product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
ROCK-II
catalog :
610623
quantity :
50 µg
price :
207.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
21/ROCK-II
reactivity :
human, mouse, rat, dog
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 10
Published Application/Species/Sample/DilutionReference
  • western blot; dog; 1:2000; loading ...; fig 6a
Raya Sandino A, Castillo Kauil A, Domínguez Calderón A, Alarcón L, Flores Benitez D, Cuellar Perez F, et al. Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function. Biochim Biophys Acta Mol Cell Res. 2017;1864:1714-1733 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 7fs1
Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson Peer K, et al. YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. elife. 2017;6: pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 1a
  • western blot; human; fig 2c
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 1f
Rath N, Morton J, Julian L, Helbig L, Kadir S, McGhee E, et al. ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. EMBO Mol Med. 2017;9:198-218 pubmed publisher
  • western blot; human; 1:300; fig s4h-i
Priya R, Gomez G, Budnar S, Verma S, Cox H, Hamilton N, et al. Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions. Nat Cell Biol. 2015;17:1282-93 pubmed publisher
  • western blot; mouse; fig 3
Arroyo A, Camoletto P, Morando L, Sassoè Pognetto M, Giustetto M, Van Veldhoven P, et al. Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model. EMBO Mol Med. 2014;6:398-413 pubmed publisher
Georgouli M, Herraiz C, Crosas Molist E, Fanshawe B, Maiques O, Perdrix A, et al. Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment. Cell. 2019;176:757-774.e23 pubmed publisher
Eisler S, Curado F, Link G, Schulz S, Noack M, Steinke M, et al. A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions. elife. 2018;7: pubmed publisher
Thuault S, Comunale F, Hasna J, Fortier M, Planchon D, Elarouci N, et al. The RhoE/ROCK/ARHGAP25 signaling pathway controls cell invasion by inhibition of Rac activity. Mol Biol Cell. 2016;27:2653-61 pubmed publisher
Aguilar H, Tracey C, Zielnik B, Mitchell B. Rho-kinase mediates diphosphorylation of myosin regulatory light chain in cultured uterine, but not vascular smooth muscle cells. J Cell Mol Med. 2012;16:2978-89 pubmed publisher
Heikkilä T, Wheatley E, Crighton D, Schröder E, Boakes A, Kaye S, et al. Co-crystal structures of inhibitors with MRCK?, a key regulator of tumor cell invasion. PLoS ONE. 2011;6:e24825 pubmed publisher
product information
Cat.# :
610623
Brand :
BD Transduction Laboratories
Name :
ROCK-II
Format :
Purified
Clone :
21/ROCK-II
Isotype :
Ms IgG 1
React :
Hu , Ms , Rat , Dog
Conc :
250 µg/ml
Apps :
IF , IHC , IP , WB
Size :
50 µg
Status :
RUO
List Price :
207.00 USD
more info or order :
company information