product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
N-Cadherin
catalog :
610920
quantity :
50 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
32/N-Cadherin
reactivity :
human, mouse, rat, dogs, chicken
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 159
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; human; 1:500; fig 2j
Cho A, Jin Y, An Y, Kim J, Choi Y, Lee J, et al. Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids. Nat Commun. 2021;12:4730 pubmed publisher
  • western blot; human; loading ...; fig 1e
Lee S, Jung J, Lee Y, Kim S, Kim J, Kim B, et al. Targeting HSF1 as a Therapeutic Strategy for Multiple Mechanisms of EGFR Inhibitor Resistance in EGFR Mutant Non-Small-Cell Lung Cancer. Cancers (Basel). 2021;13: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig s1e
  • immunocytochemistry; mouse; loading ...; fig 1c
Nasu M, Esumi S, Hatakeyama J, Tamamaki N, Shimamura K. Two-Phase Lineage Specification of Telencephalon Progenitors Generated From Mouse Embryonic Stem Cells. Front Cell Dev Biol. 2021;9:632381 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2f
Kariya Y, Oyama M, Suzuki T, Kariya Y. αvβ3 Integrin induces partial EMT independent of TGF-β signaling. Commun Biol. 2021;4:490 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 3b
Roth J, Muench K, Asokan A, Mallett V, Gai H, Verma Y, et al. 16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development. elife. 2020;9: pubmed publisher
  • western blot; human; 1:2500; loading ...; fig 5
Liang W, Gao R, Yang M, Wang X, Cheng K, Shi X, et al. MARCKSL1 promotes the proliferation, migration and invasion of lung adenocarcinoma cells. Oncol Lett. 2020;19:2272-2280 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 3a
Moon H, Hippenmeyer S, Luo L, Wynshaw Boris A. LIS1 determines cleavage plane positioning by regulating actomyosin-mediated cell membrane contractility. elife. 2020;9: pubmed publisher
  • western blot; human; 1:500; loading ...; fig 1g
Xiong G, Chen J, Zhang G, Wang S, Kawasaki K, Zhu J, et al. Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction. Proc Natl Acad Sci U S A. 2020;117:3748-3758 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2c
Li Q, Mao F, Zhou B, Huang Y, Zou Z, Dendekker A, et al. p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells. Cell Rep. 2020;30:465-480.e6 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 5s1a
Dos Santos Carvalho S, Moreau M, Hien Y, Garcia M, Aubailly N, Henderson D, et al. Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth. elife. 2020;9: pubmed publisher
  • immunocytochemistry; human; 1:250; loading ...; fig 4e
Hiepen C, Jatzlau J, Hildebrandt S, Kampfrath B, Goktas M, Murgai A, et al. BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics. PLoS Biol. 2019;17:e3000557 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 7h
Matsumoto S, Yamamichi T, Shinzawa K, Kasahara Y, Nojima S, Kodama T, et al. GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling. Nat Commun. 2019;10:3882 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1e
Slobodnyuk K, Radic N, Ivanova S, Lladó A, Trempolec N, Zorzano A, et al. Autophagy-induced senescence is regulated by p38α signaling. Cell Death Dis. 2019;10:376 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:300; loading ...; fig 6a
  • western blot; mouse; 1:200; loading ...; fig 6c
Novielli Kuntz N, Jelen M, Barr K, DeLalio L, Feng Q, Isakson B, et al. Ablation of both Cx40 and Panx1 results in similar cardiovascular phenotypes exhibited in Cx40 knockout mice. Biosci Rep. 2019;39: pubmed publisher
  • western blot; human; loading ...; fig 4d
Lee C, Cheng Y, Chang C, Lin C, Chang J. Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial-mesenchymal transition suppression and cell polarity disruption. Sci Rep. 2018;8:17477 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:150; loading ...; fig 7s2g
Eley L, Alqahtani A, MacGrogan D, Richardson R, Murphy L, Salguero Jimenez A, et al. A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice. elife. 2018;7: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:250-1:500
  • immunohistochemistry - paraffin section; human; 1:250-1:500
Rickelt S, Hynes R. Antibodies and methods for immunohistochemistry of extracellular matrix proteins. Matrix Biol. 2018;71-72:10-27 pubmed publisher
  • western blot; human; loading ...; fig 2b
