product summary
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company name :
Bio-Rad
other brands :
Biogenesis, Serotec, AbD Serotec, Oxford Biotechnology
product type :
antibody
product name :
Rat anti Mouse CD45
catalog :
MCA1388
quantity :
0.25 mg
price :
408 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
IBL-3/16
reactivity :
mouse
application :
immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
Bio-Rad product webpage
citations: 27
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 3a
Une H, Yamasaki R, Nagata S, Yamaguchi H, Nakamuta Y, Indiasari U, et al. Brain gray matter astroglia-specific connexin 43 ablation attenuates spinal cord inflammatory demyelination. J Neuroinflammation. 2021;18:126 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 5s1e
Ma W, Silverman S, Zhao L, Villasmil R, Campos M, Amaral J, et al. Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization. elife. 2019;8: pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 1a
Gardner P, Liyanage S, Cristante E, Sampson R, Dick A, Ali R, et al. Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye. Sci Rep. 2017;7:40830 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:250; fig s1
Szalay G, Martinecz B, Lénárt N, Kornyei Z, Orsolits B, Judák L, et al. Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke. Nat Commun. 2016;7:11499 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 3a
Tzekov R, Dawson C, Orlando M, Mouzon B, Reed J, Evans J, et al. Sub-Chronic Neuropathological and Biochemical Changes in Mouse Visual System after Repetitive Mild Traumatic Brain Injury. PLoS ONE. 2016;11:e0153608 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250
Crawford G, Boldison J, Copland D, Adamson P, Gale D, Brandt M, et al. The role of lipoprotein-associated phospholipase A2 in a murine model of experimental autoimmune uveoretinitis. PLoS ONE. 2015;10:e0122093 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:250
Lee S, Xu G, Jay T, Bhatta S, Kim K, Jung S, et al. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. J Neurosci. 2014;34:12538-46 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 2
Lambertsen K, Østergaard K, Clausen B, Hansen S, Stenvang J, Thorsen S, et al. No effect of ablation of surfactant protein-D on acute cerebral infarction in mice. J Neuroinflammation. 2014;11:123 pubmed publisher
  • immunohistochemistry - frozen section; mouse
Hultman K, Cortes Canteli M, Bounoutas A, Richards A, Strickland S, Norris E. Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain. J Thromb Haemost. 2014;12:701-12 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:250
Bhaskar K, Maphis N, Xu G, Varvel N, Kokiko Cochran O, Weick J, et al. Microglial derived tumor necrosis factor-? drives Alzheimer's disease-related neuronal cell cycle events. Neurobiol Dis. 2014;62:273-85 pubmed publisher
Markova L, Umek N, Horvat S, Hadzic A, Kuroda M, Pintaric T, et al. Neurotoxicity of bupivacaine and liposome bupivacaine after sciatic nerve block in healthy and streptozotocin-induced diabetic mice. BMC Vet Res. 2020;16:247 pubmed publisher
Boza Serrano A, Ruiz R, Sanchez Varo R, García Revilla J, Yang Y, Jimenez Ferrer I, et al. Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease. Acta Neuropathol. 2019;: pubmed publisher
Sawicki C, Kim J, Weber M, Faw T, McKim D, Madalena K, et al. Microglia Promote Increased Pain Behavior through Enhanced Inflammation in the Spinal Cord during Repeated Social Defeat Stress. J Neurosci. 2019;39:1139-1149 pubmed publisher
Bemiller S, Maphis N, Formica S, Wilson G, Miller C, Xu G, et al. Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy. J Neuroinflammation. 2018;15:278 pubmed publisher
Liao F, Li A, Xiong M, Bien Ly N, Jiang H, Zhang Y, et al. Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. J Clin Invest. 2018;128:2144-2155 pubmed publisher
He P, Cheng X, Staufenbiel M, Li R, Shen Y. Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of ?-secretase in a mouse model of Alzheimer's disease. PLoS ONE. 2013;8:e55091 pubmed publisher
Kou J, Song M, Pattanayak A, Lim J, Yang J, Cao D, et al. Combined treatment of A? immunization with statin in a mouse model of Alzheimer's disease. J Neuroimmunol. 2012;244:70-83 pubmed publisher
Gruenenfelder F, Thomson G, Penderis J, Edgar J. Axon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease. J Anat. 2011;219:33-43 pubmed publisher
Lodygensky G, West T, Moravec M, Back S, Dikranian K, Holtzman D, et al. Diffusion characteristics associated with neuronal injury and glial activation following hypoxia-ischemia in the immature brain. Magn Reson Med. 2011;66:839-45 pubmed publisher
Jørgensen L, Blain A, Greally E, Laval S, Blamire A, Davison B, et al. Long-term blocking of calcium channels in mdx mice results in differential effects on heart and skeletal muscle. Am J Pathol. 2011;178:273-83 pubmed publisher
Santos A, Martín Oliva D, Ferrer Martín R, Tassi M, Calvente R, Sierra A, et al. Microglial response to light-induced photoreceptor degeneration in the mouse retina. J Comp Neurol. 2010;518:477-92 pubmed publisher
