Published Application/Species/Sample/Dilution | Reference |
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- western blot knockout validation; mouse; fig 2
- immunohistochemistry - paraffin section; mouse; fig 3
| Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, et al. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circ Res. 2015;116:264-78 pubmed publisher
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- western blot knockout validation; human; fig 1a
| Yamano K, Fogel A, Wang C, van der Bliek A, Youle R. Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy. elife. 2014;3:e01612 pubmed publisher
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- western blot; rat; 1:1000; loading ...; fig 1b
| Yin W, Li R, Feng X, James Kang Y. The Involvement of Cytochrome c Oxidase in Mitochondrial Fusion in Primary Cultures of Neonatal Rat Cardiomyocytes. Cardiovasc Toxicol. 2018;18:365-373 pubmed publisher
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- western blot; Drosophila melanogaster; loading ...; fig 4h
| Anding A, Wang C, Chang T, Sliter D, Powers C, Hofmann K, et al. Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance. Curr Biol. 2018;28:287-295.e6 pubmed publisher
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- western blot; rat; 1:1000; loading ...; fig 4a
| Parajuli N, Shrum S, Tobacyk J, Harb A, Arthur J, Macmillan Crow L. Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins. PLoS ONE. 2017;12:e0185542 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 5d
| Zhao Y, Tian J, Sui S, Yuan X, Chen H, Qu C, et al. Loss of succinyl-CoA synthase ADP-forming β subunit disrupts mtDNA stability and mitochondrial dynamics in neurons. Sci Rep. 2017;7:7169 pubmed publisher
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- western blot; mouse; loading ...; fig 4a
- western blot; human; loading ...; fig 1a
| Zhao F, Wang W, Wang C, Siedlak S, Fujioka H, Tang B, et al. Mfn2 protects dopaminergic neurons exposed to paraquat both in vitro and in vivo: Implications for idiopathic Parkinson's disease. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1359-1370 pubmed publisher
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- western blot; rat; 1:1000; loading ...; fig 7b
| Merdzo I, Rutkai I, Sure V, McNulty C, Katakam P, Busija D. Impaired Mitochondrial Respiration in Large Cerebral Arteries of Rats with Type 2 Diabetes. J Vasc Res. 2017;54:1-12 pubmed publisher
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- western blot; human; 1:1000; loading ...
| Borgia D, Malena A, Spinazzi M, Desbats M, Salviati L, Russell A, et al. Increased mitophagy in the skeletal muscle of spinal and bulbar muscular atrophy patients. Hum Mol Genet. 2017;26:1087-1103 pubmed publisher
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- western blot; mouse; 1:2000; loading ...; fig s2b
| Hull T, Boddu R, Guo L, Tisher C, Traylor A, Patel B, et al. Heme oxygenase-1 regulates mitochondrial quality control in the heart. JCI Insight. 2016;1:e85817 pubmed
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- immunocytochemistry; human; fig 4
- western blot; human; fig 4
| Siu G, Zhou F, Yu M, Zhang L, Wang T, Liang Y, et al. Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIα to induce mitochondrial fragmentation. Sci Rep. 2016;6:23464 pubmed publisher
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- western blot; rat; 1:1000; fig 6
| Merdzo I, Rutkai I, Tokés T, Sure V, Katakam P, Busija D. The mitochondrial function of the cerebral vasculature in insulin-resistant Zucker obese rats. Am J Physiol Heart Circ Physiol. 2016;310:H830-8 pubmed publisher
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- immunoprecipitation; rat
- immunocytochemistry; rat; 1:500; fig 2
- western blot; rat; 1:1000
| Torres G, Morales P, GarcÃa Miguel M, Norambuena Soto I, Cartes Saavedra B, Vidal Peña G, et al. Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation. Biochem Pharmacol. 2016;104:52-61 pubmed publisher
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- western blot; mouse; fig s2
| Korwitz A, Merkwirth C, Richter Dennerlein R, Tröder S, Sprenger H, Quirós P, et al. Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. 2016;212:157-66 pubmed publisher
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- western blot; mouse; fig 4