Zhao H, Klausen C, Li Y, Zhu H, Wang Y, Leung P. Bone morphogenetic protein 2 promotes human trophoblast cell invasion by upregulating N-cadherin via non-canonical SMAD2/3 signaling. Cell Death Dis. 2018;9:174 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 8a
Hamada N, Iwamoto I, Tabata H, Nagata K. MUNC18-1 gene abnormalities are involved in neurodevelopmental disorders through defective cortical architecture during brain development. Acta Neuropathol Commun. 2017;5:92 pubmed publisher
  • western blot; human; 1:2500; loading ...; fig 4a
Cottard F, Madi Berthélémy P, Erdmann E, Schaff Wendling F, Keime C, Ye T, et al. Dual effects of constitutively active androgen receptor and full-length androgen receptor for N-cadherin regulation in prostate cancer. Oncotarget. 2017;8:72008-72020 pubmed publisher
  • immunohistochemistry - frozen section; rat; loading ...; fig 6c
  • western blot; rat; loading ...; fig 6i
Roberts S, Dun X, Doddrell R, Mindos T, Drake L, Onaitis M, et al. Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve. Development. 2017;144:3114-3125 pubmed publisher
  • western blot; mouse; loading ...; fig 7b
Liu S, Cheng C. Akt Signaling Is Sustained by a CD44 Splice Isoform-Mediated Positive Feedback Loop. Cancer Res. 2017;77:3791-3801 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; tbl 1
Sai K, Wang S, Kaito A, Fujiwara T, Maruo T, Itoh Y, et al. Multiple roles of afadin in the ultrastructural morphogenesis of mouse hippocampal mossy fiber synapses. J Comp Neurol. 2017;525:2719-2734 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4c
  • western blot; human; loading ...; fig 4a
Yoon C, Cho S, Chang K, Park D, Ryeom S, Yoon S. Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma. Mol Cancer Res. 2017;15:1106-1116 pubmed publisher
  • western blot; human; 1:1000; fig 5b
Wu Y, Jhao Y, Cheng Y, Chen Y. 15-Deoxy-?12,14-prostaglandin J2 inhibits migration of human thyroid carcinoma cells by disrupting focal adhesion complex and adherens junction. Oncol Lett. 2017;13:2569-2576 pubmed publisher
  • western blot; human; loading ...; fig 4c
Li P, Wang Y, Mao X, Jiang Y, Liu J, Li J, et al. CRB3 downregulation confers breast cancer stem cell traits through TAZ/?-catenin. Oncogenesis. 2017;6:e322 pubmed publisher
  • immunocytochemistry; human; fig 2b
Bershteyn M, Nowakowski T, Pollen A, Di Lullo E, Nene A, Wynshaw Boris A, et al. Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia. Cell Stem Cell. 2017;20:435-449.e4 pubmed publisher
  • immunocytochemistry; human; 1:2000; fig 4b
  • western blot; human; 1:2000; loading ...; fig 1b
Yu J, Lei R, Zhuang X, Li X, Li G, Lev S, et al. MicroRNA-182 targets SMAD7 to potentiate TGF?-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nat Commun. 2016;7:13884 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 8a
Bosch P, Fuller L, Sleeth C, Weiner J. Akirin2 is essential for the formation of the cerebral cortex. Neural Dev. 2016;11:21 pubmed
  • western blot; mouse; 1:1000; loading ...; fig 5a
Gilbert J, Man H. The X-Linked Autism Protein KIAA2022/KIDLIA Regulates Neurite Outgrowth via N-Cadherin and ?-Catenin Signaling. Eneuro. 2016;3: pubmed
  • immunoprecipitation; mouse; loading ...; fig 5b
  • immunocytochemistry; human; loading ...; fig s6i
Lian G, Dettenhofer M, Lu J, Downing M, Chenn A, Wong T, et al. Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway. Development. 2016;143:4509-4520 pubmed
  • immunocytochemistry; human; fig 1b
  • western blot; human; fig 1a
Che D, Zhou T, Lan Y, Xie J, Gong H, Li C, et al. High glucose-induced epithelial-mesenchymal transition contributes to the upregulation of fibrogenic factors in retinal pigment epithelial cells. Int J Mol Med. 2016;38:1815-1822 pubmed publisher
  • western blot; rat; 1:2000; fig 3b
Takeuchi S, Iwama S, Takagi H, Kiyota A, Nakashima K, Izumida H, et al. Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons. PLoS ONE. 2016;11:e0164544 pubmed publisher
  • western blot; human; loading ...; fig s2a
  • western blot; mouse; fig s2a
Shenoy A, Jin Y, Luo H, Tang M, Pampo C, Shao R, et al. Epithelial-to-mesenchymal transition confers pericyte properties on cancer cells. J Clin Invest. 2016;126:4174-4186 pubmed publisher
  • western blot; human; loading ...; fig 4e
Mai H, Xu X, Mei G, Hong T, Huang J, Wang T, et al. The interplay between HPIP and casein kinase 1? promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway. Oncogenesis. 2016;5:e260 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 3
