Published Application/Species/Sample/Dilution | Reference |
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- chromatin immunoprecipitation; human
- western blot; human; 1:1000
| Greenhough A, Bagley C, Heesom K, Gurevich D, Gay D, Bond M, et al. Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis. EMBO Mol Med. 2018;10: pubmed publisher
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- immunocytochemistry; human; 1:100; loading ...; fig 5A
- western blot; human; 1:1000; loading ...; fig 1E
| Miles A, Burr S, Grice G, Nathan J. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1? prolyl hydroxylation by regulating cellular iron levels. elife. 2017;6: pubmed publisher
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- western blot; human; loading ...; fig 3b
| Li J, Yakushi T, Parlati F, MacKinnon A, Pérez C, Ma Y, et al. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol. 2017;13:486-493 pubmed publisher
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- western blot; human; loading ...; fig 2f
| Kozlova N, Wottawa M, Katschinski D, Kristiansen G, Kietzmann T. Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. Oncotarget. 2017;8:9885-9898 pubmed publisher
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- western blot; human; loading ...; fig 2a
| Fulcher L, MacArtney T, Bozatzi P, Hornberger A, Rojas Fernandez A, Sapkota G. An affinity-directed protein missile system for targeted proteolysis. Open Biol. 2016;6: pubmed
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- western blot; human; loading ...; fig s2a
| Pradhan S, Mahajan D, Kaur P, Pandey N, Sharma C, Srivastava T. Scriptaid overcomes hypoxia-induced cisplatin resistance in both wild-type and mutant p53 lung cancer cells. Oncotarget. 2016;7:71841-71855 pubmed publisher
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- western blot; human; fig 5
| Masola V, Zaza G, Gambaro G, Onisto M, Bellin G, Vischini G, et al. Heparanase: A Potential New Factor Involved in the Renal Epithelial Mesenchymal Transition (EMT) Induced by Ischemia/Reperfusion (I/R) Injury. PLoS ONE. 2016;11:e0160074 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig s11a
| Bigot P, Colli L, Machiela M, Jessop L, Myers T, Carrouget J, et al. Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41. Nat Commun. 2016;7:12098 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 3a
| Mandl M, Lieberum M, Depping R. A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT. Cell Death Dis. 2016;7:e2284 pubmed publisher
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- western blot; human; loading ...; fig 4e
| Salvi V, Vermi W, Gianello V, Lonardi S, Gagliostro V, Naldini A, et al. Dendritic cell-derived VEGF-A plays a role in inflammatory angiogenesis of human secondary lymphoid organs and is driven by the coordinated activation of multiple transcription factors. Oncotarget. 2016;7:39256-39269 pubmed publisher
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- western blot; human; fig 3
| Lim S, Liu H, Madeira da Silva L, Arora R, Liu Z, Phillips J, et al. Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1?. Cancer Res. 2016;76:2231-42 pubmed publisher
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- other; human; loading ...; fig st1
| Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
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- western blot; human; fig 4
| Dai X, Zhuang L, Wang D, Zhou T, Chang L, Gai R, et al. Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells. Oncotarget. 2016;7:6933-47 pubmed publisher
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- western blot; human; fig 4c
| Azoitei N, Becher A, Steinestel K, Rouhi A, Diepold K, Genze F, et al. PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation. Mol Cancer. 2016;15:3 pubmed publisher
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- western blot; human; fig
s1
| de Bruin A, A Cornelissen P, Kirchmaier B, Mokry M, Iich E, Nirmala E, et al. Genome-wide analysis reveals NRP1 as a direct HIF1?-E2F7 target in the regulation of motorneuron guidance in vivo. Nucleic Acids Res. 2016;44:3549-66 pubmed publisher
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- western blot; human; 1:500; fig 2b
| Weijer R, Broekgaarden M, Krekorian M, Alles L, van Wijk A, Mackaaij C, et al. Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy. Oncotarget. 2016;7:3341-56 pubmed publisher
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- western blot; human; loading ...; fig s10b
| Bowser J, Blackburn M, Shipley G, Molina J, Dunner K, Broaddus R. Loss of CD73-mediated actin polymerization promotes endometrial tumor progression. J Clin Invest. 2016;126:220-38 pubmed publisher
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- western blot; human; fig 1
| Adam M, Matt S, Christian S, Hess Stumpp H, Haegebarth A, Hofmann T, et al. SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status. Cell Cycle. 2015;14:3734-47 pubmed publisher
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- western blot; human; 1:1000; fig 2a
| Mandl M, Lieberum M, Dunst J, Depping R. The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment. Radiat Oncol. 2015;10:229 pubmed publisher