| Sharoar M, Shi Q, Ge Y, He W, Hu X, Perry G, et al. Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease. Mol Psychiatry. 2016;21:1263-71 pubmed publisher
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- western blot; mouse; fig 7
| Winter L, Kuznetsov A, Grimm M, Zeöld A, Fischer I, Wiche G. Plectin isoform P1b and P1d deficiencies differentially affect mitochondrial morphology and function in skeletal muscle. Hum Mol Genet. 2015;24:4530-44 pubmed publisher
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| Picard M, Azuelos I, Jung B, Giordano C, Matecki S, Hussain S, et al. Mechanical ventilation triggers abnormal mitochondrial dynamics and morphology in the diaphragm. J Appl Physiol (1985). 2015;118:1161-71 pubmed publisher
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| Martínez Torres A, Quiney C, Attout T, Boullet H, Herbi L, Vela L, et al. CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans. PLoS Med. 2015;12:e1001796 pubmed publisher
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- immunocytochemistry; mouse; 1:100
| Wu L, Russell D, Wong S, Chen M, Tsai T, St John J, et al. Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors. Development. 2015;142:681-91 pubmed publisher
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- western blot; rat; 1:1000; fig 3
| Rutkai I, Katakam P, Dutta S, Busija D. Sustained mitochondrial functioning in cerebral arteries after transient ischemic stress in the rat: a potential target for therapies. Am J Physiol Heart Circ Physiol. 2014;307:H958-66 pubmed publisher
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- western blot; mouse; fig 2
| Furuya N, Ikeda S, Sato S, Soma S, Ezaki J, Oliva Trejo J, et al. PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy. 2014;10:631-41 pubmed publisher
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- immunoprecipitation; human
| Landry M, Champagne C, Boulanger M, Jetté A, Fuchs M, Dziengelewski C, et al. A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases. J Biol Chem. 2014;289:2230-49 pubmed publisher
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- immunohistochemistry; rat
- western blot; rat
| Haun F, Nakamura T, Shiu A, Cho D, Tsunemi T, Holland E, et al. S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease. Antioxid Redox Signal. 2013;19:1173-84 pubmed publisher
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- immunocytochemistry; human
- western blot; human
| Van Beersel G, Tihon E, Demine S, Hamer I, Jadot M, Arnould T. Different molecular mechanisms involved in spontaneous and oxidative stress-induced mitochondrial fragmentation in tripeptidyl peptidase-1 (TPP-1)-deficient fibroblasts. Biosci Rep. 2013;33:e00023 pubmed publisher
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| Wolf D, Segawa M, Kondadi A, Anand R, Bailey S, Reichert A, et al. Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. EMBO J. 2019;38:e101056 pubmed publisher
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| Oleinik N, Kim J, Roth B, Selvam S, Gooz M, Johnson R, et al. Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress. Sci Adv. 2019;5:eaax1978 pubmed publisher
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| Chung K, Hsu C, Fan L, Huang Z, Bhatia D, Chen Y, et al. Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis. Nat Commun. 2019;10:3390 pubmed publisher
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| Aggarwal S, Gabrovsek L, Langeberg L, Golkowski M, Ong S, Smith F, et al. Depletion of dAKAP1-protein kinase A signaling islands from the outer mitochondrial membrane alters breast cancer cell metabolism and motility. J Biol Chem. 2019;294:3152-3168 pubmed publisher
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| Bahat A, Goldman A, Zaltsman Y, Khan D, Halperin C, Amzallag E, et al. MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells. Nat Commun. 2018;9:5132 pubmed publisher
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| Bertolin G, Bulteau A, Alves Guerra M, Burel A, Lavault M, Gavard O, et al. Aurora kinase A localises to mitochondria to control organelle dynamics and energy production. elife. 2018;7: pubmed publisher