Dubail J, Vasudevan D, Wang L, Earp S, Jenkins M, Haltiwanger R, et al. Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome. Sci Rep. 2016;6:33974 pubmed publisher
  • western blot; human; fig 6a
  • immunocytochemistry; dogs; fig 6d
  • western blot; dogs; fig 6a
Kim M, Jeong J, Seo J, Kim H, Kim S, Jin W. Dysregulated JAK2 expression by TrkC promotes metastasis potential, and EMT program of metastatic breast cancer. Sci Rep. 2016;6:33899 pubmed publisher
  • western blot; mouse; loading ...; fig 2c
  • western blot; human; loading ...; fig 3b, 4c
Vardaki I, Ceder S, Rutishauser D, Baltatzis G, Foukakis T, Panaretakis T. Periostin is identified as a putative metastatic marker in breast cancer-derived exosomes. Oncotarget. 2016;7:74966-74978 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 6c
  • immunocytochemistry; human; loading ...; fig 5d
  • western blot; human; loading ...; fig 5c
Kim R, Kaushik N, Suh Y, Yoo K, Cui Y, Kim M, et al. Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer. Oncotarget. 2016;7:53430-53442 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig st1
Ku T, Swaney J, Park J, Albanese A, Murray E, Cho J, et al. Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues. Nat Biotechnol. 2016;34:973-81 pubmed publisher
  • immunocytochemistry; human; fig 2a
Pailler E, Oulhen M, Billiot F, Galland A, Auger N, Faugeroux V, et al. Method for semi-automated microscopy of filtration-enriched circulating tumor cells. BMC Cancer. 2016;16:477 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 1
Dorland Y, Malinova T, van Stalborch A, Grieve A, van Geemen D, Jansen N, et al. The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions. Nat Commun. 2016;7:12210 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 7
Cox A, Barrandon O, Cai E, Rios J, Chavez J, Bonnyman C, et al. Resolving Discrepant Findings on ANGPTL8 in ?-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy. PLoS ONE. 2016;11:e0159276 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 4
  • western blot; mouse; fig 6
Folmsbee S, Wilcox D, Tyberghein K, De Bleser P, Tourtellotte W, van Hengel J, et al. ?T-catenin in restricted brain cell types and its potential connection to autism. J Mol Psychiatry. 2016;4:2 pubmed publisher
  • western blot; human; 1:10,000; fig 1
García Bea A, Walker M, Hyde T, Kleinman J, Harrison P, Lane T. Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study. Schizophr Res. 2016;177:18-27 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 2
Jackson S, Olufs Z, Tran K, Zaidan N, Sridharan R. Alternative Routes to Induced Pluripotent Stem Cells Revealed by Reprogramming of the Neural Lineage. Stem Cell Reports. 2016;6:302-11 pubmed publisher
  • western blot; human; 1:2000; fig 2f
Wang X, Jung Y, Jun S, Lee S, Wang W, Schneider A, et al. PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness. Nat Commun. 2016;7:10633 pubmed publisher
  • western blot; human; fig 3
Wang G, Yu Y, Sun C, Liu T, Liang T, Zhan L, et al. STAT3 selectively interacts with Smad3 to antagonize TGF-β signalling. Oncogene. 2016;35:4388-98 pubmed publisher
  • western blot; human; fig 3
Bartscht T, Rosien B, Rades D, Kaufmann R, Biersack H, Lehnert H, et al. Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action. Mol Cancer. 2015;14:199 pubmed publisher
  • western blot; human; 1:2500; loading ...; fig 2a
Lyon C, Wadey K, George S. Soluble N-cadherin: A novel inhibitor of VSMC proliferation and intimal thickening. Vascul Pharmacol. 2016;78:53-62 pubmed publisher
  • immunohistochemistry; human; 1:25; fig s2
Fridriksdottir A, Kim J, Villadsen R, Klitgaard M, Hopkinson B, Petersen O, et al. Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture. Nat Commun. 2015;6:8786 pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig 1d
Koudelkova P, Weber G, Mikulits W. Liver Sinusoidal Endothelial Cells Escape Senescence by Loss of p19ARF. PLoS ONE. 2015;10:e0142134 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; fig 8
Burns J, Kelly M, Hoa M, Morell R, Kelley M. Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear. Nat Commun. 2015;6:8557 pubmed publisher
  • immunohistochemistry; mouse
Arya P, Rainey M, Bhattacharyya S, Mohapatra B, George M, Kuracha M, et al. The endocytic recycling regulatory protein EHD1 Is required for ocular lens development. Dev Biol. 2015;408:41-55 pubmed publisher
