product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
Ataxin-2
catalog :
611378
quantity :
50 µg
price :
207.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
22/Ataxin-2
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 12
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:4000; loading ...; fig 1a
Paul S, Dansithong W, Figueroa K, Scoles D, Pulst S. Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration. Nat Commun. 2018;9:3648 pubmed publisher
  • western blot; human; 1:4000; loading ...; fig 2b
Scoles D, Meera P, Schneider M, Paul S, Dansithong W, Figueroa K, et al. Antisense oligonucleotide therapy for spinocerebellar ataxia type 2. Nature. 2017;544:362-366 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2e
  • western blot; human; 1:1000; loading ...; fig 2d
Becker L, Huang B, Bieri G, Ma R, Knowles D, Jafar Nejad P, et al. Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice. Nature. 2017;544:367-371 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6g
Boeynaems S, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, et al. Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics. Mol Cell. 2017;65:1044-1055.e5 pubmed publisher
  • western blot; mouse; 1:3000; fig 1
  • western blot; human; 1:3000; fig 1
Dansithong W, Paul S, Figueroa K, Rinehart M, Wiest S, Pflieger L, et al. Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model. PLoS Genet. 2015;11:e1005182 pubmed publisher
  • immunoprecipitation; human; 1:400; loading ...; fig 1g
  • western blot; human; 1:400; loading ...; fig 1g
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 2
  • immunoprecipitation; mouse; 1:400; loading ...; fig 2a
  • western blot; mouse; 1:400; loading ...; fig 1g,1h
Halbach M, Stehning T, Damrath E, Jendrach M, Åžen N, BaÅŸak A, et al. Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated. PLoS ONE. 2015;10:e0121089 pubmed publisher
  • immunocytochemistry; human; 1:200
Kaehler C, Guenther A, Uhlich A, Krobitsch S. PRMT1-mediated arginine methylation controls ATXN2L localization. Exp Cell Res. 2015;334:114-25 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Mori F, Watanabe Y, Miki Y, Tanji K, Odagiri S, Eto K, et al. Ubiquitin-negative, eosinophilic neuronal cytoplasmic inclusions associated with stress granules and autophagy: an immunohistochemical investigation of two cases. Neuropathology. 2014;34:140-7 pubmed
  • immunocytochemistry; human; 1:200
Kaehler C, Isensee J, Hucho T, Lehrach H, Krobitsch S. 5-Fluorouracil affects assembly of stress granules based on RNA incorporation. Nucleic Acids Res. 2014;42:6436-47 pubmed publisher
  • immunocytochemistry; human; fig 7
Ariumi Y, Kuroki M, Kushima Y, Osugi K, Hijikata M, Maki M, et al. Hepatitis C virus hijacks P-body and stress granule components around lipid droplets. J Virol. 2011;85:6882-92 pubmed publisher
Halbach M, Gispert S, Stehning T, Damrath E, Walter M, Auburger G. Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway. Cerebellum. 2017;16:68-81 pubmed publisher
Sun X, Li P, Zhu S, Cohen R, Marque L, Ross C, et al. Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65. Sci Rep. 2015;5:12521 pubmed publisher
product information
Cat.# :
611378
Brand :
BD Transduction Laboratories
Name :
Ataxin-2
Format :
Purified
Clone :
22/Ataxin-2
Isotype :
Ms IgG 1
React :
Hu , Rat
Conc :
250 µg/ml
Apps :
IF , WB
Size :
50 µg
Status :
RUO
List Price :
207.00 USD
more info or order :
company information