product summary
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company name :
Bio-Rad
other brands :
Biogenesis, Serotec, AbD Serotec, Oxford Biotechnology
product type :
antibody
product name :
Mouse anti Human CD163
catalog :
MCA1853
quantity :
0.2 mg
price :
384 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
EDHu-1
reactivity :
human, rhesus macaque
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, other
more info or order :
Bio-Rad product webpage
citations: 34
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:300; loading ...; fig s2n
Zimmer T, Broekaart D, Luinenburg M, Mijnsbergen C, Anink J, Sim N, et al. Balloon cells promote immune system activation in focal cortical dysplasia type 2b. Neuropathol Appl Neurobiol. 2021;47:826-839 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 4d
Kubli S, Bassi C, Roux C, Wakeham A, Göbl C, Zhou W, et al. AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer. Proc Natl Acad Sci U S A. 2019;116:3604-3613 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 1d
Georgouli M, Herraiz C, Crosas Molist E, Fanshawe B, Maiques O, Perdrix A, et al. Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment. Cell. 2019;176:757-774.e23 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; fig s4
Berthel A, Zoernig I, Valous N, Kahlert C, Klupp F, Ulrich A, et al. Detailed resolution analysis reveals spatial T cell heterogeneity in the invasive margin of colorectal cancer liver metastases associated with improved survival. Oncoimmunology. 2017;6:e1286436 pubmed publisher
  • immunohistochemistry; human; 1:400; loading ...; fig 4k
van den Bosch T, Caliskan K, Kraaij M, Constantinescu A, Manintveld O, Leenen P, et al. CD16+ Monocytes and Skewed Macrophage Polarization toward M2 Type Hallmark Heart Transplant Acute Cellular Rejection. Front Immunol. 2017;8:346 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:750; tbl 5
Maglietta A, Maglietta R, Staiano T, Bertoni R, Ancona N, Marra G, et al. The Immune Landscapes of Polypoid and Nonpolypoid Precancerous Colorectal Lesions. PLoS ONE. 2016;11:e0159373 pubmed publisher
  • immunohistochemistry - paraffin section; rhesus macaque; 1:5000; fig 2
Williams D, Engle E, Shirk E, Queen S, Gama L, Mankowski J, et al. Splenic Damage during SIV Infection: Role of T-Cell Depletion and Macrophage Polarization and Infection. Am J Pathol. 2016;186:2068-2087 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 1a
Endo N, Tsuboi N, Furuhashi K, Shi Y, Du Q, Abe T, et al. Urinary soluble CD163 level reflects glomerular inflammation in human lupus nephritis. Nephrol Dial Transplant. 2016;31:2023-2033 pubmed
  • immunohistochemistry; human; fig 3d
Val Bernal J, Mayorga M, Terán Villagrá N. Extracutaneous intravascular histiocytosis of the aortic valve: Report of two cases. Pathol Res Pract. 2016;212:258-63 pubmed publisher
  • immunohistochemistry - paraffin section; human; 0.5 ug/ml; loading ...; fig 5a
Soendergaard C, Kvist P, Seidelin J, Pelzer H, Nielsen O. Systemic and intestinal levels of factor XIII-A: the impact of inflammation on expression in macrophage subtypes. J Gastroenterol. 2016;51:796-807 pubmed publisher
  • western blot; human; fig 2
Tarin C, Carril M, Martin Ventura J, Markuerkiaga I, Padro D, Llamas Granda P, et al. Targeted gold-coated iron oxide nanoparticles for CD163 detection in atherosclerosis by MRI. Sci Rep. 2015;5:17135 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 7
Nakamura R, Sene A, Santeford A, Gdoura A, Kubota S, Zapata N, et al. IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. Nat Commun. 2015;6:7847 pubmed publisher
  • other; rhesus macaque; fig 5
Pincus S, Bhaskaran M, Brey R, Didier P, Doyle Meyers L, Roy C. Clinical and Pathological Findings Associated with Aerosol Exposure of Macaques to Ricin Toxin. Toxins (Basel). 2015;7:2121-33 pubmed publisher
  • immunohistochemistry - paraffin section; rhesus macaque
Lakritz J, Bodair A, Shah N, O Donnell R, Polydefkis M, Miller A, et al. Monocyte Traffic, Dorsal Root Ganglion Histopathology, and Loss of Intraepidermal Nerve Fiber Density in SIV Peripheral Neuropathy. Am J Pathol. 2015;185:1912-23 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Young O, Tang Z, Niven Fairchild T, Tadesse S, Krikun G, Norwitz E, et al. Toll-like receptor-mediated responses by placental Hofbauer cells (HBCs): a potential pro-inflammatory role for fetal M2 macrophages. Am J Reprod Immunol. 2015;73:22-35 pubmed publisher