  • western blot; rat; 1:500; fig 4b
Poitelon Y, Bogni S, Matafora V, Della Flora Nunes G, Hurley E, Ghidinelli M, et al. Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination. Nat Commun. 2015;6:8303 pubmed publisher
  • western blot; mouse
Noritake K, Aki T, Funakoshi T, Unuma K, Uemura K. Direct Exposure to Ethanol Disrupts Junctional Cell-Cell Contact and Hippo-YAP Signaling in HL-1 Murine Atrial Cardiomyocytes. PLoS ONE. 2015;10:e0136952 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 6
Xu J, Wan P, Wang M, Zhang J, Gao X, Hu B, et al. AIP1-mediated actin disassembly is required for postnatal germ cell migration and spermatogonial stem cell niche establishment. Cell Death Dis. 2015;6:e1818 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 4
Preuße K, Tveriakhina L, Schuster Gossler K, Gaspar C, Rosa A, Henrique D, et al. Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo. PLoS Genet. 2015;11:e1005328 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 2c
  • western blot; human; 1:1000; loading ...; fig 6b
Lee Y, Han M, Baek S, Kim S, Oh S. MED30 Regulates the Proliferation and Motility of Gastric Cancer Cells. PLoS ONE. 2015;10:e0130826 pubmed publisher
  • western blot; human; 1:500; fig 3
Zhang W, Gu Y, Sun Q, Siegel D, Tolias P, Yang Z, et al. Ex Vivo Maintenance of Primary Human Multiple Myeloma Cells through the Optimization of the Osteoblastic Niche. PLoS ONE. 2015;10:e0125995 pubmed publisher
  • western blot; human; fig 4d
Giribaldi M, Muñoz A, Halvorsen K, Patel A, Rai P. MTH1 expression is required for effective transformation by oncogenic HRAS. Oncotarget. 2015;6:11519-29 pubmed
  • western blot; human; fig 3b
Li Y, Drabsch Y, Pujuguet P, Ren J, van Laar T, Zhang L, et al. Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models. Breast Cancer Res. 2015;17:28 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 5b
Yarilin D, Xu K, Turkekul M, Fan N, Romin Y, Fijisawa S, et al. Machine-based method for multiplex in situ molecular characterization of tissues by immunofluorescence detection. Sci Rep. 2015;5:9534 pubmed publisher
  • western blot; human; loading ...; fig 1a
Qiao Y, Shiue C, Zhu J, Zhuang T, Jonsson P, Wright A, et al. AP-1-mediated chromatin looping regulates ZEB2 transcription: new insights into TNFα-induced epithelial-mesenchymal transition in triple-negative breast cancer. Oncotarget. 2015;6:7804-14 pubmed
  • western blot; human; 1:5000
Yuan L, Seong E, Beuscher J, Arikkath J. δ-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions. J Biol Chem. 2015;290:10947-57 pubmed publisher
  • western blot; mouse
Cai K, Wang Y, Smith E, Smedberg J, Yang D, Yang W, et al. Global deletion of Trp53 reverts ovarian tumor phenotype of the germ cell-deficient white spotting variant (Wv) mice. Neoplasia. 2015;17:89-100 pubmed publisher
  • western blot; human; fig 4
Gong X, Yi J, Carmon K, Crumbley C, Xiong W, Thomas A, et al. Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness. Oncogene. 2015;34:4692-701 pubmed publisher
  • immunocytochemistry; human
Busskamp V, Lewis N, Guye P, Ng A, Shipman S, Byrne S, et al. Rapid neurogenesis through transcriptional activation in human stem cells. Mol Syst Biol. 2014;10:760 pubmed publisher
  • western blot; human; fig 4
Phillips Krawczak C, Singla A, Starokadomskyy P, Deng Z, Osborne D, Li H, et al. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. Mol Biol Cell. 2015;26:91-103 pubmed publisher
  • western blot; human; 1:1000
Sun Q, Cibas E, Huang H, Hodgson L, Overholtzer M. Induction of entosis by epithelial cadherin expression. Cell Res. 2014;24:1288-98 pubmed publisher
  • western blot; human
Suh S, Yoo J, Cui R, Kaur B, Huebner K, Lee T, et al. FHIT suppresses epithelial-mesenchymal transition (EMT) and metastasis in lung cancer through modulation of microRNAs. PLoS Genet. 2014;10:e1004652 pubmed publisher
  • immunocytochemistry; human; fig 1
  • western blot; human; fig 1
Cai X, Dai Z, Reeves R, Caballero Benítez A, Duran K, Delrow J, et al. Autonomous stimulation of cancer cell plasticity by the human NKG2D lymphocyte receptor coexpressed with its ligands on cancer cells. PLoS ONE. 2014;9:e108942 pubmed publisher
  • western blot; human; 1:1000; fig s1
Lu H, Clauser K, Tam W, Fröse J, Ye X, Eaton E, et al. A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol. 2014;16:1105-17 pubmed publisher
  • western blot; human
