product summary
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company name :
Bio-Rad
other brands :
Biogenesis, Serotec, AbD Serotec, Oxford Biotechnology
product type :
antibody
product name :
Mouse anti Human Cytochrome P450 Aromatase
catalog :
MCA2077S
quantity :
1 ml
price :
702 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H4
reactivity :
human, rat, chicken, pigs
application :
western blot, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Bio-Rad product webpage
citations: 30
Published Application/Species/Sample/DilutionReference
  • western blot; pigs ; 1:250; loading ...; fig 2h
Ziecik A, Klos J, Gromadzka Hliwa K, Dietrich M, Slowinska M, Likszo P, et al. Endocrine and molecular milieus of ovarian follicles are diversely affected by human chorionic gonadotropin and gonadotropin-releasing hormone in prepubertal and mature gilts. Sci Rep. 2021;11:13465 pubmed publisher
  • immunohistochemistry - frozen section; chicken; 1:250; loading ...; fig 2e
Ioannidis J, Taylor G, Zhao D, Liu L, Idoko Akoh A, Gong D, et al. Primary sex determination in birds depends on DMRT1 dosage, but gonadal sex does not determine adult secondary sex characteristics. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  • western blot; human; 1:500; loading ...; fig 4d
Baravalle R, Di Nardo G, Bandino A, Barone I, Catalano S, Ando S, et al. Impact of R264C and R264H polymorphisms in human aromatase function. J Steroid Biochem Mol Biol. 2017;167:23-32 pubmed publisher
  • western blot; human; 1:100; loading ...; fig 3
Honkisz E, Wójtowicz A. Modulation of estradiol synthesis and aromatase activity in human choriocarcinoma JEG-3 cells exposed to tetrabromobisphenol A. Toxicol In Vitro. 2015;29:44-50 pubmed publisher
  • western blot; rat; 1:200
Castro B, Sanchez P, Torres J, Ortega E. Effects of adult exposure to bisphenol a on genes involved in the physiopathology of rat prefrontal cortex. PLoS ONE. 2013;8:e73584 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:800
Kuhn E, Ayhan A, Shih I, Seidman J, Kurman R. Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. Eur J Cancer. 2013;49:3839-49 pubmed publisher
  • immunohistochemistry - paraffin section; pigs
Noguchi J, Nakai M, Kikuchi K, Kaneko H, Imaeda N. Early regression of spermatogenesis in boars of an inbred Duroc strain caused by incident orchitis/epididymo-orchitis. J Reprod Dev. 2013;59:273-81 pubmed
  • immunohistochemistry - paraffin section; rat; 1:50
  • western blot; rat; 1:200
Castro B, Sanchez P, Torres J, Preda O, del Moral R, Ortega E. Bisphenol A exposure during adulthood alters expression of aromatase and 5?-reductase isozymes in rat prostate. PLoS ONE. 2013;8:e55905 pubmed publisher
  • western blot; human; 1:250
Schech A, Nemieboka B, Brodie A. Zoledronic acid inhibits aromatase activity and phosphorylation: potential mechanism for additive zoledronic acid and letrozole drug interaction. J Steroid Biochem Mol Biol. 2012;132:195-202 pubmed publisher
Rzemieniec J, Wnuk A, Lason W, Bilecki W, Kajta M. The neuroprotective action of 3,3'-diindolylmethane against ischemia involves an inhibition of apoptosis and autophagy that depends on HDAC and AhR/CYP1A1 but not ERα/CYP19A1 signaling. Apoptosis. 2019;24:435-452 pubmed publisher
Catalano S, Barone I, Andò S. Rapid estrogen effects on aromatase phosphorylation in breast cancer cells. Methods Mol Biol. 2014;1204:155-63 pubmed publisher
Huhtinen K, Saloniemi Heinonen T, Keski Rahkonen P, Desai R, Laajala D, Ståhle M, et al. Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions. J Clin Endocrinol Metab. 2014;99:E2188-97 pubmed publisher
