product summary
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company name :
Bio-Rad
other brands :
Biogenesis, Serotec, AbD Serotec, Oxford Biotechnology
product type :
antibody
product name :
Rabbit anti Mouse Collagen IV
catalog :
2150-1470
quantity :
0.1 ml
price :
542 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
Bio-Rad product webpage
citations: 30
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig 1c
Wang T, Zhou P, Xie X, Tomita Y, Cho S, Tsirukis D, et al. Myeloid lineage contributes to pathological choroidal neovascularization formation via SOCS3. EBioMedicine. 2021;73:103632 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 7a
Kaucka M, Szarowska B, Kavkova M, Kastriti M, Kameneva P, Schmidt I, et al. Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges. Cell Mol Life Sci. 2021;78:6033-6049 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s7a, s7b
Krausová A, Buresova P, Sarnova L, Oyman Eyrilmez G, Skarda J, Wohl P, et al. Plectin ensures intestinal epithelial integrity and protects colon against colitis. Mucosal Immunol. 2021;14:691-702 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:300; loading ...; fig 7a
Zarb Y, Sridhar S, Nassiri S, Utz S, Schaffenrath J, Maheshwari U, et al. Microglia control small vessel calcification via TREM2. Sci Adv. 2021;7: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:300; loading ...; fig 5l
Zhou H, Qin L, Jiang Q, Murray K, Zhang H, Li B, et al. Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model. Nat Commun. 2021;12:504 pubmed publisher
  • immunohistochemistry; human; 1:200; loading ...; fig 1b
Bennett R, Hu M, Fernandes A, Pérez Rando M, Robbins A, Kamath T, et al. Tau reduction in aged mice does not impact Microangiopathy. Acta Neuropathol Commun. 2020;8:137 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 2e
  • western blot; mouse; 1:1000; loading ...; fig 2i
van de Vlekkert D, Demmers J, Nguyen X, Campos Y, Machado E, Annunziata I, et al. Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis. Sci Adv. 2019;5:eaav3270 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:300; loading ...; fig 7s2d
Benz F, Wichitnaowarat V, Lehmann M, Germano R, Mihova D, Macas J, et al. Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice. elife. 2019;8: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; fig s2h
Dias D, Kim H, Holl D, Werne Solnestam B, Lundeberg J, Carlen M, et al. Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury. Cell. 2018;173:153-165.e22 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 1f
Kim J, Kim Y, Kim J, Park D, Bae H, Lee D, et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017;127:3441-3461 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; fig s10i
Kammertoens T, Friese C, Arina A, Idel C, Briesemeister D, Rothe M, et al. Tumour ischaemia by interferon-? resembles physiological blood vessel regression. Nature. 2017;545:98-102 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:300; loading ...; fig 2a
Yanagida K, Liu C, Faraco G, Galvani S, Smith H, Burg N, et al. Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proc Natl Acad Sci U S A. 2017;114:4531-4536 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 5e
Hasanov Z, Ruckdeschel T, König C, Mogler C, Kapel S, Korn C, et al. Endosialin Promotes Atherosclerosis Through Phenotypic Remodeling of Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 2017;37:495-505 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 7c
Benito Jardón M, Klapproth S, Gimeno LLuch I, Petzold T, Bharadwaj M, Müller D, et al. The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes. elife. 2017;6: pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; tbl 1
Bassett E, Tokarew N, Allemano E, Mazerolle C, Morin K, Mears A, et al. Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation. elife. 2016;5: pubmed publisher
  • immunocytochemistry; human; 1:300; fig 4a
Jenny Zhou H, Qin L, Zhang H, Tang W, Ji W, He Y, et al. Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation. Nat Med. 2016;22:1033-1042 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; fig S1
Chen Q, Zhang H, Liu Y, Adams S, Eilken H, Stehling M, et al. Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells. Nat Commun. 2016;7:12422 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:250; fig 3
Gurnik S, Devraj K, Macas J, Yamaji M, Starke J, Scholz A, et al. Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling. Acta Neuropathol. 2016;131:753-73 pubmed publisher
  • immunohistochemistry; mouse; 1:400; fig 1c
Franco C, Jones M, Bernabeu M, Vion A, Barbacena P, Fan J, et al. Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling. elife. 2016;5:e07727 pubmed publisher
Liu H, Zhang C, Xu J, Jin J, Cheng L, Miao X, et al. Huntingtin silencing delays onset and slows progression of Huntington's disease: a biomarker study. Brain. 2021;: pubmed publisher
Andrade J, Shi C, Costa A, Choi J, Kim J, Doddaballapur A, et al. Control of endothelial quiescence by FOXO-regulated metabolites. Nat Cell Biol. 2021;23:413-423 pubmed publisher
Park H, Yamamoto H, Mohn L, Ambühl L, Kanai K, Schmidt I, et al. Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy. Nat Commun. 2019;10:5243 pubmed publisher
Bachg A, Horsthemke M, Skryabin B, Klasen T, Nagelmann N, Faber C, et al. Phenotypic analysis of Myo10 knockout (Myo10tm2/tm2) mice lacking full-length (motorized) but not brain-specific headless myosin X. Sci Rep. 2019;9:597 pubmed publisher