Li J, Liu J, Li P, Mao X, Li W, Yang J, et al. Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion. J Exp Clin Cancer Res. 2014;33:70 pubmed publisher
  • immunohistochemistry; rat
Friedman L, Riemslagh F, Sullivan J, Mesias R, Williams F, Huntley G, et al. Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits. J Comp Neurol. 2015;523:75-92 pubmed publisher
  • western blot; rat; 1:1000
Gong K, Kung L, Magni G, Bhargava A, Jasmin L. Increased response to glutamate in small diameter dorsal root ganglion neurons after sciatic nerve injury. PLoS ONE. 2014;9:e95491 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100
  • western blot; mouse; 1:100
Hatakeyama J, Wakamatsu Y, Nagafuchi A, Kageyama R, Shigemoto R, Shimamura K. Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates. Development. 2014;141:1671-82 pubmed publisher
  • western blot; mouse
Toyoshima D, Mandai K, Maruo T, Supriyanto I, Togashi H, Inoue T, et al. Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons. PLoS ONE. 2014;9:e89763 pubmed publisher
  • western blot; human
Yoshida T, Ozawa Y, Kimura T, Sato Y, Kuznetsov G, Xu S, et al. Eribulin mesilate suppresses experimental metastasis of breast cancer cells by reversing phenotype from epithelial-mesenchymal transition (EMT) to mesenchymal-epithelial transition (MET) states. Br J Cancer. 2014;110:1497-505 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Peitsch W, Doerflinger Y, Fischer Colbrie R, Huck V, Bauer A, Utikal J, et al. Desmoglein 2 depletion leads to increased migration and upregulation of the chemoattractant secretoneurin in melanoma cells. PLoS ONE. 2014;9:e89491 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 2
  • western blot; mouse; fig 1
Moore R, Tao W, Meng Y, Smith E, Xu X. Cell adhesion and sorting in embryoid bodies derived from N- or E-cadherin deficient murine embryonic stem cells. Biol Open. 2014;3:121-8 pubmed publisher
  • western blot; human
Miura S, Hamada S, Masamune A, Satoh K, Shimosegawa T. CUB-domain containing protein 1 represses the epithelial phenotype of pancreatic cancer cells. Exp Cell Res. 2014;321:209-18 pubmed publisher
  • western blot; human
Zaganjor E, Osborne J, Weil L, Díaz Martínez L, Gonzales J, Singel S, et al. Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells. Oncogene. 2014;33:5457-66 pubmed publisher
  • western blot; human
Almenar Queralt A, Kim S, Benner C, Herrera C, Kang D, Garcia Bassets I, et al. Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. J Biol Chem. 2013;288:35222-36 pubmed publisher
  • western blot; human
Kumar M, Allison D, Baranova N, Wamsley J, Katz A, Bekiranov S, et al. NF-?B regulates mesenchymal transition for the induction of non-small cell lung cancer initiating cells. PLoS ONE. 2013;8:e68597 pubmed publisher
  • western blot; mouse
Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D Hooge R, et al. Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions. J Neurosci. 2013;33:12915-28, 12928a pubmed publisher
  • immunohistochemistry - frozen section; mouse
Maddaluno L, Rudini N, Cuttano R, Bravi L, Giampietro C, Corada M, et al. EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature. 2013;498:492-6 pubmed publisher
  • western blot; human
Ezponda T, Popovic R, Shah M, Martinez Garcia E, Zheng Y, Min D, et al. The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer. Oncogene. 2013;32:2882-90 pubmed publisher
  • western blot; human; fig 5
Walenda T, Bork S, Horn P, Wein F, Saffrich R, Diehlmann A, et al. Co-culture with mesenchymal stromal cells increases proliferation and maintenance of haematopoietic progenitor cells. J Cell Mol Med. 2010;14:337-50 pubmed publisher
  • immunohistochemistry; mouse
Ivaniutsin U, Chen Y, Mason J, Price D, Pratt T. Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex. Neural Dev. 2009;4:3 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000
Akins M, Greer C. Axon behavior in the olfactory nerve reflects the involvement of catenin-cadherin mediated adhesion. J Comp Neurol. 2006;499:979-89 pubmed
Azarnia Tehran D, Kochlamazashvili G, Pampaloni N, Sposini S, Shergill J, Lehmann M, et al. Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity. Sci Adv. 2022;8:eabl5032 pubmed publisher
Zhang J, Zhang Z, Holst S, Blöchl C, Madunić K, Wuhrer M, et al. Transforming growth factor-β challenge alters the N-, O-, and glycosphingolipid glycomes in PaTu-S pancreatic adenocarcinoma cells. J Biol Chem. 2022;298:101717 pubmed publisher
