Published Application/Species/Sample/Dilution | Reference |
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- western blot; human; 1:500; loading ...; fig 6b
| Sangwan S, Sahay S, Murray K, Morgan S, Guenther E, Jiang L, et al. Inhibition of synucleinopathic seeding by rationally designed inhibitors. elife. 2020;9: pubmed publisher
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- immunocytochemistry; rat; 1:500; loading ...; fig s4a
| Ludtmann M, Angelova P, Horrocks M, Choi M, Rodrigues M, Baev A, et al. α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease. Nat Commun. 2018;9:2293 pubmed publisher
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- immunocytochemistry; human; loading ...; fig 1b
- western blot; human; 1:2000; loading ...; fig 1a
| Aprile F, Källstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C. The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation. Sci Rep. 2017;7:9039 pubmed publisher
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- immunohistochemistry; rat; loading ...; fig 6c
| de Oliveira R, Vicente Miranda H, Francelle L, Pinho R, Szego E, Martinho R, et al. The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biol. 2017;15:e2000374 pubmed publisher
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- western blot; rat; 1:2000; loading ...; fig 6a
| Roberts H, Schneider B, Brown D. α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP. PLoS ONE. 2017;12:e0171925 pubmed publisher
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- western blot; human; fig 1
| Jiang P, Gan M, Yen S, McLean P, Dickson D. Histones facilitate α-synuclein aggregation during neuronal apoptosis. Acta Neuropathol. 2017;133:547-558 pubmed publisher
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- western blot; mouse; 1:1000; fig 3g
| Sambri I, D Alessio R, Ezhova Y, Giuliano T, Sorrentino N, Cacace V, et al. Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases. EMBO Mol Med. 2017;9:112-132 pubmed publisher
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- western blot; human; loading ...; fig 2b
| Watanabe Y, Tsujimura A, Taguchi K, Tanaka M. HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis. Autophagy. 2017;13:133-148 pubmed publisher
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- western blot; rat; loading ...; fig 4a
| Cóppola Segovia V, Cavarsan C, Maia F, Ferraz A, Nakao L, Lima M, et al. ER Stress Induced by Tunicamycin Triggers ?-Synuclein Oligomerization, Dopaminergic Neurons Death and Locomotor Impairment: a New Model of Parkinson's Disease. Mol Neurobiol. 2017;54:5798-5806 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 3a
- western blot; mouse; 1:1000; loading ...; fig 3a
| Zha J, Liu X, Zhu J, Liu S, Lu S, Xu P, et al. A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses. Sci Rep. 2016;6:36631 pubmed publisher
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- immunocytochemistry; human; 1:1000; loading ...; fig 1d
| Kuan W, Bennett N, He X, Skepper J, Martynyuk N, Wijeyekoon R, et al. ?-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function. Exp Neurol. 2016;285:72-81 pubmed publisher
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- western blot; mouse; loading ...; fig 2b
| Emanuele M, Esposito A, Camerini S, Antonucci F, Ferrara S, Seghezza S, et al. Exogenous Alpha-Synuclein Alters Pre- and Post-Synaptic Activity by Fragmenting Lipid Rafts. EBioMedicine. 2016;7:191-204 pubmed publisher
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- immunocytochemistry; human; 1:1000; loading ...; fig 1b
- western blot; human; loading ...; fig 1d
| Tatenhorst L, Eckermann K, Dambeck V, Fonseca Ornelas L, Walle H, Lopes da Fonseca T, et al. Fasudil attenuates aggregation of ?-synuclein in models of Parkinson's disease. Acta Neuropathol Commun. 2016;4:39 pubmed publisher
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- western blot; human; fig 1b
| Jiang P, Gan M, Yen S, Moussaud S, McLean P, Dickson D. Proaggregant nuclear factor(s) trigger rapid formation of ?-synuclein aggregates in apoptotic neurons. Acta Neuropathol. 2016;132:77-91 pubmed publisher
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- immunocytochemistry; human; 1:400; fig 1
- western blot; human; 1:1000; fig 1
| Oliveira L, Falomir Lockhart L, Botelho M, Lin K, Wales P, Koch J, et al. Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells. Cell Death Dis. 2015;6:e1994 pubmed publisher
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- western blot; human; 1:500; fig ev3
| Fernández Santiago R, Carballo Carbajal I, Castellano G, Torrent R, Richaud Y, Sánchez Danés A, et al. Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients. EMBO Mol Med. 2015;7:1529-46 pubmed publisher
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- western blot; human; 1:5000; loading ...; fig 4
| Pieri L, Chafey P, Le Gall M, Clary G, Melki R, Redeker V. Cellular response of human neuroblastoma cells to α-synuclein fibrils, the main constituent of Lewy bodies. Biochim Biophys Acta. 2016;1860:8-19 pubmed publisher
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- western blot; human; 1:1500; fig 3
