product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
OPA1
catalog :
612607
quantity :
150 µg
price :
415.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
18/OPA1
reactivity :
human, mouse, rat, dogs, chicken
application :
western blot, immunocytochemistry
more info or order :
citations: 21
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 4c
Simula L, Corrado M, Accordi B, Di Rita A, Nazio F, Antonucci Y, et al. JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction. Cell Death Differ. 2020;: pubmed publisher
  • western blot; mouse; 1:5000; loading ...; fig e5k
Hoshino A, Wang W, Wada S, McDermott Roe C, Evans C, Gosis B, et al. The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Nature. 2019;575:375-379 pubmed publisher
  • western blot; human; loading ...; fig 5b
Richter F, Dennerlein S, Nikolov M, Jans D, Naumenko N, Aich A, et al. ROMO1 is a constituent of the human presequence translocase required for YME1L protease import. J Cell Biol. 2019;218:598-614 pubmed publisher
  • western blot; mouse; loading ...; fig s1c
Simula L, Pacella I, Colamatteo A, Procaccini C, Cancila V, Bordi M, et al. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming. Cell Rep. 2018;25:3059-3073.e10 pubmed publisher
  • western blot; human; loading ...; fig 2b
Mattie S, Riemer J, Wideman J, McBride H. A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space. J Cell Biol. 2018;217:507-515 pubmed publisher
  • western blot; human; loading ...; fig 2c
Janer A, Prudent J, Paupe V, Fahiminiya S, Majewski J, Sgarioto N, et al. SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome. EMBO Mol Med. 2016;8:1019-38 pubmed publisher
  • western blot; mouse; fig 6
Oettinghaus B, D Alonzo D, Barbieri E, Restelli L, Savoia C, Licci M, et al. DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress. Biochim Biophys Acta. 2016;1857:1267-1276 pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig 3B
  • western blot; mouse; 1:1000; fig 3C
Sin J, Andres A, Taylor D, Weston T, Hiraumi Y, Stotland A, et al. Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts. Autophagy. 2016;12:369-80 pubmed publisher
  • western blot; mouse; loading ...; fig 1c
  • western blot; human; loading ...; fig 6b
Moncunill Massaguer C, Saura Esteller J, Pérez Perarnau A, Palmeri C, Núñez Vázquez S, Cosialls A, et al. A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation. Oncotarget. 2015;6:41750-65 pubmed publisher
  • western blot; human; fig 4
Macvicar T, Mannack L, Lees R, Lane J. Targeted siRNA Screens Identify ER-to-Mitochondrial Calcium Exchange in Autophagy and Mitophagy Responses in RPE1 Cells. Int J Mol Sci. 2015;16:13356-80 pubmed publisher
  • western blot; human; 1:1000
Sanderson T, Raghunayakula S, Kumar R. Release of mitochondrial Opa1 following oxidative stress in HT22 cells. Mol Cell Neurosci. 2015;64:116-22 pubmed publisher
  • western blot; rat; 1:1000
Alaimo A, Gorojod R, Beauquis J, Muñoz M, Saravia F, Kotler M. Deregulation of mitochondria-shaping proteins Opa-1 and Drp-1 in manganese-induced apoptosis. PLoS ONE. 2014;9:e91848 pubmed publisher
Fung T, Ji W, Higgs H, Chakrabarti R. Two distinct actin filament populations have effects on mitochondria, with differences in stimuli and assembly factors. J Cell Sci. 2019;132: pubmed publisher
Ortiz M, Ahmed S, Burns M, Henssen A, Hollmann T, Macarthur I, et al. Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms' tumor. JCI Insight. 2019;4: pubmed publisher
McWilliams T, Barini E, Pohjolan Pirhonen R, Brooks S, Singh F, Burel S, et al. Phosphorylation of Parkin at serine 65 is essential for its activation in vivo. Open Biol. 2018;8: pubmed publisher
Amini P, Stojkov D, Felser A, Jackson C, Courage C, Schaller A, et al. Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production. Nat Commun. 2018;9:2958 pubmed publisher
Yamada T, Murata D, Adachi Y, Itoh K, Kameoka S, Igarashi A, et al. Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease. Cell Metab. 2018;28:588-604.e5 pubmed publisher
Sanderson T, Raghunayakula S, Kumar R. Neuronal hypoxia disrupts mitochondrial fusion. Neuroscience. 2015;301:71-8 pubmed publisher
Ferreira da Silva A, Valacca C, Rios E, Pópulo H, Soares P, Sobrinho Simões M, et al. Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration. PLoS ONE. 2015;10:e0122308 pubmed publisher
Macvicar T, Lane J. Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation. J Cell Sci. 2014;127:2313-25 pubmed publisher
Zhang Z, Wakabayashi N, Wakabayashi J, Tamura Y, Song W, Sereda S, et al. The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell. 2011;22:2235-45 pubmed publisher
product information
Cat.# :
612607
Brand :
BD Transduction Laboratories
Name :
OPA1
Format :
Purified
Clone :
18/OPA1
Isotype :
Ms IgG 1
React :
Hu , Ms , Rat , Dog , Chick
Conc :
250 µg/ml
Apps :
IF , WB
Size :
150 µg
Status :
RUO
List Price :
415.00 USD
more info or order :
company information