Wu T, Chen Y, Ho C, Yeh T, Sun G, Tseng C, et al. 3H-1,2-Dithiole-3-Thione Protects Lens Epithelial Cells against Fructose-Induced Epithelial-Mesenchymal Transition via Activation of AMPK to Eliminate AKR1B1-Induced Oxidative Stress in Diabetes Mellitus. Antioxidants (Basel). 2021;10: pubmed publisher
Akhand S, Chen H, Purdy S, Liu Z, Anderson J, Willey C, et al. Fibroblast growth factor receptor facilitates recurrence of minimal residual disease following trastuzumab emtansine therapy. NPJ Breast Cancer. 2021;7:5 pubmed publisher
Munthe E, Raiborg C, Stenmark H, Wenzel E. Clathrin regulates Wnt/β-catenin signaling by affecting Golgi to plasma membrane transport of transmembrane proteins. J Cell Sci. 2020;133: pubmed publisher
Grimsley Myers C, Isaacson R, Cadwell C, Campos J, Hernandes M, Myers K, et al. VE-cadherin endocytosis controls vascular integrity and patterning during development. J Cell Biol. 2020;219: pubmed publisher
Fukui S, Nagasaka K, Miyagawa Y, Kikuchi Koike R, Kawata Y, Kanda R, et al. The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer. Oncotarget. 2019;10:5932-5948 pubmed publisher
Esposito M, Mondal N, Greco T, Wei Y, Spadazzi C, Lin S, et al. Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis. Nat Cell Biol. 2019;21:627-639 pubmed publisher
Zhang H, Brown R, Wei Y, Zhao P, Liu S, Liu X, et al. CD44 splice isoform switching determines breast cancer stem cell state. Genes Dev. 2019;33:166-179 pubmed publisher
Savci Heijink C, Halfwerk H, Hooijer G, Koster J, Horlings H, Meijer S, et al. Epithelial-to-mesenchymal transition status of primary breast carcinomas and its correlation with metastatic behavior. Breast Cancer Res Treat. 2019;174:649-659 pubmed publisher
Wörthmüller J, Blum W, Pecze L, Salicio V, Schwaller B. Calretinin promotes invasiveness and EMT in malignant mesothelioma cells involving the activation of the FAK signaling pathway. Oncotarget. 2018;9:36256-36272 pubmed publisher
Sato T, Muramatsu T, Tanabe M, Inazawa J. Identification and characterization of transforming growth factor beta-induced in circulating tumor cell subline from pancreatic cancer cell line. Cancer Sci. 2018;109:3623-3633 pubmed publisher
Tu Y, Duman J, Tolias K. The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling. J Neurosci. 2018;38:8388-8406 pubmed publisher
Yang M, Yu X, Li X, Luo B, Yang W, Lin Y, et al. TNFAIP3 is required for FGFR1 activation-promoted proliferation and tumorigenesis of premalignant DCIS.COM human mammary epithelial cells. Breast Cancer Res. 2018;20:97 pubmed publisher
Veeraraghavan R, Hoeker G, Alvarez Laviada A, Hoagland D, Wan X, King D, et al. The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation. elife. 2018;7: pubmed publisher
Yuan L, Singh D, Buescher J, Arikkath J. A role for proteolytic regulation of δ-catenin in remodeling a subpopulation of dendritic spines in the rodent brain. J Biol Chem. 2018;293:11625-11638 pubmed publisher
Ramanathan M, Majzoub K, Rao D, Neela P, Zarnegar B, Mondal S, et al. RNA-protein interaction detection in living cells. Nat Methods. 2018;15:207-212 pubmed publisher
Vassilev V, Platek A, Hiver S, Enomoto H, Takeichi M. Catenins Steer Cell Migration via Stabilization of Front-Rear Polarity. Dev Cell. 2017;43:463-479.e5 pubmed publisher
Shlyakhtina Y, Pavet V, Gronemeyer H. Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells. Cell Death Dis. 2017;8:e3025 pubmed publisher
Mody H, Hung S, Naidu K, Lee H, Gilbert C, Hoang T, et al. SET contributes to the epithelial-mesenchymal transition of pancreatic cancer. Oncotarget. 2017;8:67966-67979 pubmed publisher
Clements M, Byrne E, Camarillo Guerrero L, Cattin A, Zakka L, Ashraf A, et al. The Wound Microenvironment Reprograms Schwann Cells to Invasive Mesenchymal-like Cells to Drive Peripheral Nerve Regeneration. Neuron. 2017;96:98-114.e7 pubmed publisher
Basu R, Duan X, Taylor M, Martin E, Muralidhar S, Wang Y, et al. Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus. Neuron. 2017;96:160-176.e8 pubmed publisher
Balasubramaniam S, Gopalakrishnapillai A, Petrelli N, Barwe S. Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells. J Biol Chem. 2017;292:11388-11399 pubmed publisher
Iwamori T, Iwamori N, Matsumoto M, Ono E, Matzuk M. Identification of KIAA1210 as a novel X-chromosome-linked protein that localizes to the acrosome and associates with the ectoplasmic specialization in testes. Biol Reprod. 2017;96:469-477 pubmed publisher