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- western blot; human; 1:1000; fig 9C
| Konzack A, Jakupovic M, Kubaichuk K, Görlach A, Dombrowski F, Miinalainen I, et al. Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis. Antioxid Redox Signal. 2015;23:1059-75 pubmed publisher
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- western blot; human; loading ...; fig 3c
| Högel H, Miikkulainen P, Bino L, Jaakkola P. Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27. Mol Cancer. 2015;14:143 pubmed publisher
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- western blot; human; 1:1000
| Lin A, Abbas S, Kim S, Ortega M, Bouamar H, Escobedo Y, et al. D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2. Nat Commun. 2015;6:7768 pubmed publisher
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- western blot; human; fig 3
| Cimmino F, Pezone L, Avitabile M, Acierno G, Andolfo I, Capasso M, et al. Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells. Sci Rep. 2015;5:11158 pubmed publisher
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- western blot; human; 1:250; loading ...; fig 6a
| Sotoodehnejadnematalahi F, Staples K, Chrysanthou E, Pearson H, Ziegler Heitbrock L, Burke B. Mechanisms of Hypoxic Up-Regulation of Versican Gene Expression in Macrophages. PLoS ONE. 2015;10:e0125799 pubmed publisher
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- western blot; human; loading ...; fig 1b
| Choi H, Gillespie D, Berg S, Rice C, Couldwell S, Gu J, et al. Intermittent induction of HIF-1α produces lasting effects on malignant progression independent of its continued expression. PLoS ONE. 2015;10:e0125125 pubmed publisher
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- immunoprecipitation; human; loading ...; fig 1d
| Alig S, Stampnik Y, Pircher J, Rotter R, Gaitzsch E, Ribeiro A, et al. The tyrosine phosphatase SHP-1 regulates hypoxia inducible factor-1α (HIF-1α) protein levels in endothelial cells under hypoxia. PLoS ONE. 2015;10:e0121113 pubmed publisher
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- western blot; human; fig s4
| Staudacher J, Naarmann de Vries I, Ujvari S, Klinger B, Kasim M, Benko E, et al. Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum. Nucleic Acids Res. 2015;43:3219-36 pubmed publisher
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- western blot; mouse; 1:1000; fig 5,6
| Hsiao H, Hsu T, Liu W, Hsieh W, Chou T, Wu Y, et al. Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo. Nat Commun. 2015;6:6353 pubmed publisher
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- western blot; human; 1:500
| He Z, Li B, Rankin G, Rojanasakul Y, Chen Y. Selecting bioactive phenolic compounds as potential agents to inhibit proliferation and VEGF expression in human ovarian cancer cells. Oncol Lett. 2015;9:1444-1450 pubmed
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| Singleton D, Rouhi P, Zois C, Haider S, Li J, Kessler B, et al. Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. Oncogene. 2015;34:4713-22 pubmed publisher
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- western blot; mouse; fig 6
| Olayanju A, Copple I, Bryan H, Edge G, Sison R, Wong M, et al. Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2. Free Radic Biol Med. 2015;78:202-12 pubmed publisher
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- western blot; human; 1:1000; fig 4
| Lei Q, Qiang F, Chao D, Di W, Guoqian Z, Bo Y, et al. Amelioration of hypoxia and LPS-induced intestinal epithelial barrier dysfunction by emodin through the suppression of the NF-κB and HIF-1α signaling pathways. Int J Mol Med. 2014;34:1629-39 pubmed publisher
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| Sena J, Wang L, Pawlus M, Hu C. HIFs enhance the transcriptional activation and splicing of adrenomedullin. Mol Cancer Res. 2014;12:728-41 pubmed publisher
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| Avena P, Anselmo W, Whitaker Menezes D, Wang C, Pestell R, Lamb R, et al. Compartment-specific activation of PPAR? governs breast cancer tumor growth, via metabolic reprogramming and symbiosis. Cell Cycle. 2013;12:1360-70 pubmed publisher
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- ChIP-Seq; human
- western blot; human
| Wu C, Tang S, Wang P, Lee H, Ko J. Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation. J Biol Chem. 2012;287:25292-302 pubmed publisher
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| Chew E, Hagen T. Substrate-mediated regulation of cullin neddylation. J Biol Chem. 2007;282:17032-40 pubmed
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| Wang Y, Zhong S, Schofield C, Ratcliffe P, Lu X. Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively. J Cell Sci. 2018;131: pubmed publisher
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| Gorissen B, de Bruin A, Miranda Bedate A, Korthagen N, Wolschrijn C, de Vries T, et al. Hypoxia negatively affects senescence in osteoclasts and delays osteoclastogenesis. J Cell Physiol. 2018;234:414-426 pubmed publisher