| Bae E, Yang N, Lee C, Kim S, Lee H, Lee S. Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates. Cell Death Dis. 2015;6:e1901 pubmed publisher
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- immunohistochemistry; human; 1:7000; fig 1b
| Prusiner S, Woerman A, Mordes D, Watts J, Rampersaud R, Berry D, et al. Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc Natl Acad Sci U S A. 2015;112:E5308-17 pubmed publisher
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- western blot; human; fig 1
| Koch J, Bitow F, Haack J, D Hedouville Z, Zhang J, Tönges L, et al. Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons. Cell Death Dis. 2015;6:e1811 pubmed publisher
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- western blot; human; 1:3000; fig 2
- western blot; rat; 1:400; fig 1
| Dettmer U, Newman A, Soldner F, Luth E, Kim N, von Saucken V, et al. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015;6:7314 pubmed publisher
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- western blot; Japanese rice fish; 1:2000; fig 3
| Uemura N, Koike M, Ansai S, Kinoshita M, Ishikawa Fujiwara T, Matsui H, et al. Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein. PLoS Genet. 2015;11:e1005065 pubmed publisher
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- immunoprecipitation; swine; loading ...; fig 3
- western blot; swine; loading ...; fig 1d,3
- immunoprecipitation; human; loading ...; fig 3
- western blot; human; loading ...; fig 1c
| Betzer C, Movius A, Shi M, Gai W, Zhang J, Jensen P. Identification of synaptosomal proteins binding to monomeric and oligomeric α-synuclein. PLoS ONE. 2015;10:e0116473 pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:7000
| Yang Y, Shepherd C, Halliday G. Aneuploidy in Lewy body diseases. Neurobiol Aging. 2015;36:1253-60 pubmed publisher
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| Ronzitti G, Bucci G, Emanuele M, Leo D, Sotnikova T, Mus L, et al. Exogenous ?-synuclein decreases raft partitioning of Cav2.2 channels inducing dopamine release. J Neurosci. 2014;34:10603-15 pubmed publisher
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- western blot; mouse; 1:1000
| Zondler L, Miller Fleming L, Repici M, Goncalves S, Tenreiro S, Rosado Ramos R, et al. DJ-1 interactions with ?-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease. Cell Death Dis. 2014;5:e1350 pubmed publisher
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- western blot; mouse; 1:5000
| Subramaniam S, Vergnes L, Franich N, Reue K, Chesselet M. Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein. Neurobiol Dis. 2014;70:204-13 pubmed publisher
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| Tsika E, Glauser L, Moser R, Fiser A, Daniel G, Sheerin U, et al. Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Hum Mol Genet. 2014;23:4621-38 pubmed publisher
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- western blot; human; loading ...; fig 1c
| Murphy K, Gysbers A, Abbott S, Tayebi N, Kim W, Sidransky E, et al. Reduced glucocerebrosidase is associated with increased ?-synuclein in sporadic Parkinson's disease. Brain. 2014;137:834-48 pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:500; fig 4
| Bodi I, Curran O, Selway R, Elwes R, Burrone J, Laxton R, et al. Two cases of multinodular and vacuolating neuronal tumour. Acta Neuropathol Commun. 2014;2:7 pubmed publisher
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- immunohistochemistry - frozen section; rat; 1:100; loading ...; fig 8
| Pienaar I, Harrison I, Elson J, Bury A, Woll P, Simon A, et al. An animal model mimicking pedunculopontine nucleus cholinergic degeneration in Parkinson's disease. Brain Struct Funct. 2015;220:479-500 pubmed publisher
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- western blot; human; 1:1000; fig 2
- western blot; rat; 1:1000
| Yang W, Wang X, Duan C, Lu L, Yang H. Alpha-synuclein overexpression increases phospho-protein phosphatase 2A levels via formation of calmodulin/Src complex. Neurochem Int. 2013;63:180-94 pubmed publisher
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| Mandemakers W, Abuhatzira L, Xu H, Caromile L, Hébert S, Snellinx A, et al. Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 ?: identification of miR-153 target genes with functions related to IA-2? in pancreas and brain. Diabetologia. 2013;56:1547-56 pubmed publisher
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- western blot; mouse; 1:500; fig s1
| Kurz A, Double K, Lastres Becker I, Tozzi A, Tantucci M, Bockhart V, et al. A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice. PLoS ONE. 2010;5:e11464 pubmed publisher
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| Ryan T, Bamm V, Stykel M, Coackley C, Humphries K, Jamieson Williams R, et al. Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. Nat Commun. 2018;9:817 pubmed publisher
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| Zunke F, Moise A, Belur N, Gelyana E, Stojkovska I, Dzaferbegovic H, et al. Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide. Neuron. 2018;97:92-107.e10 pubmed publisher
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| Kim H, Ham S, Jo M, Lee G, Lee Y, Shin J, et al. CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation. Int J Mol Sci. 2017;18: pubmed publisher