Subramanian L, Bershteyn M, Paredes M, Kriegstein A. Dynamic behaviour of human neuroepithelial cells in the developing forebrain. Nat Commun. 2017;8:14167 pubmed publisher
Smith E, Meng Y, Moore R, Tse J, Xu A, Xu X. Nuclear envelope structural proteins facilitate nuclear shape changes accompanying embryonic differentiation and fidelity of gene expression. BMC Cell Biol. 2017;18:8 pubmed publisher
Hsu C, Huang S, Wang J, Chu W, Nien J, Chen W, et al. Interplay of N-Cadherin and matrix metalloproteinase 9 enhances human nasopharyngeal carcinoma cell invasion. BMC Cancer. 2016;16:800 pubmed
Li S, Zhang H, Du Z, Li C, An M, Zong Z, et al. Induction of epithelial-mesenchymal transition (EMT) by Beclin 1 knockdown via posttranscriptional upregulation of ZEB1 in thyroid cancer cells. Oncotarget. 2016;7:70364-70377 pubmed publisher
Lee N, Lee J, Kim W, Yun S, Youn Y, Park C, et al. Promoter methylation of PCDH10 by HOTAIR regulates the progression of gastrointestinal stromal tumors. Oncotarget. 2016;7:75307-75318 pubmed publisher
Chen G, Xie J, Huang P, Yang Z. Overexpression of TAZ promotes cell proliferation, migration and epithelial-mesenchymal transition in ovarian cancer. Oncol Lett. 2016;12:1821-1825 pubmed
Martino V, Sabljic T, Deschamps P, Green R, Akula M, Peacock E, et al. Conditional deletion of AP-2? in mouse cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma. Dis Model Mech. 2016;9:849-61 pubmed publisher
Obayashi M, Yoshida M, Tsunematsu T, Ogawa I, Sasahira T, Kuniyasu H, et al. microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer. Oncotarget. 2016;7:8223-39 pubmed publisher
Durst R, Sauls K, Peal D, deVlaming A, Toomer K, Leyne M, et al. Mutations in DCHS1 cause mitral valve prolapse. Nature. 2015;525:109-13 pubmed publisher
Li H, Yu P, Huang K, Su H, Hsiao T, Chang C, et al. NKX6.1 functions as a metastatic suppressor through epigenetic regulation of the epithelial-mesenchymal transition. Oncogene. 2016;35:2266-78 pubmed publisher
Fisher M, Adhikary G, Xu W, Kerr C, Keillor J, Eckert R. Type II transglutaminase stimulates epidermal cancer stem cell epithelial-mesenchymal transition. Oncotarget. 2015;6:20525-39 pubmed
Shankar J, Nabi I. Actin cytoskeleton regulation of epithelial mesenchymal transition in metastatic cancer cells. PLoS ONE. 2015;10:e0119954 pubmed publisher
Kim R, Cui Y, Yoo K, Kim I, Lee M, Choi Y, et al. Radiation promotes malignant phenotypes through SRC in breast cancer cells. Cancer Sci. 2015;106:78-85 pubmed publisher
Gomez A, Froemke R, Burden S. Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4. elife. 2014;3:e04287 pubmed publisher
Yuki K, Yoshida Y, Inagaki R, Hiai H, Noda M. E-cadherin-downregulation and RECK-upregulation are coupled in the non-malignant epithelial cell line MCF10A but not in multiple carcinoma-derived cell lines. Sci Rep. 2014;4:4568 pubmed publisher
Zhang Y, Zhao Y, Jiang G, Zhang X, Zhao H, Wu J, et al. Impact of p120-catenin isoforms 1A and 3A on epithelial mesenchymal transition of lung cancer cells expressing E-cadherin in different subcellular locations. PLoS ONE. 2014;9:e88064 pubmed publisher
Chen Y, Pan H, Tseng H, Chu H, Hung Y, Yen Y, et al. Differentiated epithelial- and mesenchymal-like phenotypes in subcutaneous mouse xenografts using diffusion weighted-magnetic resonance imaging. Int J Mol Sci. 2013;14:21943-59 pubmed publisher
Lancaster M, Renner M, Martin C, Wenzel D, Bicknell L, Hurles M, et al. Cerebral organoids model human brain development and microcephaly. Nature. 2013;501:373-9 pubmed publisher
Wang Q, Wang Y, Zhang Y, Zhang Y, Xiao W. The role of uPAR in epithelial-mesenchymal transition in small airway epithelium of patients with chronic obstructive pulmonary disease. Respir Res. 2013;14:67 pubmed publisher
Zhou D, Tan R, Zhou L, Li Y, Liu Y. Kidney tubular ?-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication. Sci Rep. 2013;3:1878 pubmed publisher
Cottard F, Asmane I, Erdmann E, Bergerat J, Kurtz J, Ceraline J. Constitutively active androgen receptor variants upregulate expression of mesenchymal markers in prostate cancer cells. PLoS ONE. 2013;8:e63466 pubmed publisher
BRUSES J. Cell surface localization of ?3?4 nicotinic acetylcholine receptors is regulated by N-cadherin homotypic binding and actomyosin contractility. PLoS ONE. 2013;8:e62435 pubmed publisher
