product summary
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company name :
Bio-Rad
other brands :
Biogenesis, Serotec, AbD Serotec, Oxford Biotechnology
product type :
antibody
product name :
Mouse anti Poly(ADP-Ribose) Polymerase-1
catalog :
MCA1522G
quantity :
0.1 mg
price :
264 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
A6.4.12
reactivity :
human, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, western blot knockout validation
more info or order :
Bio-Rad product webpage
citations: 9
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; loading ...; fig 1a
  • immunohistochemistry; human; loading ...; fig 1b
Hanzlikova H, Gittens W, Krejcikova K, Zeng Z, Caldecott K. Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin. Nucleic Acids Res. 2017;45:2546-2557 pubmed publisher
  • western blot; human; loading ...; fig 4b
Hoch N, Hanzlikova H, Rulten S, Tetreault M, Komulainen E, Ju L, et al. XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. Nature. 2017;541:87-91 pubmed publisher
  • western blot; human; 1:1000; fig 3
Breslin C, Hornyak P, Ridley A, Rulten S, Hanzlikova H, Oliver A, et al. The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function. Nucleic Acids Res. 2015;43:6934-44 pubmed publisher
  • immunocytochemistry; rat; 1:500
Allen K, Gourov A, HARTE C, Gao P, Lee C, Sylvain D, et al. Nucleolar integrity is required for the maintenance of long-term synaptic plasticity. PLoS ONE. 2014;9:e104364 pubmed publisher
Hanzlikova H, Kalasová I, Demin A, Pennicott L, Cihlarova Z, Caldecott K. The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication. Mol Cell. 2018;71:319-331.e3 pubmed publisher
Meisenberg C, Ashour M, El Shafie L, Liao C, Hodgson A, Pilborough A, et al. Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Res. 2017;45:1159-1176 pubmed publisher
Yeo A, Becherel O, Luff J, Cullen J, Wongsurawat T, Jenjaroenpun P, et al. R-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxias. PLoS ONE. 2014;9:e90219 pubmed publisher
Buchsbaum S, Bercovich B, Ciechanover A. FAT10 is a proteasomal degradation signal that is itself regulated by ubiquitination. Mol Biol Cell. 2012;23:225-32 pubmed publisher
Alexander B, Wang X, Niemierko A, Weaver D, Mak R, Roof K, et al. DNA repair biomarkers predict response to neoadjuvant chemoradiotherapy in esophageal cancer. Int J Radiat Oncol Biol Phys. 2012;83:164-71 pubmed publisher
image
image 1 :
Bio-Rad MCA1522G image 1
HeLa Nuclear Extract probed with Mouse anti Poly (ADP-Ribose) Polymerase ( MCA1522G )
product information
Entity Type :
Monoclonal Antibody
Entity Category :
Antibodies
ProductCode :
MCA1522G
Description :
Mouse anti Poly(ADP-Ribose) Polymerase-1
Specificity :
Poly(ADP-Ribose) Polymerase-1
TargetSpecies :
Human
Host :
Mouse
Format :
Purified
Isotypes :
IgG1
Applications :
WB,P,IP,C,E,IF
ApplicationTypes :
Western Blotting,Immunohistology - Paraffin,Immunoprecipitation,Immunohistology - Frozen,ELISA,Immunofluorescence
Cross Reactivities :
Hamster,Mouse,Drosophila,Xenopus,Rat
Clone :
A6.4.12
Quantity :
0.1 mg
Quantity Value :
0.1
Quantity Type :
mg
GO Accessions :
GO:0003677,GO:0003950,GO:0005635,GO:0005667,GO:0005730,GO:0006366,GO:0006471,GO:0008134,GO:0008270,GO:0042802,GO:0032869,GO:0045449,GO:0047485
GOTerms :
DNA binding,NAD+ ADP-ribosyltransferase activity,nuclear envelope,transcription factor complex,nucleolus,transcription from RNA polymerase II promoter,protein ADP-ribosylation,transcription factor binding,zinc ion binding,identical protein binding,cellular response to insulin stimulus,regulation of transcription,protein N-terminus binding
Uniprot Accessions :
P09874
Gene :
PARP1
GeneID URL :
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=142
Entity Formats :
Purified
UNSPSC :
41116161
Concentration :
IgG concentration 1.0 mg/ml
Product Form :
Purified IgG - liquid
PriceGBP :
189
PriceEUR :
264
PriceUSD :
264 USD
PriceCHF :
287
PriceSEK :
2878
PriceNOK :
2892
PriceDKK :
1968
more info or order :
Bio-Rad product webpage
company information
Bio-Rad
Endeavour House, Langford Business Park
Langford Lane, Kidlington
OXON, OX5 1GE
antibody_sales_uk@bio-rad.com
https://www.bio-rad-antibodies.com
1 800 265 7376 (North America)
44 (0)1865 852 700 (Rest of World)
headquarters: UK
Bio-Rad is one of the world's leading antibody manufacturers, offering over 12,000 antibodies and related reagents for a focused range of research areas such as immunology, cancer, veterinary research and cell biology through its antibody experts formerly known as AbD Serotec.
The range includes apoptosis kits, autophagy reagents, CD markers, epitope tag antibodies, immunology antibodies, neuroscience antibodies, and veterinary reagents.
Bio-Rad has an ISO 9001 and ISO 13485 certified production facility in the United Kingdom as well as ISO 9001 certified facilities in Germany and the United States.
Our expertise extends to traditional and recombinant antibody generation and production services. Our custom generation service delivers antibodies in as little as 8 weeks with greater than 90% success. The in vitro technology enables selection of antibodies to challenging targets, long term consistent supply, and provision of the antibody sequence.
At Bio-Rad we are committed to your success when using our antibodies and we focus on providing the technology, products and all the supporting information you need to excel in your research.