Stone O, El Brolosy M, Wilhelm K, Liu X, Romão A, Grillo E, et al. Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells. Nat Commun. 2018;9:4077 pubmed publisher
Rossow L, Veitl S, Vorlova S, Wax J, Kuhn A, Maltzahn V, et al. LOX-catalyzed collagen stabilization is a proximal cause for intrinsic resistance to chemotherapy. Oncogene. 2018;37:4921-4940 pubmed publisher
Jeong H, Hernández Rodríguez B, Kim J, Kim K, Enriquez Gasca R, Yoon J, et al. Transcriptional regulation of endothelial cell behavior during sprouting angiogenesis. Nat Commun. 2017;8:726 pubmed publisher
Toffoli B, Gilardi F, Winkler C, Söderberg M, Kowalczuk L, Arsenijevic Y, et al. Nephropathy in Pparg-null mice highlights PPARγ systemic activities in metabolism and in the immune system. PLoS ONE. 2017;12:e0171474 pubmed publisher
Fernández Robredo P, Selvam S, Powner M, Sim D, Fruttiger M. Neuropilin 1 Involvement in Choroidal and Retinal Neovascularisation. PLoS ONE. 2017;12:e0169865 pubmed publisher
Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich M, Lim R, et al. FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature. 2016;529:216-20 pubmed publisher
Wu W, Georgiadis A, Copland D, Liyanage S, Luhmann U, Robbie S, et al. IL-4 regulates specific Arg-1(+) macrophage sFlt-1-mediated inhibition of angiogenesis. Am J Pathol. 2015;185:2324-35 pubmed publisher
image
image 1 :
Bio-Rad 2150-1470 image 1
Published customer image: . Rabbit anti Mouse collagen 4 antibody ( 2150-1470 ) used for detectiuon of collagen 4 in rat retina by immunofluorescence on cryostat sections. Image caption: . Retinal gliosis and subretinal neovascularization in RCS rats. Double label immunostaining was performed using antibodies against vimentin (red) and collagen type IV (green) on frozen sections. (A) Non-dystrophic rat at 21 weeks (w) of age showed a normal distribution of retinal vessels confined to the inner retina and absence of glial cells in the subretinal space. (B, C) RCS rats at 6 w (B) and 9 w (C) of age showed activation of Muller cells but without subretinal neovascularization. Muller cell invasion into the subretinal space was more obvious at 9 w compared with 6 w of age (arrows in C). (D) Subretinal neovascularization (arrows) in RCS rats at 13 w of age. GCL = ganglion cell layer, INL = inner nuclear layer, OPL = outer plexiform layer, ONL = outer nuclear layer, SP = subretinal space, CC = choroidal capillaries. Scale bars: 50 um. From: Shen W, Chung SH, Irhimeh MR, Li S, Lee S-R, et al. (2014). Systemic Administration of Erythropoietin Inhibits Retinopathy in RCS Rats. PLoS ONE 9(8): e104759 .
product information
Entity Type :
Polyclonal Antibody
Entity Category :
Antibodies
ProductCode :
2150-1470
Description :
Rabbit anti Mouse Collagen IV
Specificity :
Collagen IV
TargetSpecies :
Mouse
Host :
Rabbit
Format :
Purified
Isotypes :
Polyclonal IgG
Applications :
P,E,IF,C
ApplicationTypes :
Immunohistology - Paraffin,ELISA,Immunofluorescence,Immunohistology - Frozen
Cross Reactivities :
Orangutan,Rat,Human
Quantity :
0.1 ml
Quantity Value :
0.1
Quantity Type :
ml
GO Accessions :
GO:0001525,GO:0005201,GO:0005587,GO:0007528,GO:0005488,GO:0032836,GO:0007155,GO:0005178,GO:0006917,GO:0006919,GO:0007166,GO:0008283,GO:0016525
GOTerms :
angiogenesis,extracellular matrix structural constituent,collagen type IV,neuromuscular junction development,binding,glomerular basement membrane development,cell adhesion,integrin binding,induction of apoptosis,activation of caspase activity,cell surface receptor linked signaling pathway,cell proliferation,negative regulation of angiogenesis
Uniprot Accessions :
P02463,P08122,Q9QZS0,Q9QZR9,Q80V57,Q6PFB1
Gene :
Col4a1,Col4a2,Col4a4,Col4a3
GeneID URL :
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=12826, http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=12827, http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=12829, http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=12828
Entity Formats :
Purified
UNSPSC :
41116161
Product Form :
Purified Ig - liquid
PriceGBP :
389
PriceEUR :
542
PriceUSD :
542 USD
PriceCHF :
590
PriceSEK :
6179
PriceNOK :
6170
PriceDKK :
4043
more info or order :
Bio-Rad product webpage
company information
Bio-Rad
Endeavour House, Langford Business Park
Langford Lane, Kidlington
OXON, OX5 1GE
antibody_sales_uk@bio-rad.com
https://www.bio-rad-antibodies.com
1 800 265 7376 (North America)
44 (0)1865 852 700 (Rest of World)
headquarters: UK
Bio-Rad is one of the world's leading antibody manufacturers, offering over 12,000 antibodies and related reagents for a focused range of research areas such as immunology, cancer, veterinary research and cell biology through its antibody experts formerly known as AbD Serotec.
The range includes apoptosis kits, autophagy reagents, CD markers, epitope tag antibodies, immunology antibodies, neuroscience antibodies, and veterinary reagents.
Bio-Rad has an ISO 9001 and ISO 13485 certified production facility in the United Kingdom as well as ISO 9001 certified facilities in Germany and the United States.
Our expertise extends to traditional and recombinant antibody generation and production services. Our custom generation service delivers antibodies in as little as 8 weeks with greater than 90% success. The in vitro technology enables selection of antibodies to challenging targets, long term consistent supply, and provision of the antibody sequence.
At Bio-Rad we are committed to your success when using our antibodies and we focus on providing the technology, products and all the supporting information you need to excel in your research.