Takeichi M, Nimura K, Mori M, Nakagami H, Kaneda Y. The transcription factors Tbx18 and Wt1 control the epicardial epithelial-mesenchymal transition through bi-directional regulation of Slug in murine primary epicardial cells. PLoS ONE. 2013;8:e57829 pubmed publisher
Ji K, Akgul G, Wollmuth L, Tsirka S. Microglia actively regulate the number of functional synapses. PLoS ONE. 2013;8:e56293 pubmed publisher
Burns J, Collado M, Oliver E, Corwin J. Specializations of intercellular junctions are associated with the presence and absence of hair cell regeneration in ears from six vertebrate classes. J Comp Neurol. 2013;521:1430-48 pubmed publisher
Taylor W, Morley R, Krasavin A, Gregory L, Wilkinson D, Poliakov A. A mechanical model of cell segregation driven by differential adhesion. PLoS ONE. 2012;7:e43226 pubmed publisher
Lin Z, Chu H, Yen Y, Lewis B, Chen Y. Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression. PLoS ONE. 2012;7:e43593 pubmed publisher
Kong X, Li G, Yuan Y, He Y, Wu X, Zhang W, et al. MicroRNA-7 inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via targeting FAK expression. PLoS ONE. 2012;7:e41523 pubmed publisher
Matise L, Palmer T, Ashby W, Nashabi A, Chytil A, Aakre M, et al. Lack of transforming growth factor-? signaling promotes collective cancer cell invasion through tumor-stromal crosstalk. Breast Cancer Res. 2012;14:R98 pubmed publisher
Wu X, Zhu Z, Li W, Fu X, Su D, Fu L, et al. Chromodomain helicase DNA binding protein 5 plays a tumor suppressor role in human breast cancer. Breast Cancer Res. 2012;14:R73 pubmed
Stück E, Christensen R, Huie J, Tovar C, Miller B, Nout Y, et al. Tumor necrosis factor alpha mediates GABA(A) receptor trafficking to the plasma membrane of spinal cord neurons in vivo. Neural Plast. 2012;2012:261345 pubmed publisher
Knopfova L, Benes P, Pekarčíková L, Hermanova M, Masarik M, Pernicová Z, et al. c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis. Mol Cancer. 2012;11:15 pubmed publisher
Deckelbaum R, Holmes G, Zhao Z, Tong C, Basilico C, Loomis C. Regulation of cranial morphogenesis and cell fate at the neural crest-mesoderm boundary by engrailed 1. Development. 2012;139:1346-58 pubmed publisher
Hu P, Chu G, Zhu G, Yang H, Luthringer D, Prins G, et al. Multiplexed quantum dot labeling of activated c-Met signaling in castration-resistant human prostate cancer. PLoS ONE. 2011;6:e28670 pubmed publisher
Thumkeo D, Shinohara R, Watanabe K, Takebayashi H, Toyoda Y, Tohyama K, et al. Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia. PLoS ONE. 2011;6:e25465 pubmed publisher
Sosa García B, Gunduz V, Vázquez Rivera V, Cress W, Wright G, Bian H, et al. A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation. PLoS ONE. 2010;5:e13954 pubmed publisher
Marchong M, Yurkowski C, Ma C, Spencer C, Pajovic S, Gallie B. Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death. PLoS Genet. 2010;6:e1000923 pubmed publisher
Williams H, Johnson J, Jackson C, White S, George S. MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis. Cardiovasc Res. 2010;87:137-46 pubmed publisher
Gundry R, Raginski K, Tarasova Y, Tchernyshyov I, Bausch Fluck D, Elliott S, et al. The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation. Mol Cell Proteomics. 2009;8:2555-69 pubmed publisher
Arnsdorf E, Tummala P, Jacobs C. Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate. PLoS ONE. 2009;4:e5388 pubmed publisher
Maarouf C, Daugs I, Spina S, Vidal R, Kokjohn T, Patton R, et al. Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations. Mol Neurodegener. 2008;3:20 pubmed publisher
Ke X, Qu Y, Goldfinger N, Rostad K, Hovland R, Akslen L, et al. Epithelial to mesenchymal transition of a primary prostate cell line with switches of cell adhesion modules but without malignant transformation. PLoS ONE. 2008;3:e3368 pubmed publisher
Seki T, Namba T, Mochizuki H, Onodera M. Clustering, migration, and neurite formation of neural precursor cells in the adult rat hippocampus. J Comp Neurol. 2007;502:275-90 pubmed
Akins M, Benson D, Greer C. Cadherin expression in the developing mouse olfactory system. J Comp Neurol. 2007;501:483-97 pubmed
product information
Cat.# :
610920
Brand :
BD Transduction Laboratories
Name :
N-Cadherin
Format :
Purified
Clone :
32/N-Cadherin
Isotype :
Ms IgG 1
React :
Hu , Ms , Rat , Chick
Conc :
250 µg/ml
Apps :
IF , WB
Size :
50 µg
Status :
RUO
more info or order :
company information