product summary
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company name :
Bio-Rad
other brands :
Biogenesis, Serotec, AbD Serotec, Oxford Biotechnology
product type :
antibody
product name :
Rat anti Mouse CD68
catalog :
MCA1957T
quantity :
25 µg
price :
100 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
FA-11
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
Bio-Rad product webpage
citations: 34
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 8a
Passman A, Strauss R, McSpadden S, Finch Edmondson M, Andrewartha N, Woo K, et al. Maraviroc Prevents HCC Development by Suppressing Macrophages and the Liver Progenitor Cell Response in a Murine Chronic Liver Disease Model. Cancers (Basel). 2021;13: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:10; loading ...; fig s1c
Gajeton J, Krukovets I, Yendamuri R, Verbovetskiy D, Vasanji A, Sul L, et al. miR-467 regulates inflammation and blood insulin and glucose. J Cell Mol Med. 2021;25:2549-2562 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 6
Varasteh Z, De Rose F, Mohanta S, Li Y, Zhang X, Miritsch B, et al. Imaging atherosclerotic plaques by targeting Galectin-3 and activated macrophages using (89Zr)-DFO- Galectin3-F(ab')2 mAb. Theranostics. 2021;11:1864-1876 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 4g
Shi H, Wang Q, Zheng M, Hao S, Lum J, Chen X, et al. Supplement of microbiota-accessible carbohydrates prevents neuroinflammation and cognitive decline by improving the gut microbiota-brain axis in diet-induced obese mice. J Neuroinflammation. 2020;17:77 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5a
  • immunohistochemistry; mouse; loading ...; fig 5b
Chakarov S, Lim H, Tan L, Lim S, See P, Lum J, et al. Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches. Science. 2019;363: pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 3f
Chute C, Yang X, Meyer K, Yang N, O Neil K, Kasza I, et al. Syndecan-1 induction in lung microenvironment supports the establishment of breast tumor metastases. Breast Cancer Res. 2018;20:66 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 7d
Ziegler Waldkirch S, d Errico P, Sauer J, Erny D, Savanthrapadian S, Loreth D, et al. Seed-induced Aβ deposition is modulated by microglia under environmental enrichment in a mouse model of Alzheimer's disease. EMBO J. 2018;37:167-182 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 9a
Gawlik K, Holmberg J, Svensson M, Einerborg M, Oliveira B, Deierborg T, et al. Potent pro-inflammatory and pro-fibrotic molecules, osteopontin and galectin-3, are not major disease modulators of laminin α2 chain-deficient muscular dystrophy. Sci Rep. 2017;7:44059 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 7a
Badea A, Kane L, Anderson R, Qi Y, Foster M, Cofer G, et al. The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease. Neuroimage. 2016;142:498-511 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2c
Parsa R, Lund H, Georgoudaki A, Zhang X, Ortlieb Guerreiro Cacais A, Grommisch D, et al. BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis. J Exp Med. 2016;213:1537-53 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:200; fig 5
Winston C, Noël A, Neustadtl A, Parsadanian M, Barton D, Chellappa D, et al. Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. Am J Pathol. 2016;186:552-67 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 3d
Bulla R, Tripodo C, Rami D, Ling G, Agostinis C, Guarnotta C, et al. C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation. Nat Commun. 2016;7:10346 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; fig 2
Osman A, Neumann S, Kuhn H, Blomgren K. Caspase inhibition impaired the neural stem/progenitor cell response after cortical ischemia in mice. Oncotarget. 2016;7:2239-48 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 2j
Roth Flach R, Skoura A, Matevossian A, Danai L, Zheng W, Cortes C, et al. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Nat Commun. 2015;6:8995 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 4
Harney A, Arwert E, Entenberg D, Wang Y, Guo P, Qian B, et al. Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA. Cancer Discov. 2015;5:932-43 pubmed publisher
  • flow cytometry; mouse
Conde P, Rodriguez M, van der Touw W, Jimenez A, Burns M, Miller J, et al. DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance. Immunity. 2015;42:1143-58 pubmed publisher
  • immunohistochemistry - frozen section; mouse
Nishikawa K, Iwaya K, Kinoshita M, Fujiwara Y, Akao M, Sonoda M, et al. Resveratrol increases CD68⁺ Kupffer cells colocalized with adipose differentiation-related protein and ameliorates high-fat-diet-induced fatty liver in mice. Mol Nutr Food Res. 2015;59:1155-70 pubmed publisher
  • flow cytometry; mouse
Fontana M, Baccarella A, Pancholi N, Pufall M, Herbert D, Kim C. JUNB is a key transcriptional modulator of macrophage activation. J Immunol. 2015;194:177-86 pubmed publisher
  • western blot; human; fig 2C
Voss M, Künzel U, Higel F, Kuhn P, Colombo A, Fukumori A, et al. Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. EMBO J. 2014;33:2890-905 pubmed publisher
  • immunohistochemistry - frozen section; mouse
  • immunohistochemistry - paraffin section; mouse
Uchida Y, Ke B, Freitas M, Ji H, Zhao D, Benjamin E, et al. The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse. Hepatology. 2010;51:1363-72 pubmed publisher
