product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
Smad2/3
catalog :
610842
quantity :
50 µg
price :
207.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
18/Smad2/3
reactivity :
human, mouse, rat, dog
application :
western blot, immunocytochemistry, chromatin immunoprecipitation, other
more info or order :
citations: 25
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 7h
Cyr Depauw C, Northey J, Tabariès S, Annis M, Dong Z, Cory S, et al. Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion. Mol Cell Biol. 2016;36:1509-25 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 1
  • western blot; mouse; fig 1
Dhawan S, Dirice E, Kulkarni R, Bhushan A. Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication. Diabetes. 2016;65:1208-18 pubmed publisher
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • western blot; mouse; 1:350
Bacallao K, Plaza Parrochia F, Cerda A, Gabler F, Romero C, Vantman D, et al. Levels of Regulatory Proteins Associated With Cell Proliferation in Endometria From Untreated Patients Having Polycystic Ovarian Syndrome With and Without Endometrial Hyperplasia. Reprod Sci. 2016;23:211-8 pubmed publisher
  • immunocytochemistry; human; 1:500
  • western blot; human; 1:1000
Carthy J, Sundqvist A, Heldin A, van Dam H, Kletsas D, Heldin C, et al. Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2. J Cell Physiol. 2015;230:3084-92 pubmed publisher
  • western blot; human; fig 4c
Li Y, Drabsch Y, Pujuguet P, Ren J, van Laar T, Zhang L, et al. Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models. Breast Cancer Res. 2015;17:28 pubmed publisher
  • western blot; human; fig 2
Aki S, Yoshioka K, Okamoto Y, Takuwa N, Takuwa Y. Phosphatidylinositol 3-kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells. J Biol Chem. 2015;290:6086-105 pubmed publisher
  • western blot; mouse; fig s4
Scherz Shouval R, Santagata S, Mendillo M, Sholl L, Ben Aharon I, Beck A, et al. The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy. Cell. 2014;158:564-78 pubmed publisher
  • western blot; human
  • western blot; mouse; fig 2
Sakaki Yumoto M, Liu J, Ramalho Santos M, Yoshida N, Derynck R. Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state. J Biol Chem. 2013;288:18546-60 pubmed publisher
  • western blot; mouse
  • western blot; rat
Geng H, Lan R, Singha P, Gilchrist A, Weinreb P, Violette S, et al. Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and G?q-mediated Rho and ?v?6 integrin-dependent activation of TGF-?. Am J Pathol. 2012;181:1236-49 pubmed publisher
  • western blot; mouse; 1:500
Hardee M, Marciscano A, Medina Ramirez C, Zagzag D, Narayana A, Lonning S, et al. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-?. Cancer Res. 2012;72:4119-29 pubmed publisher
Zhang H, Fredericks T, Xiong G, Qi Y, Rychahou P, Li J, et al. Membrane associated collagen XIII promotes cancer metastasis and enhances anoikis resistance. Breast Cancer Res. 2018;20:116 pubmed publisher
Zonneville J, Safina A, Truskinovsky A, Arteaga C, Bakin A. TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association. BMC Cancer. 2018;18:670 pubmed publisher
Fueyo R, Iacobucci S, PAPPA S, Estarás C, Lois S, Vicioso Mantis M, et al. Lineage specific transcription factors and epigenetic regulators mediate TGF?-dependent enhancer activation. Nucleic Acids Res. 2018;46:3351-3365 pubmed publisher
Kawarada Y, Inoue Y, Kawasaki F, Fukuura K, Sato K, Tanaka T, et al. TGF-β induces p53/Smads complex formation in the PAI-1 promoter to activate transcription. Sci Rep. 2016;6:35483 pubmed publisher
Komatsu Y, Ibi M, Chosa N, Kyakumoto S, Kamo M, Shibata T, et al. Zoledronic acid suppresses transforming growth factor-?-induced fibrogenesis by human gingival fibroblasts. Int J Mol Med. 2016;38:139-47 pubmed publisher
García Álvaro M, Addante A, Roncero C, Fernández M, Fabregat I, Sánchez A, et al. BMP9-Induced Survival Effect in Liver Tumor Cells Requires p38MAPK Activation. Int J Mol Sci. 2015;16:20431-48 pubmed publisher
Deglincerti A, Haremaki T, Warmflash A, Sorre B, Brivanlou A. Coco is a dual activity modulator of TGFβ signaling. Development. 2015;142:2678-85 pubmed publisher
Sun G, Hu Z, Min Z, Yan X, Guan Z, Su H, et al. Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor β (TGFβ)-mediated Germ Layer Induction in Xenopus Embryos. J Biol Chem. 2015;290:17239-49 pubmed publisher
Park C, Skarra D, Rivera A, Arriola D, Thackray V. Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes. PLoS ONE. 2014;9:e113839 pubmed publisher
Portela R, Fadl Alla B, Pondenis H, Byrum M, Garrett L, Wycislo K, et al. Pro-tumorigenic effects of transforming growth factor beta 1 in canine osteosarcoma. J Vet Intern Med. 2014;28:894-904 pubmed publisher
Serrano I, McDonald P, Lock F, Muller W, Dedhar S. Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase. Nat Commun. 2013;4:2976 pubmed publisher
Zhang S, Li J, Lea R, Amaya E, Dorey K. A functional genome-wide in vivo screen identifies new regulators of signalling pathways during early Xenopus embryogenesis. PLoS ONE. 2013;8:e79469 pubmed publisher
Herrera B, García Álvaro M, Cruz S, Walsh P, Fernandez M, Roncero C, et al. BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells. PLoS ONE. 2013;8:e69535 pubmed publisher
Patsialou A, Wang Y, Lin J, Whitney K, Goswami S, Kenny P, et al. Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. Breast Cancer Res. 2012;14:R139 pubmed publisher
product information
Cat.# :
610842
Brand :
BD Transduction Laboratories
Name :
Smad2/3
Format :
Purified
Clone :
18/Smad2/3
Isotype :
Ms IgG 1
React :
Hu , Ms , Rat , Dog
Conc :
250 µg/ml
Apps :
IF , WB
Size :
50 µg
Status :
RUO
List Price :
207.00 USD
more info or order :
company information