| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry knockout validation; mouse; 1:200; fig 1e
- western blot knockout validation; mouse; fig 1c
- immunohistochemistry - paraffin section; mouse; 1:200; fig 1e
| Maddala R, Chauhan B, Walker C, Zheng Y, Robinson M, Lang R, et al. Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. Dev Biol. 2011;360:30-43 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2a
| Shang P, Stepicheva N, Teel K, McCauley A, Fitting C, Hose S, et al. βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells. Commun Biol. 2021;4:850 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3c
| Polacheck W, Kutys M, Yang J, Eyckmans J, Wu Y, Vasavada H, et al. A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature. 2017;552:258-262 pubmed publisher |
- western blot; human; loading ...; fig 1b
| Ruhe F, Olling A, Abromeit R, Rataj D, Grieschat M, Zeug A, et al. Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB. Front Cell Infect Microbiol. 2017;7:67 pubmed publisher |
- western blot; human; loading ...; fig 6a
| Eppler F, Quast T, Kolanus W. Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion. PLoS ONE. 2017;12:e0172443 pubmed publisher |
- western blot; human; loading ...; fig s3c
| Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, et al. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016;538:350-355 pubmed publisher |
- western blot; human; loading ...; fig 5b
| Frank S, Köllmann C, van Lidth de Jeude J, Thiagarajah J, Engelholm L, Frödin M, et al. The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion. Oncogene. 2017;36:1816-1828 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Blas Rus N, Bustos Morán E, Perez de Castro I, de Carcer G, Borroto A, Camafeita E, et al. Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat Commun. 2016;7:11389 pubmed publisher |
- western blot; hamsters; loading ...; fig 3e
| Estevez B, Kim K, Delaney M, Stojanovic Terpo A, Shen B, Ruan C, et al. Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation. Blood. 2016;127:626-36 pubmed publisher |
- western blot; human; fig 3
| Hwang D, Kohl S, Fan X, Vivante A, Chan S, Dworschak G, et al. Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract. Hum Genet. 2015;134:905-16 pubmed publisher |
- western blot; human; fig 4
| Grikscheit K, Frank T, Wang Y, Grosse R. Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1. J Cell Biol. 2015;209:367-76 pubmed publisher |
- western blot; mouse; 1:1000; fig 4
| Lu J, Luo C, Bali K, Xie R, Mains R, Eipper B, et al. A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses. Nat Commun. 2015;6:6820 pubmed publisher |
- immunocytochemistry; human; fig 6
- western blot; human; fig 7
| Giehl K, Keller C, Muehlich S, Goppelt Struebe M. Actin-mediated gene expression depends on RhoA and Rac1 signaling in proximal tubular epithelial cells. PLoS ONE. 2015;10:e0121589 pubmed publisher |
- western blot; human; fig 5
| Zhu G, Fan Z, Ding M, Mu L, Liang J, Ding Y, et al. DNA damage induces the accumulation of Tiam1 by blocking ?-TrCP-dependent degradation. J Biol Chem. 2014;289:15482-94 pubmed publisher |
| Barbosa S, Greville Heygate S, Bonnet M, Godwin A, Fagotto Kaufmann C, Kajava A, et al. Opposite Modulation of RAC1 by Mutations in TRIO Is Associated with Distinct, Domain-Specific Neurodevelopmental Disorders. Am J Hum Genet. 2020;106:338-355 pubmed publisher |
| Adame García S, Cervantes Villagrana R, Orduña Castillo L, Del Rio J, Gutkind J, Reyes Cruz G, et al. cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits. J Biol Chem. 2019;294:2232-2246 pubmed publisher |
| Tam J, Hamza T, Ma B, Chen K, Beilhartz G, Ravel J, et al. Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota. Nat Commun. 2018;9:5233 pubmed publisher |
| Bai Y, Guo D, Sun X, Tang G, Liao T, Peng Y, et al. Balanced Rac1 activity controls formation and maintenance of neuromuscular acetylcholine receptor clusters. J Cell Sci. 2018;131: pubmed publisher |
| Chang W, Liu Y, Dang Y, Jiang X, Xu H, Huang X, et al. PLAC8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration. Development. 2018;145: pubmed publisher |
| Liu Y, Dhall S, Castro A, Chan A, Alamat R, Martins Green M. Insulin regulates multiple signaling pathways leading to monocyte/macrophage chemotaxis into the wound tissue. Biol Open. 2018;7: pubmed publisher |
| Mody H, Hung S, Naidu K, Lee H, Gilbert C, Hoang T, et al. SET contributes to the epithelial-mesenchymal transition of pancreatic cancer. Oncotarget. 2017;8:67966-67979 pubmed publisher |
| Sayedyahossein S, Xu S, Rudkouskaya A, McGavin M, McCormick J, Dagnino L. Staphylococcus aureus keratinocyte invasion is mediated by integrin-linked kinase and Rac1. FASEB J. 2015;29:711-23 pubmed publisher |
| André G, Sandoval J, Retailleau K, Loufrani L, Toumaniantz G, Offermanns S, et al. Smooth muscle specific Rac1 deficiency induces hypertension by preventing p116RIP3-dependent RhoA inhibition. J Am Heart Assoc. 2014;3:e000852 pubmed publisher |
| Yoon S, Han E, Choi Y, Kee H, Jeong Y, Yoon J, et al. Inhibition of cell proliferation and migration by miR-509-3p that targets CDK2, Rac1, and PIK3C2A. Mol Cells. 2014;37:314-21 pubmed publisher |
| Taha M, Nouri K, Milroy L, Moll J, Herrmann C, Brunsveld L, et al. Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. PLoS ONE. 2014;9:e91465 pubmed publisher |
| Weidemann A, Breyer J, Rehm M, Eckardt K, Daniel C, Cicha I, et al. HIF-1? activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells. Cell Commun Signal. 2013;11:80 pubmed publisher |
| de Kreuk B, Schaefer A, Anthony E, Tol S, Fernandez Borja M, Geerts D, et al. The human minor histocompatibility antigen 1 is a RhoGAP. PLoS ONE. 2013;8:e73962 pubmed publisher |
| Murk K, Blanco Suarez E, Cockbill L, Banks P, Hanley J. The antagonistic modulation of Arp2/3 activity by N-WASP, WAVE2 and PICK1 defines dynamic changes in astrocyte morphology. J Cell Sci. 2013;126:3873-83 pubmed publisher |
| Veland I, Montjean R, Eley L, Pedersen L, Schwab A, Goodship J, et al. Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration. PLoS ONE. 2013;8:e60193 pubmed publisher |
| Han G, Bian L, Li F, Cotrim A, Wang D, Lu J, et al. Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis. Nat Med. 2013;19:421-8 pubmed publisher |
| Brooks R, Williamson R, Bass M. Syndecan-4 independently regulates multiple small GTPases to promote fibroblast migration during wound healing. Small Gtpases. 2012;3:73-9 pubmed publisher |
| ten Klooster J, Jaffer Z, Chernoff J, Hordijk P. Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol. 2006;172:759-69 pubmed |
