product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
Caveolin 1
catalog :
610406
quantity :
50 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2297/Caveolin 1
reactivity :
African green monkey, human, mouse, rat, dogs, chicken
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section, western blot knockout validation, immunohistochemistry knockout validation
more info or order :
citations: 39
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 1a
  • western blot knockout validation; mouse; loading ...; fig 3b
Lim J, Nguyen K, Han J, Jang I, Fabian C, Cho K. Direct Regulation of TLR5 Expression by Caveolin-1. Mol Cells. 2015;38:1111-7 pubmed publisher
  • western blot; human; fig 1
  • western blot knockout validation; mouse; fig 1
Li W, Liu H, Zhou J, Cao J, Zhou X, Choi A, et al. Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2). J Biol Chem. 2012;287:20922-30 pubmed publisher
  • immunohistochemistry knockout validation; mouse; 1:100; fig 1
El Yazbi A, Cho W, Cena J, Schulz R, Daniel E. Smooth muscle NOS, colocalized with caveolin-1, modulates contraction in mouse small intestine. J Cell Mol Med. 2008;12:1404-15 pubmed publisher
  • western blot; human; loading ...; fig 4d
Lin C, Huang P, Chen C, Wu M, Chen J, Chen J, et al. Sitagliptin attenuates arterial calcification by downregulating oxidative stress-induced receptor for advanced glycation end products in LDLR knockout mice. Sci Rep. 2021;11:17851 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 1c, 1d
Ded L, Hwang J, Miki K, Shi H, Chung J. 3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice. elife. 2020;9: pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 1a
Rangel L, Bernabé Rubio M, Fernández Barrera J, Casares Arias J, Millan J, Alonso M, et al. Caveolin-1α regulates primary cilium length by controlling RhoA GTPase activity. Sci Rep. 2019;9:1116 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig s4d
Maurya D, Bohm S, Alenius M. Hedgehog signaling regulates ciliary localization of mouse odorant receptors. Proc Natl Acad Sci U S A. 2017;114:E9386-E9394 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3c
Song Z, Xiaoli A, Zhang Q, Zhang Y, Yang E, Wang S, et al. Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein ?. J Biol Chem. 2017;292:8918-8932 pubmed publisher
  • immunohistochemistry; mouse; loading ...
Otis J, Shen M, Quinlivan V, Anderson J, Farber S. Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels. Dis Model Mech. 2017;10:283-295 pubmed publisher
  • western blot; human; loading ...; fig 1d
Parag Sharma K, Leyme A, DiGiacomo V, Marivin A, Broselid S, Garcia Marcos M. Membrane Recruitment of the Non-receptor Protein GIV/Girdin (G?-interacting, Vesicle-associated Protein/Girdin) Is Sufficient for Activating Heterotrimeric G Protein Signaling. J Biol Chem. 2016;291:27098-27111 pubmed publisher
  • immunocytochemistry; mouse; 1:200; fig 6
Hersrud S, Kovács A, Pearce D. Antigen presenting cell abnormalities in the Cln3(-/-) mouse model of juvenile neuronal ceroid lipofuscinosis. Biochim Biophys Acta. 2016;1862:1324-36 pubmed publisher
  • immunohistochemistry; dogs; 5 ug/ml; fig 5
Bach F, Zhang Y, Miranda Bedate A, Verdonschot L, Bergknut N, Creemers L, et al. Increased caveolin-1 in intervertebral disc degeneration facilitates repair. Arthritis Res Ther. 2016;18:59 pubmed publisher
  • western blot; human; 1:1000; fig 5C
Lin C, Huang P, Lai C, Chen J, Lin S, Chen J. Simvastatin Attenuates Oxidative Stress, NF-κB Activation, and Artery Calcification in LDLR-/- Mice Fed with High Fat Diet via Down-regulation of Tumor Necrosis Factor-α and TNF Receptor 1. PLoS ONE. 2015;10:e0143686 pubmed publisher
  • immunocytochemistry; human; loading ...; fig s5b
Albecka A, Laine R, Janssen A, Kaminski C, Crump C. HSV-1 Glycoproteins Are Delivered to Virus Assembly Sites Through Dynamin-Dependent Endocytosis. Traffic. 2016;17:21-39 pubmed publisher
  • western blot; human
Jang D, Kwon H, Jeong K, Lee J, Pak Y. Essential role of flotillin-1 palmitoylation in the intracellular localization and signaling function of IGF-1 receptor. J Cell Sci. 2015;128:2179-90 pubmed publisher
  • western blot; human; fig 2
Kwon H, Lee J, Jeong K, Jang D, Pak Y. Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation. Biochim Biophys Acta. 2015;1853:1022-34 pubmed publisher
  • western blot; African green monkey; loading ...; fig 3c
  • western blot; human; loading ...; fig 7b
Han B, Tiwari A, Kenworthy A. Tagging strategies strongly affect the fate of overexpressed caveolin-1. Traffic. 2015;16:417-38 pubmed publisher
  • western blot; human
Lim H, Multhaupt H, Couchman J. Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells. Mol Cancer. 2015;14:15 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:250; fig 1
  • western blot; rat; 1:2000; fig 4