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| Lee J, Pappalardo Z, Chopra D, Hennings T, Vaughn I, Lan C, et al. A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission. Endocrinology. 2018;159:3321-3330 pubmed publisher
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| Thangaraj A, Periyasamy P, Liao K, Bendi V, Callen S, Pendyala G, et al. HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy. Autophagy. 2018;14:1596-1619 pubmed publisher
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| Wang Y, Subramanian M, Yurdagul A, Barbosa Lorenzi V, Cai B, de Juan Sanz J, et al. Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages. Cell. 2017;171:331-345.e22 pubmed publisher
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| Sabouny R, Fraunberger E, Geoffrion M, Ng A, Baird S, Screaton R, et al. The Keap1-Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1. Antioxid Redox Signal. 2017;27:1447-1459 pubmed publisher
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| Jugé R, Breugnot J, Da Silva C, Bordes S, Closs B, Aouacheria A. Quantification and Characterization of UVB-Induced Mitochondrial Fragmentation in Normal Primary Human Keratinocytes. Sci Rep. 2016;6:35065 pubmed publisher
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| Oettinghaus B, D Alonzo D, Barbieri E, Restelli L, Savoia C, Licci M, et al. DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress. Biochim Biophys Acta. 2016;1857:1267-1276 pubmed publisher
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| Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu C, et al. Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure. Circulation. 2016;133:1249-63 pubmed publisher
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| Lu L, Guo L, Gauba E, Tian J, Wang L, Tandon N, et al. Transient Cerebral Ischemia Promotes Brain Mitochondrial Dysfunction and Exacerbates Cognitive Impairments in Young 5xFAD Mice. PLoS ONE. 2015;10:e0144068 pubmed publisher
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| Wang W, Wang X, Fujioka H, Hoppel C, Whone A, Caldwell M, et al. Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes. Nat Med. 2016;22:54-63 pubmed publisher
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| Ferreira da Silva A, Valacca C, Rios E, Pópulo H, Soares P, Sobrinho Simões M, et al. Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration. PLoS ONE. 2015;10:e0122308 pubmed publisher
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| Cavallucci V, Bisicchia E, Cencioni M, Ferri A, Latini L, Nobili A, et al. Acute focal brain damage alters mitochondrial dynamics and autophagy in axotomized neurons. Cell Death Dis. 2014;5:e1545 pubmed publisher
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| Cho B, Cho H, Kim H, Jeong J, Park S, Hwang E, et al. CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation. Exp Mol Med. 2014;46:e105 pubmed publisher
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| Macvicar T, Lane J. Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation. J Cell Sci. 2014;127:2313-25 pubmed publisher
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| Moujalled D, Cook W, Murphy J, Vaux D. Necroptosis induced by RIPK3 requires MLKL but not Drp1. Cell Death Dis. 2014;5:e1086 pubmed publisher
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| Joseph A, Adhihetty P, Wawrzyniak N, Wohlgemuth S, Picca A, Kujoth G, et al. Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging. PLoS ONE. 2013;8:e69327 pubmed publisher
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| Mancini C, Roncaglia P, Brussino A, Stevanin G, Lo Buono N, Krmac H, et al. Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways. BMC Med Genomics. 2013;6:22 pubmed publisher
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| Weber T, Koob S, Heide H, Wittig I, Head B, VAN DER BLIEK A, et al. APOOL is a cardiolipin-binding constituent of the Mitofilin/MINOS protein complex determining cristae morphology in mammalian mitochondria. PLoS ONE. 2013;8:e63683 pubmed publisher
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| Wappler E, Institoris A, Dutta S, Katakam P, Busija D. Mitochondrial dynamics associated with oxygen-glucose deprivation in rat primary neuronal cultures. PLoS ONE. 2013;8:e63206 pubmed publisher
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