Brodowska A, Brodowski J, Laszczynska M, Słuczanowska Głąbowska S, Rumianowski B, Rotter I, et al. Immunoexpression of aromatase cytochrome P450 and 17?-hydroxysteroid dehydrogenase in women's ovaries after menopause. J Ovarian Res. 2014;7:52 pubmed publisher
Messuti I, Corvisieri S, Bardesono F, Rapa I, Giorcelli J, Pellerito R, et al. Impact of pregnancy on prognosis of differentiated thyroid cancer: clinical and molecular features. Eur J Endocrinol. 2014;170:659-66 pubmed publisher
Kobayashi H, Yoshida S, Sun Y, Shirasawa N, Naito A. Changes of gastric aromatase and portal venous 17?-estradiol during the postnatal development and estrus cycle in female rats. Endocrine. 2014;46:605-14 pubmed publisher
Li X, Jiang L, Cheng L, Chen H. Dibutyl phthalate-induced neurotoxicity in the brain of immature and mature rat offspring. Brain Dev. 2014;36:653-60 pubmed publisher
Argenta P, Um I, Kay C, Harrison D, Faratian D, Sueblinvong T, et al. Predicting response to the anti-estrogen fulvestrant in recurrent ovarian cancer. Gynecol Oncol. 2013;131:368-73 pubmed publisher
Kobayashi H, Yoshida S, Sun Y, Shirasawa N, Naito A. Gastric estradiol-17? (E2) and liver ER? correlate with serum E2 in the cholestatic male rat. J Endocrinol. 2013;219:39-49 pubmed publisher
Strauss L, Rantakari P, Sjögren K, Salminen A, Lauren E, Kallio J, et al. Seminal vesicles and urinary bladder as sites of aromatization of androgens in men, evidenced by a CYP19A1-driven luciferase reporter mouse and human tissue specimens. FASEB J. 2013;27:1342-50 pubmed publisher
Monica V, Longo M, Felice B, Scagliotti G, Papotti M, Novello S. Role of hormone receptor expression in patients with advanced-stage lung cancer treated with chemotherapy. Clin Lung Cancer. 2012;13:416-23 pubmed publisher
Rice S, Patel B, Bano G, Ugwumadu A, Whitehead S. Aromatase expression in abdominal omental/visceral and subcutaneous fat depots: a comparison of pregnant and obese women. Fertil Steril. 2012;97:1460-6.e1 pubmed publisher
Morita Y, Wada Hiraike O, Yano T, Shirane A, Hirano M, Hiraike H, et al. Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary. Reprod Biol Endocrinol. 2012;10:14 pubmed publisher
Evans A, Pancholi S, Farmer I, Thornhill A, Evans D, Johnston S, et al. EGFR/HER2 inhibitor AEE788 increases ER-mediated transcription in HER2/ER-positive breast cancer cells but functions synergistically with endocrine therapy. Br J Cancer. 2010;102:1235-43 pubmed publisher
Kwintkiewicz J, Nishi Y, Yanase T, Giudice L. Peroxisome proliferator-activated receptor-gamma mediates bisphenol A inhibition of FSH-stimulated IGF-1, aromatase, and estradiol in human granulosa cells. Environ Health Perspect. 2010;118:400-6 pubmed publisher
Leães C, Meurer R, Coutinho L, Ferreira N, Pereira Lima J, da Costa Oliveira M. Immunohistochemical expression of aromatase and estrogen, androgen and progesterone receptors in normal and neoplastic human meningeal cells. Neuropathology. 2010;30:44-9 pubmed publisher
Rice S, Pellatt L, Ramanathan K, Whitehead S, Mason H. Metformin inhibits aromatase via an extracellular signal-regulated kinase-mediated pathway. Endocrinology. 2009;150:4794-801 pubmed publisher
Rak A, Gregoraszczuk E. Modulatory effect of ghrelin in prepubertal porcine ovarian follicles. J Physiol Pharmacol. 2008;59:781-93 pubmed
Berstein L, Pozharisski K, Imyanitov E, Maximova N, Kovalevskij A. Aromatase, CYP1B1 and fatty acid synthase expression in breast tumors of BRCA1 mutation carriers. Pathol Oncol Res. 2009;15:407-9 pubmed publisher
