mohamad S, et al. P2RX7 purinoceptor: a therapeutic target for ameliorating the symptoms of duchenne muscular dystrophy. PLoS Med. 2015;12:e1001888 pubmed publisher
Camell C, Smith C. Dietary oleic acid increases m2 macrophages in the mesenteric adipose tissue. PLoS ONE. 2013;8:e75147 pubmed publisher
Sato A, Ohtaki H, Tsumuraya T, Song D, Ohara K, Asano M, et al. Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury. J Neuroinflammation. 2012;9:65 pubmed publisher
Colton C. Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol. 2009;4:399-418 pubmed publisher
Devey L, Ferenbach D, Mohr E, Sangster K, Bellamy C, Hughes J, et al. Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism. Mol Ther. 2009;17:65-72 pubmed publisher
Mackinnon A, Farnworth S, Hodkinson P, Henderson N, Atkinson K, Leffler H, et al. Regulation of alternative macrophage activation by galectin-3. J Immunol. 2008;180:2650-8 pubmed
image
image 1 :
Bio-Rad MCA2235GA image 1
Immunoperoxidase staining of a mouse lymph node cryosection with Rat anti Mouse CD206 antibody, clone MR5D3 ( MCA2235 ) followed by horseradish peroxidase conjugated Goat anti Rat IgG antibody ( STAR72 ). Low power
product information
Entity Type :
Monoclonal Antibody
Entity Category :
Antibodies
ProductCode :
MCA2235GA
Description :
Rat anti Mouse CD206
Specificity :
CD206
TargetSpecies :
Mouse
Host :
Rat
Format :
Purified
Isotypes :
IgG2a
Applications :
IP,F,C,IF
ApplicationTypes :
Immunoprecipitation,Flow Cytometry,Immunohistology - Frozen,Immunofluorescence
Clone :
MR5D3
Quantity :
0.1 mg
Quantity Value :
0.1
Quantity Type :
mg
GO Accessions :
GO:0016021,GO:0004888,GO:0005537,GO:0006897,GO:0009986
GOTerms :
integral to membrane,transmembrane receptor activity,mannose binding,endocytosis,cell surface
Uniprot Accessions :
Q61830
Gene :
Mrc1
GeneID URL :
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=17533
Published Synonyms :
Mannose Receptor C Type 1
Entity Formats :
Alexa Fluor® 488,Alexa Fluor® 647,Biotin,FITC,Pacific Blue®,Purified,RPE
UNSPSC :
41116161
Concentration :
IgG concentration 1.0 mg/ml
Product Form :
Purified IgG - liquid
PriceGBP :
178
PriceEUR :
249
PriceUSD :
249 USD
PriceCHF :
271
PriceSEK :
2714
PriceNOK :
2728
PriceDKK :
1856
more info or order :
Bio-Rad product webpage
company information
Bio-Rad
Endeavour House, Langford Business Park
Langford Lane, Kidlington
OXON, OX5 1GE
antibody_sales_uk@bio-rad.com
https://www.bio-rad-antibodies.com
1 800 265 7376 (North America)
44 (0)1865 852 700 (Rest of World)
headquarters: UK
Bio-Rad is one of the world's leading antibody manufacturers, offering over 12,000 antibodies and related reagents for a focused range of research areas such as immunology, cancer, veterinary research and cell biology through its antibody experts formerly known as AbD Serotec.
The range includes apoptosis kits, autophagy reagents, CD markers, epitope tag antibodies, immunology antibodies, neuroscience antibodies, and veterinary reagents.
Bio-Rad has an ISO 9001 and ISO 13485 certified production facility in the United Kingdom as well as ISO 9001 certified facilities in Germany and the United States.
Our expertise extends to traditional and recombinant antibody generation and production services. Our custom generation service delivers antibodies in as little as 8 weeks with greater than 90% success. The in vitro technology enables selection of antibodies to challenging targets, long term consistent supply, and provision of the antibody sequence.
At Bio-Rad we are committed to your success when using our antibodies and we focus on providing the technology, products and all the supporting information you need to excel in your research.