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| Miess H, Dankworth B, Gouw A, Rosenfeldt M, Schmitz W, Jiang M, et al. The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene. 2018;37:5435-5450 pubmed publisher
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| Navarrete C, Carrillo Salinas F, Palomares B, Mecha M, Jiménez Jiménez C, Mestre L, et al. Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy. J Neuroinflammation. 2018;15:64 pubmed publisher
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| Yao X, Tan J, Lim K, Koh J, Ooi W, Li Z, et al. VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2017;7:1284-1305 pubmed publisher
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| Pascal L, Masoodi K, Liu J, Qiu X, Song Q, Wang Y, et al. Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia. J Endocrinol. 2017;235:123-136 pubmed publisher
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| Mandl M, Depping R. ARNT is a potential direct HIF-1 target gene in human Hep3B hepatocellular carcinoma cells. Cancer Cell Int. 2017;17:77 pubmed publisher
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| Voss D, Spina R, Carter D, Lim K, Jeffery C, Bar E. Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 2017;7:4292 pubmed publisher
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| Azimi I, Milevskiy M, Kaemmerer E, Turner D, Yapa K, Brown M, et al. TRPC1 is a differential regulator of hypoxia-mediated events and Akt signalling in PTEN-deficient breast cancer cells. J Cell Sci. 2017;130:2292-2305 pubmed publisher
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| Szoka L, Karna E, Hlebowicz Sarat K, Karaszewski J, Palka J. Exogenous proline stimulates type I collagen and HIF-1? expression and the process is attenuated by glutamine in human skin fibroblasts. Mol Cell Biochem. 2017;435:197-206 pubmed publisher
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| Takada M, Zhuang M, Inuzuka H, Zhang J, Zurlo G, Zhang J, et al. EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor. Oncotarget. 2017;8:6787-6795 pubmed publisher
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| Thompson J, Nguyen Q, Singh M, Pavesic M, Nesterenko I, Nelson L, et al. Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Oncogene. 2017;36:1080-1089 pubmed publisher
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| Chen T, Zhou Q, Tang H, Bozkanat M, Yuan J, Raj J, et al. miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation. J Am Heart Assoc. 2016;5: pubmed
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| Taylor S, Bagnall J, Mason D, Levy R, Fernig D, See V. Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility. Open Biol. 2016;6: pubmed
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| Wu Y, Meitzler J, Antony S, Juhasz A, Lu J, Jiang G, et al. Dual oxidase 2 and pancreatic adenocarcinoma: IFN-γ-mediated dual oxidase 2 overexpression results in H2O2-induced, ERK-associated up-regulation of HIF-1α and VEGF-A. Oncotarget. 2016;7:68412-68433 pubmed publisher
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| de Wit R, Mujić Delić A, van Senten J, Fraile Ramos A, Siderius M, Smit M. Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells. Oncotarget. 2016;7:67966-67985 pubmed publisher
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| Zhang C, Zhi W, Lu H, Samanta D, Chen I, Gabrielson E, et al. Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells. Oncotarget. 2016;7:64527-64542 pubmed publisher
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| Yeom C, Zeng L, Goto Y, Morinibu A, Zhu Y, Shinomiya K, et al. LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis. Oncotarget. 2016;7:65837-65848 pubmed publisher
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| Jou Y, Tsai Y, Lin C, Tung C, Shen C, Tsai H, et al. Foxp3 enhances HIF-1α target gene expression in human bladder cancer through decreasing its ubiquitin-proteasomal degradation. Oncotarget. 2016;7:65403-65417 pubmed publisher
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| Simko V, Takacova M, Debreova M, Laposova K, Ondriskova Panisova E, Pastorekova S, et al. Dexamethasone downregulates expression of carbonic anhydrase IX via HIF-1? and NF-?B-dependent mechanisms. Int J Oncol. 2016;49:1277-88 pubmed publisher
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| Ma J, Mi C, Wang K, Lee J, Jin X. Zinc finger protein 91 (ZFP91) activates HIF-1? via NF-?B/p65 to promote proliferation and tumorigenesis of colon cancer. Oncotarget. 2016;7:36551-36562 pubmed publisher
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| Richards R, Jenkinson M, Haylock B, See V. Cell cycle progression in glioblastoma cells is unaffected by pathophysiological levels of hypoxia. Peerj. 2016;4:e1755 pubmed publisher
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| Davies E, Dong M, Gutekunst M, Närhi K, van Zoggel H, Blom S, et al. Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices. Sci Rep. 2015;5:17187 pubmed publisher
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| Sato M, Hirose K, Kashiwakura I, Aoki M, Kawaguchi H, Hatayama Y, et al. LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells. Mol Med Rep. 2015;12:3462-3468 pubmed publisher