Traini C, Faussone Pellegrini M, Evangelista S, Mazzaferro K, Cipriani G, Santicioli P, et al. Inner and outer portions of colonic circular muscle: ultrastructural and immunohistochemical changes in rat chronically treated with otilonium bromide. PLoS ONE. 2014;9:e103237 pubmed publisher
  • immunohistochemistry - frozen section; chicken
Thomas P, Cheng A, Colby C, Liu L, Patel C, Josephs L, et al. Localization and proteomic characterization of cholesterol-rich membrane microdomains in the inner ear. J Proteomics. 2014;103:178-93 pubmed publisher
  • western blot; African green monkey
Wehmeyer L, Du Toit A, Lang D, Hapgood J. Lipid raft- and protein kinase C-mediated synergism between glucocorticoid- and gonadotropin-releasing hormone signaling results in decreased cell proliferation. J Biol Chem. 2014;289:10235-51 pubmed publisher
  • western blot; mouse; fig 4
Tan S, Shui G, Zhou J, Shi Y, Huang J, Xia D, et al. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy. 2014;10:226-42 pubmed publisher
  • western blot; human
Linderoth E, Pilia G, Mahajan N, Ferby I. Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death. J Biol Chem. 2013;288:32922-31 pubmed publisher
  • western blot; human
Avena P, Anselmo W, Whitaker Menezes D, Wang C, Pestell R, Lamb R, et al. Compartment-specific activation of PPAR? governs breast cancer tumor growth, via metabolic reprogramming and symbiosis. Cell Cycle. 2013;12:1360-70 pubmed publisher
  • western blot; mouse
Rahman A, Ekman M, Shakirova Y, Andersson K, Morgelin M, Erjefalt J, et al. Late onset vascular dysfunction in the R6/1 model of Huntington's disease. Eur J Pharmacol. 2013;698:345-53 pubmed publisher
  • immunohistochemistry - frozen section; rat
Takahashi Iwanaga H, Iwanaga T. Accumulated caveolae constitute subcellular compartments for glial calcium signaling in lanceolate sensory endings innervating rat vibrissae. J Comp Neurol. 2012;520:2053-66 pubmed publisher
Han B, Copeland C, Kawano Y, Rosenzweig E, Austin E, Shahmirzadi L, et al. Characterization of a caveolin-1 mutation associated with both pulmonary arterial hypertension and congenital generalized lipodystrophy. Traffic. 2016;17:1297-1312 pubmed publisher
Fiering S, Ang L, Lacoste J, Smith T, Griner E. Registered report: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. elife. 2015;4:e04796 pubmed publisher
Pugh S, MacDougall D, Agarwal S, Harvey R, Porter K, Calaghan S. Caveolin contributes to the modulation of basal and β-adrenoceptor stimulated function of the adult rat ventricular myocyte by simvastatin: a novel pleiotropic effect. PLoS ONE. 2014;9:e106905 pubmed publisher
Chen Z, Cao J, Zhou J, Liu H, Che L, Mizumura K, et al. Interaction of caveolin-1 with ATG12-ATG5 system suppresses autophagy in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2014;306:L1016-25 pubmed publisher
Getty A, Kovács A, Lengyel Nelson T, Cardillo A, Hof C, Chan C, et al. Osmotic stress changes the expression and subcellular localization of the Batten disease protein CLN3. PLoS ONE. 2013;8:e66203 pubmed publisher
Hitkova I, Yuan G, Anderl F, Gerhard M, Kirchner T, Reu S, et al. Caveolin-1 protects B6129 mice against Helicobacter pylori gastritis. PLoS Pathog. 2013;9:e1003251 pubmed publisher
Capparelli C, Chiavarina B, Whitaker Menezes D, Pestell T, Pestell R, Hulit J, et al. CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Cell Cycle. 2012;11:3599-610 pubmed publisher
Capparelli C, Guido C, Whitaker Menezes D, Bonuccelli G, Balliet R, Pestell T, et al. Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Cell Cycle. 2012;11:2285-302 pubmed publisher
Surgucheva I, Surguchov A. Expression of caveolin in trabecular meshwork cells and its possible implication in pathogenesis of primary open angle glaucoma. Mol Vis. 2011;17:2878-88 pubmed
Kozera L, White E, Calaghan S. Caveolae act as membrane reserves which limit mechanosensitive I(Cl,swell) channel activation during swelling in the rat ventricular myocyte. PLoS ONE. 2009;4:e8312 pubmed publisher
Robenek H, Weissen Plenz G, Severs N. Freeze-fracture replica immunolabelling reveals caveolin-1 in the human cardiomyocyte plasma membrane. J Cell Mol Med. 2008;12:2519-21 pubmed publisher
Heathfield S, Le Maitre C, Hoyland J. Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration. Arthritis Res Ther. 2008;10:R87 pubmed publisher
Cho W, Chow A, Schulz R, Daniel E. Matrix metalloproteinase-2, caveolins, focal adhesion kinase and c-Kit in cells of the mouse myocardium. J Cell Mol Med. 2007;11:1069-86 pubmed
product information
Cat.# :
610406
Brand :
BD Transduction Laboratories
Name :
Caveolin 1
Format :
Purified
Clone :
2297/Caveolin 1
Isotype :
Ms IgG 1
React :
Hu , Ms , Rat , Dog , Chick
Conc :
250 µg/ml
Apps :
IF , IHC , IP , WB
Size :
50 µg
Status :
RUO
more info or order :
company information