product summary
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company name :
Bio-Rad
other brands :
Biogenesis, Serotec, AbD Serotec, Oxford Biotechnology
product type :
antibody
product name :
Rat anti Mouse CD206
catalog :
MCA2235
quantity :
0.25 mg
price :
372 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
MR5D3
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
Bio-Rad product webpage
citations: 35
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:200; loading ...; fig 2c
Jiao B, An C, Tran M, Du H, Wang P, Zhou D, et al. Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis. Front Immunol. 2021;12:735014 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig 5b
Burfeind K, Zhu X, Norgard M, Levasseur P, Huisman C, Buenafe A, et al. Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer. elife. 2020;9: pubmed publisher
  • immunohistochemistry - free floating section; mouse; loading ...; fig s3e
Cserép C, Pósfai B, Lénárt N, Fekete R, László Z, Lele Z, et al. Microglia monitor and protect neuronal function through specialized somatic purinergic junctions. Science. 2020;367:528-537 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 4g
Jordão M, Sankowski R, Brendecke S, Sagar -, Locatelli G, Tai Y, et al. Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation. Science. 2019;363: pubmed publisher
  • immunohistochemistry; human; loading ...; fig 1d
Carmona Fontaine C, Deforet M, Akkari L, Thompson C, Joyce J, Xavier J. Metabolic origins of spatial organization in the tumor microenvironment. Proc Natl Acad Sci U S A. 2017;114:2934-2939 pubmed publisher
  • flow cytometry; mouse; fig s1c
Wang X, Cao Q, Yu L, Shi H, Xue B, Shi H. Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity. JCI Insight. 2016;1:e87748 pubmed publisher
  • immunohistochemistry; mouse; fig s7h
Barnett F, Rosenfeld M, Wood M, Kiosses W, Usui Y, Marchetti V, et al. Macrophages form functional vascular mimicry channels in vivo. Sci Rep. 2016;6:36659 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 2a
Casella G, Garzetti L, Gatta A, Finardi A, Maiorino C, Ruffini F, et al. IL4 induces IL6-producing M2 macrophages associated to inhibition of neuroinflammation in vitro and in vivo. J Neuroinflammation. 2016;13:139 pubmed publisher
  • flow cytometry; mouse; fig 1
Onodera T, Fukuhara A, Jang M, Shin J, Aoi K, Kikuta J, et al. Adipose tissue macrophages induce PPARγ-high FOXP3(+) regulatory T cells. Sci Rep. 2015;5:16801 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 3
Peluffo H, Solari Saquieres P, Negro Demontel M, Francos Quijorna I, Navarro X, Lopez Vales R, et al. CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype. J Neuroinflammation. 2015;12:145 pubmed publisher
  • flow cytometry; mouse; 1:10; fig 2
Choi E, Park H, Sul O, Rajasekaran M, Yu R, Choi H. Carbon monoxide reverses adipose tissue inflammation and insulin resistance upon loss of ovarian function. Am J Physiol Endocrinol Metab. 2015;308:E621-30 pubmed publisher
  • immunocytochemistry; human; 1:50
Kumar M, Csaba Z, Peineau S, Srivastava R, Rasika S, Mani S, et al. Endogenous cerebellar neurogenesis in adult mice with progressive ataxia. Ann Clin Transl Neurol. 2014;1:968-81 pubmed publisher
  • flow cytometry; mouse; fig 4
Mehta P, Nuotio Antar A, Smith C. γδ T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice. J Leukoc Biol. 2015;97:121-34 pubmed publisher
  • immunocytochemistry; mouse; fig 3
Rauen J, Kreer C, Paillard A, van Duikeren S, Benckhuijsen W, Camps M, et al. Enhanced cross-presentation and improved CD8+ T cell responses after mannosylation of synthetic long peptides in mice. PLoS ONE. 2014;9:e103755 pubmed publisher
