Bio-Ocean

ELISA/assay

Human sCD40L ELISA Kit

EK188

96 well test

349 USD

EK188

Human sCD40L ELISA Kit

Human

ELISA

96 well test

349 USD

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human sCD40L. The Human sCD40L ELISA is for research use only. Not for diagnostic or therapeutic procedures. CD40 ligand (CD40L, CD154) is a member of the TNF superfamily of molecules and is a CD40L is a 39 kDa glycoprotein that is primarily expressed on activated T cells. 15-18 kDa soluble forms of CD40L (sCD40L) is produced by proteolytic cleavage. CD40L binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. CD40L acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells (TFH cells). On Tfh cells, CD40L promotes B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication. Monitoring of MCP-1 levels in serum provides more detailed insights in several pathological situations such as acquired immune deficiency syndrome (AIDS), systemic lupus erythematosus (SLE), chronic lymphocytic leukemia (CLL), unstable angina, atherosclerosis and acute coronary syndromes.