product summary
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company name :
Bio-Rad
other brands :
Biogenesis, Serotec, AbD Serotec, Oxford Biotechnology
product type :
antibody
product name :
Mouse anti Human CD49b
catalog :
MCA2025
quantity :
0.2 mg
price :
372 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
16B4
reactivity :
human
application :
western blot, ELISA, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
more info or order :
Bio-Rad product webpage
citations: 14
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; 1:100; fig s3
  • immunocytochemistry; human; fig s3
  • western blot; human; fig s5
De Franceschi N, Arjonen A, Elkhatib N, Denessiouk K, Wrobel A, Wilson T, et al. Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2. Nat Struct Mol Biol. 2016;23:172-9 pubmed publisher
  • immunohistochemistry - paraffin section; human
Sottnik J, Daignault Newton S, Zhang X, Morrissey C, Hussain M, Keller E, et al. Integrin alpha2beta 1 (?2?1) promotes prostate cancer skeletal metastasis. Clin Exp Metastasis. 2013;30:569-78 pubmed publisher
Piipponen M, Heino J, Kahari V, Nissinen L. Long non-coding RNA PICSAR decreases adhesion and promotes migration of squamous carcinoma cells by downregulating α2β1 and α5β1 integrin expression. Biol Open. 2018;7: pubmed publisher
Rintanen N, Karjalainen M, Alanko J, Paavolainen L, Mäki A, Nissinen L, et al. Calpains promote ?2?1 integrin turnover in nonrecycling integrin pathway. Mol Biol Cell. 2012;23:448-63 pubmed publisher
Colombel M, Eaton C, Hamdy F, Ricci E, van der Pluijm G, Cecchini M, et al. Increased expression of putative cancer stem cell markers in primary prostate cancer is associated with progression of bone metastases. Prostate. 2012;72:713-20 pubmed publisher
Vuoriluoto K, Högnäs G, Meller P, Lehti K, Ivaska J. Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through ?2?1 integrin and MT1-MMP. Matrix Biol. 2011;30:207-17 pubmed publisher
Nevo J, Mai A, Tuomi S, Pellinen T, Pentikäinen O, Heikkila P, et al. Mammary-derived growth inhibitor (MDGI) interacts with integrin ?-subunits and suppresses integrin activity and invasion. Oncogene. 2010;29:6452-63 pubmed publisher
Eaton C, Colombel M, van der Pluijm G, Cecchini M, Wetterwald A, Lippitt J, et al. Evaluation of the frequency of putative prostate cancer stem cells in primary and metastatic prostate cancer. Prostate. 2010;70:875-82 pubmed publisher
Vuoriluoto K, Jokinen J, Kallio K, Salmivirta M, Heino J, Ivaska J. Syndecan-1 supports integrin alpha2beta1-mediated adhesion to collagen. Exp Cell Res. 2008;314:3369-81 pubmed publisher
Karjalainen M, Kakkonen E, Upla P, Paloranta H, Kankaanpää P, Liberali P, et al. A Raft-derived, Pak1-regulated entry participates in alpha2beta1 integrin-dependent sorting to caveosomes. Mol Biol Cell. 2008;19:2857-69 pubmed publisher
Jansen M, Pietiäinen V, Pölönen H, Rasilainen L, Koivusalo M, Ruotsalainen U, et al. Cholesterol substitution increases the structural heterogeneity of caveolae. J Biol Chem. 2008;283:14610-8 pubmed publisher
Upla P, Marjomaki V, Nissinen L, Nylund C, Waris M, Hyypia T, et al. Calpain 1 and 2 are required for RNA replication of echovirus 1. J Virol. 2008;82:1581-90 pubmed
Pellinen T, Arjonen A, Vuoriluoto K, Kallio K, Fransen J, Ivaska J. Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. J Cell Biol. 2006;173:767-80 pubmed
Saalmuller A, Lunney J, Daubenberger C, Davis W, Fischer U, Göbel T, et al. Summary of the animal homologue section of HLDA8. Cell Immunol. 2005;236:51-8 pubmed
image
image 1 :
Bio-Rad MCA2025 image 1
Figure A. FITC conjugated mouse anti human CD61 ( MCA2588F ) and RPE conjugated mouse IgG1 isotype control ( MCA928PE ) Figure B. FITC conjugated mouse anti human CD61 ( MCA2588F ) and RPE conjugated mouse anti human CD49b ( MCA2025PE ). All experiments performed on human blood gated on platelets. Data acquired on the ZE5 Cell Analyzer
product information
Entity Type :
Monoclonal Antibody
Entity Category :
Antibodies
ProductCode :
MCA2025
Description :
Mouse anti Human CD49b
Specificity :
CD49b
TargetSpecies :
Human
Host :
Mouse
Format :
Purified
Isotypes :
IgG1
Applications :
WB,P,IP,F,C,E,FN,IF
ApplicationTypes :
Western Blotting,Immunohistology - Paraffin,Immunoprecipitation,Flow Cytometry,Immunohistology - Frozen,ELISA,Functional Assays,Immunofluorescence
Cross Reactivities :
Rat
Clone :
16B4
Quantity :
0.2 mg
Quantity Value :
0.2
Quantity Type :
mg
GO Accessions :
GO:0007596,GO:0004872,GO:0005518,GO:0008305,GO:0007160,GO:0007229,GO:0007411,GO:0042802,GO:0044419
GOTerms :
blood coagulation,receptor activity,collagen binding,integrin complex,cell-matrix adhesion,integrin-mediated signaling pathway,axon guidance,identical protein binding,interspecies interaction between organisms
Uniprot Accessions :
P17301
Gene :
ITGA2
GeneID URL :
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3673
Published Synonyms :
Integrin Alpha 2 Chain,VLA-2
Entity Formats :
Alexa Fluor® 488,Purified
UNSPSC :
41116161
Concentration :
IgG concentration 1.0 mg/ml
Product Form :
Purified IgG - liquid
PriceGBP :
266
PriceEUR :
372
PriceUSD :
372 USD
PriceCHF :
405
PriceSEK :
4055
PriceNOK :
4075
PriceDKK :
2774
more info or order :
Bio-Rad product webpage
company information
Bio-Rad
Endeavour House, Langford Business Park
Langford Lane, Kidlington
OXON, OX5 1GE
antibody_sales_uk@bio-rad.com
https://www.bio-rad-antibodies.com
1 800 265 7376 (North America)
44 (0)1865 852 700 (Rest of World)
headquarters: UK
Bio-Rad is one of the world's leading antibody manufacturers, offering over 12,000 antibodies and related reagents for a focused range of research areas such as immunology, cancer, veterinary research and cell biology through its antibody experts formerly known as AbD Serotec.
The range includes apoptosis kits, autophagy reagents, CD markers, epitope tag antibodies, immunology antibodies, neuroscience antibodies, and veterinary reagents.
Bio-Rad has an ISO 9001 and ISO 13485 certified production facility in the United Kingdom as well as ISO 9001 certified facilities in Germany and the United States.
Our expertise extends to traditional and recombinant antibody generation and production services. Our custom generation service delivers antibodies in as little as 8 weeks with greater than 90% success. The in vitro technology enables selection of antibodies to challenging targets, long term consistent supply, and provision of the antibody sequence.
At Bio-Rad we are committed to your success when using our antibodies and we focus on providing the technology, products and all the supporting information you need to excel in your research.