Clausen B, Lambertsen K, Babcock A, Holm T, Dagnaes Hansen F, Finsen B. Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice. J Neuroinflammation. 2008;5:46 pubmed publisher
Li L, Liu J, Suo W. GRK5 deficiency exaggerates inflammatory changes in TgAPPsw mice. J Neuroinflammation. 2008;5:24 pubmed publisher
Sato E, Shick H, Ransohoff R, Hirose K. Repopulation of cochlear macrophages in murine hematopoietic progenitor cell chimeras: the role of CX3CR1. J Comp Neurol. 2008;506:930-42 pubmed
Santos A, Calvente R, Tassi M, Carrasco M, Martín Oliva D, Marín Teva J, et al. Embryonic and postnatal development of microglial cells in the mouse retina. J Comp Neurol. 2008;506:224-39 pubmed
He P, Zhong Z, Lindholm K, Berning L, Lee W, Lemere C, et al. Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice. J Cell Biol. 2007;178:829-41 pubmed
Yang Y, Varvel N, Lamb B, Herrup K. Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models. J Neurosci. 2006;26:775-84 pubmed
product information
EntityType :
Monoclonal Antibody
EntityCategory :
Antibodies
ProductCode :
MCA1388
Description :
Rat anti Mouse CD45
Specificity :
CD45
TargetSpecies :
Mouse
Host :
Rat
Format :
Purified
Isotypes :
IgG1
Applications :
IP,F,C,IF
ApplicationTypes :
Immunoprecipitation,Flow Cytometry,Immunohistology - Frozen,Immunofluorescence
Clone :
IBL-3/16
Quantity :
0.25 mg
QuantityValue :
0.25
QuantityType :
mg
GOAccessions :
GO:0000187,GO:0001915,GO:0001916,GO:0001960,GO:0002925,GO:0051726,GO:0004725,GO:0005887,GO:0005925,GO:0006469,GO:0006470,GO:0007159,GO:0008201,GO:0009897,GO:0019901,GO:0030183,GO:0030890,GO:0031953,GO:0034113,GO:0042098,GO:0042100,GO:0043065,GO:0043395,GO:0043410,GO:0045059,GO:0045060,GO:0045121,GO:0045577,GO:0045588,GO:0046641,GO:0048304,GO:0050732,GO:0050852,GO:0050853,GO:0050855,GO:0050857,GO:0051209,GO:0051607
GOTerms :
activation of MAPK activity,negative regulation of T cell mediated cytotoxicity,positive regulation of T cell mediated cytotoxicity,negative regulation of cytokine-mediated signaling pathway,positive regulation of humoral immune response mediated by circulating immunoglobulin,regulation of cell cycle,protein tyrosine phosphatase activity,integral to plasma membrane,focal adhesion,negative regulation of protein kinase activity,protein dephosphorylation,leukocyte cell-cell adhesion,heparin binding,external side of plasma membrane,protein kinase binding,B cell differentiation,positive regulation of B cell proliferation,negative regulation of protein autophosphorylation,heterotypic cell-cell adhesion,T cell proliferation,B cell proliferation,positive regulation of apoptosis,heparan sulfate proteoglycan binding,positive regulation of MAPKKK cascade,positive thymic T cell selection,negative thymic T cell selection,membrane raft,regulation of B cell differentiation,positive regulation of gamma-delta T cell differentiation,positive regulation of alpha-beta T cell proliferation,positive regulation of isotype switching to IgG isotypes,negative regulation of peptidyl-tyrosine phosphorylation,T cell receptor signaling pathway,B cell receptor signaling pathway,regulation of B cell receptor signaling pathway,positive regulation of antigen receptor-mediated signaling pathway,release of sequestered calcium ion into cytosol,defense response to virus
UniprotAccessions :
P06800
Gene :
Ptprc
GeneID URL :
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=19264
PublishedSynonyms :
LCA
EntityFormats :
Purified
UNSPSC :
41116161
Concentration :
IgG concentration 0.5 mg/ml
ProductForm :
Purified IgG - liquid
PriceGBP :
284
PriceEUR :
397
PriceUSD :
408 USD
PriceCHF :
432
PriceSEK :
4427
PriceNOK :
4566
PriceDKK :
2962
more info or order :
Bio-Rad product webpage
company information
Bio-Rad
Endeavour House, Langford Business Park
Langford Lane, Kidlington
OXON, OX5 1GE
antibody_sales_uk@bio-rad.com
https://www.bio-rad-antibodies.com
1 800 265 7376 (North America)
44 (0)1865 852 700 (Rest of World)
headquarters: UK
Bio-Rad is one of the world's leading antibody manufacturers, offering over 12,000 antibodies and related reagents for a focused range of research areas such as immunology, cancer, veterinary research and cell biology through its antibody experts formerly known as AbD Serotec.
The range includes apoptosis kits, autophagy reagents, CD markers, epitope tag antibodies, immunology antibodies, neuroscience antibodies, and veterinary reagents.
Bio-Rad has an ISO 9001 and ISO 13485 certified production facility in the United Kingdom as well as ISO 9001 certified facilities in Germany and the United States.
Our expertise extends to traditional and recombinant antibody generation and production services. Our custom generation service delivers antibodies in as little as 8 weeks with greater than 90% success. The in vitro technology enables selection of antibodies to challenging targets, long term consistent supply, and provision of the antibody sequence.
At Bio-Rad we are committed to your success when using our antibodies and we focus on providing the technology, products and all the supporting information you need to excel in your research.