product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
LAP2
catalog :
611000
quantity :
50 µg
price :
207.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
27/LAP2
reactivity :
human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 16
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; human; loading ...; fig 1e
Topalian S, Taube J, Pardoll D. Neoadjuvant checkpoint blockade for cancer immunotherapy. Science. 2020;367: pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 5a
Lieb S, Blaha Ostermann S, Kamper E, Rippka J, Schwarz C, Ehrenhöfer Wölfer K, et al. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells. elife. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig 3b
Mirza A, McKellar S, Urman N, Brown A, Hollmig T, Aasi S, et al. LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription. Cell. 2019;176:198-212.e15 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 1c
Platani M, Samejima I, Samejima K, Kanemaki M, Earnshaw W. Seh1 targets GATOR2 and Nup153 to mitotic chromosomes. J Cell Sci. 2018;131: pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig s3a
Takaki T, Montagner M, Serres M, Le Berre M, Russell M, Collinson L, et al. Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability. Nat Commun. 2017;8:16013 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 5h
  • western blot; mouse; 1:1000; fig 5g
Li H, Liu P, Xu S, Li Y, Dekker J, Li B, et al. FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging. J Clin Invest. 2017;127:1241-1253 pubmed publisher
  • immunocytochemistry; human; fig 3
  • western blot; human; fig 3
Li Y, Zhang W, Chang L, Han Y, Sun L, Gong X, et al. Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. Protein Cell. 2016;7:478-88 pubmed publisher
  • immunohistochemistry; mouse; 1:400
Jung H, Tatar A, Tu Y, Nobumori C, Yang S, Goulbourne C, et al. An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin. Mol Cell Biol. 2014;34:4534-44 pubmed publisher
  • immunocytochemistry; mouse
Menon M, Sawada A, Chaturvedi A, Mishra P, Schuster Gossler K, Galla M, et al. Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis. PLoS Genet. 2014;10:e1004558 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400
Jung H, Nobumori C, Goulbourne C, Tu Y, Lee J, Tatar A, et al. Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A. 2013;110:E1923-32 pubmed publisher
Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, et al. Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Nat Commun. 2019;10:3329 pubmed publisher
Wu Z, Zhang W, Song M, Wang W, Wei G, Li W, et al. Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. Protein Cell. 2018;9:333-350 pubmed publisher
Wang S, Hu B, Ding Z, Dang Y, Wu J, Li D, et al. ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells. Cell Discov. 2018;4:2 pubmed publisher
Mimura Y, Takagi M, Clever M, Imamoto N. ELYS regulates the localization of LBR by modulating its phosphorylation state. J Cell Sci. 2016;129:4200-4212 pubmed
Plasilova M, Chattopadhyay C, Ghosh A, Wenzel F, Demougin P, Noppen C, et al. Discordant gene expression signatures and related phenotypic differences in lamin A- and A/C-related Hutchinson-Gilford progeria syndrome (HGPS). PLoS ONE. 2011;6:e21433 pubmed publisher
Liu G, Barkho B, Ruiz S, Diep D, Qu J, Yang S, et al. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature. 2011;472:221-5 pubmed publisher
product information
Cat.# :
611000
Brand :
BD Transduction Laboratories
Name :
LAP2
Format :
Purified
Clone :
27/LAP2
Isotype :
Ms IgG 1
React :
Hu , Ms , Rat , Dog
Conc :
250 µg/ml
Apps :
IF , WB
Size :
50 µg
Status :
RUO
List Price :
207.00 USD
more info or order :
company information