  • flow cytometry; rhesus macaque
  • immunohistochemistry; rhesus macaque
Holder G, McGary C, Johnson E, Zheng R, John V, Sugimoto C, et al. Expression of the mannose receptor CD206 in HIV and SIV encephalitis: a phenotypic switch of brain perivascular macrophages with virus infection. J Neuroimmune Pharmacol. 2014;9:716-26 pubmed publisher
  • immunocytochemistry; human
  • immunohistochemistry; human
Bullers S, Baker S, Ingham E, Southgate J. The human tissue-biomaterial interface: a role for PPAR?-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype. Tissue Eng Part A. 2014;20:2390-401 pubmed publisher
  • immunohistochemistry; human
Preza G, Tanner K, Elliott J, Yang O, Anton P, Ochoa M. Antigen-presenting cell candidates for HIV-1 transmission in human distal colonic mucosa defined by CD207 dendritic cells and CD209 macrophages. AIDS Res Hum Retroviruses. 2014;30:241-9 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Tang Z, Buhimschi I, Buhimschi C, Tadesse S, Norwitz E, Niven Fairchild T, et al. Decreased levels of folate receptor-? and reduced numbers of fetal macrophages (Hofbauer cells) in placentas from pregnancies with severe pre-eclampsia. Am J Reprod Immunol. 2013;70:104-15 pubmed publisher
  • western blot; human; 1:2000
Tang Z, Niven Fairchild T, Tadesse S, Norwitz E, Buhimschi C, Buhimschi I, et al. Glucocorticoids enhance CD163 expression in placental Hofbauer cells. Endocrinology. 2013;154:471-82 pubmed publisher
Molina Hernandez V, Ruiz Campillo M, Martínez Moreno F, Buffoni L, Martínez Moreno A, Zafra R, et al. A Partially Protective Vaccine for Fasciola hepatica Induced Degeneration of Adult Flukes Associated to a Severe Granulomatous Reaction in Sheep. Animals (Basel). 2021;11: pubmed publisher
Konjevic Sabolek M, Held K, Beltrán E, Niedl A, Meinl E, Hohlfeld R, et al. Communication of CD8+ T cells with mononuclear phagocytes in multiple sclerosis. Ann Clin Transl Neurol. 2019;6:1151-1164 pubmed publisher
Chen J, Wang H, Bai J, Liu W, Liu X, Yu D, et al. Generation of Pigs Resistant to Highly Pathogenic-Porcine Reproductive and Respiratory Syndrome Virus through Gene Editing of CD163. Int J Biol Sci. 2019;15:481-492 pubmed publisher
Traina Dorge V, Palmer B, Coleman C, Hunter M, Frieman A, Gilmore A, et al. Reactivation of Simian Varicella Virus in Rhesus Macaques after CD4 T Cell Depletion. J Virol. 2019;93: pubmed publisher
Pedragosa J, Salas Perdomo A, Gallizioli M, Cugota R, Miro Mur F, Briansó F, et al. CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage. Acta Neuropathol Commun. 2018;6:76 pubmed publisher
Hinchcliff M, Toledo D, Taroni J, Wood T, Franks J, Ball M, et al. Mycophenolate Mofetil Treatment of Systemic Sclerosis Reduces Myeloid Cell Numbers and Attenuates the Inflammatory Gene Signature in Skin. J Invest Dermatol. 2018;138:1301-1310 pubmed publisher
Fry L, Schneider D, Frevert C, Nelson D, Morrison W, Knowles D. East Coast Fever Caused by Theileria parva Is Characterized by Macrophage Activation Associated with Vasculitis and Respiratory Failure. PLoS ONE. 2016;11:e0156004 pubmed publisher
Fjeldborg K, Pedersen S, Møller H, Rask P, Danielsen A, Stødkilde Jørgensen H, et al. Intrahepatic fat content correlates with soluble CD163 in relation to weight loss induced by Roux-en-Y gastric bypass. Obesity (Silver Spring). 2015;23:154-61 pubmed publisher
Dassanayake R, Truscott T, Ozyiğit M, Zhuang D, Schneider D, O Rourke K. Accumulation profiles of PrP(Sc) in hemal nodes of naturally and experimentally scrapie-infected sheep. BMC Vet Res. 2013;9:82 pubmed publisher
Carus A, Ladekarl M, Hager H, Nedergaard B, Donskov F. Tumour-associated CD66b+ neutrophil count is an independent prognostic factor for recurrence in localised cervical cancer. Br J Cancer. 2013;108:2116-22 pubmed publisher
Herrmann Hoesing L, Noh S, Snekvik K, White S, Schneider D, Truscott T, et al. Ovine progressive pneumonia virus capsid antigen as found in CD163- and CD172a-positive alveolar macrophages of persistently infected sheep. Vet Pathol. 2010;47:518-28 pubmed publisher
