product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
LEDGF
catalog :
611714
quantity :
50 µg
price :
207.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
26/LEDGF
reactivity :
human
application :
western blot, immunocytochemistry, western blot knockout validation
more info or order :
citations: 10
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; fig 2
Badia R, Pauls E, Riveira-Munoz E, Clotet B, Este J, Ballana E. Zinc finger endonuclease targeting PSIP1 inhibits HIV-1 integration. Antimicrob Agents Chemother. 2014;58:4318-27 pubmed publisher
  • immunocytochemistry; human; fig 1
  • western blot; human; 1:500; fig 1
Lopez A, Kugelman J, Garcia-Rivera J, Urias E, Salinas S, Fernandez-Zapico M, et al. The Structure-Specific Recognition Protein 1 Associates with Lens Epithelium-Derived Growth Factor Proteins and Modulates HIV-1 Replication. J Mol Biol. 2016;428:2814-31 pubmed publisher
  • western blot; human; fig 4
Kanu N, Gronroos E, Martinez P, Burrell R, Yi Goh X, Bartkova J, et al. SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair. Oncogene. 2015;34:5699-708 pubmed publisher
  • western blot; human; 1:500
Fadel H, Morrison J, Saenz D, Fuchs J, Kvaratskhelia M, Ekker S, et al. TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism. J Virol. 2014;88:9704-17 pubmed publisher
  • immunocytochemistry; human; 1:200
  • western blot; human; 1:2000
Morchikh M, Naughtin M, Di Nunzio F, Xavier J, Charneau P, Jacob Y, et al. TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication. PLoS ONE. 2013;8:e81217 pubmed publisher
Sharma A, Slaughter A, Jena N, Feng L, Kessl J, Fadel H, et al. A new class of multimerization selective inhibitors of HIV-1 integrase. PLoS Pathog. 2014;10:e1004171 pubmed publisher
Meehan A, Saenz D, Morrison J, Garcia-Rivera J, Peretz M, Llano M, et al. LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors. PLoS Pathog. 2009;5:e1000522 pubmed publisher
Yan N, Cherepanov P, Daigle J, Engelman A, Lieberman J. The SET complex acts as a barrier to autointegration of HIV-1. PLoS Pathog. 2009;5:e1000327 pubmed publisher
Bhargavan B, Fatma N, Chhunchha B, Singh V, Kubo E, Singh D. LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathway. Cell Death Dis. 2012;3:e316 pubmed publisher
Astiazaran P, Bueno M, Morales E, Kugelman J, Garcia-Rivera J, Llano M. HIV-1 integrase modulates the interaction of the HIV-1 cellular cofactor LEDGF/p75 with chromatin. Retrovirology. 2011;8:27 pubmed publisher
product information
Cat.# :
611714
Brand :
BD Transduction Laboratories
Name :
LEDGF
Format :
Purified
Clone :
26/LEDGF
Isotype :
Ms IgG 1
React :
Hu
Conc :
250 µg/ml
Apps :
Bioimg , IF , WB
Size :
50 µg
Status :
RUO
List Price :
207.00 USD
more info or order :
company information
BD Biosciences