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| Chen R, Xu M, Nagati J, Hogg R, Das A, Gerard R, et al. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. PLoS ONE. 2015;10:e0116515 pubmed publisher
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| Asnaghi L, Lin M, Lim K, Lim K, Tripathy A, Wendeborn M, et al. Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation. PLoS ONE. 2014;9:e105372 pubmed publisher
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| Hunter B, Eustace A, Irlam J, Valentine H, Denley H, Oguejiofor K, et al. Expression of hypoxia-inducible factor-1? predicts benefit from hypoxia modification in invasive bladder cancer. Br J Cancer. 2014;111:437-43 pubmed publisher
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| Poulsen R, Knowles H, Carr A, Hulley P. Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure. Cell Death Dis. 2014;5:e1074 pubmed publisher
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| Camps C, Saini H, Mole D, Choudhry H, Reczko M, Guerra Assunção J, et al. Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia. Mol Cancer. 2014;13:28 pubmed publisher
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| Kazi A, Gilani R, Schech A, Chumsri S, Sabnis G, Shah P, et al. Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer. Breast Cancer Res. 2014;16:R15 pubmed publisher
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| Bagnall J, Leedale J, Taylor S, Spiller D, White M, Sharkey K, et al. Tight control of hypoxia-inducible factor-? transient dynamics is essential for cell survival in hypoxia. J Biol Chem. 2014;289:5549-64 pubmed publisher
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| Liu X, Cai T, Zhu H, Cao J, Su Y, Hu Y, et al. Q6, a novel hypoxia-targeted drug, regulates hypoxia-inducible factor signaling via an autophagy-dependent mechanism in hepatocellular carcinoma. Autophagy. 2014;10:111-22 pubmed publisher
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| Lai D, Tan C, Gunaratne J, Quek L, Nei W, Thierry F, et al. Localization of HPV-18 E2 at mitochondrial membranes induces ROS release and modulates host cell metabolism. PLoS ONE. 2013;8:e75625 pubmed publisher
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| Yentrapalli R, Azimzadeh O, Sriharshan A, Malinowsky K, Merl J, Wojcik A, et al. The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation. PLoS ONE. 2013;8:e70024 pubmed publisher
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| Tan C, Hagen T. mTORC1 dependent regulation of REDD1 protein stability. PLoS ONE. 2013;8:e63970 pubmed publisher
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| Chen J, Li Z, Chen A, Ye X, Luo H, Rankin G, et al. Inhibitory effect of baicalin and baicalein on ovarian cancer cells. Int J Mol Sci. 2013;14:6012-25 pubmed publisher
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| Kelly C, Glover L, Campbell E, Kominsky D, Ehrentraut S, Bowers B, et al. Fundamental role for HIF-1? in constitutive expression of human ? defensin-1. Mucosal Immunol. 2013;6:1110-8 pubmed publisher
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| Capparelli C, Whitaker Menezes D, Guido C, Balliet R, Pestell T, Howell A, et al. CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Cell Cycle. 2012;11:2272-84 pubmed publisher
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| Doublier S, Belisario D, Polimeni M, Annaratone L, Riganti C, Allia E, et al. HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast. BMC Cancer. 2012;12:4 pubmed publisher
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| Högel H, Rantanen K, Jokilehto T, Grenman R, Jaakkola P. Prolyl hydroxylase PHD3 enhances the hypoxic survival and G1 to S transition of carcinoma cells. PLoS ONE. 2011;6:e27112 pubmed publisher
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| Wollenick K, Hu J, Kristiansen G, Schraml P, Rehrauer H, Berchner Pfannschmidt U, et al. Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling. Nucleic Acids Res. 2012;40:1928-43 pubmed publisher
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| Chen A, Kleiboeker S, Qiu J. Productive parvovirus B19 infection of primary human erythroid progenitor cells at hypoxia is regulated by STAT5A and MEK signaling but not HIF?. PLoS Pathog. 2011;7:e1002088 pubmed publisher
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| Pascal L, Ai J, Rigatti L, Lipton A, Xiao W, Gnarra J, et al. EAF2 loss enhances angiogenic effects of Von Hippel-Lindau heterozygosity on the murine liver and prostate. Angiogenesis. 2011;14:331-43 pubmed publisher
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| Brockmeier U, Platzek C, Schneider K, Patak P, Bernardini A, Fandrey J, et al. The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. PLoS ONE. 2011;6:e19151 pubmed publisher
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| Bluff J, Menakuru S, Cross S, Higham S, Balasubramanian S, Brown N, et al. Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease. Br J Cancer. 2009;101:666-72 pubmed publisher
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