Bio-Ocean

ELISA/assay

Mouse IL-4 ELISA Kit

EK204

96 well test

349 USD

EK204

Mouse IL-4 ELISA Kit

Mouse

ELISA

96 well test

349 USD

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of mouse IL-4. The Mouse IL-4 ELISA is for research use only. Not for diagnostic or therapeutic procedures. Interleukin 4 (IL-4) is an approximately 18-20 kDa monomeric cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Mouse IL-4 is synthesized as a 140 amino acid (aa) precursor with a 20 aa signal sequence and a 120 aa mature chain and mature mouse IL-4 shares 43%, and 63% aa sequence identity with human and rat IL-4. IL-4 is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. The cell that initially produces IL-4, thus inducing Th0 differentiation, has not been identified, but recent studies suggest that basophils may be the effector cell. It is closely related and has functions similar to IL-13. IL-4 also has been shown to drive mitogenesis, dedifferentiation,and metastasis in rhabdomyosarcoma. IL-4, along with other Th2 cytokines, is involved in the airway inflammation observed in the lungs of patients with allergic asthma.