Published customer image: . Rabbit anti Beta amyloid antibody (AHP677) used for the demonstration of total amyloid load in mouse brain by immunohistochemistry on free floating tissue sections. Image caption: . Total A load is reduced following intracranial administration of intact anti-A antibody and deglycosylated anti-A antibody. Panels B, D, and F show total A immunostaining in the left (untreated) hippocampal regions of 20 mo. old APP transgenic mice. Panels A, C, and E show total A staining in right hippocampal regions of 20 mo. old APP transgenic mice receiving intracranial injection of control antibody (panel A) or anti-A C-terminal antibody (2H6; panel C), or deglycosylated anti-A C-terminal antibody (de-2H6; panel E). Magnification = 40×, scale bar = 50 mm. Panel G shows quantification of the A load as the ratio of injected (right) side to uninjected (left) side for both the hippocampal and frontal cortical injection sites * indicates P 0.05 compared to mice injected with control IgG. From: Carty NC, Wilcock DM, Rosenthal A, Grimm J, Pons J, Ronan V, Gottschall PE, Gordon MN, Morgan D. Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice. J Neuroinflammation. 2006 May 10;3:11 .