Vodret S, Bortolussi G, Jašprová J, Vitek L, Muro A. Inflammatory signature of cerebellar neurodegeneration during neonatal hyperbilirubinemia in Ugt1 -/- mouse model. J Neuroinflammation. 2017;14:64 pubmed publisher
Cuccarese M, Dubach J, Pfirschke C, Engblom C, Garris C, Miller M, et al. Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. Nat Commun. 2017;8:14293 pubmed publisher
Sloboda D, Brooks S. Treatment with selectin blocking antibodies after lengthening contractions of mouse muscle blunts neutrophil accumulation but does not reduce damage. Physiol Rep. 2016;4: pubmed publisher
Mondragon A, Betts Obregon B, Moritz R, Parvathaneni K, Navarro M, Kim H, et al. BIGH3 protein and macrophages in retinal endothelial cell apoptosis. Apoptosis. 2015;20:29-37 pubmed publisher
Duque Correa M, Kühl A, Rodriguez P, Zedler U, Schommer Leitner S, Rao M, et al. Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas. Proc Natl Acad Sci U S A. 2014;111:E4024-32 pubmed publisher
Levine E, Zam A, Zhang P, Pechko A, Wang X, Fitzgerald P, et al. Rapid light-induced activation of retinal microglia in mice lacking Arrestin-1. Vision Res. 2014;102:71-9 pubmed publisher
Duarte S, Kato H, Kuriyama N, Suko K, Ishikawa T, Busuttil R, et al. Hepatic ischemia and reperfusion injury in the absence of myeloid cell-derived COX-2 in mice. PLoS ONE. 2014;9:e96913 pubmed publisher
Bachstetter A, Webster S, Van Eldik L, Cambi F. Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain. J Neuroinflammation. 2013;10:146 pubmed publisher
Bachstetter A, Rowe R, Kaneko M, Goulding D, Lifshitz J, Van Eldik L. The p38? MAPK regulates microglial responsiveness to diffuse traumatic brain injury. J Neurosci. 2013;33:6143-53 pubmed publisher
Teplova I, Lozy F, Price S, Singh S, Barnard N, Cardiff R, et al. ATG proteins mediate efferocytosis and suppress inflammation in mammary involution. Autophagy. 2013;9:459-75 pubmed publisher
Haka A, Potteaux S, Fraser H, Randolph G, Maxfield F. Quantitative analysis of monocyte subpopulations in murine atherosclerotic plaques by multiphoton microscopy. PLoS ONE. 2012;7:e44823 pubmed
Püntener U, Booth S, Perry V, Teeling J. Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia. J Neuroinflammation. 2012;9:146 pubmed publisher
Sun Y, Jia L, Williams M, Zamzow M, Ran H, Quinn B, et al. Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice. BMC Neurosci. 2008;9:76 pubmed publisher
Hapfelmeier S, Müller A, Stecher B, Kaiser P, Barthel M, Endt K, et al. Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis. J Exp Med. 2008;205:437-50 pubmed publisher
image
image 1 :
Bio-Rad MCA1957T image 1
Flow cytometric staining of mouse peritoneal macrophages cells with Rat anti Mouse CD68 ( MCA1957 ) following permeablisation with Leucoperm ( BUF09 ), visualised with Mouse adsorbed FITC conjugated F(ab )2 Goat anti Rat IgG: ( STAR69 )
product information
Entity Type :
Monoclonal Antibody
Entity Category :
Antibodies
ProductCode :
MCA1957T
Description :
Rat anti Mouse CD68
Specificity :
CD68
TargetSpecies :
Mouse
Host :
Rat
Format :
Purified
Isotypes :
IgG2a
Applications :
WB,P,IP,F,C,IF
ApplicationTypes :
Western Blotting,Immunohistology - Paraffin,Immunoprecipitation,Flow Cytometry,Immunohistology - Frozen,Immunofluorescence
Clone :
FA-11
Quantity :
25 µg
Quantity Value :
25
Quantity Type :
µg
GO Accessions :
GO:0005886,GO:0016021,GO:0005765,GO:0010008
GOTerms :
plasma membrane,integral to membrane,lysosomal membrane,endosome membrane
Uniprot Accessions :
P31996
Gene :
Cd68
GeneID URL :
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=12514
Published Synonyms :
Macrosialin
Entity Formats :
Alexa Fluor® 488,Alexa Fluor® 647,Biotin,FITC,Low Endotoxin,Purified,RPE,Alexa Fluor® 700,Amethyst Orange
UNSPSC :
41116161
Concentration :
IgG concentration 1.0 mg/ml
Product Form :
Purified IgG - liquid
PriceGBP :
71
PriceEUR :
100
PriceUSD :
100 USD
PriceCHF :
109
PriceSEK :
1090
PriceNOK :
1095
PriceDKK :
746
more info or order :
Bio-Rad product webpage
company information
Bio-Rad
Endeavour House, Langford Business Park
Langford Lane, Kidlington
OXON, OX5 1GE
antibody_sales_uk@bio-rad.com
https://www.bio-rad-antibodies.com
1 800 265 7376 (North America)
44 (0)1865 852 700 (Rest of World)
headquarters: UK
Bio-Rad is one of the world's leading antibody manufacturers, offering over 12,000 antibodies and related reagents for a focused range of research areas such as immunology, cancer, veterinary research and cell biology through its antibody experts formerly known as AbD Serotec.
The range includes apoptosis kits, autophagy reagents, CD markers, epitope tag antibodies, immunology antibodies, neuroscience antibodies, and veterinary reagents.
Bio-Rad has an ISO 9001 and ISO 13485 certified production facility in the United Kingdom as well as ISO 9001 certified facilities in Germany and the United States.
Our expertise extends to traditional and recombinant antibody generation and production services. Our custom generation service delivers antibodies in as little as 8 weeks with greater than 90% success. The in vitro technology enables selection of antibodies to challenging targets, long term consistent supply, and provision of the antibody sequence.
At Bio-Rad we are committed to your success when using our antibodies and we focus on providing the technology, products and all the supporting information you need to excel in your research.