Taus N, Schneider D, Oaks J, Yan H, Gailbreath K, Knowles D, et al. Sheep (Ovis aries) airway epithelial cells support ovine herpesvirus 2 lytic replication in vivo. Vet Microbiol. 2010;145:47-53 pubmed publisher
Jørgensen J, Sørensen F, Bendix K, Nielsen J, Funder A, Karkkainen M, et al. Expression level, tissue distribution pattern, and prognostic impact of vascular endothelial growth factors VEGF and VEGF-C and their receptors Flt-1, KDR, and Flt-4 in different subtypes of non-Hodgkin lymphomas. Leuk Lymphoma. 2009;50:1647-60 pubmed publisher
Wang X, Deavers M, Patenia R, Bassett R, Mueller P, Ma Q, et al. Monocyte/macrophage and T-cell infiltrates in peritoneum of patients with ovarian cancer or benign pelvic disease. J Transl Med. 2006;4:30 pubmed
image
image 1 :
Bio-Rad MCA1853 image 1
Figure A. Alexa Fluor700 conjugated mouse anti human CD14 ( MCA596A700 ) and Alexa Fluor488 conjugated mouse IgG1 isotype control ( MCA928A488 ). Figure B. Alexa Fluor700 conjugated mouse anti human CD14 ( MCA596A700 ) and Alexa Fluor488 conjugated mouse anti human CD163 ( MCA1853A488 ). All experiments performed on red cell lysed human blood gated on mononuclear cells in the presence of Human Seroblock ( BUF070A ). Data acquired on the ZE5™ cell analyzer.
product information
Entity Type :
Monoclonal Antibody
Entity Category :
Antibodies
ProductCode :
MCA1853
Description :
Mouse anti Human CD163
Specificity :
CD163
TargetSpecies :
Human
Host :
Mouse
Format :
Purified
Isotypes :
IgG1
Applications :
F,WB,E,C,P,IF,IY
ApplicationTypes :
Flow Cytometry,Western Blotting,ELISA,Immunohistology - Frozen,Immunohistology - Paraffin,Immunofluorescence,Immunoassay
Cross Reactivities :
Rhesus Monkey,Sheep,Pig,Guinea Pig,Bovine,Cynomolgus monkey
Clone :
EDHu-1
Quantity :
0.2 mg
Quantity Value :
0.2
Quantity Type :
mg
GO Accessions :
GO:0005515,GO:0006953,GO:0005576,GO:0005044,GO:0005887
GOTerms :
protein binding,acute-phase response,extracellular region,scavenger receptor activity,integral to plasma membrane
Uniprot Accessions :
Q86VB7
Gene :
CD163
GeneID URL :
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9332
Entity Formats :
Alexa Fluor® 488,FITC,Purified,RPE,StarBright Blue 700,StarBright Violet 440,StarBright Violet 515,StarBright Violet 610,StarBright Violet 670,StarBright Violet 570,StarBright Violet 710,StarBright Violet 790,StarBright Violet 475,StarBright UltraViolet 400,StarBright UltraViolet 665,StarBright UltraViolet 795,StarBright Violet 760,StarBright UltraViolet 445,StarBright UltraViolet 510,StarBright UltraViolet 740,StarBright UltraViolet 575,StarBright UltraViolet 605
UNSPSC :
41116161
Concentration :
IgG concentration 1.0 mg/ml
Product Form :
Purified IgG - liquid
PriceGBP :
274
PriceEUR :
384
PriceUSD :
384 USD
PriceCHF :
418
PriceSEK :
4378
PriceNOK :
4371
PriceDKK :
2864
more info or order :
Bio-Rad product webpage
company information
Bio-Rad
Endeavour House, Langford Business Park
Langford Lane, Kidlington
OXON, OX5 1GE
antibody_sales_uk@bio-rad.com
https://www.bio-rad-antibodies.com
1 800 265 7376 (North America)
44 (0)1865 852 700 (Rest of World)
headquarters: UK
Bio-Rad is one of the world's leading antibody manufacturers, offering over 12,000 antibodies and related reagents for a focused range of research areas such as immunology, cancer, veterinary research and cell biology through its antibody experts formerly known as AbD Serotec.
The range includes apoptosis kits, autophagy reagents, CD markers, epitope tag antibodies, immunology antibodies, neuroscience antibodies, and veterinary reagents.
Bio-Rad has an ISO 9001 and ISO 13485 certified production facility in the United Kingdom as well as ISO 9001 certified facilities in Germany and the United States.
Our expertise extends to traditional and recombinant antibody generation and production services. Our custom generation service delivers antibodies in as little as 8 weeks with greater than 90% success. The in vitro technology enables selection of antibodies to challenging targets, long term consistent supply, and provision of the antibody sequence.
At Bio-Rad we are committed to your success when using our antibodies and we focus on providing the technology, products and all the supporting information you need to excel in your research.