Inaoka Y, Yazawa T, Mizutani T, Kokame K, Kangawa K, Uesaka M, et al. Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production. Reprod Biol Endocrinol. 2008;6:62 pubmed publisher
Wojtowicz A, Milewicz T, Gregoraszczuk E. DDT and its metabolite DDE alter steroid hormone secretion in human term placental explants by regulation of aromatase activity. Toxicol Lett. 2007;173:24-30 pubmed
image
image 1 :
Bio-Rad MCA2077S image 1
Western blot analysis of human placenta extract probed with Mouse anti Human Cytochrome P450 Aromatase (MCA2077S) followed by F(ab )2 Rabbit anti Mouse IgG:HRP ( STAR13B )
product information
Entity Type :
Monoclonal Antibody
Entity Category :
Antibodies
ProductCode :
MCA2077S
Description :
Mouse anti Human Cytochrome P450 Aromatase
Specificity :
Cytochrome P450 Aromatase
TargetSpecies :
Human
Host :
Mouse
Format :
10 X Concentrate
Isotypes :
IgG2a
Applications :
WB,P,IF
ApplicationTypes :
Western Blotting,Immunohistology - Paraffin,Immunofluorescence
Cross Reactivities :
Rat,Marmoset,Chicken,Mouse,Pig,Baboon,Bovine,Horse,Great fruit eating bat,Rabbit,Sheep,Collared peccary,Goat,Giraffe,Minke whale,Bryde's whale,Sei whale,Impala
Clone :
H4
Quantity :
1 ml
Quantity Value :
1
Quantity Type :
ml
GO Accessions :
GO:0009055,GO:0005624,GO:0005789,GO:0055114,GO:0006703,GO:0006805,GO:0008395,GO:0019825,GO:0020037,GO:0070330
GOTerms :
electron carrier activity,membrane fraction,endoplasmic reticulum membrane,oxidation-reduction process,estrogen biosynthetic process,xenobiotic metabolic process,steroid hydroxylase activity,oxygen binding,heme binding,aromatase activity
Uniprot Accessions :
P11511
Gene :
CYP19A1
GeneID URL :
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1588
Entity Formats :
10 X Concentrate
UNSPSC :
41116161
Product Form :
Concentrated tissue culture supernatant - liquid
PriceGBP :
445
PriceEUR :
765
PriceUSD :
702 USD
PriceCHF :
832
PriceSEK :
8339
PriceNOK :
8380
PriceDKK :
5704
NotForSaleInCountries :
AU
more info or order :
Bio-Rad product webpage
company information
Bio-Rad
Endeavour House, Langford Business Park
Langford Lane, Kidlington
OXON, OX5 1GE
antibody_sales_uk@bio-rad.com
https://www.bio-rad-antibodies.com
1 800 265 7376 (North America)
44 (0)1865 852 700 (Rest of World)
headquarters: UK
Bio-Rad is one of the world's leading antibody manufacturers, offering over 12,000 antibodies and related reagents for a focused range of research areas such as immunology, cancer, veterinary research and cell biology through its antibody experts formerly known as AbD Serotec.
The range includes apoptosis kits, autophagy reagents, CD markers, epitope tag antibodies, immunology antibodies, neuroscience antibodies, and veterinary reagents.
Bio-Rad has an ISO 9001 and ISO 13485 certified production facility in the United Kingdom as well as ISO 9001 certified facilities in Germany and the United States.
Our expertise extends to traditional and recombinant antibody generation and production services. Our custom generation service delivers antibodies in as little as 8 weeks with greater than 90% success. The in vitro technology enables selection of antibodies to challenging targets, long term consistent supply, and provision of the antibody sequence.
At Bio-Rad we are committed to your success when using our antibodies and we focus on providing the technology, products and all the supporting information you need to excel in your research.