  • flow cytometry; human
Zhu Y, Knolhoff B, Meyer M, Nywening T, West B, Luo J, et al. CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. Cancer Res. 2014;74:5057-69 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500
Eskilsson A, Tachikawa M, Hosoya K, Blomqvist A. Distribution of microsomal prostaglandin E synthase-1 in the mouse brain. J Comp Neurol. 2014;522:3229-44 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:25
Tan J, Chan S, Wallace E, Lim R. Human amnion epithelial cells mediate lung repair by directly modulating macrophage recruitment and polarization. Cell Transplant. 2014;23:319-28 pubmed publisher
  • immunohistochemistry; mouse; tbl 3
  • western blot; mouse; tbl 3
Colton C. Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol. 2009;4:399-418 pubmed publisher
Schwabenland M, Bruck W, Priller J, Stadelmann C, Lassmann H, Prinz M. Analyzing microglial phenotypes across neuropathologies: a practical guide. Acta Neuropathol. 2021;142:923-936 pubmed publisher
Lund H, Pieber M, Parsa R, Han J, Grommisch D, Ewing E, et al. Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells. Nat Commun. 2018;9:4845 pubmed publisher
Beckers L, Stroobants S, D Hooge R, Baes M. Neuronal Dysfunction and Behavioral Abnormalities Are Evoked by Neural Cells and Aggravated by Inflammatory Microglia in Peroxisomal β-Oxidation Deficiency. Front Cell Neurosci. 2018;12:136 pubmed publisher
Maxson M, Naj X, O Meara T, Plumb J, Cowen L, Grinstein S. Integrin-based diffusion barrier separates membrane domains enabling the formation of microbiostatic frustrated phagosomes. elife. 2018;7: pubmed publisher
RAHMAN K, Vengrenyuk Y, Ramsey S, Vila N, Girgis N, Liu J, et al. Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression. J Clin Invest. 2017;127:2904-2915 pubmed publisher
Park L, Uekawa K, Garcia Bonilla L, Koizumi K, Murphy M, Pistik R, et al. Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides. Circ Res. 2017;121:258-269 pubmed publisher
Øie C, Snapkov I, Elvevold K, Sveinbjørnsson B, Smedsrød B. FITC Conjugation Markedly Enhances Hepatic Clearance of N-Formyl Peptides. PLoS ONE. 2016;11:e0160602 pubmed publisher
Arnold L, Perrin H, de Chanville C, Saclier M, Hermand P, Poupel L, et al. CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production. Nat Commun. 2015;6:8972 pubmed publisher
Ohtsuki T, Kimura K, Tokunaga Y, Tsukiyama Kohara K, Tateno C, Hayashi Y, et al. M2 Macrophages Play Critical Roles in Progression of Inflammatory Liver Disease in Hepatitis C Virus Transgenic Mice. J Virol. 2016;90:300-7 pubmed publisher
Sawano S, Suzuki T, Do M, Ohtsubo H, Mizunoya W, Ikeuchi Y, et al. Supplementary immunocytochemistry of hepatocyte growth factor production in activated macrophages early in muscle regeneration. Anim Sci J. 2014;85:994-1000 pubmed publisher
Kuribayashi K, Motoyama S, Sasaki T, Sato Y, Yoshino K, Wakita A, et al. C-reactive protein reduces the relative number of tumor-associated M2 macrophages and intratumoral angiogenesis in mice. Tohoku J Exp Med. 2014;233:249-55 pubmed
Sakaguchi S, Shono J, Suzuki T, Sawano S, Anderson J, Do M, et al. Implication of anti-inflammatory macrophages in regenerative moto-neuritogenesis: promotion of myoblast migration and neural chemorepellent semaphorin 3A expression in injured muscle. Int J Biochem Cell Biol. 2014;54:272-85 pubmed publisher
Matsuwaki T, Eskilsson A, Kugelberg U, Jönsson J, Blomqvist A. Interleukin-1? induced activation of the hypothalamus-pituitary-adrenal axis is dependent on interleukin-1 receptors on non-hematopoietic cells. Brain Behav Immun. 2014;40:166-73 pubmed publisher