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| Pathak D, Berthet A, Bendor J, Yu K, Sellnow R, Orr A, et al. Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. Eneuro. 2017;4: pubmed publisher
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| Guhathakurta S, Evangelista B, Ghosh S, Basu S, Kim Y. Hypomethylation of intron1 of ?-synuclein gene does not correlate with Parkinson's disease. Mol Brain. 2017;10:6 pubmed publisher
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| Pieri L, Madiona K, Melki R. Structural and functional properties of prefibrillar ?-synuclein oligomers. Sci Rep. 2016;6:24526 pubmed publisher
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| Davis M, Trinh K, Thomas R, Yu S, Germanos A, Whitley B, et al. Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration. PLoS Genet. 2016;12:e1005944 pubmed publisher
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| Delenclos M, Trendafilova T, Jones D, Moussaud S, Baine A, Yue M, et al. A Rapid, Semi-Quantitative Assay to Screen for Modulators of Alpha-Synuclein Oligomerization Ex vivo. Front Neurosci. 2015;9:511 pubmed publisher
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| Brahic M, Bousset L, Bieri G, Melki R, Gitler A. Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1. Acta Neuropathol. 2016;131:539-48 pubmed publisher
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| Liu L, Song J, Lu J, Huang Y, Zeng Y, Chen L, et al. Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson's disease. Sci Rep. 2015;5:16862 pubmed publisher
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| Van Kampen J, Baranowski D, Robertson H, Shaw C, Kay D. The Progressive BSSG Rat Model of Parkinson's: Recapitulating Multiple Key Features of the Human Disease. PLoS ONE. 2015;10:e0139694 pubmed publisher
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| Eggers S, Horn A, Roeber S, Härtig W, Nair G, Reich D, et al. Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets. PLoS ONE. 2015;10:e0132075 pubmed publisher
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| Ysselstein D, Joshi M, Mishra V, Griggs A, Asiago J, McCabe G, et al. Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicity. Neurobiol Dis. 2015;79:150-63 pubmed publisher
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| Bae E, Yang N, Lee C, Lee H, Kim S, Sardi S, et al. Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation. Exp Mol Med. 2015;47:e153 pubmed publisher
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| Bae E, Lee C, Lee H, Kim S, Lee S. ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter α-Synuclein Metabolism in SH-SY5Y Cells. Exp Neurobiol. 2014;23:365-71 pubmed publisher
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| Betemps D, Verchère J, Brot S, Morignat E, Bousset L, Gaillard D, et al. Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological ?-synuclein by enhanced ELISA. Acta Neuropathol Commun. 2014;2:29 pubmed publisher
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| Howitt J, Gysbers A, Ayton S, Carew Jones F, Putz U, Finkelstein D, et al. Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels. PLoS ONE. 2014;9:e87119 pubmed publisher
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| Murphy K, Cottle L, Gysbers A, Cooper A, Halliday G. ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies. Acta Neuropathol Commun. 2013;1:11 pubmed publisher
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| Farrell K, Krishnamachari S, Villanueva E, Lou H, Alerte T, Peet E, et al. Non-motor parkinsonian pathology in aging A53T ?-synuclein mice is associated with progressive synucleinopathy and altered enzymatic function. J Neurochem. 2014;128:536-46 pubmed publisher
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| Oaks A, Frankfurt M, Finkelstein D, Sidhu A. Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function. PLoS ONE. 2013;8:e60378 pubmed publisher
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| Sekigawa A, Fujita M, Sekiyama K, Takamatsu Y, Hatano T, Rockenstein E, et al. Distinct mechanisms of axonal globule formation in mice expressing human wild type ?-synuclein or dementia with Lewy bodies-linked P123H ?-synuclein. Mol Brain. 2012;5:34 pubmed publisher
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| Devine M, Ryten M, Vodicka P, Thomson A, Burdon T, Houlden H, et al. Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus. Nat Commun. 2011;2:440 pubmed publisher
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| Pierre S, Lemmens M, Figueiredo Pereira M. Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice. J Neuroinflammation. 2009;6:18 pubmed publisher
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| Moran L, Hickey L, Michael G, Derkacs M, Christian L, Kalaitzakis M, et al. Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies. Acta Neuropathol. 2008;115:471-8 pubmed
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| Olzmann J, Bordelon J, Muly E, Rees H, Levey A, Li L, et al. Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. J Comp Neurol. 2007;500:585-99 pubmed
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