Camell C, Smith C. Dietary oleic acid increases m2 macrophages in the mesenteric adipose tissue. PLoS ONE. 2013;8:e75147 pubmed publisher
Shono J, Sakaguchi S, Suzuki T, Do M, Mizunoya W, Nakamura M, et al. Preliminary time-course study of antiinflammatory macrophage infiltration in crush-injured skeletal muscle. Anim Sci J. 2013;84:744-50 pubmed publisher
Chertoff M, Shrivastava K, Gonzalez B, Acarin L, Gimenez Llort L. Differential modulation of TREM2 protein during postnatal brain development in mice. PLoS ONE. 2013;8:e72083 pubmed publisher
Rateri D, Howatt D, Moorleghen J, Charnigo R, Cassis L, Daugherty A. Prolonged infusion of angiotensin II in apoE(-/-) mice promotes macrophage recruitment with continued expansion of abdominal aortic aneurysm. Am J Pathol. 2011;179:1542-8 pubmed publisher
image
image 1 :
Bio-Rad MCA2235 image 1
Immunoperoxidase staining of a mouse lymph node cryosection with Rat anti Mouse CD206 antibody, clone MR5D3 ( MCA2235 ) followed by horseradish peroxidase conjugated Goat anti Rat IgG antibody ( STAR72 ). Low power
product information
Entity Type :
Monoclonal Antibody
Entity Category :
Antibodies
ProductCode :
MCA2235
Description :
Rat anti Mouse CD206
Specificity :
CD206
TargetSpecies :
Mouse
Host :
Rat
Format :
Purified
Isotypes :
IgG2a
Applications :
F,C,IP,IF
ApplicationTypes :
Flow Cytometry,Immunohistology - Frozen,Immunoprecipitation,Immunofluorescence
Clone :
MR5D3
Quantity :
0.25 mg
Quantity Value :
0.25
Quantity Type :
mg
GO Accessions :
GO:0016021,GO:0004888,GO:0005537,GO:0006897,GO:0009986
GOTerms :
integral to membrane,transmembrane receptor activity,mannose binding,endocytosis,cell surface
Uniprot Accessions :
Q61830
Gene :
Mrc1
GeneID URL :
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=17533
Published Synonyms :
Mannose Receptor C Type 1
Entity Formats :
Alexa Fluor® 488,Alexa Fluor® 647,Biotin,FITC,Pacific Blue®,Purified,RPE
UNSPSC :
41116161
Concentration :
IgG concentration 1.0 mg/ml
Product Form :
Purified IgG - liquid
PriceGBP :
266
PriceEUR :
372
PriceUSD :
372 USD
PriceCHF :
405
PriceSEK :
4055
PriceNOK :
4075
PriceDKK :
2774
more info or order :
Bio-Rad product webpage
company information
Bio-Rad
Endeavour House, Langford Business Park
Langford Lane, Kidlington
OXON, OX5 1GE
antibody_sales_uk@bio-rad.com
https://www.bio-rad-antibodies.com
1 800 265 7376 (North America)
44 (0)1865 852 700 (Rest of World)
headquarters: UK
Bio-Rad is one of the world's leading antibody manufacturers, offering over 12,000 antibodies and related reagents for a focused range of research areas such as immunology, cancer, veterinary research and cell biology through its antibody experts formerly known as AbD Serotec.
The range includes apoptosis kits, autophagy reagents, CD markers, epitope tag antibodies, immunology antibodies, neuroscience antibodies, and veterinary reagents.
Bio-Rad has an ISO 9001 and ISO 13485 certified production facility in the United Kingdom as well as ISO 9001 certified facilities in Germany and the United States.
Our expertise extends to traditional and recombinant antibody generation and production services. Our custom generation service delivers antibodies in as little as 8 weeks with greater than 90% success. The in vitro technology enables selection of antibodies to challenging targets, long term consistent supply, and provision of the antibody sequence.
At Bio-Rad we are committed to your success when using our antibodies and we focus on providing the technology, products and all the supporting information you need to excel in your research.